H. Yoshimura

发表

Enzymic reduction of N-hydroxyamphetamine: the role of electron transfer system containing cytochrome b5.

H. Yamada, T. Baba, K. Oguri, 1988, Biochemical pharmacology.

Pharmacological effects in mice of anandamide and its related fatty acid ethanolamides, and enhancement of cataleptogenic effect of anandamide by phenylmethylsulfonyl fluoride.

I. Yamamoto, Kazuhito Watanabe, T. Matsunaga, 1999, Biological & pharmaceutical bulletin.

Regiochemical differences in cytochrome P450 isozymes responsible for the oxidation of methylenedioxyphenyl groups by rabbit liver.

A. Cho, H. Yamada, Y. Kumagai, 1992, Molecular pharmacology.

Species differences in metabolism of codeine: urinary excretion of codeine glucuronide, morphine-3-glucuronide and morphine-6-glucuronide in mice, rats, guinea pigs and rabbits.

N. Hanioka, K. Oguri, H. Yoshimura, 1990, Xenobiotica; the fate of foreign compounds in biological systems.

Polychlorinated biphenyls and dibenzofurans in patients with yusho and their toxicological significance: a review.

Y. Masuda, H. Yoshimura, 1984, American journal of industrial medicine.

Metabolic and toxicologic evaluation of 2,34,3',4'-pentachlorobiphenyl in rats and mice.

H. Yoshimura, T. Yamamoto, H. Yamamoto, 1976, Chemical & pharmaceutical bulletin.

Cytochrome P-450 isozymes involved in the oxidative metabolism of delta 9-tetrahydrocannabinol by liver microsomes of adult female rats.

I. Yamamoto, S. Imaoka, Y. Funae, 1992, Drug metabolism and disposition: the biological fate of chemicals.

Anandamide, an endogenous cannabinoid receptor ligand, also interacts with 5-hydroxytryptamine (5-HT) receptor.

I. Yamamoto, Kazuhito Watanabe, T. Ohta, 1998, Biological & pharmaceutical bulletin.

Sex difference in hepatic microsomal aldehyde oxygenase activity in different strains of mice.

I. Yamamoto, S. Narimatsu, T. Matsunaga, 1992, Research communications in chemical pathology and pharmacology.

[Stimulating effect of squalene on fecal excretion of a high toxic 2,3,4,7,8-pentachlorodibenzofuran (PenCDF) in rats].

K. Oguri, H. Yoshimura, H. Kamimura, 1985, Fukuoka igaku zasshi = Hukuoka acta medica.

Stimulating effect of activated charcoal beads on fecal excretion of 2,3,4,7,8-pentachlorodibenzofuran in rats

M. Nakano, K. Oguri, H. Yoshimura, 1986 .

Cannabielsoin as a new metabolite of cannabidiol in mammals

I. Yamamoto, Kazuhito Watanabe, S. Narimatsu, 1991, Pharmacology Biochemistry and Behavior.

Metabolism in vitro of sulindac. Sulfoxide-reducing enzyme systems in guinea pig liver.

S. Kitamura, H. Yoshimura, K. Tatsumi, 1980, Journal of pharmacobio-dynamics.

Tissue-specific expression, induction, and inhibition through metabolic intermediate-complex formation of guinea pig cytochrome P450 belonging to the CYP2B subfamily.

H. Yamada, K. Takeuchi, K. Oguri, 1992, Archives of biochemistry and biophysics.

Analysis and pharmacotoxicity of feruloyltyramine as a new constituent and p-coumaroyltyramine in Cannabis sativa L.

I. Yamamoto, Kazuhito Watanabe, T. Matsunaga, 1991, Pharmacology Biochemistry and Behavior.

Identification of cannabielsoin, a new metabolite of cannabidiol formed by guinea-pig hepatic microsomal enzymes, and its pharmacological activity in mice.

I. Yamamoto, S. Narimatsu, H. Yoshimura, 1988, Journal of pharmacobio-dynamics.

Accumulation of polychlorinated dibenzofurans in the livers of monkeys and rats.

Y. Masuda, H. Yoshimura, H. Kuroki, 1980, Food and cosmetics toxicology.

Metabolism in vivo of 3,4,3',4'-tetrachlorobiphenyl and toxicological assessment of the metabolites in rats.

H. Yamada, K. Oguri, H. Yoshimura, 1987, Xenobiotica; the fate of foreign compounds in biological systems.

Unique features of subcellular distribution of 2,3,4,7,8-pentachlorodibenzofuran in rat liver

H. Yoshimura, N. Koga, J. Kuroki, 1987 .

[Acute toxicity, inductive effects of liver enzymes and distribution in the liver of 1,2,3,7,8-pentachlorodibenzo-p-dioxin in rats].

Y. Masuda, H. Yoshimura, H. Nakashima, 1991, Fukuoka igaku zasshi = Hukuoka acta medica.

Enhanced faecal excretion of 2,3,4,7,8-pentachlorodibenzofuran in rats by a long-term treatment with activated charcoal beads.

M. Nakano, K. Oguri, H. Yoshimura, 1988, Xenobiotica; the fate of foreign compounds in biological systems.

High affinity of 2,3,4,7,8-pentachlorodibenzofuran to cytochrome P-450 in the hepatic microsomes of rats

H. Yoshimura, N. Koga, J. Kuroki, 1986 .

Deamination of amphetamines by cytochromes P450: studies on substrate specificity and regioselectivity with microsomes and purified CYP2C subfamily isozymes.

A. Cho, H. Yamada, Y. Kumagai, 1997, The Journal of toxicological sciences.

Major role of the CYP2C isozymes in deamination of amphetamine and benzphetamine: evidence for the quinidine-specific inhibition of the reactions catalysed by rabbit enzyme.

A. Cho, H. Yamada, Y. Kumagai, 1997, Xenobiotica; the fate of foreign compounds in biological systems.

Involvement of cytochrome b5 in the metabolism of tetrachlorobiphenyls catalyzed by CYP2B1 and CYP1A1.

K. Matsusue, K. Oguri, H. Yoshimura, 1996, Chemosphere.

Role of cytochrome b5 in the oxidative metabolism of polychlorinated biphenyls catalyzed by cytochrome P450.

