R. Sparidans

发表

Liquid chromatography-tandem mass spectrometric assay for diclofenac and three primary metabolites in mouse plasma.

J. Schellens, J. Beijnen, J. S. Lagas, 2008, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

MIDAZOLAM AND CYCLOSPORIN A METABOLISM IN TRANSGENIC MICE WITH LIVER-SPECIFIC EXPRESSION OF HUMAN CYP3A4

J. Schellens, J. Beijnen, A. V. van Herwaarden, 2005, Drug Metabolism and Disposition.

P-glycoprotein (MDR1/ABCB1) and breast cancer resistance protein (BCRP/ABCG2) restrict brain accumulation of the JAK1/2 inhibitor, CYT387.

J. Beijnen, A. Schinkel, S. Durmuş, 2013, Pharmacological research.

Dendrimer-based macromolecular conjugate for the kidney-directed delivery of a multitargeted sunitinib analogue.

G. Kéri, W. Hennink, R. Kok, 2012, Macromolecular bioscience.

Inhibition and Stimulation of Intestinal and Hepatic CYP3A Activity: Studies in Humanized CYP3A4 Transgenic Mice Using Triazolam

J. Beijnen, A. V. van Herwaarden, A. Schinkel, 2009, Drug Metabolism and Disposition.

Inhibition and stimulation of intestinal and hepatic CYP3A activity: studies in humanized CYP3A4 transgenic mice using triazolam

J. Beijnen, A. Schinkel, R. Sparidans, 2009 .

In vitro characterization of the biotransformation of thiocoraline, a novel marine anti-cancer drug

J. Schellens, J. Beijnen, E. Brandon, 2004, Investigational New Drugs.

Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export

J. Lankelma, R. Evers, J. Beijnen, 2000, British Journal of Cancer.

In vitro characterization of the human biotransformation and CYP reaction phenotype of ET-743 (Yondelis®, Trabectidin®), a novel marine anti-cancer drug

J. Schellens, J. Beijnen, E. Brandon, 2006, Investigational New Drugs.

In-vitro cytotoxicity of ET-743 (Trabectedin, Yondelis), a marine anti-cancer drug, in the Hep G2 cell line: influence of cytochrome P450 and phase II inhibition, and cytochrome P450 induction

J. Schellens, J. Beijnen, E. Brandon, 2005, Anti-cancer drugs.

Analysis of poly(styrene—co-methyl acrylate) and poly(styrene—co-butyl acrylate) by high-performance liquid chromatography

A. Herk, H. Claessens, R. Sparidans, 1990 .

Chloroquine Administration in Breastfeeding Mothers Associates with Increased HIV-1 Plasma Viral Loads

W. Paxton, J. Beijnen, F. Wit, 2020 .

Liquid chromatography-tandem mass spectrometric assay for sorafenib and sorafenib-glucuronide in mouse plasma and liver homogenate and identification of the glucuronide metabolite.

J. Schellens, J. Beijnen, M. Vlaming, 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Pharmacokinetic Drug–Drug Interaction of the Novel Anticancer Agent E7070 and Acenocoumarol

J. Schellens, J. Beijnen, H. D. van den Bongard, 2004, Investigational New Drugs.

Liquid chromatography-tandem mass spectrometric assay for the T790M mutant EGFR inhibitor osimertinib (AZD9291) in human plasma.

J. Schellens, J. Beijnen, R. Sparidans, 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Midazolam Metabolism in Cytochrome P450 3A Knockout Mice Can Be Attributed to Up-Regulated CYP2C Enzymes

J. Goldstein, J. Beijnen, A. V. van Herwaarden, 2008, Molecular Pharmacology.

Degradation kinetics of aplidine, a new marine antitumoural cyclic peptide, in aqueous solution.

J. Beijnen, H. Lingeman, A. Bult, 2001, Journal of chromatography. B, Biomedical sciences and applications.

Oral availability and brain penetration of the B-RAFV600E inhibitor vemurafenib can be enhanced by the P-GLYCOprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridar.

J. Beijnen, A. Schinkel, S. Durmuş, 2012, Molecular pharmaceutics.

Cyclin-Dependent Kinase Inhibitor AT7519 as a Potential Drug for MYCN-Dependent Neuroblastoma

R. Versteeg, H. Caron, S. Robinson, 2015, Clinical Cancer Research.

Liquid chromatography-tandem mass spectrometric assay for the JAK2 inhibitor CYT387 in plasma.

J. Schellens, J. Beijnen, A. Schinkel, 2012, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Liquid chromatography-tandem mass spectrometric assay for the PI3K/mTOR inhibitor GSK2126458 in mouse plasma and tumor homogenate.

