A. Giordani

发表

Novel analgesic/anti-inflammatory agents: 1,5-diarylpyrrole nitrooxyalkyl ethers and related compounds as cyclooxygenase-2 inhibiting nitric oxide donors.

Simone Brogi, C. Ghelardini, A. Rossi, 2013, Journal of medicinal chemistry.

In vitro effects of VA441, a new selective cyclooxygenase-2 inhibitor, on human osteoarthritic chondrocytes exposed to IL-1β.

A. Fioravanti, A. Cappelli, M. Galeazzi, 2012, Journal of pharmacological sciences.

Overall impact of the regulatory requirements for genotoxic impurities on the drug development process.

H. Gally, W. Kobel, A. Giordani, 2011, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Enlarging the NSAIDs family: ether, ester and acid derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents.

M. Botta, C. Ghelardini, N. Galeotti, 2011, Current medicinal chemistry.

(2S)-1-(arylacetyl)-2-(aminomethyl)piperidine derivatives: novel, highly selective kappa opioid analgesics.

A. Giordani, V. Vecchietti, G. Clarke, 1991, Journal of medicinal chemistry.

The novel anti-inflammatory agent VA694, endowed with both NO-releasing and COX2-selective inhibiting properties, exhibits NO-mediated positive effects on blood pressure, coronary flow and endothelium in an experimental model of hypertension and endothelial dysfunction.

M. Breschi, C. Ghelardini, L. Sautebin, 2013, Pharmacological research.

The Pros and the Cons for the Use of Silybin-Rich Oral Formulations in Treatment of Liver Damage (NAFLD in Particular).

C. Tiribelli, L. Rovati, N. Rosso, 2015, Current medicinal chemistry.

4-Phenyl-4-oxo-butanoic acid derivatives inhibitors of kynurenine 3-hydroxylase.

P. Pevarello, M. Varasi, C. Speciale, 1998, Bioorganic & medicinal chemistry letters.

Analgesic efficacy of CR4056, a novel imidazoline-2 receptor ligand, in rat models of inflammatory and neuropathic pain

S. Mandelli, A. Giordani, O. Letari, 2011, Journal of pain research.

Chondroprotective effect of three different classes of anti-inflammatory agents on human osteoarthritic chondrocytes exposed to IL-1β.

G. Valacchi, A. Fioravanti, N. Pascarelli, 2015, International immunopharmacology.

Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors.

C. Ghelardini, A. Rossi, L. Sautebin, 2014, Bioorganic & medicinal chemistry.

In vitro comprehensive analysis of VA692 a new chemical entity for the treatment of osteoarthritis

A. Fioravanti, F. Blanco, M. Anzini, 2018, International immunopharmacology.

Design, synthesis, and biological evaluation of AT1 angiotensin II receptor antagonists based on the pyrazolo[3,4-b]pyridine and related heteroaromatic bicyclic systems.

Walter Peris, Andrea Gallelli, A. Cappelli, 2008, Journal of medicinal chemistry.

Synthesis and biological evaluation of amidine, guanidine, and thiourea derivatives of 2-amino(6-trifluoromethoxy)benzothiazole as neuroprotective agents potentially useful in brain diseases.

M. Frosini, J. Magistretti, A. Cappelli, 2010, Journal of medicinal chemistry.

A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity.

S. Schenone, C. Ghelardini, A. Rossi, 2013, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of a new class of benzothiazines as neuroprotective agents.

M. Frosini, J. Magistretti, Simone Brogi, 2017, European journal of medicinal chemistry.

Nucleophilic substitution on α-mesyloxy-O-alkyloximes—II. Enantiospecific synthesis of 2-(imidazol-1-yl)-1-cyclohexyl-3-phenylpropan-1-one O-alkyloximes

P. Cozzi, A. Giordani, V. Pinciroli, 1997 .

Synthesis and structure-activity relationship studies in translocator protein ligands based on a pyrazolo[3,4-b]quinoline scaffold.

G. Biggio, C. Ghelardini, L. di Cesare Mannelli, 2011, Journal of medicinal chemistry.

Novel analgesic/anti-inflammatory agents: diarylpyrrole acetic esters endowed with nitric oxide releasing properties.

C. Ghelardini, A. Rossi, L. Sautebin, 2011, Journal of medicinal chemistry.

Multivalent supramolecular dendrimer-based drugs.

E. W. Meijer, E. Meijer, Marco Paolino, 2010, Biomacromolecules.

Improving the solubility of a new class of antiinflammatory pharmacodynamic hybrids, that release nitric oxide and inhibit cycloxygenase-2 isoenzyme.