K. Matsusue, K. Oguri, H. Yoshimura, 1996, Xenobiotica; the fate of foreign compounds in biological systems.

A cytochrome P450 isozyme having aldehyde oxygenase activity plays a major role in metabolizing cannabinoids by mouse hepatic microsomes.

I. Yamamoto, S. Narimatsu, T. Matsunaga, 1993, Biochemical pharmacology.

Metabolism in vitro of 3,4,3',4'- and 2,5,2',5'-tetrachlorobiphenyl by rat liver microsomes and highly purified cytochrome P-450.

N. Hanioka, H. Yoshimura, N. Koga, 1991, Journal of pharmacobio-dynamics.

Sex difference in the oxidative metabolism of Δ9-tetrahydrocannabinol in the rat

I. Yamamoto, Kazuhito Watanabe, S. Narimatsu, 1991 .

Inhibitory effect of cannabidiol hydroxy-quinone, an oxidative product of cannabidiol, on the hepatic microsomal drug-metabolizing enzymes of mice.

I. Yamamoto, N. Usami, H. Yoshimura, 1991, Journal of pharmacobio-dynamics.

Mechanism of biological formation of cannabielsoin from cannabidiol in the guinea-pig, mouse, rat and rabbit.

I. Yamamoto, S. Narimatsu, H. Yoshimura, 1989, Journal of pharmacobio-dynamics.

In vivo effects of tetrahydrocannabinols and their eight monooxygenated metabolites of the hepatic microsomal drug-metabolizing enzyme systems of mice.

I. Yamamoto, S. Narimatsu, H. Yoshimura, 1987, Journal of pharmacobio-dynamics.

Self-catalyzed inactivation of cytochrome P-450 during microsomal metabolism of cannabidiol.

I. Yamamoto, Kazuhito Watanabe, S. Narimatsu, 1987, Biochemical pharmacology.

Change in hypothermia and catalepsy induced by cannabinoids or morphine in mice tolerant to these substances.

I. Yamamoto, S. Narimatsu, H. Yoshimura, 1987, European journal of pharmacology.

Effects of two cannabinoids on hepatic microsomal cytochrome P-450.

I. Yamamoto, S. Narimatsu, H. Yoshimura, 1986, Journal of pharmacobio-dynamics.

Stereospecific hydrolysis of 8α,9α- and 8β,9β-epoxyhexahydrocannabinols in the mouse in vivo and in vitro

I. Yamamoto, S. Narimatsu, H. Yoshimura, 1985 .

Metabolism and nephrotoxicity of phenacetin and sulfanilamide.

H. Yoshimura, R. Eyanagi, H. Shigematsu, 1985, Journal of pharmacobio-dynamics.

Difference in epoxides formation and their further metabolism between delta 9- and delta 8-tetrahydrocannabinols by human liver microsomes.

I. Yamamoto, S. Narimatsu, H. Yoshimura, 1984, Journal of pharmacobio-dynamics.

Altered thiamine propyl disulfide metabolism in rats with liver injury induced by carbon tetrachloride and D-galactosamine.

S. Yamano, H. Yoshimura, M. Shimizu, 1983, Journal of pharmacobio-dynamics.

8α,9α-Epoxyhexahydrocannabinol formation from Δ8-tetrahydrocannabinol by mouse liver microsomes

I. Yamamoto, Kazuhito Watanabe, S. Narimatsu, 1982 .

Enhancement of sulfanilamide N4-hydroxylase activity in kidney and liver microsomes of rats by pretreatment with 3-methylcholanthrene type-polychlorinated biphenyl.

H. Yoshimura, R. Eyanagi, H. Shigematsu, 1982, Journal of pharmacobio-dynamics.

In vitro and in vivo interactions of delta 8-tetra-hydrocannabinol and its metabolites with hepatic microsomal drug metabolizing enzyme systems of mice.

I. Yamamoto, K. Oguri, H. Yoshimura, 1981, Journal of pharmacobio-dynamics.

Metabolism in vivo of 3,4,5,3',4'-pentachlorobiphenyl and toxicological assessment of the metabolite in rats.

H. Yoshimura, N. Koga, M. Beppu, 1990, Journal of pharmacobio-dynamics.

Inductive effect on hepatic enzymes and toxicity of congeners of PCBs and PCDFs.

Y. Hokama, H. Yoshimura, K. Nagata, 1985, Environmental health perspectives.

Inductive effect of polychlorinated biphenyls mixture and individual isomers on the hepatic microsomal enzymes.

N. Ozawa, H. Yoshimura, S. Saeki, 1978, Chemical & pharmaceutical bulletin.

Modification of the gluconeogenesis is not involved in the co-planar PCB toxicity in highly sensitive guinea pigs

Y. Ishii, K. Oguri, H. Yoshimura, 1993 .

[Acute toxicity and inductive effect on liver enzymes of 3,4,5,3',4'-pentachlorobiphenyl in guinea pigs (author's transl)].

H. Yoshimura, K. Nagata, N. Koga, 1981, Fukuoka igaku zasshi = Hukuoka acta medica.

Purification and characterization of a newly identified isoform of cytochrome P450 responsible for 3-hydroxylation of 2,5,2',5'-tetrachlorobiphenyl in hamster liver.

N. Harada, H. Yamada, Y. Ishii, 1995, Archives of biochemistry and biophysics.

Toxicological assessment of highly chlorinated biphenyl congeners retained in the Yusho patients

Y. Masuda, H. Yoshimura, H. Kuroki, 1979 .

Purification and characterization of two forms of chicken liver cytochrome P-450 induced by 3,4,5,3',4'-pentachlorobiphenyl.

Y. Hokama, H. Yoshimura, N. Koga, 1988, Journal of biochemistry.

Oxygenation mechanism in conversion of aldehyde to carboxylic acid catalyzed by a cytochrome P-450 isozyme.

I. Yamamoto, S. Narimatsu, H. Yoshimura, 1991, The Journal of biological chemistry.

Biochemical basis for analgesic activity of morphine-6-glucuronide. I. Penetration of morphine-6-glucuronide in the brain of rats.

K. Oguri, H. Yoshimura, S. Ida, 1973, Biochemical pharmacology.

Induction of bilirubin UDP-glucuronyltransferase and CYP4A1 P450 by co-planar PCBs: Different responsiveness of guinea pigs and rats

Y. Funae, Y. Ishii, M. Tsuda, 1994 .

Multiplicity of liver microsomal flavin-containing monooxygenase in the guinea pig: its purification and characterization.

