A. Kawase

发表

Stereoselective Inhibition of Methotrexate Excretion by Glucuronides of Nonsteroidal Anti-inflammatory Drugs via Multidrug Resistance Proteins 2 and 4

M. Iwaki, Sachiko Egashira, A. Kawase, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Stereoselective inhibition of methotrexate excretion by glucuronides of non-steroidal anti-inflammatory drugs via multidrug resistance protein 2 and multidrug resistance protein 4

M. Iwaki, Sachiko Egashira, A. Kawase, 2015 .

Involvement of Reactive Metabolites of Diclofenac in Cytotoxicity in Sandwich-Cultured Rat Hepatocytes

M. Iwaki, Hiroaki Shimada, A. Kawase, 2016, International journal of toxicology.

Differential effects of chrysin on nitrofurantoin pharmacokinetics mediated by intestinal breast cancer resistance protein in rats and mice.

M. Iwaki, A. Kawase, Yukako Matsumoto, 2009, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

Protein Kinase N Family Negatively Regulates Constitutive Androstane Receptor-Mediated Transcriptional Induction of Cytochrome P450 2b10 in the Livers of Mice

H. Mukai, R. Sugiura, Ryosuke Satoh, 2021, The Journal of Pharmacology and Experimental Therapeutics.

Relationship between the risk of idiosyncratic drug toxicity and formation and degradation profiles of acyl-glucuronide metabolites of nonsteroidal anti-inflammatory drugs in rat liver microsomes.

M. Iwaki, Hiroaki Shimada, A. Kawase, 2022, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Comparative evaluation of 12 immature citrus fruit extracts for the inhibition of cytochrome P450 isoform activities.

T. Fujita, M. Iwaki, A. Kawase, 2008, Biological & pharmaceutical bulletin.

The regulatory mechanism involved in the prostaglandin E2 disposition in carbon tetrachloride-induced liver injury.

T. Nakanishi, M. Iwaki, Hiroaki Shimada, 2020, Prostaglandins, leukotrienes, and essential fatty acids.

Effects of High-cholesterol Diet on Pravastatin Disposition in the Perfused Rat Liver

M. Iwaki, A. Kawase, A. Handa, 2016, European Journal of Drug Metabolism and Pharmacokinetics.

Increased effects of ginsenosides on the expression of cholesterol 7α-hydroxylase but not the bile salt export pump are involved in cholesterol metabolism

M. Iwaki, A. Kawase, H. Matsuda, 2012, Journal of Natural Medicines.

Involvement of diclofenac acyl-β-d-glucuronide in diclofenac-induced cytotoxicity in glutathione-depleted isolated murine hepatocytes co-cultured with peritoneal macrophages

M. Iwaki, Hiroaki Shimada, A. Kawase, 2019, Toxicology mechanisms and methods.

Decrease in Multidrug Resistance-associated Protein 2 Activities by Knockdown of Phosphatidylinositol 4-phosphate 5-kinase in Hepatocytes and Cancer Cells.

M. Iwaki, Hiroaki Shimada, A. Kawase, 2019, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

Impaired intrinsic chiral inversion activity of ibuprofen in rats with adjuvant-induced arthritis

M. Iwaki, A. Kawase, H. Komura, 2008, Xenobiotica; the fate of foreign compounds in biological systems.

M. Iwaki, A. Kawase, Ayano Yamada, 2015, European Journal of Drug Metabolism and Pharmacokinetics.

Changes in transporters and metabolizing enzymes in the livers of rats with bile duct ligation.

Distinct alterations in ATP-binding cassette transporter expression in liver, kidney, small intestine, and brain in adjuvant-induced arthritic rats.