S. Schenone, C. Ghelardini, A. Rossi, 2012, European journal of medicinal chemistry.

Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents.

M. Botta, C. Ghelardini, A. Rossi, 2008, Bioorganic & medicinal chemistry.

A New Synthesis of 3′-Fluoro-3′-deoxyadenosine

A. Giordani, A. Ermoli, C. Battisthi, 1991 .

Novel ester and acid derivatives of the 1,5-diarylpyrrole scaffold as anti-inflammatory and analgesic agents. Synthesis and in vitro and in vivo biological evaluation.

M. Botta, C. Ghelardini, N. Galeotti, 2010, Journal of medicinal chemistry.

Il genere Allium L. (Alliaceae) in Italia. XX. Allium strictum Schrader

A. Giordani, F. Garbari, G. D. Vesco, 2003 .

Agents combining thromboxane receptor antagonism with thromboxane synthase inhibition: [[[2-(1H-imidazol-1-yl)ethylidene]amino]oxy]alkanoic acids.

D. Volpi, P. Cozzi, A. Giordani, 1994, Journal of medicinal chemistry.

Exploring Translocator Protein (TSPO) Medicinal Chemistry: An Approach for Targeting Radionuclides and Boron Atoms to Mitochondria.

M. Menziani, R. Moresco, M. Matarrese, 2021, Journal of medicinal chemistry.

Antiproliferative effect of two novel COX-2 inhibitors on human keratinocytes.

G. Valacchi, A. Cappelli, M. Anzini, 2013, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds.

Simone Brogi, Marco Lanza, Giuseppe Campiani, 2013, European journal of medicinal chemistry.

Benzoylalanine analogues as inhibitors of rat brain kynureninase and kynurenine 3-hydroxylase.

R. Schwarcz, M. Varasi, P. Guidetti, 1996, Advances in experimental medicine and biology.

Phenylindenone isomers as divergent modulators of p38α MAP kinase.

M. Menziani, A. Cappelli, M. Anzini, 2016, Bioorganic & medicinal chemistry letters.

Synthesis, biological evaluation, and enzyme docking simulations of 1,5-diarylpyrrole-3-alkoxyethyl ethers as selective cyclooxygenase-2 inhibitors endowed with anti-inflammatory and antinociceptive activity.

M. Botta, C. Ghelardini, A. Rossi, 2008, Journal of medicinal chemistry.

Therapeutic potential for coxibs-nitric oxide releasing hybrids in cystic fibrosis.

C. Ghelardini, L. di Cesare Mannelli, V. Calderone, 2020, European journal of medicinal chemistry.

Synthesis and biological evaluation of fluorinated 1,5-diarylpyrrole-3-alkoxyethyl ether derivatives as selective COX-2 inhibitors endowed with anti-inflammatory activity.

Simone Brogi, M. Brindisi, G. Valacchi, 2016, European journal of medicinal chemistry.

Analgesic efficacy of CR 4056 , a novel imidazoline-2 receptor ligand , in rat models of inflammatory and neuropathic pain

S. Mandelli, A. Giordani, O. Letari, 2011 .

A nanocomposite material formed by benzofulvene polymer nanoparticles loaded with a potent 5-HT3 receptor antagonist (CR3124)

E. Paccagnini, R. Mendichi, M. Fresta, 2010 .

Modulation of the kynurine pathway of tryptophan metabolism in search for neuroprotective agents. Focus on kynurenine-3-hydroxylase.

P. Pevarello, M. Varasi, C. Speciale, 2003, Advances in experimental medicine and biology.

Design, Synthesis, and Preliminary Biological Evaluation of Pyrrolo[3,4‐c]quinolin‐1‐one and Oxoisoindoline Derivatives as Aggrecanase Inhibitors

A. Cappelli, M. Anzini, S. Vomero, 2010, ChemMedChem.

Progress towards the identification of new aggrecanase inhibitors.

F. de Rienzo, M. Menziani, P. Saxena, 2009, Current medicinal chemistry.

Synthesis of 3′-Fluoro-3′-deoxyadenosine Starting from Adenosine

A. Giordani, G. Franceschi, C. Battistini, 1991 .

Phenylindenone isomers as divergent modulators of p38α MAP kinase.

M. Menziani, A. Cappelli, M. Anzini, 2016, Bioorganic & medicinal chemistry letters.

Novel ester and acid derivatives of the 1,5-diarylpyrrole scaffold as anti-inflammatory and analgesic agents. Synthesis and in vitro and in vivo biological evaluation.

M. Botta, C. Ghelardini, N. Galeotti, 2010, Journal of medicinal chemistry.