H. Yamada, K. Oguri, H. Yoshimura, 1990, Archives of biochemistry and biophysics.

A unique change of steroid metabolism in rat liver microsomes induced with highly toxic polychlorinated biphenyl(PCB) and polychlorinated dibenzofuran(PCDF).

Y. Masuda, H. Yoshimura, K. Nagata, 1982, Journal of pharmacobio-dynamics.

Further studies on metabolism in vivo of 3,4,3',4'-tetrachlorobiphenyl in rats: identification of minor metabolites in rat faeces.

H. Yoshimura, N. Koga, Hidetoshi Yoshimura, 1989, Xenobiotica; the fate of foreign compounds in biological systems.

Species difference in metabolism of strychnine with liver microsomes of mice, rats, guinea pigs, rabbits and dogs.

K. Oguri, H. Yoshimura, Y. Tanimoto, 1990, Journal of pharmacobio-dynamics.

Suppressive effect of interferon inducer, polyriboinosinic acid-polyribocytidylic acid on induction of uridine diphosphate-glucuronyltransferases and monooxygenases in liver microsomes of rats.

T. Matsunaga, N. Hanioka, K. Oguri, 1986, Journal of pharmacobio-dynamics.

Accumulation, excretion and effects on hepatic enzymes of polychlorinated quaterphenyl congeners in rats.

Y. Masuda, Y. Hokama, M. Nagase, 1985, Journal of pharmacobio-dynamics.

Studies on N-demethylation of methamphetamine by liver microsomes of guinea-pigs and rats: the role of flavin-containing mono-oxygenase and cytochrome P-450 systems.

H. Yamada, T. Baba, K. Oguri, 1984, Xenobiotica; the fate of foreign compounds in biological systems.

SELECTIVE INDUCTION OF RAT LIVER MICROSOMAL CYTOCHROME P-448 BY 3, 4, 5, 3', 4'-PENTACHLOROBIPHENYL AND ITS EFFECT ON LIVER MICROSOMAL DRUG METABOLISM

N. Ozawa, H. Yoshimura, S. Yoshihara, 1979 .

Purification and characterization of a novel 46.5-kilodalton esterase from mouse hepatic microsomes.

I. Yamamoto, T. Matsunaga, H. Yoshimura, 1993, Biochemistry and molecular biology international.

Inhibition of anandamide amidase activity in mouse brain microsomes by cannabinoids.

I. Yamamoto, Kazuhito Watanabe, T. Matsunaga, 1996, Biological & pharmaceutical bulletin.

3,4,5,3',4'-Pentachlorobiphenyl as a useful inducer for purification of rat liver microsomal cytochrome P448.

N. Ozawa, H. Yoshimura, S. Yoshihara, 1979, Biochemical and biophysical research communications.

Metabolism of 2,4,5,2',4',5'-hexachlorobiphenyl (PCB153) in guinea pig.

K. Oguri, H. Yoshimura, N. Koga, 1997, Xenobiotica; the fate of foreign compounds in biological systems.

A new metabolite of 2,4,3',4'-tetrachlorobiphenyl in rat feces.

N. Hanioka, H. Yoshimura, N. Koga, 1992, Chemical & pharmaceutical bulletin.

cDNA cloning and sequence of CYP2C29 encoding P-450 MUT-2, a microsomal aldehyde oxygenase.

I. Yamamoto, Kazuhito Watanabe, K. Watanabe, 1994, Biochimica et biophysica acta.

Analgesic effect of morphine glucuronides.

K. Oguri, H. Yoshimura, S. Ueki, 1971, The Tohoku journal of experimental medicine.

Metabolism of 2,4,5,2',4',5'-hexachlorobiphenyl with liver microsomes of phenobarbital-treated dog; the possible formation of PCB 2,3-arene oxide intermediate.

K. Oguri, H. Yoshimura, N. Koga, 1992, Xenobiotica; the fate of foreign compounds in biological systems.

Comparison in mice of pharmacological effects of delta 8-tetrahydrocannabinol and its metabolites oxidized at 11-position.

I. Yamamoto, K. Oguri, H. Yoshimura, 1980, European journal of pharmacology.

Potentiation of physical dependence by conjugation at the 6-position of nalorphine.

K. Oguri, H. Yoshimura, T. Hirano, 1984, European journal of pharmacology.

Chemical synthesis and analgesic effect of morphine ethereal sulfates.

K. Oguri, H. Yoshimura, M. Mori, 1972, Life sciences. Pt. 1: Physiology and pharmacology.

Metabolism of drugs. LXIX. Studies on the urinary metabolites of morphine in several mammlian species.

K. Oguri, H. Yoshimura, S. Ida, 1970, Chemical & pharmaceutical bulletin.

On the Structure of Morphine-6-glucuronide in a Solid State

K. Oguri, H. Yoshimura, H. Tsukamoto, 1970 .

Metabolism of drugs. LX. The synthesis of codeine and morphine glucuronides.

K. Oguri, H. Yoshimura, H. Tsukamoto, 1968, Chemical & pharmaceutical bulletin.

Species difference of site-selective glucuronidation of morphine.

N. Hanioka, K. Oguri, H. Yoshimura, 1991, Journal of pharmacobio-dynamics.

Enhanced binding of morphine and nalorphine to opioid delta receptor by glucuronate and sulfate conjugations at the 6-position.

K. Oguri, H. Yoshimura, T. Hirano, 1987, Life sciences.

Distribution and characterization of anandamide amidohydrolase in mouse brain and liver.

I. Yamamoto, K. Watanabe, T. Matsunaga, 1998, Life sciences.

Recent advances in the metabolism of cannabinoids.

I. Yamamoto, Kazuhito Watanabe, S. Narimatsu, 1995, The international journal of biochemistry & cell biology.

Brain microsomal oxidation of Δ8- and Δ9-tetrahydrocannabinol

I. Yamamoto, Kazuhito Watanabe, H. Yoshimura, 1988 .

Mode of reactions between xanthine oxidase and aromatic nitro compounds.