E. Westerhout, Mohamed Hamdi, J. Schellens, 2015, Journal of pharmaceutical and biomedical analysis.

A pharmacokinetic and pharmacodynamic model for intravenous bisphosphonate (pamidronate) in osteoporosis

S. Cremers, J. den Hartigh, S. Papapoulos, 2002, European Journal of Clinical Pharmacology.

Melphalan Antitumor Efficacy and Hepatotoxicity: The Effect of Variable Infusion Duration in the Hepatic Artery

C. V. D. van de Velde, R. Woutersen, G. Mulder, 2003, Journal of Pharmacology and Experimental Therapeutics.

Brain and Testis Accumulation of Regorafenib is Restricted by Breast Cancer Resistance Protein (BCRP/ABCG2) and P-glycoprotein (P-GP/ABCB1)

J. Beijnen, A. Schinkel, S. Durmuş, 2015, Pharmaceutical Research.

Rifampin and ritonavir increase oral availability and elacridar enhances overall exposure and brain accumulation of the NTRK inhibitor larotrectinib.

J. Beijnen, A. Schinkel, R. Sparidans, 2021, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Liquid chromatographic assay for simultaneous determination of abacavir and mycophenolic acid in human plasma using dual spectrophotometric detection.

J. Beijnen, R. Hoetelmans, R. Sparidans, 2001, Journal of chromatography. B, Biomedical sciences and applications.

P-Glycoprotein, CYP3A, and Plasma Carboxylesterase Determine Brain and Blood Disposition of the mTOR Inhibitor Everolimus (Afinitor) in Mice

J. Beijnen, A. Schinkel, S. Durmuş, 2014, Clinical Cancer Research.

Cancer Therapy : Preclinical P-Glycoprotein , CYP 3 A , and Plasma Carboxylesterase Determine Brain and Blood Disposition of themTOR Inhibitor Everolimus ( A fi nitor ) in Mice

J. Beijnen, A. Schinkel, S. Durmuş, 2014 .

Chromatographic bioanalytical assays for targeted covalent kinase inhibitors and their metabolites.

J. Beijnen, R. Sparidans, Irene A. Retmana, 2020, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Isolated lung perfusion with melphalan: Pharmacokinetics and toxicity in a pig model

M. Paul, S. Oosterling, J. R. van der Sijp, 2006, Journal of surgical oncology.

P‐glycoprotein (MDR1/ABCB1) restricts brain accumulation and cytochrome P450‐3A (CYP3A) limits oral availability of the novel ALK/ROS1 inhibitor lorlatinib

J. Beijnen, A. Schinkel, E. Wagenaar, 2018, International journal of cancer.

Bioanalytical liquid chromatography‐tandem mass spectrometric assay for the quantification of the ALK inhibitors alectinib, brigatinib and lorlatinib in plasma and mouse tissue homogenates

J. Schellens, J. Beijnen, A. Schinkel, 2018, Journal of pharmaceutical and biomedical analysis.

Randomized phase I clinical and pharmacologic study of weekly versus twice-weekly dose-intensive cisplatin and gemcitabine in patients with advanced non-small cell lung cancer.

J. Schellens, J. Beijnen, P. Baas, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

Liquid chromatography-tandem mass spectrometric assay for the ALK inhibitor crizotinib in mouse plasma.

J. Schellens, J. Beijnen, A. Schinkel, 2012, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Quantification of FGFR4 inhibitor BLU-554 in mouse plasma and tissue homogenates using liquid chromatography-tandem mass spectrometry.

J. Beijnen, A. Schinkel, B. Doğan-Topal, 2019, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Phase I clinical and pharmacologic study of a 2-weekly administration of cisplatin and gemcitabine in patients with advanced non-small cell lung cancer

J. Schellens, J. Beijnen, P. Baas, 2005, Anti-cancer drugs.

Impact of P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) Gene Dosage on Plasma Pharmacokinetics and Brain Accumulation of Dasatinib, Sorafenib, and Sunitinib

J. Beijnen, A. Schinkel, E. Wagenaar, 2013, The Journal of Pharmacology and Experimental Therapeutics.

Recent developments in the chromatographic bioanalysis of approved kinase inhibitor drugs in oncology.

J. Schellens, J. Beijnen, R. Sparidans, 2016, Journal of pharmaceutical and biomedical analysis.

Brain Accumulation of Ponatinib and Its Active Metabolite, N-Desmethyl Ponatinib, Is Limited by P-Glycoprotein (P-GP/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2).

J. Beijnen, A. Schinkel, E. Wagenaar, 2017, Molecular pharmaceutics.

P-Glycoprotein (MDR1/ABCB1) Restricts Brain Penetration of the Bruton's Tyrosine Kinase Inhibitor Ibrutinib, While Cytochrome P450-3A (CYP3A) Limits Its Oral Bioavailability.