Y. Kato, M. Iwaki, A. Kawase, 2014, Journal of pharmaceutical sciences.

Changes in mRNA Expression and Activity of Xenobiotic Metabolizing Enzymes in Livers from Adjuvant-Induced Arthritis Rats

M. Iwaki, A. Kawase, S. Wada, 2013 .

Diurnal Variation of Nuclear Receptors in Mice with or without Fasting

T. Ohgami, M. Iwaki, A. Kawase, 2013 .

Strain Differences in the Induction of Cytochrome P450 3A1/3A2 and Nuclear Receptors in the Liver by Phenobarbital and Dexamethasone in Sprague-Dawley Rats and Dark Agouti Rats

M. Iwaki, A. Kawase, H. Komura, 2011 .

Xenobiotic Metabolism in Primary Cultures of Rat Hepatocytes

M. Iwaki, A. Kawase, H. Matsuda, 2009 .

Ginseng Extracts Facilitate Cytochrome P450 Xenobiotic Metabolism in Primary Cultures of Rat Hepatocytes

M. Iwaki, A. Kawase, H. Matsuda, 2009 .

Differences in cytochrome P450 and nuclear receptor mRNA levels in liver and small intestines between SD and DA rats.

M. Iwaki, A. Kawase, H. Komura, 2008, Drug metabolism and pharmacokinetics.

Effects of Alterations in CAR on Bilirubin Detoxification in Mouse Collagen-Induced Arthritis

M. Iwaki, A. Kawase, Y. Tsunokuni, 2007, Drug Metabolism and Disposition.

Decreased PXR and CAR inhibit transporter and CYP mRNA Levels in the liver and intestine of mice with collagen-induced arthritis

M. Iwaki, A. Kawase, I. Yoshida, 2007, Xenobiotica; the fate of foreign compounds in biological systems.

Impact of a high-cholesterol diet on expression levels of Niemann–Pick C1-like 1 and intestinal transporters in rats and mice

M. Iwaki, A. Kawase, Y. Ueda, 2016, European Journal of Drug Metabolism and Pharmacokinetics.

Pravastatin Modulate Niemann-Pick C1-Like 1 and ATP-Binding Cassette G5 and G8 to Influence Intestinal Cholesterol Absorption.

M. Iwaki, A. Kawase, Seiji Hata, 2015, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

Profiling of hepatic metabolizing enzymes and nuclear receptors in rats with adjuvant arthritis by targeted proteomics

A. Kawase, S. Tateishi, Akira Kazaoka, 2018, Biopharmaceutics & drug disposition.

Effect of a Novel Ascorbic Derivative, Disodium Isostearyl 2-O-L-Ascorbyl Phosphate, on Normal Human Dermal Fibroblasts against Reactive Oxygen Species

M. Ohtsuki, K. Hanada, M. Iwaki, 2008, Bioscience, biotechnology, and biochemistry.

Inhibitory Effect of Ocimum gratissimum Leaf Extract on Postprandial Increase of Blood Glucose

M. Iwaki, Hiroaki Shimada, A. Kawase, 2019, Natural Product Communications.

Major constituents of Cistanche tubulosa, echinacoside and acteoside, inhibit sodium-dependent glucose cotransporter 1-mediated glucose uptake by intestinal epithelial cells

P. Tu, T. Morikawa, M. Iwaki, 2017 .

Effects of ginsenosides on the expression of cytochrome P450s and transporters involved in cholesterol metabolism

M. Iwaki, A. Kawase, H. Matsuda, 2014, Journal of Natural Medicines.

Diclofenac-Induced Cytotoxicity in Direct and Indirect Co-Culture of HepG2 Cells with Differentiated THP-1 Cells

M. Iwaki, Hiroaki Shimada, A. Kawase, 2022, International journal of molecular sciences.

Prediction of Hepatic Clearance of Stereoselective Metabolism of Carvedilol in Liver Microsomes and Hepatocytes of Sprague-Dawley and Cytochrome P450 2D-Deficient Dark Agouti Rats.

M. Iwaki, A. Kawase, H. Komura, 2019, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

Slc25a39 and Slc25a40 Expression in Mice with Bile Duct Ligation or Lipopolysaccharide Treatment

M. Iwaki, Hiroaki Shimada, A. Kawase, 2022, International journal of molecular sciences.

M. Iwaki, A. Kawase, Ayano Yamada, 2015, European Journal of Drug Metabolism and Pharmacokinetics.

Clotrimazole troches can alter everolimus pharmacokinetics in post‐transplant patients: A case report

A. Kawase, S. Yokoyama, M. Takada, 2019, British journal of clinical pharmacology.

Increased penetration of diphenhydramine in brain via proton-coupled organic cation antiporter in rats with lipopolysaccharide-induced inflammation