H. Yoshimura, K. Tatsumi, A. Inoue, 1981, Journal of pharmacobio-dynamics.

Toxicological evaluation of sulfur-containing metabolites of 2,5,2′,5′-tetrachlorobiphenyl in rats

Y. Masuda, Y. Hokama, H. Yoshimura, 1985 .

Cannabidiol metabolism revisited: tentative identification of novel decarbonylated metabolites of cannabidiol formed by human liver microsomes and recombinant cytochrome P450 3A4

I. Yamamoto, Kazuhito Watanabe, N. Usami, 2019, Forensic Toxicology.

Metabolic fate of strychnine in rats.

K. Oguri, H. Yoshimura, M. Mishima, 1989, Xenobiotica; the fate of foreign compounds in biological systems.

METABOLISM OF DRUGS. L. THE IN VITRO STUDY ON METABOLISM OF BRUCINE AND 4-SUBSTITUTED VERATROLES.

H. Yoshimura, T. Watabe, H. Tsukamoto, 1964, Chemical & pharmaceutical bulletin.

Comparison of pharmacological effects of tetrahydrocannabinols and their 11-hydroxy-metabolites in mice.

I. Yamamoto, S. Narimatsu, H. Yoshimura, 1990, Chemical & pharmaceutical bulletin.

Studies of metabolic fate of a new antiallergic agent, azelastine (4-(p-chlorobenzyl)-2-[N-methylperhydroazepinyl-(4)]-1-(2H)-phthalazinone hydrochloride).

H. Yamada, H. Yoshimura, K. Tatsumi, 1980, Japanese journal of pharmacology.

Formation of novel nitrofuran metabolites in xanthine oxidase-catalyzed reduction of methyl 5-nitro-2-furoate.

H. Yamada, H. Yoshimura, K. Tatsumi, 1984, Archives of biochemistry and biophysics.

Reduction of methyl 5-nitro-2-furoate by xanthine oxidase: an evidence for hydroxylaminofuran formation.

H. Yamada, H. Yoshimura, K. Tatsumi, 1982, Chemical & pharmaceutical bulletin.

Further studies on carbamate N-glucuronide formation in animal body.

H. Yoshimura, K. Tatsumi, H. Tsukamoto, 1963, Life sciences.

Studies on enzymatic reduction of aliphatic nitro compounds: reductive dimerization of beta-nitrostyrene and 1-nitro-4-phenylbutadiene.

H. Yamada, H. Yoshimura, K. Tatsumi, 1982, Archives of biochemistry and biophysics.

A rabbit liver constitutive form of cytochrome P450 responsible for amphetamine deamination.

H. Yamada, K. Oguri, H. Yoshimura, 1989, Archives of biochemistry and biophysics.

A new metabolite of methamphetamine; evidence for formation of N-[(1-methyl-2-phenyl)ethyl]ethanimine N-oxide.

H. Yamada, T. Baba, K. Oguri, 1987, Xenobiotica; the fate of foreign compounds in biological systems.

Substrate specificity of guinea pig liver flavin-containing monooxygenase for morphine, tropane and strychnos alkaloids.

H. Yamada, K. Oguri, H. Yoshimura, 1990, Biochemical pharmacology.

Metabolism of drugs. 28. Metabolic fate of meprobamate. (1). Isolation and characterization of metabolites.

H. Yoshimura, A. Yamamoto, H. Tsukamoto, 1962, Chemical & pharmaceutical bulletin.

Forensic chemical study on marihuana. I. A detection method of the principal constituents by thin-layer and gas chromatographies.

H. Yoshimura, H. Aramaki, N. Tomiyasu, 1968, Chemical & pharmaceutical bulletin.

Metabolism of strychnine in vitro.

H. Yoshimura, M. Mishima, Y. Tanimoto, 1985, Drug metabolism and disposition: the biological fate of chemicals.

Metabolism of butyl p-nitrophenyl ether in vitro with rabbit liver preparations.

H. Yoshimura, H. Tsuji, H. Tsukamoto, 1978, Xenobiotica; the fate of foreign compounds in biological systems.

Metabolism of drugs. LVII. Isolation, characterization and identification of p-nitrophenoxy acetic acid, a metabolite of butyl p-nitrophenyl ether in rats, mice and guinea pigs.

H. Yoshimura, H. Tsuji, S. Ida, 1967, Biochemical pharmacology.

Metabolism of drugs. LI. The metabolic fate of alkylaryl ethers in rabbits.

H. Yoshimura, H. Tsuji, H. Tsukamoto, 1966, Chemical & pharmaceutical bulletin.

Fluorometric assay of microsomal aldehyde oxygenase activity: 9-anthraldehyde as a substrate.

I. Yamamoto, T. Matsunaga, H. Yoshimura, 1991, Analytical biochemistry.

Possible implication of a aldehyde metabolite in aminopyrine allergy.

H. Yoshimura, H. Shimeno, 1972, Xenobiotica; the fate of foreign compounds in biological systems.

Microsomal oxygenase catalyzed oxidation of 11-hydroxy-Δ8-tetrahydrocannabinol to 11-oxo-Δ8-tetrahydrocannabinol

I. Yamamoto, Kazuhito Watanabe, K. Oguri, 1979 .

NADH-dependent O-deethylation of p-nitrophenetole with rabbit liver microsomes.

S. Yamano, H. Yoshimura, H. Shigematsu, 1976, Archives of biochemistry and biophysics.

Metabolism of drugs. LVI. The metabolic fate of phenacetylurea.

H. Yoshimura, K. Tatsumi, H. Tsukamoto, 1967, Biochemical pharmacology.

Specific expression of ES46.5K, a novel microsomal esterase, in the mouse liver and its catalytic activity for xenobiotic amide and esters.

I. Yamamoto, T. Matsunaga, H. Yoshimura, 1997, Life sciences.

Involvement of a novel mouse hepatic microsomal esterase, ES46.5K, in the hydrolysis of phthalate esters.

I. Yamamoto, T. Matsunaga, H. Yoshimura, 1997, Biological & pharmaceutical bulletin.

Enzymic cis-trans isomerization of nitrofuran derivatives: isomerizing activity of xanthine oxidase, lipoyl dehydrogenase, DT-diaphorase and liver microsomes.

S. Kitamura, P. Wardman, Y. Kato, 1979, Biochimica et biophysica acta.

Reduction of nitrofuran derivatives by xanthine oxidase and microsomes. Isolation and identification of reduction products.

