T. Ritschel

发表

Statin-Induced Myopathy Is Associated with Mitochondrial Complex III Inhibition.

R. Rodenburg, B. V. van Engelen, J. Smeitink, 2015, Cell metabolism.

Mitochondrial ADP/ATP exchange inhibition: a novel off-target mechanism underlying ibipinabant-induced myotoxicity

J. Smeitink, F. Russel, P. Willems, 2015, Scientific Reports.

Snooker Structure-Based Pharmacophore Model Explains Differences in Agonist and Blocker Binding to Bitter Receptor hTAS2R39

Marijn P. A. Sanders, J. Vincken, H. Gruppen, 2015, PloS one.

Involvement of a Hydrophobic Pocket and Helix 11 in Determining the Modes of Action of Prenylated Flavonoids and Isoflavonoids in the Human Estrogen Receptor

J. Vincken, H. Gruppen, M. Sanders, 2015, Chembiochem : a European journal of chemical biology.

Insight into the complete substrate-binding pocket of ThiT by chemical and genetic mutations.

S. Marrink, I. Faustino, D. Slotboom, 2017, MedChemComm.

Studying thiamine binding to ThiT using chemical and biochemical mutations

S. Marrink, I. Faustino, D. Slotboom, 2016 .

Potent inhibitors of tRNA-guanine transglycosylase, an enzyme linked to the pathogenicity of the Shigella bacterium: charge-assisted hydrogen bonding.

G. Klebe, F. Diederich, M. Kansy, 2007, Angewandte Chemie.

An integrative approach combining noncovalent mass spectrometry, enzyme kinetics and X-ray crystallography to decipher Tgt protein-protein and protein-RNA interaction.

G. Klebe, K. Reuter, A. van Dorsselaer, 2009, Journal of molecular biology.

High-affinity inhibitors of tRNA-guanine transglycosylase replacing the function of a structural water cluster.

G. Klebe, F. Diederich, W. Schweizer, 2009, Chemistry.

Stabilizing the closed SARS-CoV-2 spike trimer

L. Renault, J. Juraszek, J. Langedijk, 2020, Nature Communications.

From lin-benzoguanines to lin-benzohypoxanthines as ligands for Zymomonas mobilis tRNA-guanine transglycosylase: replacement of protein-ligand hydrogen bonding by importing water clusters.

Luzi J. Barandun, G. Klebe, F. Diederich, 2012, Chemistry.

Structural basis for recognition of the central conserved region of RSV G by neutralizing human antibodies

A. B. van 't Wout, J. McLellan, D. Roymans, 2018, PLoS pathogens.

Molecular interaction fingerprint approaches for GPCR drug discovery.

Tina Ritschel, Márton Vass, Chris de Graaf, 2016, Current opinion in pharmacology.

Current progress in Structure-Based Rational Drug Design marks a new mindset in drug discovery

Tina Ritschel, Ross McGuire, Nicolas Foloppe, 2018 .

Pharmacophore Fingerprint-Based Approach to Binding Site Subpocket Similarity and Its Application to Bioisostere Replacement

Tina Ritschel, David J. Wood, Jacob de Vlieg, 2012, J. Chem. Inf. Model..

Steering Siglec-Sialic Acid Interactions on Living Cells using Bioorthogonal Chemistry.

G. Adema, M. D. den Brok, C. Büll, 2017, Angewandte Chemie.

Drug Discovery and Repurposing Inhibits a Major Gut Pathogen-Derived Oncogenic Toxin

B. Dutilh, C. Sears, A. Boleij, 2019, Front. Cell. Infect. Microbiol..

Stabilizing the closed SARS-CoV-2 spike trimer

L. Renault, J. Juraszek, J. Langedijk, 2021, Nature Communications.

Synthetic polymers as substrates for a DNA‐sliding clamp protein

R. Nolte, M. Trakselis, T. Ritschel, 2018, Biopolymers.

Universal stabilization of the influenza hemagglutinin by structure-based redesign of the pH switch regions

Boerries Brandenburg, J. Juraszek, M. Jongeneelen, 2022, Proceedings of the National Academy of Sciences.

Statin Lactonization by Uridine 5'-Diphospho-glucuronosyltransferases (UGTs).

J. Smeitink, F. Russel, T. Schirris, 2015, Molecular pharmaceutics.

3D-e-Chem GPCRdb KNIME nodes: v1.0.6

Stefan Verhoeven, Chris de Graaf, Tina Ritschel, 2016 .

High-affinity inhibitors of Zymomonas mobilis tRNA-guanine transglycosylase through convergent optimization.

Luzi J. Barandun, G. Klebe, F. Diederich, 2013, Acta crystallographica. Section D, Biological crystallography.

How to Replace the Residual Solvation Shell of Polar Active Site Residues to Achieve Nanomolar Inhibition of tRNA‐Guanine Transglycosylase

Gerhard Klebe, Tina Ritschel, Gerd Neudert, 2009, ChemMedChem.

Crystal Structure Analysis and in Silico pKa Calculations Suggest Strong pKa Shifts of Ligands as Driving Force for High‐Affinity Binding to TGT

Gerhard Klebe, Tina Ritschel, François Diederich, 2009, Chembiochem : a European journal of chemical biology.

Influence of azide incorporation on binding affinity by small papain inhibitors.

J. V. van Hest, F. Rutjes, F. V. van Delft, 2014, Bioorganic & medicinal chemistry.

RSV A2-Based Prefusion F Vaccine Candidates Induce RSV A and RSV B Cross Binding and Neutralizing Antibodies and Provide Protection against RSV A and RSV B Challenge in Preclinical Models

L. van der Fits, F. Cox, Lisanne Tettero, 2023, Vaccines.

3D-e-Chem-VM: Structural Cheminformatics Research Infrastructure in a Freely Available Virtual Machine

Lars Ridder, Chris de Graaf, Tina Ritschel, 2017, J. Chem. Inf. Model..

KRIPO – a structure-based pharmacophores approach explains polypharmacological effects

Tina Ritschel, Tom JJ Schirris, Frans GM Russel, 2014, Journal of Cheminformatics.

Current progress in Structure-Based Rational Drug Design marks a new mindset in drug discovery

R. McGuire, V. Lounnas, N. Foloppe, 2013, Computational and structural biotechnology journal.

Discovery of Small Molecule CD40-TRAF6 Inhibitors

Tina Ritschel, Gert Vriend, Oliver Soehnlein, 2015, J. Chem. Inf. Model..

Current progress in Structure-Based Rational Drug Design marks a new mindset in drug discovery

R. McGuire, V. Lounnas, N. Foloppe, 2013, Computational and structural biotechnology journal.

Pharmacophore Fingerprint-Based Approach to Binding Site Subpocket Similarity and Its Application to Bioisostere Replacement

M. Wagener, J. D. Vlieg, T. Ritschel, 2012, J. Chem. Inf. Model..

In silico identification and in vitro validation of potential cholestatic compounds through 3D ligand-based pharmacophore modeling of BSEP inhibitors.

F. Russel, J. B. Koenderink, R. Greupink, 2014, Chemical research in toxicology.