P. Walker

发表

Identifying and Characterizing Stress Pathways of Concern for Consumer Safety in Next-Generation Risk Assessment

Paul Walker, Paul L Carmichael, Matthew Dent, 2020, Toxicological sciences : an official journal of the Society of Toxicology.

New approach methods supporting read-across: Two neurotoxicity AOP-based IATA case studies.

J. C. Gómez-Tamayo, M. J. Moné, G. Ecker, 2021, ALTEX.

Development of a generic zebrafish embryo PBPK model and application to the developmental toxicity assessment of valproic acid analogs.

F. Bois, T. Braunbeck, C. Fisher, 2020, Reproductive toxicology.

High-Content Screening: Understanding and Managing Mechanistic Data to Better Predict Toxicity

P. Walker, Timothy P. L. Smith, K. Frost, 2015 .

Predicting in vivo phospholipidosis-inducing potential of drugs by a combined high content screening and in silico modelling approach.

P. Walker, C. Bauch, Samantha Bevan, 2015, Toxicology in vitro : an international journal published in association with BIBRA.

Systems biology approach for evaluating the biological impact of environmental toxicants in vitro.

Rémi H. J. Dulize, M. Peitsch, A. Sewer, 2014, Chemical research in toxicology.

The genotoxicological assessment of a tobacco heating product relative to cigarette smoke using the in vitro micronucleus assay

M. Gaca, P. Walker, J. Clements, 2020, Toxicology reports.

Assessment of novel tobacco heating product THP1.0. Part 6: A comparative in vitro study using contemporary screening approaches

C. Proctor, M. Gaca, Tony Carr, 2017, Regulatory toxicology and pharmacology : RTP.

A combined in vitro approach to improve the prediction of mitochondrial toxicants.

P. Walker, J. Eakins, C. Bauch, 2016, Toxicology in vitro : an international journal published in association with BIBRA.

High Content Screening in NHBE cells shows significantly reduced biological activity of flavoured e-liquids, when compared to cigarette smoke condensate.

P. Walker, T. Walele, E. Trelles-Sticken, 2019, Toxicology in vitro : an international journal published in association with BIBRA.

Potential of the zebrafish (Danio rerio) embryo test to discriminate between chemicals of similar molecular structure—a study with valproic acid and 14 of its analogues

T. Braunbeck, S. Escher, P. Walker, 2022, Archives of Toxicology.

Comparing in vitro human liver models to in vivo human liver using RNA-Seq

J. Kleinjans, J. Hengstler, A. Ghallab, 2020, Archives of Toxicology.

Are Non-animal Systemic Safety Assessments Protective? A Toolbox and Workflow

P. Carmichael, M. Dent, Sophie Malcomber, 2022, Toxicological sciences : an official journal of the Society of Toxicology.

Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury

Y. Dragan, P. Watkins, Diane M. Longo, 2018, Toxicological sciences : an official journal of the Society of Toxicology.

Fit-For-Purpose Hepatocyte Models Enable the Identification of Early Events Contributing to Idelalisib-Induced Liver Injury

P. Watkins, P. Walker, Manisha Nautiyal, 2020 .

The evolution of strategies to minimise the risk of human drug-induced liver injury (DILI) in drug discovery and development

R. Riley, Paul A. Walker, Stephanie Ryder, 2020, Archives of Toxicology.

Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms

Paul Walker, Chris S. Pridgeon, Constanze Schlott, 2018, Archives of Toxicology.

Multiparametric assessment of mitochondrial respiratory inhibition in HepG2 and RPTEC/TERT1 cells using a panel of mitochondrial targeting agrochemicals

S. H. Bennekou, E. Danen, B. van de Water, 2020, Archives of Toxicology.

Zebrafish embryo neonicotinoid developmental neurotoxicity in the FET test and behavioral assays.

T. Braunbeck, Susanne Hougaard Bennekou, A. Forsby, 2022, ALTEX.

Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling

S. H. Bennekou, G. Ecker, U. Kraushaar, 2021, Archives of Toxicology.

A read-across case study on chronic toxicity of branched carboxylic acids (1): Integration of mechanistic evidence from new approach methodologies (NAMs) to explore a common mode of action.

Thomas E. Exner, E. Benfenati, O. Taboureau, 2021, Toxicology in Vitro.

The evolution of strategies to minimise the risk of human drug-induced liver injury (DILI) in drug discovery and development

R. Riley, S. Ryder, P. Walker, 2020, Archives of Toxicology.

Dynamic Modeling of Mitochondrial Membrane Potential Upon Exposure to Mitochondrial Inhibitors

E. Danen, B. van de Water, Huan Yang, 2021, Frontiers in Pharmacology.

Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms

Min Wei Wong, Emma L. Wilkinson, J. Sidaway, 2018, Archives of Toxicology.

Transcriptional landscape of mitochondrial electron transport chain inhibition in renal cells

S. H. Bennekou, B. van de Water, M. Leist, 2023, Cell Biology and Toxicology.

A combined in vitro approach to improve the prediction of mitochondrial toxicants.

P. Walker, J. Eakins, C. Bauch, 2016, Toxicology in vitro : an international journal published in association with BIBRA.