J. S. Lagas

发表

Transport of Diclofenac by Breast Cancer Resistance Protein (ABCG2) and Stimulation of Multidrug Resistance Protein 2 (ABCC2)-Mediated Drug Transport by Diclofenac and Benzbromarone

Jos H Beijnen, J. Beijnen, A. Schinkel, 2009, Drug Metabolism and Disposition.

Liquid chromatography-tandem mass spectrometric assay for diclofenac and three primary metabolites in mouse plasma.

J. Schellens, J. Beijnen, J. S. Lagas, 2008, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Chapter 9 Physiological and pharmacological roles of ABCG 2 ( BCRP ) : recent findings in Abcg 2 knockout mice

A. Schinkel, M. Vlaming, J. S. Lagas, 2009 .

Chapter 1 Compound transporter knockout mice : powerful tools to unravel the pharmacological and physiological functions of ATP binding cassette drug transporters

A. Schinkel, M. Vlaming, J. S. Lagas, 2009 .

Pharmacokinetic assessment of multiple ATP-binding cassette transporters: the power of combination knockout mice.

A. Schinkel, M. Vlaming, J. S. Lagas, 2009, Molecular interventions.

Liquid chromatography-tandem mass spectrometric assay for sorafenib and sorafenib-glucuronide in mouse plasma and liver homogenate and identification of the glucuronide metabolite.

J. Schellens, J. Beijnen, M. Vlaming, 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Midazolam Metabolism in Cytochrome P450 3A Knockout Mice Can Be Attributed to Up-Regulated CYP2C Enzymes

J. Goldstein, J. Beijnen, A. V. van Herwaarden, 2008, Molecular Pharmacology.

P‐glycoprotein and cytochrome P450 3A act together in restricting the oral bioavailability of paclitaxel

J. Schellens, H. Rosing, J. Beijnen, 2013, International journal of cancer.

Absence of both cytochrome P450 3A and P-glycoprotein dramatically increases docetaxel oral bioavailability and risk of intestinal toxicity.

H. Rosing, J. Beijnen, A. V. van Herwaarden, 2009, Cancer research.

Severe Lactic Acidosis in a Diabetic Patient after Ethanol Abuse and Floor Cleaner Intake

J. Schellens, J. Beijnen, A. Huitema, 2014, Basic & clinical pharmacology & toxicology.

Taxanes: old drugs, new oral formulations.

J. Schellens, J. Beijnen, B. Nuijen, 2013, European journal of pharmacology.

Chapter 3 Multidrug resistance protein 2 ( Mrp 2 ; Abcc 2 ) is an important determinant of paclitaxel pharmacokinetics

H. Rosing, J. Beijnen, A. Schinkel, 2009 .

P-Glycoprotein, Multidrug-Resistance Associated Protein 2, Cyp3a, and Carboxylesterase Affect the Oral Availability and Metabolism of Vinorelbine

C. Damen, J. Beijnen, A. Schinkel, 2012, Molecular Pharmacology.

Individual and combined roles of CYP3A, P‐glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) in the pharmacokinetics of docetaxel

H. Rosing, J. Beijnen, A. Schinkel, 2010, International journal of cancer.

P-glycoprotein (P-gp/Abcb1), Abcc2, and Abcc3 Determine the Pharmacokinetics of Etoposide

J. Beijnen, O. van Tellingen, A. Schinkel, 2009, Clinical Cancer Research.

Chapter 2 Carcinogen and anti-cancer drug transport by Mrp 2 in vivo : studies using Mrp 2 ( Abcc 2 ) knockout mice

J. Schellens, H. Rosing, E. Wagenaar, 2009 .

No relation between docetaxel administration route and high‐grade diarrhea incidence

J. Schellens, H. Rosing, J. Beijnen, 2020, Pharmacology research & perspectives.

Ritonavir inhibits intratumoral docetaxel metabolism and enhances docetaxel antitumor activity in an immunocompetent mouse breast cancer model

J. Schellens, H. Rosing, J. Beijnen, 2016, International journal of cancer.

Oral co-administration of elacridar and ritonavir enhances plasma levels of oral paclitaxel and docetaxel without affecting relative brain accumulation

J. Schellens, H. Rosing, J. Beijnen, 2014, British Journal of Cancer.

Breast Cancer Resistance Protein and P-glycoprotein Limit Sorafenib Brain Accumulation

Jos H. Beijnen, Alfred H. Schinkel, J. Beijnen, 2010, Molecular Cancer Therapeutics.