J. Beijnen, A. Schinkel, E. Wagenaar, 2018, Molecular pharmaceutics.

Quantification of KRAS inhibitor sotorasib in mouse plasma and tissue homogenates using liquid chromatography-tandem mass spectrometry.

J. Beijnen, A. Schinkel, R. Sparidans, 2021, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Bioanalysis of ibrutinib, and its dihydrodiol- and glutathione cycle metabolites by liquid chromatography-tandem mass spectrometry.

J. Schellens, J. Beijnen, R. Sparidans, 2018, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Bioanalysis of EGFRm inhibitor osimertinib, and its glutathione cycle- and desmethyl metabolites by liquid chromatography-tandem mass spectrometry.

J. Beijnen, R. Sparidans, M. V. van Haren, 2020, Journal of pharmaceutical and biomedical analysis.

Liquid chromatography-tandem mass spectrometry assay for the EGFR inhibitor pelitinib in plasma.

J. Schellens, J. Beijnen, A. Schinkel, 2013, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Liquid chromatography-tandem mass spectrometric assay for the simultaneous determination of the irreversible BTK inhibitor ibrutinib and its dihydrodiol-metabolite in plasma and its application in mouse pharmacokinetic studies.

J. Schellens, J. Beijnen, A. Schinkel, 2016, Journal of pharmaceutical and biomedical analysis.

Isocratic ion-exchange chromatographic assay for the nucleotide gemcitabine triphosphate in human white blood cells.

J. Schellens, J. Beijnen, R. Sparidans, 2002, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Search for metabolites of ecteinascidin 743, a novel, marine-derived, anti-cancer agent, in man

J. Schellens, H. Rosing, J. Beijnen, 2001, Anti-cancer drugs.

Breast Cancer Resistance Protein and P-glycoprotein Limit Sorafenib Brain Accumulation

Jos H. Beijnen, Alfred H. Schinkel, J. Beijnen, 2010, Molecular Cancer Therapeutics.

The matrikine N-α-PGP couples extracellular matrix fragmentation to endothelial permeability

D. Scott, A. Gaggar, J. Blalock, 2015, Science Advances.

Liquid chromatography-tandem mass spectrometric assay for therapeutic drug monitoring of the tyrosine kinase inhibitor pazopanib in human plasma.

J. Schellens, J. Beijnen, R. Sparidans, 2012, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

P-Glycoprotein (MDR1/ABCB1) Restricts Brain Accumulation of the Novel EGFR Inhibitor EAI045 and Oral Elacridar Coadministration Enhances Its Brain Accumulation and Oral Exposure

J. Beijnen, A. Schinkel, R. Sparidans, 2022, Pharmaceuticals.

Liquid chromatography-tandem mass spectrometric assay for the multikinase inhibitor regorafenib in plasma.

J. Schellens, J. Beijnen, A. Schinkel, 2014, Biomedical chromatography : BMC.

Chemical and enzymatic stability of a cyclic depsipeptide, the novel, marine-derived, anti-cancer agent kahalalide F

J. Schellens, J. Beijnen, J. Jimeno, 2001, Anti-cancer drugs.

Effect of Mycophenolate Mofetil on the Pharmacokinetics of Antiretroviral Drugs and on Intracellular Nucleoside Triphosphate Pools

J. Beijnen, A. Huitema, D. Back, 2004, Clinical pharmacokinetics.

PI3K/mTOR inhibitor omipalisib prolongs cardiac repolarization along with a mild proarrhythmic outcome in the AV block dog model

M. Vos, R. Sparidans, A. Bossu, 2022, Frontiers in Cardiovascular Medicine.

Liquid chromatography-tandem mass spectrometric assay for ponatinib and N-desmethyl ponatinib in mouse plasma.

J. Schellens, J. Beijnen, A. Schinkel, 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Breast Cancer Resistance Protein (BCRP/ABCG2) and P-glycoprotein (P-GP/ABCB1) Restrict Oral Availability and Brain Accumulation of the PARP Inhibitor Rucaparib (AG-014699)

J. Beijnen, A. Schinkel, S. Durmuş, 2014, Pharmaceutical Research.

Liquid chromatography-tandem mass spectrometric assay for the light sensitive tyrosine kinase inhibitor axitinib in human plasma.

J. Schellens, J. Beijnen, A. Schinkel, 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Liquid chromatography-tandem mass spectrometric assay for the light sensitive survivin suppressant sepantronium bromide (YM155) in mouse plasma.

J. Schellens, J. Beijnen, J. Molenaar, 2014, Journal of pharmaceutical and biomedical analysis.

Bioanalytical assay for the quantification of the ALK inhibitor lorlatinib in mouse plasma using liquid chromatography-tandem mass spectrometry.