S. Kitamura, H. Yoshimura, K. Tatsumi, 1976, Archives of biochemistry and biophysics.

Purification and characterization of seven distinct forms of liver microsomal cytochrome P-450 from untreated and inducer-treated male Wistar rats.

T. Matsunaga, H. Yoshimura, K. Nagata, 1985, Journal of biochemistry.

The synthesis of codeine and morphine glucuronides.

K. Oguri, H. Yoshimura, Hidetoshi Yoshimura, 1968, Tetrahedron letters.

A Colorimetric Method for the Determination of Cannabinoids with Fast Blue BB Salt

I. Yamamoto, Kazuhito Watanabe, H. Yoshimura, 1979 .

Metabolism of furazolidone by milk xanthine oxidase and rat liver 9000g supernatant: formation of a unique nitrofuran metabolite and an aminofuran derivative.

H. Yamada, H. Yoshimura, K. Tatsumi, 1981, Archives of biochemistry and biophysics.

ISOLATION AND IDENTIFICATION OF THE METABOLITE OF N-(5-NITRO-2-FURFURYLIDENE)-3-AMINO-2-OXAZOLIDONE (FURAZOLI-DONE)

T. Horiuchi, H. Yoshimura, H. Yamada, 1978 .

STUDIES ON METABOLIC ACTIVATION OF NITROFURANS : FORMATION OF ACTIVE METABOLITES AND THEIR BINDING TO CYSTEINE AND GLUTATHIONE

S. Kitamura, H. Yoshimura, K. Tatsumi, 1978 .

Cis-trans isomerization of nitrofuran derivatives by xanthine oxidase.

H. Yoshimura, K. Tatsumi, Y. Kato, 1976, Biochemical and biophysical research communications.

Susceptibility of aromatic nitro compounds to xanthine oxidase-catalyzed reduction.

S. Kitamura, H. Yoshimura, K. Tatsumi, 1978, Chemical & pharmaceutical bulletin.

Metabolism of drugs. LII. Enzymatic study on secobarbital metabolism.

H. Yoshimura, H. Tsukamoto, H. Ide, 1967, Chemical & pharmaceutical bulletin.

Metabolism of Drugs. XXXII. The Metabolic Fate of Secobarbital [5-Allyl-5-(1-methylbutyl) barbituric Acid].

H. Yoshimura, H. Tsukamoto, H. Ide, 1963 .

Metabolism of drugs. XVII. Metabolic fate of methylhexabital (5-cyclohexenyl-3,5-dimethylbarbituric acid). 7. Separation and identification of biotransformation products of methylhexabital in the urine of rabbits by paper chromatography.

H. Yoshimura, S. Toki, H. Tsukamoto, 1958, Chemical & pharmaceutical bulletin.

Synthesis and pharmacological evaluation in mice of halogenated cannabidiol derivatives.

I. Yamamoto, N. Usami, H. Yoshimura, 1999, Chemical & pharmaceutical bulletin.

Microsomal alcohol oxygenase: purification and characterization of a cytochrome P450 responsible for oxidation of 7-hydroxy-delta 8-tetrahydrocannabinol to 7-oxo-delta 8-tetrahydrocannabinol in guinea pig liver.

I. Yamamoto, Kazuhito Watanabe, K. Watanabe, 1997, Archives of biochemistry and biophysics.

Brain microsomal oxidation of delta 8- and delta 9-tetrahydrocannabinol.

I. Yamamoto, H. Yoshimura, K. Watanabe, 1988, Biochemical and Biophysical Research Communications - BBRC.

Regiochemistry of cytochrome P450 isozymes.

H. Yamada, K. Oguri, H. Yoshimura, 1994, Annual review of pharmacology and toxicology.

Sex difference in the oxidative metabolism of delta 9-tetrahydrocannabinol in the rat.

I. Yamamoto, S. Narimatsu, H. Yoshimura, 1991, Biochemical pharmacology.

Cytochrome P-450 isozymes in metabolic activation of delta 9-tetrahydrocannabinol by rat liver microsomes.

I. Yamamoto, S. Imaoka, Y. Funae, 1990, Drug metabolism and disposition: the biological fate of chemicals.

Cross-tolerance to the hypothermic effect of Δ8-tetrahydrocannabinol 11-hydroxy-Δ8-tetrahydrocannabinol and chlorpromazine in the mouse

I. Yamamoto, Kazuhito Watanabe, S. Narimatsu, 1985 .

Development of tolerance and cross-tolerance to the cataleptogenic effects of delta 8-tetrahydrocannabinol and 11-hydroxy-delta 8-tetrahydrocannabinol in mice.

I. Yamamoto, H. Yoshimura, K. Watanabe, 1983, European journal of pharmacology.

Metabolic fate of noscapine. II. Isolation and identification of novel metabolites produced by C-C bond cleavage.

N. Tsunoda, H. Yoshimura, 1979, Xenobiotica; the fate of foreign compounds in biological systems.

Metabolism of drugs. LIX. A new metabolite of antipyrine.

H. Yoshimura, H. Tsukamoto, H. Shimeno, 1968, Biochemical Pharmacology.

Determination of oxycodone metabolites in urines and feces of several mammalian species.

K. Oguri, H. Yoshimura, T. Ishida, 1982, Journal of pharmacobio-dynamics.

Metabolism of drugs. LXX. Further study on antipyrine metabolism.

H. Yoshimura, H. Tsukamoto, H. Shimeno, 1971, Chemical & pharmaceutical bulletin.

Studies on rat liver cytochrome P-450s involved in the metabolism of antipyrine: phenobarbital- and 3-methylcholanthrene-inducible isozymes possessing 4-hydroxylase activity.

H. Yamada, H. Yoshimura, N. Koga, 1986, Biochemical pharmacology.

Major cytochrome P450 enzyme responsible for oxidation of secondary alcohols to the corresponding ketones in mouse hepatic microsomes. Oxidation of 7-hydroxy-delta8-tetrahydrocannabinol to 7-oxo-delta8-tetrahydrocannabinol.

I. Yamamoto, T. Matsunaga, H. Yoshimura, 1998, Drug metabolism and disposition: the biological fate of chemicals.

Participation of cytochrome P-450 isozymes in N-demethylation, N-hydroxylation and aromatic hydroxylation of methamphetamine.

H. Yamada, T. Baba, K. Oguri, 1988, Xenobiotica; the fate of foreign compounds in biological systems.

Effects of several factors on urinary excretion of methamphetamine and its metabolites in rats.

