K. Sugano

Y. Yoshihashi, K. Sugano, Mizuki Higuchi, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Prediction of negative food effect induced by bile micelle binding on oral absorption of hydrophilic cationic drugs.

T. Fujita, K. Sugano, Soichiro Ito, 2020, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Theoretical Investigation of Dissolution Test Criteria for Waiver of Clinical Bioequivalence Study.

K. Sugano, 2016, Journal of pharmaceutical sciences.

Theoretical Framework II: Dissolution

K. Sugano, 2012 .

Bioequivalence and Biopharmaceutical Classification System

K. Sugano, 2012 .

Processing of Biopharmaceutical Profiling Data in Drug Discovery

Kouki Obata, K. Sugano, R. Saitoh, 2007 .

Alkyl Radical Substitution on Disulfide in the Presence of Cobalt(II) Complexes.

T. Yoshihara, K. Sugano, M. Tada, 1995 .

A Critical Overview of the Biological Effects of Excipients (Part II): Scientific Considerations and Tools for Oral Product Development

David J Brayden, D. Brayden, F. Kesisoglou, 2022, The AAPS Journal.

Simple bicarbonate buffer system for dissolution testing: Floating lid method and its application to colonic drug delivery system

Yasuhiro Abe, K. Sugano, K. Izutsu, 2021 .

Effect of buffer capacity on dissolution and supersaturation profiles of pioglitazone hydrochloride

Jumpei Oki, K. Sugano, Daisuke Inoue, 2020 .

Efficacy of a Side Hole-type Plastic Needle for Dissolving Abraxane®

Keiji Mashimo, D. Hira, M. Kakumoto, 2020, Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences).

Mechanism of Supersaturation Suppression in Dissolution Process of Acidic Drug Salt.

Jumpei Oki, K. Sugano, Taiga Uekusa, 2019, Molecular pharmaceutics.

Physicochemical and crystal structure analysis of pranlukast pseudo-polymorphs II: Solvate and cocrystal.

Y. Yoshihashi, E. Yonemochi, K. Terada, 2015, Journal of pharmaceutical and biomedical analysis.

Physicochemical and crystal structure analysis of pranlukast pseudo-polymorphs I: anhydrates and hydrate.

Y. Yoshihashi, E. Yonemochi, K. Terada, 2015, Journal of pharmaceutical and biomedical analysis.

Development of bicarbonate buffer flow-through cell dissolution test and its application in prediction of in vivo performance of colon targeting tablets.

H. Nakagawa, K. Sugano, T. Kai, 2022, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Quantitative estimation of drug permeation through nasal mucosa using in vitro membrane permeability across Calu-3 cell layers for predicting in vivo bioavailability after intranasal administration to rats.

K. Sugano, A. Tanaka, T. Sakane, 2020, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Radical substitution on a thioester by a methyl radical generated from methyl(L)cobaloxime

T. Yoshihara, K. Sugano, M. Tada, 1995 .

Solution-Mediated Phase Transformation on Crystal Facets of Carbamazepine–Saccharin Cocrystals

K. Sugano, Maaya Omori, 2021, Crystal Growth & Design.

Thermodynamic Correlation between Liquid–Liquid Phase Separation and Crystalline Solubility of Drug-Like Molecules

Tomohiro Watanabe, K. Sugano, Taiga Uekusa, 2022, Pharmaceutics.

Oral Absorption of Poorly Water-Soluble Drugs: Computer Simulation of Fraction Absorbed in Humans from a Miniscale Dissolution Test

Kiyohiko Sugano, Yoshiki Hayashi, Minoru Machida, 2006, Pharmaceutical Research.

Prediction of food effect by bile micelles on oral drug absorption considering free fraction in intestinal fluid.

Kiyohiko Sugano, Makoto Kataoka, M. Kataoka, 2010, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Permeation characteristics of a hydrophilic basic compound across a bio-mimetic artificial membrane.

M. Machida, Y. Nabuchi, K. Sugano, 2004, International journal of pharmaceutics.

Biopharmaceutical Modeling for Miscellaneous Cases

K. Sugano, 2012 .

Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network.

Clive G. Wilson, B. Griffin, P. Artursson, 2021, Advanced drug delivery reviews.

Rate- and Extent-Limiting Factors of Oral Drug Absorption: Theory and Applications.

K. Terada, K. Sugano, 2015, Journal of pharmaceutical sciences.

Validation of Mechanistic Models

K. Sugano, 2012 .

Fraction of a dose absorbed estimation for structurally diverse low solubility compounds.