The bioanalysis of vinorelbine and 4-O-deacetylvinorelbine in human and mouse plasma using high-performance liquid chromatography coupled with heated electrospray ionization tandem mass-spectrometry.

C. Damen, J. Schellens, H. Rosing, 2009, Biomedical chromatography : BMC.

A sensitive assay for the quantitative analysis of vinorelbine in mouse and human EDTA plasma by high-performance liquid chromatography coupled with electrospray tandem mass spectrometry.

C. Damen, J. Schellens, H. Rosing, 2008, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Toxicokinetics of a dipyridamole (Persantin) intoxication: Case report

J. Beijnen, J. S. Lagas, D. Brandjes, 2011, Human & experimental toxicology.

Pharmacological functions of multidrug transporters: studies employing combination transporter knockout mice

J. S. Lagas, 2009 .

Physiological and pharmacological roles of ABCG2 (BCRP): recent findings in Abcg2 knockout mice.

A. Schinkel, M. Vlaming, J. S. Lagas, 2009, Advanced drug delivery reviews.

Liquid chromatography-tandem mass spectrometric assays for salinomycin in mouse plasma, liver, brain and small intestinal contents and in OptiMEM cell culture medium.

J. Schellens, J. Beijnen, J. S. Lagas, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Brain Accumulation of Dasatinib Is Restricted by P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) and Can Be Enhanced by Elacridar Treatment

Jos H. Beijnen, Alfred H. Schinkel, H. Rosing, 2009, Clinical Cancer Research.

P-Glycoprotein Limits Oral Availability, Brain Penetration, and Toxicity of an Anionic Drug, the Antibiotic Salinomycin

Jos H. Beijnen, Alfred H. Schinkel, J. Beijnen, 2007, Antimicrobial Agents and Chemotherapy.

Carcinogen and Anticancer Drug Transport by Mrp2 in Vivo: Studies Using Mrp2 (Abcc2) Knockout Mice

J. Schellens, H. Rosing, J. Beijnen, 2006, Journal of Pharmacology and Experimental Therapeutics.

Multidrug Resistance Protein 2 Is an Important Determinant of Paclitaxel Pharmacokinetics

H. Rosing, J. Beijnen, O. van Tellingen, 2006, Clinical Cancer Research.

Hepatic Clearance of Reactive Glucuronide Metabolites of Diclofenac in the Mouse Is Dependent on Multiple ATP-Binding Cassette Efflux Transporters

J. Beijnen, A. Schinkel, E. Wagenaar, 2010, Molecular Pharmacology.

Drug Formulations: How these Affects Anticancer Drug

J. Schellens, J. Beijnen, B. Nuijen, 2014 .

Lethal morphine intoxication in a patient with a sickle cell crisis and renal impairment: Case report and a review of the literature

J. Beijnen, A. Huitema, M. Hillebrand, 2011, Human & experimental toxicology.

Brain accumulation of sunitinib is restricted by P‐glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration

Jos H Beijnen, H. Rosing, J. Beijnen, 2012, International journal of cancer.

P‐glycoprotein and cytochrome P450 3A act together in restricting the oral bioavailability of paclitaxel

J. Schellens, H. Rosing, J. Beijnen, 2013, International journal of cancer.

Brain Accumulation of Dasatinib Is Restricted by P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) and Can Be Enhanced by Elacridar Treatment

H. Rosing, J. Beijnen, M. Hillebrand, 2009, Clinical Cancer Research.