H. Yamada, K. Oguri, H. Yoshimura, 1986, Xenobiotica; the fate of foreign compounds in biological systems.

Metabolic fate of fenetylline in rat and man.

H. Yamada, K. Oguri, H. Yoshimura, 1988, Xenobiotica; the fate of foreign compounds in biological systems.

Species difference in codeine uridine diphosphate-glucuronyltransferase activity of liver microsomes.

N. Hanioka, K. Oguri, H. Yoshimura, 1990, Journal of pharmacobio-dynamics.

Metabolism of drugs. XIII. The metabolic fate of methylhexabital (5-cyclohexenyl-3,5-dimethylbarbituric acid). 5. Further studies on isolation, characterisation, and identification of biotransformation products of the drug excreted in the urine of rabbit.

H. Yoshimura, 1957, Pharmaceutical bulletin.

Cross‐tolerance development to the prolongation of pentobarbitone‐induced sleep by Δ8‐tetrahydrocannabinol and 11‐hydroxy‐Δ8‐tetrahydrocannabinol in mice

I. Yamamoto, S. Narimatsu, H. Yoshimura, 1987 .

Difference in tolerance development to hypothermia and pentobarbital-induced sleep prolongating effect of 11-hydroxy-Δ8-tetrahydrocannabinol and 11-oxo-Δ8-tetrahydrocannabinol in mice

I. Yamamoto, Kazuhito Watanabe, S. Narimatsu, 1982 .

Suppression of liver microsomal drug-metabolizing enzyme activities in adult female rats pretreated with cannabidiol.

I. Yamamoto, S. Imaoka, Y. Funae, 1993, Biological & pharmaceutical bulletin.

Mechanisms for stimulated fecal excretion of 2,3,4,7,8-pentachlorodibenzofuran in rats by treatment with squalane and liquid paraffin

K. Oguri, H. Yoshimura, H. Kamimura, 1987 .

Isolation and identification of urinary metabolites of AF-2 (3-(5-nitro-2-furyl)-2-(2-furyl)acrylamide) in rabbits.

H. Yoshimura, K. Tatsumi, T. Ou, 1977, Biochemical and biophysical research communications.

Metabolism of 3,5,3',5'-tetrachlorobiphenyl by rat liver microsomes and purified P4501A1.

Y. Masuda, H. Yoshimura, H. Kuroki, 1994, Xenobiotica; the fate of foreign compounds in biological systems.

POSSIBLE CORRELATION BETWEEN INDUCTION MODES OF HEPATIC ENZYMES BY PCBs AND THEIR TOXICITY IN RATS

N. Ozawa, S Yoshihara, H Yoshimura, 1979, Annals of the New York Academy of Sciences.

Synthesis and pharmacological activities in mice of halogenated delta 9-tetrahydrocannabinol derivatives.

I. Yamamoto, N. Usami, H. Yoshimura, 1998, Chemical & pharmaceutical bulletin.

METABOLISM OF DRUGS. XLI. THE METABOLIC FATE OF STRYCHNINE IN RABBIT LIVER.

K. Oguri, H. Yoshimura, T. Watabe, 1964, Journal of biochemistry.

Determination of urinary metabolites of thiamine propyl disulfide in humans.

S. Yamano, H. Yoshimura, 1982, Journal of pharmacobio-dynamics.

Metabolic fate of noscapine. III. Further studies on identification and determination of the metabolites.

N. Tsunoda, H. Yoshimura, 1981, Xenobiotica; the fate of foreign compounds in biological systems.

Synthesis and Pharmacological Activities in Mice of Halogenated Δ9-Tetrahydrocannabinol Derivatives.

I. Yamamoto, Kazuhito Watanabe, N. Usami, 1999 .

Cytochrome P450 isozymes catalyzing the hepatic microsomal oxidation of 9-anthraldehyde to 9-anthracene carboxylic acid in adult male rats.

I. Yamamoto, S. Imaoka, Y. Funae, 1993, Biological & pharmaceutical bulletin.

Changes in 5-HT receptor binding induced by tetrahydrocannabinol metabolites in bovine cerebral cortex

I. Yamamoto, Kazuhito Watanabe, T. Ohta, 1996 .

Cannabinoid metabolite interacts with benzodiazepine receptor

I. Yamamoto, H. Yoshimura, T. Kimura, 1992 .

Involvement of CYP2C in the metabolism of cannabinoids by human hepatic microsomes from an old woman.

I. Yamamoto, Y. Funae, T. Matsunaga, 1995, Biological & pharmaceutical bulletin.

The pharmacological activity of cannabinol and its major metabolite, 11-hydroxycannabinol.

I. Yamamoto, S. Narimatsu, H. Yoshimura, 1987, Chemical and pharmaceutical bulletin.

Pharmacology and Toxicology of Major Constituents of Marijuana—On the Metabolic Activation of Cannabinoids and Its Mechanism

I. Yamamoto, Kazuhito Watanabe, T. Matsunaga, 2003 .

Mouse hepatic microsomal oxidation of aliphatic aldehydes (C8 to C11) to carboxylic acids.

I. Yamamoto, S. Narimatsu, T. Matsunaga, 1992, Biochemical and biophysical research communications.

Metabolism in vivo of the tropane alkaloid, scopolamine, in several mammalian species.

H. Yamada, K. Oguri, H. Yoshimura, 1991, Xenobiotica; the fate of foreign compounds in biological systems.

The metabolism of phenyl o-(2-N-morpholinoethoxy)-phenyl ether hydrochloride in the rabbit and rat.

S. Kitamura, H. Yoshimura, K. Tatsumi, 1975, Xenobiotica; the fate of foreign compounds in biological systems.

Metabolism of prolintane in rats and the effect of prolintane metabolites on general activities in mice.

H. Yoshimura, S. Yoshihara, 1974, Xenobiotica; the fate of foreign compounds in biological systems.

Comparison of DT-diaphorases purified from the liver cytosol of untreated, and 3,4,5,3',4'-pentachlorobiphenyl- and 3-methylcholanthrene-treated rats.

Y. Hokama, H. Yoshimura, N. Koga, 1987, Journal of biochemistry.

The properties of UDP-glucuronyltransferase for cannabinoids in rat liver microsomes.