K. Sugano, 2011, International journal of pharmaceutics.

Computational Oral Absorption Simulation for Low‐Solubility Compounds

K. Sugano, 2009, Chemistry & biodiversity.

Passive lipoidal diffusion and carrier-mediated cell uptake are both important mechanisms of membrane permeation in drug disposition.

Li Di, Manfred Kansy, Kiyohiko Sugano, 2014, Molecular pharmaceutics.

The Critical Role of Passive Permeability in Designing Successful Drugs

L. Benet, M. Kansy, J. Houston, 2020, ChemMedChem.

Prediction of passive intestinal absorption using bio-mimetic artificial membrane permeation assay and the paracellular pathway model.

Kiyohiko Sugano, Minoru Machida, K. Terada, 2002, International journal of pharmaceutics.

Effect of co-solutes and process variables on crystallinity and the crystal form of freeze-dried myo-inositol.

K. Terada, Y. Goda, R. Arai, 2016, International journal of pharmaceutics.

Estimation of effective intestinal membrane permeability considering bile micelle solubilisation.

K. Sugano, 2009, International journal of pharmaceutics.

Lost in modelling and simulation?

K. Sugano, 2021, ADMET & DMPK.

Application of the BCS biowaiver approach to assessing bioequivalence of orally disintegrating tablets with immediate release formulations.

K. Sugano, Asami Ono, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Dissolution Kinetics of Nifedipine—Ionizable Polymer Amorphous Solid Dispersion: Comparison Between Bicarbonate and Phosphate Buffers

K. Sugano, Aoi Sakamoto, 2021, Pharmaceutical Research.

Evaluation of Using Dogs to Predict Fraction of Oral Dose Absorbed in Humans for Poorly Water-Soluble Drugs.

S. Yamashita, K. Sugano, J. Katagi, 2018, Journal of pharmaceutical sciences.

Identification and physicochemical characterization of caffeine-citric acid co-crystal polymorphs.

K. Terada, Yuka Watanabe, K. Sugano, 2015, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Effect of coformer and polymer on particle surface solution-mediated phase transformation of cocrystal in aqueous media.

Jumpei Oki, K. Sugano, Tomohiro Watanabe, 2020, Molecular pharmaceutics.

Solution-mediated phase transformation at particle surface during cocrystal dissolution

Jumpei Oki, K. Sugano, Daisuke Inoue, 2020 .

Time-dependent phase separation of amorphous solid dispersions: Implications for accelerated stability studies

Y. Yoshihashi, K. Terada, K. Kawakami, 2018, Journal of Drug Delivery Science and Technology.

Physiology of Gastrointestinal Tract and Other Administration Sites in Humans and Animals

K. Sugano, 2012 .

Effect of cerebrospinal fluid circulation on nose-to-brain direct delivery and distribution of caffeine in rats.

K. Sugano, A. Tanaka, T. Sakane, 2020, Molecular pharmaceutics.

8th IAPC Meeting : : Book of Abstracts

E. Giovannetti, N. Funel, G. Peters, 2017 .

Biopharmaceutics Classification by High Throughput Solubility Assay and PAMPA

M. Machida, Y. Aso, Kouki Obata, 2004, Drug development and industrial pharmacy.

Bottom-Up Physiologically Based Oral Absorption Modeling of Free Weak Base Drugs

T. Fujita, K. Sugano, Naoya Matsumura, 2020, Pharmaceutics.

Dissolution Profiles of Carbamazepine Cocrystals with Cis–Trans Isomeric Coformers

K. Sugano, Maaya Omori, Hibiki Yamamoto, 2022, Pharmaceutical Research.

Theoretical investigation of passive intestinal membrane permeability using Monte Carlo method to generate drug-like molecule population.

K. Sugano, 2009, International journal of pharmaceutics.

Prediction of human intestinal permeability using artificial membrane permeability.

Kiyohiko Sugano, Minoru Machida, M. Machida, 2003, International journal of pharmaceutics.

Physicochemical and cell-based approach for early screening of phospholipidosis-inducing potential.

Kiyohiko Sugano, Hiroshi Yamada, Ikuo Horii, 2006, The Journal of toxicological sciences.

High throughput solubility measurement with automated polarized light microscopy analysis.

Kiyohiko Sugano, Teruhisa Kato, Takashi Mano, 2006, Journal of pharmaceutical sciences.

Harmonizing solubility measurement to lower inter-laboratory variance – progress of consortium of biopharmaceutical tools (CoBiTo) in Japan

T. Fujita, K. Sugano, Naoya Matsumura, 2019, ADMET & DMPK.

Dissolution Profiles of Poorly Soluble Drug Salts in Bicarbonate Buffer

K. Sugano, Aoi Sakamoto, 2023, Pharmaceutical Research.

Polymeric precipitation inhibitor differently affects cocrystal surface and bulk solution phase transformations

K. Sugano, Maaya Omori, Marii Shigemura, 2021, Journal of Drug Delivery Science and Technology.

Prediction Accuracy of Mechanism-Based Oral Absorption Model for Dogs.