J. Schellens, J. Beijnen, A. Schinkel, 2018, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Simple and sensitive method for quantification of low tobramycin concentrations in human plasma using HPLC-MS/MS.

H. O. Oudemans-van Straaten, R. Sparidans, E. Franssen, 2008, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Liquid chromatography-tandem mass spectrometric assay for the VEGFR inhibitor cediranib and its primary human metabolite cediranib-N⁺-glucuronide in plasma.

J. Schellens, J. Beijnen, A. Schinkel, 2012, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Evaluation of human neutrophil peptide-1, -2 and -3 as serum markers for colorectal cancer.

J. Schellens, J. Beijnen, A. Cats, 2010, Cancer biomarkers : section A of Disease markers.

Brain and Testis Accumulation of Regorafenib is Restricted by Breast Cancer Resistance Protein (BCRP/ABCG2) and P-glycoprotein (P-GP/ABCB1)

J. Beijnen, A. Schinkel, S. Durmuş, 2015, Pharmaceutical Research.

Improved and simplified liquid chromatographic assay for adefovir, a novel antiviral drug, in human plasma using derivatization with chloroacetaldehyde.

J. Beijnen, R. Hoetelmans, R. Sparidans, 1999, Journal of chromatography. B, Biomedical sciences and applications.

Breast Cancer Resistance Protein (BCRP/ABCG2) and P-glycoprotein (P-GP/ABCB1) Restrict Oral Availability and Brain Accumulation of the PARP Inhibitor Rucaparib (AG-014699)

J. Beijnen, A. Schinkel, S. Durmuş, 2014, Pharmaceutical Research.

Liquid chromatography-tandem mass spectrometric assay for the cyclin-dependent kinase inhibitor AT7519 in mouse plasma.

J. Schellens, J. Beijnen, J. Molenaar, 2014, Journal of pharmaceutical and biomedical analysis.

Quantitative bioanalysis of peptides by liquid chromatography coupled to (tandem) mass spectrometry.

Jos H Beijnen, Irene van den Broek, J. Schellens, 2008, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Liquid chromatography/tandem mass spectrometric method for the quantification of eight proteolytic fragments of ITIH4 with biomarker potential in human plasma and serum.

J. Schellens, J. Beijnen, R. Sparidans, 2008, Rapid communications in mass spectrometry : RCM.

Enzymatic digestion as a tool for the LC-MS/MS quantification of large peptides in biological matrices: measurement of chymotryptic fragments from the HIV-1 fusion inhibitor enfuvirtide and its metabolite M-20 in human plasma.

J. Schellens, J. Beijnen, R. Sparidans, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Development and validation of a quantitative assay for the measurement of two HIV-fusion inhibitors, enfuvirtide and tifuvirtide, and one metabolite of enfuvirtide (M-20) in human plasma by liquid chromatography-tandem mass spectrometry.

J. Schellens, J. Beijnen, A. Huitema, 2006, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Population Pharmacokinetics of Itraconazole in Thai HIV-1-Infected Persons

J. Beijnen, A. Huitema, J. Lange, 2003, Therapeutic drug monitoring.

Selective high-performance liquid chromatographic assay for itraconazole and hydroxyitraconazole in plasma from human immunodeficiency virus-infected patients.

J. Beijnen, R. Sparidans, C. Koks, 2002, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Drug-drug interaction between itraconazole and the antiretroviral drug lopinavir/ritonavir in an HIV-1-infected patient with disseminated histoplasmosis.

J. Schellens, J. Beijnen, A. Huitema, 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

The bioanalysis of the major Echinacea purpurea constituents dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamides in human plasma using LC-MS/MS.

J. Schellens, H. Rosing, J. Beijnen, 2012, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

A sensitive LC-MS/MS method for the quantitative analysis of the Echinacea purpurea constituent undeca-2-ene-8,10-diynoic acid isobutylamide in human plasma.

J. Schellens, H. Rosing, J. Beijnen, 2011, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Pretreatment of body fluids by preparative isotachophoresis prior to chromatographic analysis

F. Everaerts, H. Claessens, R. Sparidans, 1988 .

ABCB1 and ABCG2, but not CYP3A4 limit oral availability and brain accumulation of the RET inhibitor pralsetinib.

J. Beijnen, A. Schinkel, R. Sparidans, 2021, Pharmacological research.

High-performance ion-exchange chromatography with in-line complexation of bisphosphonates and their quality control in pharmaceutical preparations.

J. den Hartigh, R. Sparidans, P. Vermeij, 1995, Journal of pharmaceutical and biomedical analysis.

Liquid chromatography-tandem mass spectrometric assay for the PARP inhibitor rucaparib in plasma.

J. Schellens, J. Beijnen, A. Schinkel, 2014, Journal of pharmaceutical and biomedical analysis.

Liquid chromatography-tandem mass spectrometric assay for the nucleoside reverse transcriptase inhibitor emtricitabine in human plasma.

