B. Choudhary

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G-quadruplex Structures Contribute to Differential Radiosensitivity of the Human Genome

Supriya V. Vartak, S. Raghavan, V. Gopalakrishnan, 2019, iScience.

Classification of Grain Amaranths Using Chromosome-Level Genome Assembly of Ramdana, A. hypochondriacus

Nivedita Hariharan, Eswarayya Ramireddy, P. Stevanato, 2020, bioRxiv.

Classification of Grain Amaranths Using Chromosome-Level Genome Assembly of Ramdana, A. hypochondriacus

Nivedita Hariharan, Eswarayya Ramireddy, P. Stevanato, 2020, Frontiers in Plant Science.

Synthesis and evaluation of the biological activity of N′-[2-oxo-1,2 dihydro-3H-indol-3-ylidene] benzohydrazides as potential anticancer agents

E. Clercq, D. Schols, S. Raghavan, 2015 .

ST08 Altered NF-κB Pathway in Breast Cancer Cells In Vitro as Revealed by miRNA-mRNA Analysis and Enhanced the Effect of Cisplatin on Tumour Reduction in EAC Mouse Model

B. Choudhary, S. Nirgude, S. Desai, 2022, Frontiers in Oncology.

Extracts of Strawberry Fruits Induce Intrinsic Pathway of Apoptosis in Breast Cancer Cells and Inhibits Tumor Progression in Mice

S. Raghavan, M. Hegde, Ranganatha R. Somasagara, 2012, PloS one.

Cardiovascular malformations with normal smooth muscle differentiation in neural crest-specific type II TGFbeta receptor (Tgfbr2) mutant mice.

Y. Chai, Yoshihiro Ito, H. Sucov, 2006, Developmental biology.

Epicardial induction of fetal cardiomyocyte proliferation via a retinoic acid-inducible trophic factor.

Tao Chang, H. Sucov, J. Burch, 2002, Developmental biology.

A Benzothiazole Derivative (5g) Induces DNA Damage And Potent G2/M Arrest In Cancer Cells

C. Kavitha, K. Rangappa, Supriya V. Vartak, 2017, Scientific Reports.

Extract of Vernonia condensata, Inhibits Tumor Progression and Improves Survival of Tumor-allograft Bearing Mouse

S. Raghavan, Ranganatha R. Somasagara, V. Gopalakrishnan, 2016, Scientific Reports.

Effects of green synthesised silver nanoparticles (ST06-AgNPs) using curcumin derivative (ST06) on human cervical cancer cells (HeLa) in vitro and EAC tumor bearing mice models

C. M. Gupta, B. Choudhary, Amrita Singh, 2019, International journal of nanomedicine.

SCR7, an inhibitor of NHEJ can sensitize tumor cells to ionization radiation

Supriya V. Vartak, S. Raghavan, V. Gopalakrishnan, 2021, Molecular carcinogenesis.

ST09, A Novel Curcumin Derivative, Blocks Cell Migration by Inhibiting Matrix Metalloproteases in Breast Cancer Cells and Inhibits Tumor Progression in EAC Mouse Tumor Models

V. Gopalakrishnan, B. Choudhary, Sujeet Kumar, 2020, Molecules.

Autocyclized and oxidized forms of SCR7 induce cancer cell death by inhibiting nonhomologous DNA end joining in a Ligase IV dependent manner

J. Charbonnier, Supriya V. Vartak, S. Raghavan, 2018, The FEBS journal.

A Near-Chromosome Level Genome Assembly of Anopheles stephensi

S. Subramani, Naveen Kumar, C. Ghosh, 2020, bioRxiv.

Propyl-2-(8-(3,4-Difluorobenzyl)-2′,5′-Dioxo-8-Azaspiro[Bicyclo[3.2.1] Octane-3,4′-Imidazolidine]-1′-yl) Acetate Induces Apoptosis in Human Leukemia Cells through Mitochondrial Pathway following Cell Cycle Arrest

C. Kavitha, K. Rangappa, U. Rathore, 2013, PloS one.

Integrated Transcriptome and Metabolomic Analysis Reveal Anti-Angiogenic Properties of Disarib, a Novel Bcl2-Specific Inhibitor

Venketesh Sivaramakrishnan, B. Choudhary, Raksha Rao K, 2022, Genes.