I. Yamamoto, K. Oguri, H. Yoshimura, 1983, Journal of pharmacobio-dynamics.

Catalytic activity of cytochrome P450 isozymes purified from rat liver in converting 11-oxo-Δ8-tetrahydrocannabinol to Δ8-tetrahydrocannabinol-11-oic acid

I. Yamamoto, Kazuhito Watanabe, S. Imaoka, 1991 .

Metabolism of drugs. LXXX. The metabolic fate of nitrofuran derivatives. 3. Studies on enzymes in small intestinal mucosa of rat catalyzing degradation of nitrofuran derivatives.

T. Yamaguchi, H. Yoshimura, K. Tatsumi, 1973, Chemical & pharmaceutical bulletin.

Chemical reactivity of morphine and morphine-6-conjugates and their binding to rat brain.

K. Oguri, H. Yoshimura, S. Ida, 1976, Chemical & pharmaceutical bulletin.

Mechanism for inhibitory effect of cannabidiol on microsomal testosterone oxidation in male rat liver.

I. Yamamoto, S. Narimatsu, H. Yoshimura, 1988, Drug metabolism and disposition: the biological fate of chemicals.

Immunochemical characterization of a cytochrome P450 isozyme and a protein purified from liver microsomes of male guinea pigs and their roles in the oxidative metabolism of delta 9-tetrahydrocannabinol by guinea pig liver microsomes.

I. Yamamoto, K. Watanabe, S. Narimatsu, 1992, Biochemical pharmacology.

METABOLIC DISPOSITION OF 8α, 9α-AND 8β, 9β-EPOXYHEXAHYDROCANNABINOLS IN THE MOUSE

I. Yamamoto, Kazuhito Watanabe, S. Narimatsu, 1984 .

Participation of cytochrome P450-2B and -2D isozymes in the demethylenation of methylenedioxymethamphetamine enantiomers by rats.

A. Cho, H. Yamada, S. Narimatsu, 1994, Molecular pharmacology.

Metabolism of delta 9-tetrahydrocannabinol by cytochrome P450 isozymes purified from hepatic microsomes of monkeys.

I. Yamamoto, T. Matsunaga, H. Yoshimura, 1995, Life sciences.

UDP-glucuronyltransferase activities of rabbit liver microsomes for cannabinoids.

I. Yamamoto, K. Oguri, H. Yoshimura, 1980, Journal of Pharmacobio-Dynamics.

Synthesis of delta 8-tetrahydrocannabinol glucuronide and sulfate, and their metabolic disposition in rats.

K. Oguri, H. Yoshimura, K. Watanabe, 1979, Chemical & pharmaceutical bulletin.

Purification of a phenobarbital-inducible UDP-glucuronosyltransferase isoform from dog liver which catalyzes morphine and testosterone glucuronidation.

Y. Ishii, M. Tanaka, K. Oguri, 1996, Archives of biochemistry and biophysics.

Metabolism of drugs. LXII. Isolation and identification of morphine glucuronides in urine and bile of rabbits.

K. Oguri, H. Yoshimura, H. Tsukamoto, 1969, Biochemical pharmacology.

Microsomal aldehyde oxygenase (MALDO): purification and characterization of a cytochrome P450 isozyme responsible for oxidation of 9-anthraldehyde to 9-anthracenecarboxylic acid in monkey liver.

I. Yamamoto, K. Watanabe, T. Matsunaga, 1996, Journal of Biochemistry (Tokyo).

Inhibition of hepatic microsomal cytochrome P450 by cannabidiol in adult male rats.

I. Yamamoto, S. Imaoka, Y. Funae, 1990, Chemical and pharmaceutical bulletin.

Hepatic microsomal oxygenation of aldehydes to carboxylic acids.

I. Yamamoto, S. Narimatsu, H. Yoshimura, 1990, Biochemical and Biophysical Research Communications - BBRC.

Oxygenation mechanism in the oxidation of xenobiotic aldehyde to carboxylic acid by mouse hepatic microsomes.

I. Yamamoto, S. Narimatsu, H. Yoshimura, 1988, Biochemical and biophysical research communications.

IDENTIFICATION AND DETERMINATION OF 11-OXO-Δ8-TETRAHYDROCANNABINOL AS AN INTERMEDIATE METABOLITE OF Δ8-TETRAHYDROCANNABINOL IN THE MOUSE BRAIN AND LIVER

I. Yamamoto, Kazuhito Watanabe, K. Oguri, 1980 .

Synthesis and pharmacological activity of a phosphate ester of .DELTA.8-tetrahydrocannabinol

Kazuhito Watanabe, K. Oguri, H. Yoshimura, 1978 .

Mechanism of hepatic microsomal oxidation of 11-hydroxy-delta 8-tetrahydrocannabinol to 11-oxo-delta 8-tetrahydrocannabinol. Evidence for hydration of the aldehyde formed.

I. Yamamoto, S. Narimatsu, T. Matsunaga, 1992, Journal of pharmacobio-dynamics.

Identification and determination of 8α,9α-epoxyhexahydrocannabinol as a metabolite of δ8-tetrahydrocannabinol of mice in vitro

I. Yamamoto, Kazuhito Watanabe, S. Narimatsu, 1982 .

Metabolic Reaction of Tolualdehydes by Microsomal Aldehyde Oxygenase (MALDO) in Lung (Proceedings of the 19th Symposium on Toxicology and Environmental Health)

I. Yamamoto, Kazuhito Watanabe, T. Matsunaga, 1994 .

Metabolic disposition of delta 8-tetrahydrocannabinol and its active metabolites, 11-hydroxy-delta 8-tetrahydrocannabinol and 11-oxo-delta 8-tetrahydrocannabinol, in mice.

I. Yamamoto, K. Oguri, H. Yoshimura, 1981, Drug metabolism and disposition: the biological fate of chemicals.

A constitutive form of guinea pig liver cytochrome P450 closely related to phenobarbital inducible P450b(e).

H. Yamada, K. Oguri, H. Yoshimura, 1991, Archives of biochemistry and biophysics.

Unique induction of cytochrome P-450 isozymes in rat liver microsomes by treatment with 3,4,5,3',4'-pentachlorobiphenyl and its effect on testosterone metabolism.