J. Schellens, J. Beijnen, J. Prins, 2007, Biomedical chromatography : BMC.

Liquid chromatographic assay for the antiviral nucleotide analogue tenofovir in plasma using derivatization with chloroacetaldehyde.

J. Schellens, J. Beijnen, R. Sparidans, 2003, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Liquid chromatography-tandem mass spectrometric assay for the analysis of uracil, 5,6-dihydrouracil and beta-ureidopropionic acid in urine for the measurement of the activities of the pyrimidine catabolic enzymes.

J. Schellens, J. Beijnen, R. Sparidans, 2006, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Organic anion-transporting polypeptides 1a/1b control the hepatic uptake of pravastatin in mice.

J. Beijnen, E. van de Steeg, A. Schinkel, 2012, Molecular pharmaceutics.

Differential Impact of P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) on Axitinib Brain Accumulation and Oral Plasma Pharmacokinetics

Jos H Beijnen, J. Beijnen, A. Schinkel, 2011, Drug Metabolism and Disposition.

Collagen degradation and neutrophilic infiltration: a vicious circle in inflammatory bowel disease

A. Kraneveld, J. Garssen, H. Verspaget, 2013, Gut.

Anti-GD2 Immunoliposomes for Targeted Delivery of the Survivin Inhibitor Sepantronium Bromide (YM155) to Neuroblastoma Tumor Cells

W. Hennink, Shima Gholizadeh, R. Kok, 2018, Pharmaceutical Research.

Increased oral availability and brain accumulation of the ALK inhibitor crizotinib by coadministration of the P‐glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridar

J. Beijnen, A. Schinkel, E. Wagenaar, 2014, International journal of cancer.

Liquid chromatography-tandem mass spectrometric assays for salinomycin in mouse plasma, liver, brain and small intestinal contents and in OptiMEM cell culture medium.

J. Schellens, J. Beijnen, J. S. Lagas, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Phase I and pharmacological study of the farnesyltransferase inhibitor tipifarnib (Zarnestra®, R115777) in combination with gemcitabine and cisplatin in patients with advanced solid tumours

J. Beijnen, A. Howes, W. S. Siegel-Lakhai, 2005, British Journal of Cancer.

P‐glycoprotein (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) affect brain accumulation and intestinal disposition of encorafenib in mice

J. Beijnen, A. Schinkel, E. Wagenaar, 2017, Pharmacological research.

Breast cancer resistance protein (BCRP/ABCG2) and P‐glycoprotein (P‐gp/ABCB1) transport afatinib and restrict its oral availability and brain accumulation☆

J. Beijnen, A. Schinkel, E. Wagenaar, 2017, Pharmacological research.

Brain accumulation of the EML4-ALK inhibitor ceritinib is restricted by P-glycoprotein (P-GP/ABCB1) and breast cancer resistance protein (BCRP/ABCG2).

J. Beijnen, A. Schinkel, E. Wagenaar, 2015, Pharmacological research.

PI3K–mTOR Pathway Inhibition Exhibits Efficacy Against High-grade Glioma in Clinically Relevant Mouse Models

J. Beijnen, T. Würdinger, M. D. de Gooijer, 2016, Clinical Cancer Research.

Cooperative induction of apoptosis in NRAS mutant melanoma by inhibition of MEK and ROCK

A. Heck, J. Beijnen, D. Peeper, 2015, Pigment cell & melanoma research.

Targeting of a platinum-bound sunitinib analog to renal proximal tubular cells

G. Kéri, W. Hennink, R. Kok, 2012, International journal of nanomedicine.

ABCB1 limits brain exposure of the KRASG12C inhibitor sotorasib, whereas ABCB1, CYP3A, and possibly OATP1a/1b restrict its oral availability.

J. Beijnen, A. Schinkel, R. Sparidans, 2022, Pharmacological research.

Liquid chromatography-tandem mass spectrometric assay for therapeutic drug monitoring of the B-Raf inhibitor encorafenib, the EGFR inhibitors afatinib, erlotinib and gefitinib and the O-desmethyl metabolites of erlotinib and gefitinib in human plasma.

J. Schellens, H. Rosing, J. Beijnen, 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

OATP1A/1B, CYP3A, ABCB1, and ABCG2 limit oral availability of the NTRK inhibitor larotrectinib, while ABCB1 and ABCG2 also restrict its brain accumulation

J. Beijnen, A. Schinkel, R. Sparidans, 2020, British journal of pharmacology.

P‐glycoprotein and breast cancer resistance protein restrict brigatinib brain accumulation and toxicity, and, alongside CYP3A, limit its oral availability

J. Beijnen, A. Schinkel, R. Sparidans, 2018, Pharmacological research.

P-Glycoprotein Limits Oral Availability, Brain Penetration, and Toxicity of an Anionic Drug, the Antibiotic Salinomycin

Jos H. Beijnen, Alfred H. Schinkel, J. Beijnen, 2007, Antimicrobial Agents and Chemotherapy.