A Novel Resveratrol Based Tubulin Inhibitor Induces Mitotic Arrest and Activates Apoptosis in Cancer Cells

S. Raghavan, M. Hegde, V. Gopalakrishnan, 2016, Scientific Reports.

Whole-exome sequencing of Indian prostate cancer reveals a novel therapeutic target: POLQ

S. Desai, B. Choudhary, S. Srinivasan, 2022, Journal of Cancer Research and Clinical Oncology.

Characterization of DNA double‐strand break repair pathways in diffuse large B cell lymphoma

S. Raghavan, V. Gopalakrishnan, Sumedha Dahal, 2018, Molecular carcinogenesis.

Absence of TGFβ signaling in embryonic vascular smooth muscle leads to reduced lysyl oxidase expression, impaired elastogenesis, and aneurysm

V. Kaartinen, H. Sucov, P. Li, 2009, Genesis.

Novel derivatives of spirohydantoin induce growth inhibition followed by apoptosis in leukemia cells.

C. Kavitha, K. Rangappa, S. Raghavan, 2009, Biochemical pharmacology.

A novel structural derivative of natural alkaloid ellipticine, MDPSQ, induces necrosis in leukemic cells

S. Raghavan, Mridula Nambiar, B. Choudhary, 2011, Investigational New Drugs.

Differential genomic arrangements in Caryophyllales through deep transcriptome sequencing of A. hypochondriacus

Nivedita Hariharan, B. Choudhary, S. Srinivasan, 2017, PloS one.

Novel Levamisole Derivative Induces Extrinsic Pathway of Apoptosis in Cancer Cells and Inhibits Tumor Progression in Mice

K. Rangappa, K. Panjamurthy, S. Raghavan, 2012, PloS one.

Acute toxicity analysis of an inhibitor of BCL2, Disarib, in rats

S. Raghavan, B. Choudhary, K. Varsha, 2021, Scientific Reports.

A novel DNA intercalator, 8‐methoxy pyrimido[4′,5′:4,5]thieno (2,3‐b)quinoline‐4(3H)‐one induces apoptosis in cancer cells, inhibits the tumor progression and enhances lifespan in mice with tumor

Sheetal Sharma, K. Panjamurthy, S. Raghavan, 2013, Molecular carcinogenesis.

Differential regulation of MRN (Mre11-Rad50-Nbs1) complex subunits and telomerase activity in cancer cells.

C. Kavitha, S. Raghavan, K. Muniyappa, 2010, Biochemical and biophysical research communications.

Transcriptomic profiling of Indian breast cancer patients revealed subtype-specific mRNA and lncRNA signatures

B. Choudhary, S. Nirgude, M. Manjunath, 2022, Frontiers in Genetics.

Acute toxicity analysis of Disarib, an inhibitor of BCL2

S. Raghavan, V. Gopalakrishnan, Susmita Kumari, 2020, Scientific Reports.

Exposure to endosulfan can cause long term effects on general biology, including the reproductive system of mice

S. Raghavan, Arigesavan Kaninathan, Sumedha Dahal, 2022, Frontiers in Genetics.

Nonamer dependent RAG cleavage at CpGs can explain mechanism of chromosomal translocations associated to lymphoid cancers

S. Raghavan, S. Desai, B. Choudhary, 2022, PLoS genetics.

Amplification of chromosomal translocation junctions from paraffin-embedded tissues of follicular lymphoma patients

S. Raghavan, Mridula Nambiar, B. Choudhary, 2008, Biomedical materials.

Regioselective synthesis and biological studies of novel 1-aryl-3, 5-bis (het) aryl pyrazole derivatives as potential antiproliferative agents

