J. Land

发表

The Effect of HMG-CoA Reductase Inhibitors on Coenzyme Q10

S. Heales, A. Duncan, I. Hargreaves, 2005, Drug safety.

Glutamate metabolism and transport in rat brain mitochondria.

S. Dennis, J. Clark, J. Land, 1976, The Biochemical journal.

Poor maternal nutrition followed by accelerated postnatal growth leads to alterations in DNA damage and repair, oxidative and nitrosative stress, and oxidative defense capacity in rat heart

C. Aiken, S. Ozanne, I. Hargreaves, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Assessment of mitochondrial electron transport chain function in a primary astrocyte cell model of hyperhomocystinaemia

E. Murphy, I. Hargreaves, J. Land, 2013, Toxicology mechanisms and methods.

A Mutation in the Mitochondrial Fission Gene Dnm1l Leads to Cardiomyopathy

S. Wells, S. Bhattacharya, H. Watkins, 2010, PLoS genetics.

Oxidative stress and mitochondrial dysfunction in neurodegeneration; cardiolipin a critical target?

S. Heales, S. Pope, J. Land, 2008, Biochimica et biophysica acta.

Neonatal hypoglycaemia in Nepal 1. Prevalence and risk factors

A. Costello, S. Rajbhandari, D. Pal, 2000, Archives of disease in childhood. Fetal and neonatal edition.

Secondary coenzyme Q10 deficiency and oxidative stress in cultured fibroblasts from patients with riboflavin responsive multiple Acyl-CoA dehydrogenation deficiency.

N. Gregersen, T. Corydon, I. Hargreaves, 2013, Human molecular genetics.

Rosuvastatin lowers coenzyme Q10 levels, but not mitochondrial adenosine triphosphate synthesis, in children with familial hypercholesterolemia.

R. Wanders, J. Ruiter, F. Wijburg, 2011, The Journal of pediatrics.

Prevention of cardiovascular disease in general practice: a proposed model.

E. Anggard, J. Shepherd, L. Ritchie, 1986, British medical journal.

Dopamine but not l-dopa stimulates neural glutathione metabolism. Potential implications for Parkinson’s and other dopamine deficiency states

S. Heales, I. Hargreaves, J. Land, 2013, Neurochemistry International.

Nitric oxide, energy metabolism and neurological disease.

J. Bolaños, S. Heales, P. Foppa, 1997, Biochemical Society transactions.

Diagnosis of developmental delay: the metabolic biochemist's approach

J. Land, 1994 .

Tetrahydrobiopterin Availability in Parkinson’s and Alzheimer’s Disease; Potential Pathogenic Mechanisms

S. Heales, J. Land, R. Foxton, 2007, Neurochemical Research.

Biochemical Diagnosis of Coenzyme Q10 Deficiency

R. Artuch, S. Heales, I. Hargreaves, 2014, Molecular Syndromology.

Mitochondrial myopathy Biochemical studies revealing a deficiency of NADH-cytochrome b reductase activity

J. Morgan-Hughes, J. Land, J. Clark, 1981, Journal of the Neurological Sciences.

Adaptation of the Nitrate Reductase and Griess Reaction Methods for the Measurement of Serum Nitrate plus Nitrite Levels

G. Giovannoni, S. Heales, E. Thompson, 1997, Annals of clinical biochemistry.

Age Dependent Changes in the Cerebrospinal Fluid Concentration of Nitrite and Nitrate

R. Surtees, J. Bolaños, S. Heales, 1996, Annals of clinical biochemistry.

Coenzyme Q10 quantification in muscle, fibroblasts and cerebrospinal fluid by liquid chromatography/tandem mass spectrometry using a novel deuterated internal standard.

K. Mills, S. Heales, S. Eaton, 2013, Rapid communications in mass spectrometry : RCM.

Neonatal hypoglycaemia in Nepal 2. Availability of alternative fuels

A. Costello, S. Rajbhandari, D. Pal, 2000, Archives of disease in childhood. Fetal and neonatal edition.

Phenotypic variability of mitochondrial disease caused by a nuclear mutation in complex II.

A. Pagnamenta, M. Bitner-Glindzicz, S. Rahman, 2006, Molecular genetics and metabolism.

Decreased Ubiquinone Availability and Impaired Mitochondrial Cytochrome Oxidase Activity Associated With Statin Treatment

S. Heales, A. Duncan, I. Hargreaves, 2009, Toxicology mechanisms and methods.

Glutathione protects astrocytes from peroxynitrite-mediated mitochondrial damage: implications for neuronal/astrocytic trafficking and neurodegeneration.