Liquid chromatography-tandem mass spectrometric assay for the mutated BRAF inhibitor dabrafenib in mouse plasma.

J. Schellens, J. Beijnen, A. Schinkel, 2013, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Extrahepatic metabolism of ibrutinib

J. Beijnen, A. Schinkel, R. Masereeuw, 2020, Investigational New Drugs.

Semi-automatic liquid chromatographic analysis of pamidronate in urine after derivatization with 1-naphthylisothiocyanate.

J. Beijnen, S. Cremers, J. den Hartigh, 1999, Journal of chromatography. B, Biomedical sciences and applications.

Reduced Liver Uptake of Arterially Infused Melphalan during Retrograde Rat Liver Perfusion with Unaffected Liver Tumor Uptake

H. Putter, C. V. D. van de Velde, J. Beijnen, 2002, Journal of Pharmacology and Experimental Therapeutics.

Simple high-performance liquid chromatographic assay for melphalan in perfusate, rat liver and tumour tissue.

J. Schellens, J. Beijnen, G. Mulder, 2003, Biomedical chromatography : BMC.

Population Pharmacokinetics and Pharmacodynamics of Mitomycin During Intraoperative Hyperthermic Intraperitoneal Chemotherapy

J. Beijnen, F. Zoetmulder, R. Mathôt, 2004, Clinical pharmacokinetics.

Liquid chromatography-tandem mass spectrometric assay for the PARP-1 inhibitor olaparib in combination with the nitrogen mustard melphalan in human plasma.

J. Schellens, J. Beijnen, L. V. Valkenburg-van Iersel, 2011, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Hepatic artery infusion of high-dose melphalan at reduced flow during isolated hepatic perfusion for the treatment of colorectal metastases confined to the liver: a clinical and pharmacologic evaluation.

R. Tollenaar, C. V. D. van de Velde, A. Vahrmeijer, 2007, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

Bisphosphonates in bone diseases

R. Sparidans, S. Talbot, I. Twiss, 1998, Pharmacy World and Science.

P-glycoprotein (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) limit brain accumulation of the FLT3 inhibitor quizartinib in mice.

J. Beijnen, A. Schinkel, R. Sparidans, 2019, International journal of pharmaceutics.

Quantitative bioanalytical assay for the selective RET inhibitors selpercatinib and pralsetinib in mouse plasma and tissue homogenates using liquid chromatography-tandem mass spectrometry.

J. Beijnen, A. Schinkel, R. Sparidans, 2020, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

The potency of clobetasol propionate: Serum levels of clobetasol propionate and adrenal function during therapy with 0.05% clobetasol propionate in patients with severe atopic dermatitis

Marlise P. de Roos, R. Sparidans, I. Haeck, 2012, The Journal of dermatological treatment.

Population pharmacokinetics of caffeine and its metabolites theobromine, paraxanthine and theophylline after inhalation in combination with diacetylmorphine.

W. van den Brink, J. Beijnen, A. Zandvliet, 2005, Basic & clinical pharmacology & toxicology.

Validation of a quantitative assay for human neutrophil peptide-1, -2, and -3 in human plasma and serum by liquid chromatography coupled to tandem mass spectrometry.

J. Schellens, J. Beijnen, R. Sparidans, 2010, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Brain accumulation of osimertinib and its active metabolite AZ5104 is restricted by ABCB1 (P-glycoprotein) and ABCG2 (breast cancer resistance protein).

J. Beijnen, A. Schinkel, E. Wagenaar, 2019, Pharmacological research.

Specific Investigation of Sample Handling Effects on Protease Activities and Absolute Serum Concentrations of Various Putative Peptidome Cancer Biomarkers

J. Schellens, J. Beijnen, R. Sparidans, 2010, Clinical Proteomics.

The absolute quantification of eight inter‐α‐trypsin inhibitor heavy chain 4 (ITIH4)‐derived peptides in serum from breast cancer patients

Marie-Christine W. Gast, J. Schellens, J. Beijnen, 2010, Proteomics. Clinical applications.

Chromatographic analysis of bisphorphonates

J. den Hartigh, R. Sparidans, 1999, Pharmacy World and Science.

The determination of pamidronate in pharmaceutical preparations by ion-pair liquid chromatography after derivatization with phenylisothiocyanate.