K. Rangappa, S. Raghavan, Kothanahally S Sharath Kumar, 2016, Molecular and Cellular Biochemistry.

Identification of a novel BCL2‐specific inhibitor that binds predominantly to the BH1 domain

A. Surolia, N. Kalakonda, Supriya V. Vartak, 2016, The FEBS journal.

Sapodilla Plum (Achras sapota) Induces Apoptosis in Cancer Cell Lines and Inhibits Tumor Progression in Mice

S. Raghavan, M. Hegde, B. Choudhary, 2014, Scientific Reports.

A novel DNA intercalator, butylamino-pyrimido[4′,5′:4,5]selenolo(2,3-b)quinoline, induces cell cycle arrest and apoptosis in leukemic cells

S. Raghavan, Mridula Nambiar, B. Choudhary, 2010, Investigational New Drugs.

Methyl angolensate, a natural tetranortriterpenoid induces intrinsic apoptotic pathway in leukemic cells

S. Raghavan, Mridula Nambiar, B. Choudhary, 2008, FEBS letters.

Quercetin, a Natural Flavonoid Interacts with DNA, Arrests Cell Cycle and Causes Tumor Regression by Activating Mitochondrial Pathway of Apoptosis

Mahesh Hegde, Shikha Srivastava, S. Raghavan, 2016, Scientific Reports.

MicroRNA miR-29c regulates RAG1 expression and modulates V(D)J recombination during B cell development.

A. Liston, A. van Nieuwenhuijze, S. Raghavan, 2021, Cell reports.

DNA Damage Repair Genes and Noncoding RNA in High-Grade Gliomas and Its Clinical Relevance

B. Choudhary, Febina Ravindran, T. R. Parashar, 2021, CNS Malignancies [Working Title].

SCR7, a potent cancer therapeutic agent and a biochemical inhibitor of nonhomologous DNA end‐joining

S. Raghavan, B. Choudhary, M. Manjunath, 2021, Cancer reports.

MiRAGDB: A Knowledgebase of RAG Regulators

S. Raghavan, S. Desai, B. Choudhary, 2022, Frontiers in Immunology.

Anti-apoptotic Protein BCL2 Down-regulates DNA End Joining in Cancer Cells*

S. Raghavan, Mridula Nambiar, B. Choudhary, 2010, The Journal of Biological Chemistry.

Ovarian Cancer: Molecular Classification and Targeted Therapy

B. Choudhary, Febina Ravindran, 2021, Ovarian Cancer - Updates in Tumour Biology and Therapeutics [Working Title].

Curcumin alters distinct molecular pathways in breast cancer subtypes revealed by integrated miRNA/mRNA expression analysis

S. Desai, B. Choudhary, S. Nirgude, 2022, Cancer reports.

Telomere and telomerase in stem cells: relevance in ageing and disease.

A. Karande, S. Raghavan, B. Choudhary, 2012, Frontiers in bioscience.

Formation of a G-quadruplex at the BCL2 major breakpoint region of the t(14;18) translocation in follicular lymphoma

M. Lieber, S. Raghavan, R. Hosur, 2010, Nucleic acids research.

Novel BCL2 inhibitor, Disarib induces apoptosis by disruption of BCL2‐BAK interaction

A. Surolia, Sheetal Sharma, Supriya V. Vartak, 2017, Biochemical pharmacology.

A novel inhibitor of BCL2, Disarib abrogates tumor growth while sparing platelets, by activating intrinsic pathway of apoptosis.

P. Ray, Supriya V. Vartak, S. Raghavan, 2016, Biochemical pharmacology.

An Inhibitor of Nonhomologous End-Joining Abrogates Double-Strand Break Repair and Impedes Cancer Progression

A. De, Sheetal Sharma, P. Ray, 2012, Cell.

The Draft Genome and Transcriptome of Amaranthus hypochondriacus: A C4 Dicot Producing High-Lysine Edible Pseudo-Cereal

Saurabh Gupta, B. Panda, B. Choudhary, 2014, DNA research : an international journal for rapid publication of reports on genes and genomes.

