M. Verwei

发表

The use of in vitro toxicity data and physiologically based kinetic modeling to predict dose-response curves for in vivo developmental toxicity of glycol ethers in rat and man.

Bas J Blaauboer, Aldert H Piersma, Johannes J M van de Sandt, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

Predicting carrier-mediated hepatic disposition of rosuvastatin in man by scaling from individual transfected cell-lines in vitro using absolute transporter protein quantification and PBPK modeling.

Sieto Bosgra, K. Verhoeckx, H. Wortelboer, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

The effect of chitosan on the bioaccessibility and intestinal permeability of acyclovir

H. Wortelboer, P. Augustijns, P. Langguth, 2019, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

In vitro models for the prediction of in vivo performance of oral dosage forms.

Anette Müllertz, Patrick Augustijns, Bertil Abrahamsson, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

A new approach to predict human intestinal absorption using porcine intestinal tissue and biorelevant matrices.

Cyrille A M Krul, C. Krul, H. Wortelboer, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Physiologically Based Pharmacokinetic Modeling of Cyclohexane as a Tool for Integrating Animal and Human Test Data

R. H. Mckee, L. Sweeney, H. Muijser, 2009, International journal of toxicology.

Prediction of in vivo developmental toxicity of all-trans-retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling

I. Rietjens, I. Rietjens, B. Blaauboer, 2014, Archives of Toxicology.

Drug-Drug Interactions between Rosuvastatin and Oral Antidiabetic Drugs Occurring at the Level of OATP1B1

K. Verhoeckx, M. Monshouwer, H. Wortelboer, 2013, Drug Metabolism and Disposition.

Model studies for evaluating the neurobehavioral effects of complex hydrocarbon solvents III. PBPK modeling of white spirit constituents as a tool for integrating animal and human test data.

R. H. Mckee, H. Muijser, A. Freidig, 2007, Neurotoxicology.

Folic Acid and 5-Methyltetrahydrofolate in Fortiﬁed Milk Are Bioaccessible as Determined in a Dynamic In Vitro Gastrointestinal Model 1

G. Schaafsma, R. Havenaar, C. Witthöft, 2003 .

Toward in vitro biomarkers for developmental toxicity and their extrapolation to the in vivo situation

R. Woutersen, I. Rietjens, B. Blaauboer, 2012, Expert opinion on drug metabolism & toxicology.

A Review of the Implementation of the Embryonic Stem Cell Test (EST)

Aldert Piersma, Vera Rogiers, Horst Spielmann, 2009, Alternatives to laboratory animals : ATLA.

Prediction of in vivo embryotoxic effect levels with a combination of in vitro studies and PBPK modelling.

Johannes J M van de Sandt, Cyrille A M Krul, J. J. van de Sandt, 2006, Toxicology letters.

Bioaccessibility of folic acid and (6S)-5-methyltetrahydrofolate decreases after the addition of folate-binding protein to yogurt as studied in a dynamic in vitro gastrointestinal model.

R. Havenaar, C. Witthöft, M. Verwei, 2003, The Journal of nutrition.

Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach

Hedi Peterson, Daniel Gerhard, Raivo Kolde, 2012, Archives of Toxicology.

Bioavailability of folate from fortified milk products

M. Verwei, 2004 .

Prediction of in vivo developmental toxicity of all-trans-retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling

I. Rietjens, B. Blaauboer, J. Louisse, 2014, Archives of Toxicology.

Relative developmental toxicity potencies of retinoids in the embryonic stem cell test compared with their relative potencies in in vivo and two other in vitro assays for developmental toxicity.

I. Rietjens, J. Louisse, M. Verwei, 2011, Toxicology letters.

Decrease of intracellular pH as possible mechanism of embryotoxicity of glycol ether alkoxyacetic acid metabolites.

J. J. van de Sandt, I. Rietjens, B. Blaauboer, 2010, Toxicology and applied pharmacology.

Development of a QSAR for worst case estimates of acute toxicity of chemically reactive compounds.

M Verwei, J. Bessems, S. Dekkers, 2007, Toxicology letters.

Bioavailability of folic acid from fortified pasteurised and UHT-treated milk in humans

E. Siebelink, J. Castenmiller, C. West, 2005, European Journal of Clinical Nutrition.

Effect of folate–binding protein on intestinal transport of folic acid and 5–methyltetrahydrofolate across Caco–2 cells

J. Groten, R. Havenaar, M. Verwei, 2005, European journal of nutrition.

Biochemical and Molecular Actions of Nutrients The Binding of Folic Acid and 5-Methyltetrahydrofolate to Folate-Binding Proteins during Gastric Passage Differs in a Dynamic In Vitro Gastrointestinal Model 1

J. Groten, R. Havenaar, M. Verwei, 2003 .

Folic acid and 5-methyltetrahydrofolate in fortified milk are bioaccessible as determined in a dynamic in vitro gastrointestinal model.

G. Schaafsma, R. Havenaar, C. Witthöft, 2003, The Journal of nutrition.

The effect of folate-binding proteins on bioavailability of folate from milk products

J. Groten, R. Havenaar, C. Witthöft, 2005 .

Oral biopharmaceutics tools - time for a new initiative - an introduction to the IMI project OrBiTo.

H Lennernäs, A Lindahl, B Abrahamsson, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Predicted serum folate concentrations based on in vitro studies and kinetic modeling are consistent with measured folate concentrations in humans.

J. Groten, R. Havenaar, A. Freidig, 2006, The Journal of nutrition.

Evaluation of two dynamic in vitro models simulating fasted and fed state conditions in the upper gastrointestinal tract (TIM-1 and tiny-TIM) for investigating the bioaccessibility of pharmaceutical compounds from oral dosage forms.

R. Havenaar, M. Minekus, E. Zeijdner, 2016, International journal of pharmaceutics.

Relative developmental toxicity of glycol ether alkoxy acid metabolites in the embryonic stem cell test as compared with the in vivo potency of their parent compounds.

Bas J Blaauboer, Aldert H Piersma, Johannes J M van de Sandt, 2009, Toxicological sciences : an official journal of the Society of Toxicology.

Drug-Drug Interactions between Rosuvastatin and Oral Antidiabetic Drugs Occurring at the Level of OATP1B1

K. Verhoeckx, M. Monshouwer, H. Wortelboer, 2013, Drug Metabolism and Disposition.