J. Tepe

发表

Attenuation of collagen-induced arthritis by orally available imidazoline-based NF-κB inhibitors.

R. W. Henry, Theresa A Lansdell, J. Mccormick, 2012, Bioorganic & medicinal chemistry letters.

Reprint of BMCL_19101.

R. W. Henry, Theresa A Lansdell, J. Mccormick, 2012, Bioorganic & medicinal chemistry letters.

Nuclear factor-kappaB mediated inhibition of cytokine production by imidazoline scaffolds.

R. D. Dyer, A. D. Jones, R. W. Henry, 2009, Journal of medicinal chemistry.

Palau'amine and related oroidin alkaloids dibromophakellin and dibromophakellstatin inhibit the human 20S proteasome.

K. S. Feldman, Theresa A Lansdell, P. Baran, 2012, Journal of natural products.

Total synthesis of the natural product (±)-dibromophakellin and analogues.

J. Tepe, N. Hewlett, 2011, Organic letters.

Pipecolic esters as minimized templates for proteasome inhibition.

P. Osmulski, M. Gaczynska, J. Tepe, 2019, Organic & biomolecular chemistry.

Structural-activity relationship study of highly-functionalized imidazolines as potent inhibitors of nuclear transcription factor-kappaB mediated IL-6 production.

Theresa A Lansdell, D. K. Kahlon, J. Tepe, 2009, Bioorganic & medicinal chemistry.

Small Molecule 20S Proteasome Enhancer Regulates MYC Protein Stability and Exhibits Antitumor Activity in Multiple Myeloma

Y. Yang, E. Ellsworth, Theresa A Lansdell, 2022, Biomedicines.

Enhancing c-MYC degradation via 20S proteasome activation induces in vivo anti-tumor efficacy

Y. Yang, E. Ellsworth, Theresa A Lansdell, 2020, bioRxiv.

Substituted quinolines as noncovalent proteasome inhibitors.

Theresa A Lansdell, L. Azevedo, J. Tepe, 2016, Bioorganic & medicinal chemistry.

The preparation of (4H)-imidazol-4-ones and their application in the total synthesis of natural products.

J. Tepe, Katarina L Keel, 2020, Organic chemistry frontiers : an international journal of organic chemistry.

Mechanistic insights into the multistage gas-phase fragmentation behavior of phosphoserine- and phosphothreonine-containing peptides.

G. Reid, Amanda M Palumbo, J. Tepe, 2008, Journal of proteome research.

Design, Synthesis, and Biological Evaluation of Potent 20S Proteasome Activators for the Potential Treatment of α-Synucleinopathies.

J. Tepe, Corey L Jones, Sophia D Staerz, 2022, Journal of medicinal chemistry.

Sensitization of tumor cells toward chemotherapy: enhancing the efficacy of camptothecin with imidazolines.

Theresa A Lansdell, J. Tepe, Satyamaheshwar Peddibhotla, 2004, Chemistry & biology.

Differential effects of FR900482 and FK317 on apoptosis, IL-2 gene expression, and induction of vascular leak syndrome.

Robert M. Williams, R. Reeves, J. Tepe, 2002, Chemistry & biology.

Inhibition of cytokine production by hymenialdisine derivatives.

Theresa A Lansdell, J. Tepe, Guangyi Jin, 2004, Journal of medicinal chemistry.

Substrate Controlled Regioselective Bromination of Acylated Pyrroles Using Tetrabutylammonium Tribromide (TBABr3).

J. E. Jackson, Shuang Gao, J. Tepe, 2018, The Journal of organic chemistry.

Indolo-phakellins as β5-specific noncovalent proteasome inhibitors.

M. Groll, Theresa A Lansdell, J. Tepe, 2015, Angewandte Chemie.

Sensitization of cancer cells to DNA damaging agents by imidazolines.

J. Tepe, Satyamaheshwar Peddibhotla, Vasudha Sharma, 2006, Journal of the American Chemical Society.

FR900482 class of anti-tumor drugs cross-links oncoprotein HMG I/Y to DNA in vivo.

R. Reeves, R. Williams, J. Tepe, 2000, Chemistry & biology.

7.16 – DNA Topoisomerase Inhibitors

T. Macdonald, J. Tepe, M. Labroli, 1999 .

Rh(III)-Catalyzed C-H Activation/Annulation of Benzohydroxamates and 2-Imidazolones: Access to Urea-Fused-Dihydroisoquinolone Scaffolds Reminiscent of Pyrrole Alkaloid Natural Products.

J. Tepe, G. E. Hubbell, 2022, Organic letters.

One-pot synthesis of 2-imidazolines via the ring expansion of imidoyl chlorides with aziridines.

J. Tepe, W. Wulff, Michael R. Kuszpit, 2011, The Journal of organic chemistry.

Diastereoselective One-Pot Synthesis of Oxazolines Using Sulfur Ylides and Acyl Imines.