T. Fujita, K. Sugano, Y. Nomura, 2019, Journal of pharmaceutical sciences.

Emerging Full Mechanistic Physiologically Based Modeling

K. Sugano, 2014 .

Computational oral absorption simulation of free base drugs.

K. Sugano, 2010, International journal of pharmaceutics.

Theoretical dissolution model of poly-disperse drug particles in biorelevant media.

Kiyohiko Sugano, Takashi Mano, T. Mano, 2008, Journal of pharmaceutical sciences.

Investigation of biopharmaceutical and physicochemical drug properties suitable for orally disintegrating tablets

K. Terada, T. Ogihara, K. Sugano, 2016 .

Application of Dissolution/Permeation System for Evaluation of Formulation Effect on Oral Absorption of Poorly Water-Soluble Drugs in Drug Development

Y. Masaoka, M. Kataoka, S. Yamashita, 2012, Pharmaceutical Research.

Effect of Seed Particles on Precipitation of Weak Base Drugs in Physiological Intestinal Conditions.

K. Terada, K. Sugano, Masataka Ito, 2016, Molecular pharmaceutics.

Evidence-based approach to assess passive diffusion and carrier-mediated drug transport.

G. Ecker, M. Kansy, J. Houston, 2012, Drug discovery today.

Development of pH shift bicarbonate buffer dissolution test using floating lid and its feasibility for evaluating enteric-coated tablet

K. Sugano, Aoi Sakamoto, Fumiya Matsui, 2023, Journal of Drug Delivery Science and Technology.

5.19 – Artificial Membrane Technologies to Assess Transfer and Permeation of Drugs in Drug Discovery

K. Sugano, 2007 .

Permeability Comparison between Hepatocyte and Low Efflux MDCKII Cell Monolayer

L. Di, Patrick E. Trapa, Y. Lai, 2014, The AAPS Journal.

Prediction of coning phenomena for irregular particles in paddle dissolution test.

Y. Yoshihashi, K. Sugano, Mizuki Higuchi, 2015, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

A simulation of oral absorption using classical nucleation theory.

Kiyohiko Sugano, K. Sugano, 2009, International journal of pharmaceutics.

Introduction to computational oral absorption simulation.

Kiyohiko Sugano, K. Sugano, 2009, Expert opinion on drug metabolism & toxicology.

Effect of divalent and trivalent metal ions on artificial membrane permeation of fluoroquinolones

K. Sugano, Nanami Nakatani, 2022, ADMET & DMPK.

Stability order of caffeine co-crystals determined by co-crystal former exchange reaction and its application for the validation of in silico models.

K. Terada, K. Sugano, Makoto Mukaida, 2015, Chemical and pharmaceutical bulletin.

Computational Oral Absorption Simulation for Low-Solubility Compounds.

K. Sugano, 2010 .

Aqueous boundary layers related to oral absorption of a drug: from dissolution of a drug to carrier mediated transport and intestinal wall metabolism.

Kiyohiko Sugano, K. Sugano, 2010, Molecular pharmaceutics.

Theoretical Framework I: Solubility

K. Sugano, 2012 .

Application of Dissolution/Permeation System for Evaluation of Formulation Effect on Oral Absorption of Poorly Water-Soluble Drugs in Drug Development

Y. Masaoka, M. Kataoka, S. Yamashita, 2011, Pharmaceutical Research.

Effect of Food Viscosity on Drug Dissolution.

K. Sugano, Rika Hirose, 2023, Pharmaceutical research.

Coning phenomena under laminar flow.

K. Terada, K. Sugano, Mizuki Higuchi, 2015, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Permeation characteristics of tetracyclines in parallel artificial membrane permeation assay

K. Sugano, Sachika Yamauchi, 2019, ADMET & DMPK.

Food and bile micelle binding of quaternary ammonium compounds

K. Sugano, Sumiji Takeru, 2023, ADMET & DMPK.

Prediction of Liquid-Liquid Phase Separation at the Dissolving Drug Salt Particle Surface.

K. Sugano, Taiga Uekusa, 2023, Molecular pharmaceutics.

Salt solubility and disproportionation - uses and limitations of equations for pHmax and the in-silico prediction of pHmax.

A. Avdeef, K. Sugano, 2021, Journal of pharmaceutical sciences.