J. Bolaños, S. Heales, J. Clark, 1996, Developmental neuroscience.

Successful reversal of propionic acidaemia associated cardiomyopathy: evidence for low myocardial coenzyme Q10 status and secondary mitochondrial dysfunction as an underlying pathophysiological mechanism.

M. Ashworth, G. Anderson, J. Baruteau, 2014, Mitochondrion.

Determination of coenzyme Q10 status in blood mononuclear cells, skeletal muscle, and plasma by HPLC with di-propoxy-coenzyme Q10 as an internal standard.

K. Mills, S. Heales, S. Eaton, 2005, Clinical chemistry.

Depletion of brain glutathione results in a decrease of glutathione reductase activity; an enzyme susceptible to oxidative damage

J. Bolaños, S. Heales, J. Land, 1996, Brain Research.

Potential mechanisms for nitric oxide-mediated impairment of brain mitochondrial energy metabolism.

Á. Almeida, J. Bolaños, S. Heales, 1997, Biochemical Society transactions.

The potential role of nitric oxide in multiple sclerosis

G. Giovannoni, S. Heales, E. Thompson, 1998, Multiple sclerosis.

Pretreatment of Astrocytes with Interferon‐α/β Impairs Interferon‐γ Induction of Nitric Oxide Synthase

W. Mcdonald, G. Giovannoni, S. Heales, 1997 .

Pretreatment of astrocytes with interferon-alpha/beta impairs interferon-gamma induction of nitric oxide synthase.

W. Mcdonald, G. Giovannoni, J. Clark, 1997, Journal of neurochemistry.

Pyridoxal 5′‐phosphate deficiency causes a loss of aromatic l‐amino acid decarboxylase in patients and human neuroblastoma cells, implications for aromatic l‐amino acid decarboxylase and vitamin B6 deficiency states

P. Clayton, P. Clayton, J. Fitzgerald, 2010, Journal of neurochemistry.

Treatable childhood neuronopathy caused by mutations in riboflavin transporter RFVT2

S. Züchner, M. Lek, F. Muntoni, 2013, Brain : a journal of neurology.

Pretreatment of Astrocytes with Interferon‐α/β Prevents Neuronal Mitochondrial Respiratory Chain Damage

S. Heales, J. Land, V. Stewart, 1998 .

Diagnostic Value of Succinate Ubiquinone Reductase Activity in the Identification of Patients with Mitochondrial DNA Depletion

S. Rahman, S. Heales, J. Leonard, 2002, Journal of Inherited Metabolic Disease.

Contribution of nitric oxide to exercise-induced hypotension in human sympathetic denervation

C. Mathias, G. Giovannoni, J. Land, 1999, Clinical Autonomic Research.

Effect of Coenzyme Q10 supplementation on mitochondrial electron transport chain activity and mitochondrial oxidative stress in Coenzyme Q10 deficient human neuronal cells.

S. Rahman, S. Heales, A. Abramov, 2014, The international journal of biochemistry & cell biology.

Coenzyme Q₁₀ deficiency in mitochondrial DNA depletion syndromes.

R. Artuch, J. Montoya, E. López-Gallardo, 2013, Mitochondrion.

Nitric Oxide‐Mediated Mitochondrial Damage in the Brain: Mechanisms and Implications for Neurodegenerative Diseases

J M Land, Á. Almeida, J. Bolaños, 1997, Journal of neurochemistry.

Comparison of mitochondrial respiratory chain enzyme activities in rodent astrocytes and neurones and a human astrocytoma cell line

S. Heales, J. Land, V. Stewart, 1998, Neuroscience Letters.

Effect of phenylpyruvate on pyruvate dehydrogenase activity in rat brain mitochondria.

J. Clark, J. Land, 1973, The Biochemical journal.

Bezafibrate induced increase in mitochondrial electron transport chain complex IV activity in human astrocytoma cells: Implications for mitochondrial cytopathies and neurodegenerative diseases

S. Heales, I. Hargreaves, J. Land, 2010, BioFactors.

Dilated cardiomyopathy due to type II X-linked 3-methylglutaconic aciduria: successful treatment with pantothenic acid.

J. Land, I. Ostman-Smith, A. Johnson, 1994, British heart journal.

Copper deficiency as a treatable cause of poor balance

Z. Khaleeli, G. Giovannoni, D. Healy, 2010, BMJ : British Medical Journal.

Pretreatment of astrocytes with interferon-alpha/beta prevents neuronal mitochondrial respiratory chain damage.

S. Heales, J. Clark, J. Land, 1998, Journal of neurochemistry.

Inhibition of mitochondrial complex IV leads to secondary loss complex II-III activity: implications for the pathogenesis and treatment of mitochondrial encephalomyopathies.