J. Tepe, Md Shafaat Al Mehedi, 2019, The Journal of organic chemistry.

Structure-activity relationship for DNA topoisomerase II-induced DNA cleavage by azatoxin analogues.

T. Macdonald, K. Werbovetz, J. Tepe, 1997, Bioorganic & medicinal chemistry.

Inhibition of DNA topoisomerase II by azaelliptitoxins functionalized in the variable substituent domain.

T. Macdonald, J. Tepe, J. Madalengoitia, 1996, Journal of medicinal chemistry.

Sc(OTf)3 mediated one pot synthesis of 2,3-disubstituted quinolines from anilines and epoxides.

J. Tepe, Md Shafaat Al Mehedi, 2020, The Journal of organic chemistry.

Stereoselective syntheses of quaternary substituted α-amino acids using oxazol-5-(4H)-ones

J. Tepe, J. Fisk, R. A. Mosey, 2008 .

The diverse chemistry of oxazol-5-(4H)-ones.

J. Tepe, J. Fisk, R. A. Mosey, 2007, Chemical Society reviews.

Recent Advances in the Synthesis of Imidazolines (2009–2020)

J. Tepe, Shafaat Al Mehedi, 2020 .

Hydroxyamination of olefins using Br-N-(CO2Me)2.

J. Tepe, Corey L Jones, Matthew B. Giletto, 2015, The Journal of organic chemistry.

Trifluoromethanesulfonic acid catalyzed Friedel–Crafts acylation of aromatics with β-lactams

J. Tepe, K. Anderson, 2002 .

The First Intermolecular Friedel−Crafts Acylation with β-Lactams

J. Tepe, K. Anderson, 2002 .

One-pot Friedel-Crafts/Robinson-Gabriel synthesis of oxazoles using oxazolone templates.

J. Tepe, Manasi Keni, 2005, The Journal of organic chemistry.

Sc(OTf)3-Mediated One-Pot Synthesis of 3,4-Disubstituted 1H-Pyrazoles and 3,5-Disubstituted Pyridines from Hydrazine or Ammonia with Epoxides.

J. Tepe, Md Shafaat Al Mehedi, Dare E. George, 2022, The Journal of organic chemistry.

Preparation of hymenialdisine, analogues and their evaluation as kinase inhibitors.

J. Tepe, T. N. Nguyen, 2009, Current medicinal chemistry.

New synthetic route to access (±) salinosporamide A via an oxazolone-mediated ene-type reaction

J. Tepe, R. A. Mosey, 2009 .

Natural product scaffolds as inspiration for the design and synthesis of 20S human proteasome inhibitors

J. Tepe, G. E. Hubbell, 2020, RSC chemical biology.

Intermolecular ene reactions utilizing oxazolones and enol ethers.

J. Tepe, J. Fisk, 2007, Journal of the American Chemical Society.

Highly diastereoselective multicomponent synthesis of unsymmetrical imidazolines.

J. Tepe, S. Jayakumar, Satymaheshwar Peddibhotla, 2002, Organic letters.

Reactivity of Oxazol-5-(4H)-ones and Their Application towardNatural Product Synthesis

J. Tepe, C. Hupp, N. Hewlett, 2009 .

DNA Cross-Linking by a Phototriggered Dehydromonocrotaline Progenitor

J. Tepe, Robin M. Williams, 1999 .

One-Pot Friedel-Crafts/Robinson-Gabriel Synthesis of the Indole-Oxazole Scaffold and Its Application to the Synthesis of Breitfussins C, G, and H.

J. Tepe, Evan Savelson, 2022, The Journal of organic chemistry.

Total synthesis of a marine alkaloid from the tunicate Dendrodoa grossularia.

J. Tepe, C. Hupp, 2008, Organic letters.

Synthesis of tert-alkyl amino hydroxy carboxylic esters via an intermolecular ene-type reaction of oxazolones and enol ethers.

J. Tepe, J. Fisk, T. Friebe, 2008, Organic letters.

DNA interstrand cross-link formation by reductive activation of dehydropyrrolizidine progenitors

Robert M. Williams, J. Tepe, Christi Kosogof, 2002 .

Stereoselective synthesis of highly substituted Delta1-pyrrolines: exo-selective 1,3-dipolar cycloaddition reactions with azlactones.

J. Tepe, Satyamaheshwar Peddibhotla, 2004, Journal of the American Chemical Society.

Highly diastereoselective multicomponent synthesis of unsymmetrical imidazolines.

J. Tepe, S. Jayakumar, Satymaheshwar Peddibhotla, 2002, Organic letters.

Noncompetitive modulation of the proteasome by imidazoline scaffolds overcomes bortezomib resistance and delays MM tumor growth in vivo.

R. W. Henry, S. Hovde, J. Tepe, 2013, ACS chemical biology.

Diastereochemical diversity of imidazoline scaffolds via substrate controlled TMSCl mediated cycloaddition of azlactones.

J. Tepe, Vasudha Sharma, 2005, Organic letters.

1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride-mediated oxazole rearrangement: gaining access to a unique marine alkaloid scaffold.

