J. Gut

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ADRIS - The Adverse Drug Reactions Information Scheme.

H. Hug, R. Dannecker, Dario Bagatto, 2003, Clinical neuropharmacology.

Mechanisms of halothane toxicity: novel insights.

U. Christen, J. Huwyler, J. Gut, 1993, Pharmacology & therapeutics.

Molecular basis of halothane hepatitis.

J. Gut, Josef Gut, 1998, Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement.

Molecular mimicry in halothane hepatitis: biochemical and structural characterization of lipoylated autoantigens.

D. Stoffler, U. Christen, J. Gut, 1995, Toxicology.

Rotation of cytochrome P-450. I. Investigations of protein-protein interactions of cytochrome P-450 in phospholipid vesicles and liver microsomes.

S. Kawato, R. Cherry, C. Richter, 1982, The Journal of biological chemistry.

Halothane metabolism: Kupffer cells carry and partially process trifluoroacetylated protein adducts.

U. Christen, J. Gut, M. Bürgin, 1991, Biochemical and biophysical research communications.

Rotation of cytochrome P-450. Complex formation of cytochrome P-450 with NADPH-cytochrome P-450 reductase in liposomes demonstrated by combining protein rotation with antibody-induced cross-linking.

S. Kawato, R. Cherry, C. Richter, 1983, The Journal of biological chemistry.

Halothane metabolism. Impairment of hepatic omega-oxidation of leukotrienes in vivo and in vitro.

D. Keppler, J. Huwyler, J. Gut, 1992, European journal of biochemistry.

Lipid peroxidation decreases the rotational mobility of cytochrome P-450 in rat liver microsomes.

S. Kawato, R. Cherry, C. Richter, 1985, Biochimica et biophysica acta.

Debrisoquine/sparteine-type polymorphism of drug oxidation. Purification and characterization of two functionally different human liver cytochrome P-450 isozymes involved in impaired hydroxylation of the prototype substrate bufuralol.

T. Kronbach, P. Dayer, U. Meyer, 1986, The Journal of biological chemistry.

Rotation of cytochrome P-450. II. Specific interactions of cytochrome P-450 with NADPH-cytochrome P-450 reductase in phospholipid vesicles.

S. Kawato, R. Cherry, C. Richter, 1982, The Journal of biological chemistry.

Transformation of 5-hydroperoxyeicosatetraenoic acid into dihydroxy- and cysteinyl-leukotrienes by rat hepatocytes: effects of glutathione.

J. Huwyler, J. Gut, T. Zeugin, 1991, Molecular pharmacology.

T. Kronbach, P. Dayer, U. Zanger, 1986, The Journal of biological chemistry.

Leukotriene B4 formation upon halothane-induced lipid peroxidation in liver membrane fractions under low O2 concentrations in vitro.

J. Huwyler, J. Gut, 1994, European journal of biochemistry.

Single-step organic extraction of leukotrienes and related compounds and their simultaneous analysis by high-performance liquid chromatography.

J. Huwyler, J. Gut, 1990, Analytical biochemistry.

Identification of the dihydrolipoamide acetyltransferase subunit of the human pyruvate dehydrogenase complex as an autoantigen in halothane hepatitis. Molecular mimicry of trifluoroacetyl-lysine by lipoic acid.

A. J. Gandolfi, J. Quinn, U. Christen, 1994, European journal of biochemistry.

Halothane metabolism: immunochemical evidence for molecular mimicry of trifluoroacetylated liver protein adducts by constitutive polypeptides.

U. Christen, J. Gut, M. Bürgin, 1991, Molecular pharmacology.

Halothane metabolism: the dihydrolipoamide acetyltransferase subunit of the pyruvate dehydrogenase complex molecularly mimics trifluoroacetyl-protein adducts.

P. Jenö, U. Christen, J. Gut, 1993, Biochemistry.

Molecular mimicry of trifluoroacetylated human liver protein adducts by constitutive proteins and immunochemical evidence for its impairment in halothane hepatitis.

U. Christen, J. G. Kenna, J. Huwyler, 1992, European journal of biochemistry.

Homeostasis of eicosanoids in the liver critically depends on partial O2 concentrations.

J. Gut, 1994, Journal of hepatology.

Exposure to the chlorofluorocarbon substitute 2,2-dichloro-1,1,1- trifluoroethane and the anesthetic agent halothane is associated with transient protein adduct formation in the heart.

J. Huwyler, J. Gut, 1992, Biochemical and biophysical research communications.

Characterization of a common genetic defect of cytochrome P-450 function (debrisoquine-sparteine type polymorphism)--increased Michaelis is Constant (Km) and loss of stereoselectivity of bufuralol 1'-hydroxylation in poor metabolizers.

T. Kronbach, P. Dayer, M. Eichelbaum, 1984, Biochemical and biophysical research communications.

High-performance liquid chromatographic assays for bufuralol 1'-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of human liver.

T. Kronbach, U. Meyer, D. Mathys, 1987, Analytical biochemistry.

Steric configuration and polymorphic oxidation of lipophilic beta-adrenoceptor blocking agents: in vivo — in vitro correlations

T. Kronbach, T. Leemann, P. Dayer, 1985 .

The molecular mechanisms of two common polymorphisms of drug oxidation--evidence for functional changes in cytochrome P-450 isozymes catalysing bufuralol and mephenytoin oxidation.

C Skoda, T. Kronbach, P. Dayer, 1986, Xenobiotica; the fate of foreign compounds in biological systems.

Debrisoquine‐type polymorphism of drug oxidation: purification from human liver of a cytochrome P450 isozyme with high activity for bufuralol hydroxylation

T. Kronbach, P. Dayer, R. Gasser, 1984, FEBS letters.

Mephenytoin-type polymorphism of drug oxidation: purification and characterization of a human liver cytochrome P-450 isozyme catalyzing microsomal mephenytoin hydroxylation.

U. Meyer, J. Gut, U. Meier, 1986, Biochimica et biophysica acta.

Studies on the molecular basis of polymorphic drug oxidation (debrisoquine/sparteine-type) in man

T. Kronbach, P. Dayer, U. Meyer, 1985 .

ADRIS – The Adverse Drug Reactions Information Scheme

H. Hug, R. Dannecker, Dario Bagatto, 2004, Pharmacogenetics.

Structure and dynamics of the liver microsomal monoxygenase system.

C. Richter, J. Gut, B. C. Kunz, 1988, Sub-cellular biochemistry.

The kidney as a novel target tissue for protein adduct formation associated with metabolism of halothane and the candidate chlorofluorocarbon replacement 2,2-dichloro-1,1,1-trifluoroethane.

D. Aeschlimann, U. Christen, J. Huwyler, 1992, European journal of biochemistry.

Ontology-based knowledge management of troglitazone-induced hepatotoxicity.

H. Hug, A. Stephan, R. Dannecker, 2004, Drug discovery today.

Theragenomic knowledge management for individualised safety of drugs, chemicals, pollutants and dietary ingredients

Dario Bagatto, J. Gut, Joseph Gut, 2005, Expert opinion on drug metabolism & toxicology.

Genomics and the prediction of xenobiotic toxicity.

U. Meyer, J. Gut, 2002, Toxicology.

Rotation of Cytochrome P-450

S. Kawato, R. Cherry, C. Richter, 1982 .