The genome trilogy of Anopheles stephensi, an urban malaria vector, reveals structure of a locus associated with adaptation to environmental heterogeneity

S. Subramani, Mahul Chakraborty, C. Ghosh, 2021, Scientific Reports.

Genome-wide differential DNA methylation analysis of MDA-MB-231 breast cancer cells treated with curcumin derivatives, ST08 and ST09

S. Desai, B. Choudhary, S. Nirgude, 2022, BMC Genomics.

Time-dependent predominance of nonhomologous DNA end-joining pathways during embryonic development in mice.

Sheetal Sharma, A. Karande, S. Raghavan, 2012, Journal of molecular biology.

Efficiency of nonhomologous DNA end joining varies among somatic tissues, despite similarity in mechanism

Sheetal Sharma, S. Raghavan, B. Choudhary, 2011, Cellular and Molecular Life Sciences.

Water-soluble version of SCR7-pyrazine inhibits DNA repair and abrogates tumor cell proliferation

Supriya V. Vartak, S. Raghavan, R. Sebastian, 2019, Journal of Radiation and Cancer Research.

Triple-negative breast cancer: A run-through of features, classification and current therapies

B. Choudhary, M. Manjunath, 2021, Oncology letters.

Investigation of anti-cancer and migrastatic properties of novel curcumin derivatives on breast and ovarian cancer cell lines

V. Gopalakrishnan, B. Choudhary, Sujeet Kumar, 2019, BMC Complementary and Alternative Medicine.

Microhomology-mediated end joining is the principal mediator of double-strand break repair during mitochondrial DNA lesions

S. Raghavan, R. Sebastian, Sumedha Dahal, 2016, Molecular biology of the cell.

Methyl Angolensate from Callus of Indian Redwood Induces Cytotoxicity in Human Breast Cancer Cells

K. Panjamurthy, S. Raghavan, B. Choudhary, 2010, International journal of biomedical science : IJBS.

Cyanobacteria is uniquely enriched in the roots of grain amaranths

B. Choudhary, S. Srinivasan, M. Sunil, 2019, bioRxiv.

Multidimensional Mutational Profiling of the Indian HNSCC Sub-Population Provides IRAK1, a Novel Driver Gene and Potential Druggable Target

B. Choudhary, S. Srinivasan, V. Rao, 2021, Frontiers in Oncology.

Curcumin derivative 1, 2-bis [(3E, 5E)-3, 5-bis [(2-chlorophenyl) methylene]-4-oxo-1-piperidyl] ethane-1, 2-dione (ST03) induces mitochondria mediated apoptosis in ovarian cancer cells and inhibits tumor progression in EAC mouse model

B. Choudhary, S. Karki, Raghunandan Mahadeva, 2021, Translational oncology.

Normal fate and altered function of the cardiac neural crest cell lineage in retinoic acid receptor mutant embryos

K. Chien, H. Sucov, R. Maxson, 2002, Mechanisms of Development.

Identification and characterization of novel ligase I inhibitors

S. Raghavan, B. Choudhary, Sujeet Kumar, 2017, Molecular carcinogenesis.

A comprehensive study of mRNA and long noncoding RNAs in Indian Breast cancer patients using transcriptomics approach

B. Choudhary, S. Nirgude, M. Manjunath, 2022, bioRxiv.

ZnC2 module of RAG1 Contributes towards Structure-specific Nuclease activity of RAGs.

S. Raghavan, B. Choudhary, Mayilaadumveettil Nishana, 2020, The Biochemical journal.

ZnC 2 module of RAG 1 Contributes towards Structure-1 specific Nuclease activity of RAGs 2 3

S. Raghavan, B. Choudhary, Mayilaadumveettil Nishana, 2020 .

Insights into the role of GPX3, a highly efficient plasma antioxidant, in cancer.