J. den Hartigh, R. Sparidans, P. Vermeij, 1997, Journal of pharmaceutical and biomedical analysis.

Derivatization of pamidronate and other amino(bis)phosphonates with different isothiocyanates prior to ion-pair liquid chromatography

J. Beijnen, J. Hartigh, R. Sparidans, 1997 .

Quantitative assay for six potential breast cancer biomarker peptides in human serum by liquid chromatography coupled to tandem mass spectrometry.

J. Schellens, J. Beijnen, R. Sparidans, 2010, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Hepatic Clearance of Reactive Glucuronide Metabolites of Diclofenac in the Mouse Is Dependent on Multiple ATP-Binding Cassette Efflux Transporters

J. Beijnen, A. Schinkel, E. Wagenaar, 2010, Molecular Pharmacology.

Semi-automatic liquid chromatographic analysis of pamidronate in serum and citrate plasma after derivatization with 1-naphthylisothiocyanate.

J. Beijnen, J. Hartigh, J. den Hartigh, 1998, Journal of chromatography. B, Biomedical sciences and applications.

In vitro characterization of the human biotransformation pathways of aplidine, a novel marine anti-cancer drug

J. Schellens, J. Beijnen, E. Brandon, 2007, Investigational New Drugs.

Serum degradome markers for the detection of breast cancer.

Marie-Christine W. Gast, P. Peeters, J. Schellens, 2010, Journal of proteome research.

MOLECULAR CANCER THERAPEUTICS | CANCER BIOLOGYAND TRANSLATIONAL STUDIES ABCB1andABCG2RestrictBrain andTestisAccumulation and, Alongside CYP3A, Limit Oral Availability of the Novel TRK Inhibitor Selitrectinib

J. Beijnen, O. van Tellingen, A. Schinkel, 2021 .

Bioanalytical assay for the novel TRK inhibitor selitrectinib in mouse plasma and tissue homogenates using liquid chromatography-tandem mass spectrometry.

J. Beijnen, A. Schinkel, R. Sparidans, 2019, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Phase I and pharmacokinetic study of capecitabine and the oral mTOR inhibitor everolimus in patients with advanced solid malignancies

D. Richel, J. Schellens, J. Beijnen, 2011, Investigational New Drugs.

P-glycoprotein (ABCB1/MDR1) limits brain accumulation and Cytochrome P450-3A (CYP3A) restricts oral availability of the novel FGFR4 inhibitor fisogatinib (BLU-554).

J. Beijnen, A. Schinkel, R. Sparidans, 2019, International journal of pharmaceutics.

Quantitative bioanalytical assay for the tropomyosin receptor kinase inhibitor larotrectinib in mouse plasma and tissue homogenates using liquid chromatography-tandem mass spectrometry.

J. Schellens, J. Beijnen, A. Schinkel, 2018, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Bioanalysis of aplidine, a new marine antitumoral depsipeptide, in plasma by high-performance liquid chromatography after derivatization with trans-4-hydrazino-2-stilbazole.

K. Rinehart, J. Beijnen, O. van Tellingen, 1999, Journal of chromatography. B, Biomedical sciences and applications.

Bioanalysis of thiocoraline, a new marine antitumoral depsipeptide, in plasma by high-performance liquid chromatography and fluorescence detection.

J. Beijnen, J. Jimeno, R. Sparidans, 1999, Journal of chromatography. B, Biomedical sciences and applications.

Structure elucidation of aplidine metabolites formed in vitro by human liver microsomes using triple quadrupole mass spectrometry.

A. Heck, J. Schellens, J. Beijnen, 2005, Journal of Mass Spectrometry.

Bioanalytical assay for the quantification of the tyrosine kinase inhibitor EAI045 and its major metabolite PIA in mouse plasma and tissue homogenates using liquid chromatography–tandem mass spectrometry

J. Beijnen, A. Schinkel, R. Sparidans, 2022, Biomedical chromatography : BMC.

Liquid chromatographic assay for the cyclic depsipeptide aplidine, a new marine antitumor drug, in whole blood using derivatization with trans-4'-hydrazino-2-stilbazole.

J. Schellens, J. Beijnen, J. Jimeno, 2004, Biomedical chromatography : BMC.

A robust, accurate, sensitive LC–MS/MS method to measure indoxyl sulfate, validated for plasma and kidney cells

R. Masereeuw, R. Sparidans, K. Gerritsen, 2022, Biomedical chromatography : BMC.

ABCB1 restricts brain accumulation of the novel RORγ agonist cintirorgon, while OATP1A/1B and CYP3A limit its oral availability.