J. Tepe, C. Hupp, 2009, The Journal of organic chemistry.

DNA cross-linking by a phototriggered pyrrolic progenitor developed from monocrotaline

Robert M. Williams, J. Tepe, Christi Kosogof, 2001 .

Proteasome Activation to Combat Proteotoxicity

J. Tepe, Corey L Jones, 2019, Molecules.

Synthesis of 1,2,4-triazolines and triazoles utilizing oxazolones.

J. Tepe, R. Saleem, 2010, The Journal of organic chemistry.

Advances in Proteasome Enhancement by Small Molecules

J. Tepe, Dare E. George, Dare E George, 2021, Biomolecules.

Increased extracellular pressure stimulates tumor proliferation by a mechanosensitive calcium channel and PKC‐β

M. Basson, J. Tepe, M. Sirivelu, 2015, Molecular oncology.

Isolation of phosphopeptides using solid phase enrichment

J. Tepe, Theresa A. Lansdell, 2004 .

Efficient two-step synthesis of methylphytylbenzoquinones: precursor intermediates in the biosynthesis of vitamin E

D. DellaPenna, J. Tepe, Satyamaheshwar Peddibhotla, 2003 .

Efficient Two‐Step Synthesis of Methylphytylbenzoquinones: Precursor Intermediates in the Biosynthesis of Vitamin E.

D. DellaPenna, J. Tepe, Satyamaheshwar Peddibhotla, 2003 .

Proteasome Activation as a New Therapeutic Approach To Target Proteotoxic Disorders.

J. Tepe, Evert Njomen, 2019, Journal of medicinal chemistry.

Perspectives on SARS-CoV-2 Main Protease Inhibitors.

G. Wei, F. Huang, Rui Wang, 2021, Journal of medicinal chemistry.

A concise total synthesis of hymenialdisine

J. Tepe, R. Saleem, 2015 .

Regulation of Autophagic Flux by the 20S Proteasome.

J. Tepe, Evert Njomen, 2019, Cell chemical biology.

Radioprotection by hymenialdisine-derived checkpoint kinase 2 inhibitors.

R. W. Henry, S. Hovde, J. Tepe, 2012, ACS chemical biology.

Synthesis of diazo functionalized solid supports and their application towards the enrichment of phosphorylated peptides.

J. Tepe, G. E. Reid, Samantha M Frawley Cass, 2009, Organic & biomolecular chemistry.

Inhibition of the human proteasome by imidazoline scaffolds.

Jacob R. Ludwig, L. Azevedo, J. Tepe, 2013, Journal of medicinal chemistry.

Synthesis and evaluation of debromohymenialdisine-derived Chk2 inhibitors.

J. Tepe, R. Saleem, Theresa A. Lansdell, 2012, Bioorganic & medicinal chemistry.

Dihydroquinazolines enhance 20S proteasome activity and induce degradation of α-synuclein, an intrinsically disordered protein associated with neurodegeneration.

J. Tepe, Christina L Magyar, Tyler J Wall, 2021, Bioorganic & medicinal chemistry letters.

Small Molecule Modulation of Proteasome Assembly.

P. Osmulski, M. Gaczynska, J. Tepe, 2018, Biochemistry.

Potent inhibition of checkpoint kinase activity by a hymenialdisine-derived indoloazepine.

J. Tepe, Vasudha Sharma, 2004, Bioorganic & medicinal chemistry letters.

Development of a Cell-Based AlphaLISA Assay for High-Throughput Screening for Small Molecule Proteasome Modulators

R. Neubig, T. Dexheimer, J. Tepe, 2023, ACS omega.

Small Molecule Enhancement of 20S Proteasome Activity Targets Intrinsically Disordered Proteins.

T. Dexheimer, B. Sjögren, J. Tepe, 2017, ACS chemical biology.

Fluspirilene Analogs Activate the 20S Proteasome and Overcome Proteasome Impairment by Intrinsically Disordered Protein Oligomers.

J. Tepe, Katarina L Keel, Taylor J. Fiolek, 2021, ACS chemical neuroscience.

Synthesis, structure, properties, and cytotoxicity of a (quinoline)RuCp+ complex.

J. Tepe, A. Odom, Allison Vanecek, 2022, Dalton transactions.

Enhanced Degradation of Mutant C9ORF72-Derived Toxic Dipeptide Repeat Proteins by 20S Proteasome Activation Results in Restoration of Proteostasis and Neuroprotection.

R. Kalb, J. Tepe, J. Mojsilovic-Petrovic, 2023, ACS chemical neuroscience.

Enhancement of chemotherapeutic efficacy by small molecule inhibition of NF-kappaB and checkpoint kinases.

J. Tepe, C. Hupp, Vasudha Sharma, 2007, Current medicinal chemistry.

Non-competitive modulation of the proteasome by imidazoline scaffolds overcome bortezomib resistant and delay MM tumor growth in vivo

R. W. Henry, S. Hovde, J. Tepe, 2013 .