S. Heales, A. Duncan, I. Hargreaves, 2007, Mitochondrion.

Glutathione deficiency in patients with mitochondrial disease: Implications for pathogenesis and treatment

S. Heales, I. Hargreaves, Y. Sheena, 2005, Journal of Inherited Metabolic Disease.

Genetic dysfunction of MT-ATP6 causes axonal Charcot-Marie-Tooth disease

Jacqueline A Palace, R. Page, J. Holton, 2012, Neurology.

Blood mononuclear cell coenzyme Q10 concentration and mitochondrial respiratory chain succinate cytochrome-c reductase activity in phenylketonuric patients

J. Land, S. Heales, P. Lee, 2003, Journal of Inherited Metabolic Disease.

Association between mitochondrial dysfunction and severity and outcome of septic shock

John Land, Chris E Cooper, David Brealey, 2002, The Lancet.

Nitric Oxide‐Mediated Inhibition of the Mitochondrial Respiratory Chain in Cultured Astrocytes

J. Bolaños, S. Heales, J. Land, 1994, Journal of neurochemistry.

Polymeric Octahedral and Monomeric Tetrahedral Group 12 Pseudohalogeno (NCX - : X = O, S, Se) Complexes of 4-(N,N-dimethylamino)pyridine

R. G. Baughman, J. Land, H. Collier, 2000 .

CONTROL OF PYRUVATE AND β‐HYDROXYBUTYRATE UTILIZATION IN RAT BRAIN MITOCHONDRIA AND ITS RELEVANCE TO PHENYLKETONURIA AND MAPLE SYRUP URINE DISEASE

J. Mowbray, J. Clark, J. Land, 1976, Journal of neurochemistry.

Fungal endophytes of native grasses decrease insect herbivore preference and performance

Jennifer A. Rudgers, J. Land, K. Crawford, 2010, Oecologia.

Differential effects of 2-oxo acids on pyruvate utilization and fatty acid synthesis in rat brain.

J. Clark, J. Land, 1974, The Biochemical journal.

Inhibitors of mitochondrial enzymes.

J. Clark, J. Land, 1979, Pharmacology & therapeutics.

Long-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency

D. Turnbull, J. Leonard, S. Jackson, 1991, Pediatric Research.

9 The genetics of metabolic disorders of muscle

J. Poulton, J. Land, 1990 .

Mutation and biochemical analysis in carnitine palmitoyltransferase type II (CPT II) deficiency

F. Muntoni, B. Andresen, S. Rahman, 2003, Journal of Inherited Metabolic Disease.

Neonatal carnitine palmitoyltransferase-2 deficiency: a case presenting with myopathy

M. Squier, J. Land, S. Mistry, 1995, Neuromuscular Disorders.

Lethal multiple acyl-CoA dehydrogenation deficiency with dysmorphic features

M. Bennett, R. Pollitt, J. Land, 1987, Journal of Inherited Metabolic Disease.

Nitric oxide, mitochondria and neurological disease.

J M Land, J. Bolaños, S. Heales, 1999, Biochimica et biophysica acta.

β‐Amyloid inhibits integrated mitochondrial respiration  and key enzyme activities

J. Land, J. Clark, L. Canevari, 2001, Journal of neurochemistry.

Development of mitochondrial energy metabolism in rat brain.

R. Berger, J. Clark, J. Land, 1977, The Biochemical journal.

A new perspective on the treatment of aromatic L-amino acid decarboxylase deficiency.

S. Heales, J. Land, G. Allen, 2009, Molecular genetics and metabolism.

Cytochrome c oxidase deficiency associated with the first stop-codon point mutation in human mtDNA.

I. Nelson, N. Wood, S. Heales, 1998, American journal of human genetics.

Blood Mononuclear Cell Mitochondrial Respiratory Chain Complex IV Activity is Decreased in Multiple Sclerosis Patients: Effects of β-Interferon Treatment

S. Heales, I. Hargreaves, J. Land, 2018, Journal of clinical medicine.

Uncovering Genomic Causes of Co-Morbidity in Epilepsy: Gene-Driven Phenotypic Characterization of Rare Microdeletions

R. Hennekam, P. Hammond, L. Martinian, 2011, PloS one.

SURF1 deficiency: a multi-centre natural history study

Robert W. Taylor, E. Aasheim, S. Rahman, 2013, Orphanet Journal of Rare Diseases.

