C. Petersson

发表

Chapter 10 – Metabolism and pharmacokinetic optimization strategies in drug discovery

P. Ballard, K. Bui, P. Brassil, 2013 .

A comparative evaluation of models to predict human intestinal metabolism from nonclinical data

S. Peters, H. Dolgos, C. Petersson, 2017, Biopharmaceutics & drug disposition.

Prediction of active human dose: learnings from 20 years of Merck KGaA experience, illustrated by case studies.

S. Peters, A. Blaukat, H. Dolgos, 2020, Drug discovery today.

Determination of low intrinsic clearance in vitro: the benefit of a novel internal standard in human hepatocyte incubations

U. Zanelli, C. Petersson, Thomas Michna, 2019, Xenobiotica; the fate of foreign compounds in biological systems.

Current Approaches for Predicting Human PK for Small Molecule Development Candidates: Findings from the IQ Human PK Prediction Working Group Survey

A. Reichel, P. Marathe, G. Xiao, 2022, The AAPS Journal.

Prediction of volume of distribution in humans: analysis of eight methods and their application in drug discovery

O. Papasouliotis, H. Dolgos, C. Petersson, 2020, Xenobiotica; the fate of foreign compounds in biological systems.

Comparison of methods for the prediction of human clearance from hepatocyte intrinsic clearance for a set of reference compounds and an external evaluation set

T. Yamagata, U. Zanelli, H. Dolgos, 2017, Xenobiotica; the fate of foreign compounds in biological systems.

Substituted 7-amino-5-thio-thiazolo[4,5-d]pyrimidines as potent and selective antagonists of the fractalkine receptor (CX3CR1).

V. Ivanov, L. Vares, P. Svensson, 2013, Journal of medicinal chemistry.

The right compound in the right assay at the right time: an integrated discovery DMPK strategy

Peter Ballard, Patrick Brassil, Khanh H Bui, 2012, Drug metabolism reviews.

Deconvolution of Cytochrome P450 Induction Mechanisms in HepaRG Nuclear Hormone Receptor Knockout Cells

V. Lauschke, K. Georgi, P. Hewitt, 2021, Drug Metabolism and Disposition.

Discovery of 5-{2-[5-Chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic Acid, a Highly Selective in Vivo Useable Chemical Probe to Dissect MCT4 Biology.

M. Nowak, S. Minguzzi, M. Król, 2021, Journal of medicinal chemistry.

Metabolic profiling of TRPV1 antagonists of the benzothiazole amide series: implications for in vitro genotoxicity assessment

S. Czene, A. Lindgren, C. Petersson, 2013, Xenobiotica; the fate of foreign compounds in biological systems.

Differentiation of estriol glucuronide isomers by chemical derivatization and electrospray tandem mass spectrometry.

M. Hedeland, U. Bondesson, C. Petersson, 2006, Rapid communications in mass spectrometry : RCM.

Evaluation of the human prediction of clearance from hepatocyte and microsome intrinsic clearance for 52 drug compounds

P. Prusis, L. Afzelius, C. Petersson, 2010, Xenobiotica; the fate of foreign compounds in biological systems.

In Silico Absorption, Distribution, Metabolism, Excretion, and Pharmacokinetics (ADME-PK): Utility and Best Practices. An Industry Perspective from the International Consortium for Innovation through Quality in Pharmaceutical Development.

Carl Petersson, Franco Lombardo, Susanne Winiwarter, 2017, Journal of medicinal chemistry.

A Pragmatic Approach Using First-Principle Methods to Address Site of Metabolism with Implications for Reactive Metabolite Formation

Ulf Norinder, Mats Svensson, Ya-Wen Hsiao, 2012, J. Chem. Inf. Model..

Multi-Well Array Culture of Primary Human Hepatocyte Spheroids for Clearance Extrapolation of Slowly Metabolized Compounds

V. Lauschke, K. Georgi, C. Petersson, 2022, The AAPS Journal.