M. Iwaki, Hiroaki Shimada, A. Kawase, 2020, Brain, behavior, & immunity - health.

Correlation between glucuronidation and covalent adducts formation with proteins of nonsteroidal anti‐inflammatory drugs

M. Iwaki, Hiroaki Shimada, A. Kawase, 2018, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Drug interactions between tacrolimus and clotrimazole troche: a data mining approach followed by a pharmacokinetic study

A. Kawase, S. Yokoyama, M. Takada, 2019, European Journal of Clinical Pharmacology.

Effects of clotrimazole on tacrolimus pharmacokinetics in patients with heart transplants with different CYP3A5 genotypes

A. Kawase, S. Yokoyama, M. Takada, 2018, European Journal of Clinical Pharmacology.

Alteration in plasma protein binding properties of propranolol and flurbiprofen during development of adjuvant-induced arthritis in rats

M. Iwaki, A. Kawase, H. Ikuta, 2013, Xenobiotica; the fate of foreign compounds in biological systems.

Stereoselective Pharmacokinetics and Chiral Inversion of Ibuprofen in Adjuvant-induced Arthritic Rats

M. Iwaki, A. Kawase, H. Ikuta, 2017, Drug Metabolism and Disposition.

Discovery of pimozide derivatives as novel T-type calcium channel inhibitors with little binding affinity to dopamine D2 receptors for treatment of somatic and visceral pain.

A. Kawabata, F. Sekiguchi, S. Yoshida, 2022, European journal of medicinal chemistry.

Decreased intestinal CYP3A and P-glycoprotein activities in rats with adjuvant arthritis.

M. Iwaki, A. Kawase, T. Tanino, 2007, Drug metabolism and pharmacokinetics.

Stereoselective Covalent Adduct Formation of Acyl Glucuronide Metabolite of Nonsteroidal Anti-Inflammatory Drugs with UDP-Glucuronosyltransferase

M. Iwaki, Hiroaki Shimada, A. Kawase, 2022, International journal of molecular sciences.

Changes in Radixin Expression and Interaction with Efflux Transporters in the Liver of Adjuvant-Induced Arthritic Rats

M. Iwaki, Hiroaki Shimada, A. Kawase, 2019, Inflammation.

Stereoselective hepatic disposition of ibuprofen in the perfused liver of rat with adjuvant-induced arthritis

M. Iwaki, A. Kawase, M. Uraki, 2017, Xenobiotica; the fate of foreign compounds in biological systems.

Effects of Adjuvant-Induced Inflammation on Disposition of Diclofenac and Its Metabolites in Perfused Rat Liver.

M. Iwaki, A. Kawase, Hiroyuki Sayama, 2017, Journal of pharmaceutical sciences.

Pharmacokinetics , Pharmacodynamics and Drug Transport and Metabolism Effects of Adjuvant-Induced In fl ammation on Disposition of Diclofenac and Its Metabolites in Perfused Rat Liver

M. Iwaki, A. Kawase, Hiroyuki Sayama, 2017 .

Changes in mRNA expression of ABC and SLC transporters in liver and intestines of the adjuvant-induced arthritis rat.

M. Iwaki, A. Kawase, S. Uno, 2009, Biopharmaceutics & drug disposition.

Prediction of metabolic clearance of diclofenac in adjuvant-induced arthritis rats using a substrate depletion assay

M. Iwaki, A. Kawase, H. Komura, 2008 .

Species differences in liver microsomal hydrolysis of acyl glucuronide in humans and rats

M. Iwaki, Hiroaki Shimada, A. Kawase, 2022, Xenobiotica; the fate of foreign compounds in biological systems.

Effects of dose, flow rate, and bile acid on diclofenac disposition in the perfused rat liver

M. Iwaki, A. Kawase, Y. Matsushima, 2016, European Journal of Drug Metabolism and Pharmacokinetics.

Radixin knockdown improves the accumulation and efficiency of methotrexate in tumor cells.

M. Iwaki, A. Kawase, Yuta Inoue, 2019, Oncology reports.

Decreased radixin function for ATP-binding cassette transporters in liver in adjuvant-induced arthritis rats.