Levels of 5-methyltetrahydrofolate and ascorbic acid in cerebrospinal fluid are correlated: Implications for the accelerated degradation of folate by reactive oxygen species

S. Rahman, S. Heales, S. Eaton, 2013, Neurochemistry International.

COX10 mutations resulting in complex multisystem mitochondrial disease that remains stable into adulthood.

Francesco Muntoni, Jim Stalker, Rahul Phadke, 2013, JAMA neurology.

Neurodegeneration or Neuroprotection: The Pivotal Role of Astrocytes

S. Heales, A. Duncan, J. Land, 2004, Neurochemical Research.

Mitochondrial respiratory chain defects are not accompanied by an increase in the activities of lactate dehydrogenase or manganese superoxide dismutase in paediatric skeletal muscle biopsies

J. Land, S. Heales, I. Hargreaves, 1999, Journal of Inherited Metabolic Disease.

Fumarate Is Cardioprotective via Activation of the Nrf2 Antioxidant Pathway

Alan J. Robinson, Stefan Neubauer, Mark R. Viant, 2012, Cell metabolism.

Mitochondrial dysfunction in skeletal muscle of a mouse model of Rett Syndrome ( RTT ) : Implications for the disease phenotype .

P. Tam, J. Christodoulou, I. Hargreaves, 2014 .

Stimulation of glyceraldehyde‐3‐phosphate dehydrogenase by oxyhemoglobin

S. Heales, P. Brookes, J. Land, 1997, FEBS letters.

Late onset heterozygous ornithine transcarbamylase deficiency mimicking complex partial status epilepticus

J. Duncan, J. Land, A. Briddon, 2000, Journal of neurology, neurosurgery, and psychiatry.

Increased inducible nitric oxide synthase protein but limited nitric oxide formation occurs in astrocytes of the hph-1 (tetrahydrobiopterin deficient) mouse

S. Heales, J. Land, R. Hurst, 1998, Brain Research.

Severe non‐diabetic keto‐acidosis causing intrauterine death

M. Gillmer, J. Land, J. Ledingham, 1992, British journal of obstetrics and gynaecology.

[Copper deficiency as a treatable cause of poor balance].

Z. Khaleeli, G. Giovannoni, D. Healy, 2010, Praxis.

The metabolic, catecholamine and cardiovascular effects of exercise in human sympathetic denervation

C. Mathias, J. Land, F. Magnifico, 2001, Clinical Autonomic Research.

Glutaric aciduria type 1 an atypical presentation together with some observations upon treatment and the possible cause of cerebral damage.

J. Hockaday, P. Goulder, J. Land, 1992, Neuropediatrics.

Effect of Peroxynitrite on the Mitochondrial Respiratory Chain: Differential Susceptibility of Neurones and Astrocytes in Primary Culture

J. Bolaños, S. Heales, J. Land, 1995, Journal of neurochemistry.

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration

Masayuki Yamamoto, Ying Zhang, A. Dinkova-Kostova, 2013, Biology Open.

Stimulation of the Brain NO/Cyclic GMP Pathway by Peripheral Administration of Tetrahydrobiopterin in the hph‐1 Mouse

S. Heales, J. Land, J. Clark, 1999, Journal of neurochemistry.

The allopurinol load test lacks specificity for primary urea cycle defects but may indicate unrecognized mitochondrial disease

J. Bonham, J. Duley, C. Rittey, 1999, Journal of Inherited Metabolic Disease.

Peroxynitrite and Brain Mitochondria: Evidence for Increased Proton Leak

S. Heales, P. Brookes, J. Land, 1998, Journal of neurochemistry.

Nitric oxide-mediated mitochondrial damage: a potential neuroprotective role for glutathione.

J. Bolaños, S. Heales, J. Clark, 1996, Free radical biology & medicine.

Comparison of two cotside methods for the detection of hypoglycaemia among neonates in Nepal.

J. Land, N. Manandhar, A. M. de L Costello, 1996, Archives of disease in childhood. Fetal and neonatal edition.

Mitochondrial cytochrome c release: a factor to consider in mitochondrial disease?

S. Heales, S. Pope, J. Land, 2009, Journal of Inherited Metabolic Disease.

Novel C12orf65 mutations in patients with axonal neuropathy and optic atrophy

A. Singleton, J. Hardy, D. Trabzuni, 2013, Journal of Neurology, Neurosurgery & Psychiatry.

Trolox protects mitochondrial complex IV from nitric oxide-mediated damage in astrocytes

S. Heales, J. Land, J. Clark, 1994, Brain Research.

Elevated cerebrospinal fluid and serum nitrate and nitrite levels in patients with central nervous system complications of HIV-1 infection: a correlation with blood-brain-barrier dysfunction

R. Miller, G. Giovannoni, S. Heales, 1998, Journal of the Neurological Sciences.

Impairment of the nitric oxide/cyclic GMP pathway in cerebellar slices prepared from thehph-1 mouse

S. Heales, J. Clark, J. Land, 1996, Brain Research.

Raised serum nitrate and nitrite levels in patients with multiple sclerosis

R. Miller, G. Giovannoni, E. Thompson, 1997, Journal of the Neurological Sciences.

Evidence for increased nitric oxide production in multiple sclerosis.