B. Choudhary, S. Nirgude, 2020, Biochemical pharmacology.

Integrated Omic Analysis Delineates Pathways Modulating Toxic TDP-43 Protein Aggregates in Amyotrophic Lateral Sclerosis

A. Almansour, Venketesh Sivaramakrishnan, B. Choudhary, 2023, Cells.

Whole-exome sequencing of Indian prostate cancer reveals a novel therapeutic target: POLQ

S. Desai, B. Choudhary, S. Srinivasan, 2022, Journal of Cancer Research and Clinical Oncology.

Vitamin B6, B12 and folate modulate deregulated pathways and protein aggregation in yeast model of Huntington disease

Venketesh Sivaramakrishnan, B. Choudhary, M. Manjunath, 2023, 3 Biotech.

Multi-omics analysis of the Indian ovarian cancer cohort revealed histotype-specific mutation and gene expression patterns

B. Choudhary, Ramesh Gawari, Jinsha Koroth, 2023, Frontiers in Genetics.

Identification and characterization of mercaptopyrimidine‐based small molecules as inhibitors of nonhomologous DNA end joining

K. Rangappa, S. Raghavan, B. Choudhary, 2022, The FEBS journal.

Unleashing a novel function of Endonuclease G in mitochondrial genome instability

S. Raghavan, Sumedha Dahal, B. Choudhary, 2021, bioRxiv.

Curcumin derivative ST09 modulates the miR-199a-5p/DDR1 axis and regulates proliferation and migration in ovarian cancer cells

Suchitra Narayan, B. Choudhary, Febina Ravindran, 2021, Scientific Reports.

A Coumarin–Imidazothiadiazole Derivative, SP11 Abrogates Tumor Growth by Targeting HSP90 and Its Client Proteins

B. Choudhary, Sujeet Kumar, S. Karki, 2023, Molecules.

Plant-derived Tetranortriterpenoid, Methyl Angolensate Activates Apoptosis and Prevents Ehrlich Ascites Carcinoma Induced Tumorigenesis in Mice.

S. Raghavan, V. Gopalakrishnan, B. Choudhary, 2016 .

A novel loss-of-function mutation in HACE1 is linked to a genetic disorder in a patient from India

Nivedita Hariharan, P. Khanchandani, B. Choudhary, 2018, Human Genome Variation.

Integrated Multi-Omic Data Analysis and Validation with Yeast Model Show Oxidative Phosphorylation Modulate Protein Aggregation in Amyotrophic Lateral Sclerosis

Venketesh Sivaramakrishnan, B. Choudhary, R. Rao, 2021 .

A Benzothiazole Derivative (5g) Induces DNA Damage And Potent G2/M Arrest In Cancer Cells

C. Kavitha, K. Rangappa, Supriya V. Vartak, 2017, Scientific Reports.

Evaluation of potential role of R-loop and G-quadruplex DNA in the fragility of c-MYC during chromosomal translocation associated with Burkitt’s lymphoma

S. Raghavan, V. Gopalakrishnan, Nitu Kumari, 2023, The Journal of biological chemistry.

Whole transcriptome sequencing reveals HOXD11-AGAP3, a novel fusion transcript in the Indian acute leukemia cohort

S. Desai, B. Choudhary, Febina Ravindran, 2023, Frontiers in Genetics.

Disarib, a Specific BCL2 Inhibitor, Induces Apoptosis in Triple-Negative Breast Cancer Cells and Impedes Tumour Progression in Xenografts by Altering Mitochondria-Associated Processes

S. Raghavan, B. Choudhary, Febina Ravindran, 2024, International journal of molecular sciences.

Mutations at BCL11B Exon 4 Associated with T Cell Acute Lymphoblastic Leukemia Are Facilitated by AID and Formation of Non-B DNA Conformations.

S. Raghavan, Nitu Kumari, Sumedha Dahal, 2024, Molecular and cellular biology.