T. Matsunaga, H. Yoshimura, K. Nagata, 1985, Journal of pharmacobio-dynamics.

Effect of co-administration of interferon inducer, polyriboinosinic acid-polyribocytidylic acid, with SKF 525-A on hepatic drug metabolizing enzymes of rats.

T. Matsunaga, K. Oguri, H. Yoshimura, 1986, Journal of pharmacobio-dynamics.

Human liver microsomal oxidation of delta 8-tetrahydrocannabinol.

I. Yamamoto, S. Narimatsu, H. Yoshimura, 1983, Chemical & pharmaceutical bulletin.

Inductive effect on hepatic enzymes and acute toxicity of individual polychlorinated dibenzofuran congeners in rats.

Y. Masuda, K Nagata, S Yoshihara, 1981, Toxicology and applied pharmacology.

Metabolism of highly persistent PCB congener, 2,4,5,2',4',5'-hexachlorobiphenyl, by human CYP2B6.

Y. Funae, K. Oguri, H. Yoshimura, 1995, Biochemical and biophysical research communications.

Metabolism of an antiallergic agent, azelastine (4-(p-chlorobenzyl)-2-[N-methylperhydroazepinyl-(4)]-1-(2H)-p hthalazin one hydrochloride) in rats and guinea pigs.

H. Yamada, H. Mizuo, H. Yoshimura, 1984, Hiroshima journal of medical sciences.

High accumulation of 2,3,4,7,8-pentachlorodibenzofuran to hepatic microsomes of rats.

Y. Masuda, N. Fukasaku, H. Yoshimura, 1984, Journal of pharmacobio-dynamics.

Pharmacological activities in the mouse of delta 9-tetrahydrocannabinol metabolites oxidized at the 8-position.

I. Yamamoto, S. Narimatsu, H. Yoshimura, 1985, Chemical & pharmaceutical bulletin.

9 alpha, 10 alpha-epoxyhexahydrocannabinol formation from delta 9-tetrahydrocannabinol by liver microsomes of phenobarbital-treated mice and its pharmacological activities in mice.

I. Yamamoto, S. Narimatsu, H. Yoshimura, 1983, Journal of pharmacobio-dynamics.

Pharmacological activity of side chain hydroxylated metabolites of Δ9-tetrahydrocannabinol in mice

I. Yamamoto, Kazuhito Watanabe, S. Narimatsu, 1986 .

Chemical analysis and toxicity of polychlorinated biphenyls and dibenzofurans in relation to yusho.

Y. Masuda, H. Yoshimura, 1982, The Journal of toxicological sciences.

Metabolism of drugs—XLVIII. the study of selective demethylation of brucine in vivo

K. Oguri, H. Yoshimura, T. Watabe, 1964 .

Effect of morphine and its conjugates on the isolated ileal preparation of guinea-pig.

K. Oguri, H. Yoshimura, T. Ariyoshi, 1977, Chemical & pharmaceutical bulletin.

Enhanced elimination of theophylline, phenobarbital and strychnine from the bodies of rats and mice by squalane treatment.

K. Oguri, H. Yoshimura, H. Kamimura, 1992, Journal of pharmacobio-dynamics.

Site-selective oxidation of strychnine by phenobarbital inducible cytochrome P-450.

K. Oguri, H. Yoshimura, H. Kaneko, 1991, Journal of pharmacobio-dynamics.

A novel metabolite of strychnine, 22-hydroxystrychnine.

K. Oguri, H. Yoshimura, Y. Tanimoto, 1991, Xenobiotica; the fate of foreign compounds in biological systems.

Metabolic studies on polychlorinated biphenyls. 3. Complete structure and acute toxicity of the metabolites of 2,4,3',4'-tetrachlorobiphenyl.

H. Yoshimura, H. Yamamoto, H. Yoshimura, 1973, Chemical & pharmaceutical bulletin.

Metabolism of drugs. LXVII. The metabolic fate of isoprophenamine.

H. Yoshimura, K. Tatsumi, H. Tsukamoto, 1970, Chemical and pharmaceutical bulletin.

Formation of carbon monoxide during mouse hepatic microsomal oxidative metabolism of cannabidiol; identification and determination.

I. Yamamoto, N. Usami, H. Yoshimura, 1995, Biological & pharmaceutical bulletin.

Identification and Determination of Cannabinoids in Commercially Available Cannabis Seeds

I. Yamamoto, T. Matsunaga, H. Yoshimura, 1990 .

Formation of p-hydroxycocaine from cocaine by hepatic microsomes of animals and its pharmacological effects in mice.

I. Yamamoto, T. Matsunaga, H. Yoshimura, 1993, Biological & pharmaceutical bulletin.

[Metabolism of drugs. LXVI. Studies on the metabolic fate of pantethine].

K. Oguri, H. Yoshimura, H. Tsukamoto, 1970, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Synthesis and pharmacological effects in mice of halogenated cannabinol derivatives.

I. Yamamoto, N. Usami, H. Yoshimura, 1995, Chemical & pharmaceutical bulletin.

Purification and characterization of a morphine UDP-glucuronyltransferase isoform from untreated rat liver.

Y. Ishii, K. Oguri, H. Yoshimura, 1993, Biological & pharmaceutical bulletin.

Synthesis and analgesic effect of normorphine-3- and -6-glucuronides.

K. Oguri, H. Yoshimura, C. Kuo, 1989, Chemical & pharmaceutical bulletin.

Effect of liver S9 from 3,4,5,3',4'-pentachlorobiphenyl-pretreated rats on the mutagenic activity of the various carcinogens toward Salmonella typhimurium TA 98.

N. Ozawa, K. Shudo, H. Yoshimura, 1985, Journal of pharmacobio-dynamics.

[Studies on distribution, excretion and subacute toxicity of squalane in dogs].

H. Inoue, K. Oguri, H. Yoshimura, 1989, Fukuoka igaku zasshi = Hukuoka acta medica.

Metabolism of 2,3',4',5-tetrachlorobiphenyl by cytochrome P450 from rats, guinea pigs and hamsters.

K. Matsusue, K. Oguri, H. Yoshimura, 1998, Chemosphere.

In vivo metabolism of 11-hydroxy-delta-tetrahydrocannabinol to two carboxylic acids and the effects of SKF 525-A, cobaltous chloride and phenobarbital on their formation in rats.

I. Yamamoto, K. Oguri, H. Yoshimura, 1980, Chemical & pharmaceutical bulletin.