Y. Kato, M. Iwaki, A. Kawase, 2014, Journal of pharmaceutical sciences.

Enhanced Safety Profiles of the Telomerase-Specific Replication- Competent Adenovirus by Incorporation of Normal Cell-Specific microRNA-Targeted Sequences

T. Fujiwara, H. Mizuguchi, T. Hayakawa, 2011, Clinical Cancer Research.

Impact of the CYP3A5*1 Allele on the Pharmacokinetics of Tacrolimus in Japanese Heart Transplant Patients

A. Kawase, M. Takada, K. Wada, 2018, European Journal of Drug Metabolism and Pharmacokinetics.

Increased effects of ginsenosides on the expression of cholesterol 7α-hydroxylase but not the bile salt export pump are involved in cholesterol metabolism

M. Iwaki, A. Kawase, H. Matsuda, 2013, Journal of Natural Medicines.

NHERF1/EBP50 as a Target for Modulation of MRP Function in HepG2 Cells

M. Iwaki, Hiroaki Shimada, A. Kawase, 2021, Pharmaceuticals.

Application of substrate depletion assay for early prediction of nonlinear pharmacokinetics in drug discovery: assessment of nonlinearity of metoprolol, timolol, and propranolol.

M. Iwaki, A. Kawase, H. Komura, 2005, Journal of pharmaceutical sciences.

Relative contribution of rat CYP isoforms responsible for stereoselective metabolism of carvedilol.

Yukiko Nakamura, M. Iwaki, A. Kawase, 2018, Journal of Toxicological Sciences.

Effects of duration of phenytoin administration on mRNA expression of cytochrome P450 and P-glycoprotein in the liver and small intestine of rats

K. Matsuyama, M. Iwaki, A. Kawase, 2016 .

Application of substrate depletion assay to evaluation of CYP isoforms responsible for stereoselective metabolism of carvedilol.

M. Iwaki, A. Kawase, H. Komura, 2016, Drug metabolism and pharmacokinetics.

Drug interactions between tacrolimus and clotrimazole troche: a data mining approach followed by a pharmacokinetic study

A. Kawase, S. Yokoyama, M. Takada, 2019, European Journal of Clinical Pharmacology.

Changes in Radixin Expression and Interaction with Efflux Transporters in the Liver of Adjuvant-Induced Arthritic Rats

M. Iwaki, Hiroaki Shimada, A. Kawase, 2019, Inflammation.

[Trial of the integrated cross-field pharmaceutical education in the first year of faculty of pharmacy].

T. Wada, K. Matsuyama, N. Kawasaki, 2010, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Impact of a high-cholesterol diet on expression levels of Niemann–Pick C1-like 1 and intestinal transporters in rats and mice

M. Iwaki, A. Kawase, Y. Ueda, 2016, European Journal of Drug Metabolism and Pharmacokinetics.

Impact of the CYP3A5*1 Allele on the Pharmacokinetics of Tacrolimus in Japanese Heart Transplant Patients

A. Kawase, M. Takada, K. Wada, 2018, European Journal of Drug Metabolism and Pharmacokinetics.

Effects of ginsenosides on the expression of cytochrome P450s and transporters involved in cholesterol metabolism

M. Iwaki, A. Kawase, H. Matsuda, 2014, Journal of Natural Medicines.

Gum Arabic Enhances Intestinal Calcium Absorption in Rats

M. Iwaki, A. Kawase, H. Matsuda, 2007 .

Distinct alterations in ATP-binding cassette transporter expression in liver, kidney, small intestine, and brain in adjuvant-induced arthritic rats.

Y. Kato, M. Iwaki, A. Kawase, 2014, Journal of pharmaceutical sciences.

Stereoselective Pharmacokinetics and Chiral Inversion of Ibuprofen in Adjuvant-induced Arthritic Rats

M. Iwaki, A. Kawase, H. Ikuta, 2017, Drug Metabolism And Disposition.

Assessment of hepatic prostaglandin E2 level in carbamazepine induced liver injury

T. Nakanishi, M. Iwaki, Hiroaki Shimada, 2022, Endocrine Regulations.

Inhibition of 15-prostaglandin dehydrogenase attenuates acetaminophen-induced liver injury via suppression of apoptosis in liver endothelial cells.

Hiroaki Shimada, A. Kawase, Akito Yokotobi, 2024, Prostaglandins, leukotrienes, and essential fatty acids.