J. Beijnen, A. Schinkel, R. Sparidans, 2022, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

ABCB1 and ABCG2 Control Brain Accumulation and Intestinal Disposition of the Novel ROS1/TRK/ALK Inhibitor Repotrectinib, While OATP1A/1B, ABCG2, and CYP3A Limit Its Oral Availability

J. Beijnen, A. Schinkel, R. Sparidans, 2021, Pharmaceutics.

Oral coadministration of elacridar and ritonavir enhances brain accumulation and oral availability of the novel ALK/ROS1 inhibitor lorlatinib

J. Beijnen, A. Schinkel, R. Sparidans, 2019, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Bioanalytical assay for the new-generation ROS1/TRK/ALK inhibitor repotrectinib in mouse plasma and tissue homogenate using liquid chromatography-tandem mass spectrometry.

J. Beijnen, A. Schinkel, R. Sparidans, 2020, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Sensitive liquid chromatographic assay for amprenavir, a human immunodeficiency virus protease inhibitor, in human plasma, cerebrospinal fluid and semen.

J. Beijnen, R. Hoetelmans, R. Sparidans, 2000, Journal of chromatography. B, Biomedical sciences and applications.

Liquid chromatography-tandem mass spectrometric assay for the tyrosine kinase inhibitor afatinib in mouse plasma using salting-out liquid-liquid extraction.

J. Schellens, J. Beijnen, A. Schinkel, 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

P-Glycoprotein (ABCB1/MDR1) and BCRP (ABCG2) Limit Brain Accumulation and Cytochrome P450-3A (CYP3A) Restricts Oral Exposure of the RET Inhibitor Selpercatinib (RETEVMO)

J. Beijnen, A. Schinkel, R. Sparidans, 2021, Pharmaceuticals.

Quantification of cystine in human renal proximal tubule cells using liquid chromatography–tandem mass spectrometry

R. Masereeuw, R. Sparidans, J. Rood, 2018, Biomedical chromatography : BMC.

Liquid chromatographic assay for the protease inhibitor atazanavir in plasma.

J. Schellens, J. Beijnen, A. Huitema, 2006, Biomedical chromatography : BMC.

Quantitative determination of abacavir (1592U89), a novel nucleoside reverse transcriptase inhibitor, in human plasma using isocratic reversed-phase high-performance liquid chromatography with ultraviolet detection.

J. Beijnen, R. Hoetelmans, R. Sparidans, 1999, Journal of chromatography. B, Biomedical sciences and applications.

Sensitive liquid chromatography/tandem mass spectrometry assay for absolute quantification of ITIH4-derived putative biomarker peptides in clinical serum samples.

J. Schellens, J. Beijnen, R. Sparidans, 2010, Rapid communications in mass spectrometry : RCM.

Development and validation of an LC-MS/MS assay for the quantification of cintirorgon (LYC-55716) in mouse plasma and tissue homogenates.

J. Beijnen, A. Schinkel, R. Sparidans, 2021, Journal of pharmaceutical and biomedical analysis.

Bioanalysis of erlotinib, its O-demethylated metabolites OSI-413 and OSI-420, and other metabolites by liquid chromatography-tandem mass spectrometry with additional ion mobility identification.

J. Beijnen, R. Sparidans, V. J. Somovilla, 2021, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Chromatographic analysis of bisphosphonates.

S. Cremers, J. den Hartigh, R. Sparidans, 2000, Journal of chromatography. A.

Liquid chromatography-tandem mass spectrometric assay for pravastatin and two isomeric metabolites in mouse plasma and tissue homogenates.

J. Schellens, J. Beijnen, A. Schinkel, 2010, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Pharmacokinetics of the KRASG12C inhibitor adagrasib is limited by CYP3A and ABCB1, and influenced by binding to mouse plasma carboxylesterase 1c.

J. Beijnen, A. Schinkel, R. Sparidans, 2023, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Liquid chromatography-tandem mass spectrometric assay for the mutated BRAF inhibitor vemurafenib in human and mouse plasma.

J. Schellens, J. Beijnen, A. Schinkel, 2012, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Development and validation of an HPLC-MS/MS method to quantify the KRAS inhibitor adagrasib in mouse plasma and tissue-related matrices.

J. Beijnen, A. Schinkel, R. Sparidans, 2023, Biomedical chromatography : BMC.

The absolute quantification of eight inter‐α‐trypsin inhibitor heavy chain 4 (ITIH4)‐derived peptides in serum from breast cancer patients

Marie-Christine W. Gast, J. Schellens, J. Beijnen, 2010, Proteomics. Clinical applications.

Determination of pamidronate in urine by ion-pair liquid chromatography after derivatization with 1-naphthylisothiocyanate.

J. Beijnen, J. den Hartigh, R. Sparidans, 1997, Journal of chromatography. B, Biomedical sciences and applications.

Cytotoxic effects of pamidronate on monolayers of human intestinal epithelial (Caco-2) cells and its epithelial transport.

R. D. de Water, J. den Hartigh, R. Sparidans, 1994, Journal of pharmaceutical sciences.