J. Bolaños, S. Heales, E. Thompson, 1995, Journal of neurology, neurosurgery, and psychiatry.

β-Amyloid Fragment 25–35 Causes Mitochondrial Dysfunction in Primary Cortical Neurons

M. Duchen, J. Clark, J. Land, 2002, Neurobiology of Disease.

Oral phosphate supplements reverse skeletal muscle abnormalities in a case of chronic fatigue with idiopathic renal hypophosphatemia

G. Radda, G. Kemp, B. Rajagopalan, 1993, Neuromuscular Disorders.

Some Observations upon Biochemical Causes of Ataxia and a New Disease Entity Ubiquinone, CoQ10 Deficiency

S. Heales, A. Duncan, I. Hargreaves, 2007, Neurochemical Research.

A novel mitochondrial MTND5 frameshift mutation causing isolated complex I deficiency, renal failure and myopathy

Robert W. Taylor, R. Horvath, S. Heales, 2010, Neuromuscular Disorders.

Beta-amyloid fragment 25-35 causes mitochondrial dysfunction in primary cortical neurons.

M. Duchen, J. Clark, J. Land, 2002, Neurobiology of disease.

NITRIC OXIDE AND NEURODEGENERATION

J. Bolaños, J. Land, J. Clark, 1997 .

Effect of phenylpyruvate on enzymes involved in fatty acid synthesis in rat brain.

J. Clark, J. Land, 1973, The Biochemical journal.

Hypoglycaemia in the neonate: how and when is it important?

J. Land, 1994, Developmental neuroscience.

Development of enzymes of energy metabolism in the neonatal mammalian brain.

J. Clark, J. Land, T. Bates, 1993, Developmental neuroscience.

Increased urinary nitric oxide metabolites in patients with multiple sclerosis correlates with early and relapsing disease

R. Miller, G. Giovannoni, M. Feldmann, 1999, Multiple sclerosis.

Mitochondrial Disease: A Historical, Biochemical, and London Perspective

S. Heales, I. Hargreaves, J. Morgan-Hughes, 2004, Neurochemical Research.

Childhood mitochondrial myopathy with ophthalmoplegia

J. Hockaday, J. Hughes, B. Ross, 1981, Journal of the Neurological Sciences.

Tetrahydrobiopterin deficiency and brain nitric oxide synthase in thehph1 mouse

S. Heales, J. Clark, J. Land, 1995, Journal of Inherited Metabolic Disease.

Evaluation of the efficacy of potential therapeutic agents at protecting against nitric oxide synthase-mediated mitochondrial damage in activated astrocytes.

J. Bolaños, S. Heales, J. Clark, 1997, Brain research. Brain research protocols.

Primary pyruvate dehydrogenase E3 binding protein deficiency with mild hyperlactataemia and hyperalaninaemia

M. Hanna, J. Land, S. Heales, 2003, Journal of Inherited Metabolic Disease.

Molecular genetic characterization of an X‐linked form of Leigh's syndrome

G. Brown, R. Brown, M. Squier, 1993, Annals of neurology.

The diagnosis of carnitine palmitoyltransferase II deficiency is now possible in small skeletal muscle biopsies

J. Land, S. Heales, S. Olpin, 2000, Journal of Inherited Metabolic Disease.

A new perspective on the treatment of aromatic L-amino acid decarboxylase deficiency.

S. Heales, J. Land, G. Allen, 2009, Molecular genetics and metabolism.

Neonatal carnitine palmitoyltransferase deficiency: a case with a muscular presentation.

W. Squier, E. Saggerson, J. Land, 1992, Progress in clinical and biological research.

Nitric oxide and antioxidant status in glucose and oxygen deprived neonatal and adult rat brain synaptosomes

S. Heales, J. Clark, J. Land, 1996, Neurochemical Research.

Effect of Coenzyme Q10 supplementation on mitochondrial electron transport chain activity and mitochondrial oxidative stress in Coenzyme Q10 deficient human neuronal cells.

S. Rahman, S. Heales, I. Hargreaves, 2014, International Journal of Biochemistry and Cell Biology.