J. Gosset

发表

A thermoplastic microfluidic microphysiological system to recapitulate hepatic function and multicellular interactions

Mingjian Lu, J. Charest, J. Coppeta, 2019, Biotechnology and bioengineering.

Quantitative prediction of breast cancer resistant protein mediated drug‐drug interactions using physiologically‐based pharmacokinetic modeling

A. D. Rodrigues, S. Yamazaki, M. Varma, 2021, CPT: pharmacometrics & systems pharmacology.

Model-based approaches to predict drug–drug interactions associated with hepatic uptake transporters: preclinical, clinical and beyond

Hugh A Barton, Jian Lin, Hannah M Jones, 2013, Expert opinion on drug metabolism & toxicology.

Integrated Assessment of Drug Clearance and Cross‐Species Scalability

K. Beaumont, J. Gosset, C. Keefer, 2014 .

Elucidation of the biochemical basis for a clinical drug–drug interaction between atorvastatin and 5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methyl benzoic acid (CP-778 875), a subtype selective agonist of the peroxisome proliferator-activated receptor alpha

A. Kalgutkar, R. Walsky, B. Feng, 2013, Xenobiotica; the fate of foreign compounds in biological systems.

Determination of Unbound Partition Coefficient and in Vitro–in Vivo Extrapolation for SLC13A Transporter–Mediated Uptake

L. Di, D. Erion, Janice A. Brown, 2016, Drug Metabolism and Disposition.

Discovery and in Vitro Optimization of 3-Sulfamoylbenzamides as ROMK Inhibitors.

A. Carlo, M. Boehm, K. J. Filipski, 2018, ACS medicinal chemistry letters.

Discovery of Selective Small Molecule Inhibitors of Monoacylglycerol Acyltransferase 3.

C. C. Jorgensen, Hao Sun, M. Boehm, 2015, Journal of medicinal chemistry.

Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5)

P. Loria, T. Rolph, D. Hepworth, 2015, Scientific Reports.

Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family.

T. Rolph, M. Hayward, D. Erion, 2016, Journal of medicinal chemistry.

The discovery of UK-369003, a novel PDE5 inhibitor with the potential for oral bioavailability and dose-proportional pharmacokinetics.

M. Bunnage, K. Beaumont, D. Leahy, 2012, Bioorganic & medicinal chemistry.

Population Pharmacokinetic Model of the Pregabalin-Sildenafil Interaction in Rats: Application of Simulation to Preclinical PK-PD Study Design

Meindert Danhof, Scott Marshall, Keith Tan, 2009, Pharmaceutical Research.

(Kpuu) and in Vitro-in Vivo Extrapolation for SLC13A Transporter-Mediated Uptake

L. Di, D. Erion, Janice A. Brown, 2016 .

Examination of the Human Cytochrome P4503A4 Induction Potential of PF-06282999, an Irreversible Myeloperoxidase Inactivator: Integration of Preclinical, In Silico, and Biomarker Methodologies in the Prediction of the Clinical Outcome

Jeffrey R. Chabot, A. Kalgutkar, L. Buckbinder, 2017, Drug Metabolism and Disposition.

Chapter 2:ADMET for the Medicinal Chemist

K. Beaumont, J. Gosset, S. Cole, 2010 .

Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis.

P. Loria, J. Bauman, David A. Price, 2022, Journal of medicinal chemistry.

Small structural changes of the imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitors produce an improved safety profile.

D. Hepworth, T. Goosen, A. Shoieb, 2017, MedChemComm.

Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2).

C. C. Jorgensen, M. Boehm, D. Hepworth, 2015, Journal of medicinal chemistry.

Application of PBPK modelling in drug discovery and development at Pfizer

Kuresh Youdim, Hannah M Jones, Maurice Dickins, 2012, Xenobiotica; the fate of foreign compounds in biological systems.

Correction: A high-throughput microfluidic microphysiological system (PREDICT-96) to recapitulate hepatocyte function in dynamic, re-circulating flow conditions.

Mingjian Lu, S. Golmon, V. Tandon, 2020, Lab on a chip.

A high-throughput microfluidic microphysiological system (PREDICT-96) to recapitulate hepatocyte function in dynamic, re-circulating flow conditions.

Mingjian Lu, Shyam Sundhar Bale, Kelly Tan, 2019, Lab on a chip.

A cross‐species translational pharmacokinetic‐pharmacodynamic evaluation of core body temperature reduction by the TRPM8 blocker PF‐05105679

P. H. van der Graaf, K. Beaumont, W. Winchester, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Inhibition of TRPM8 Channels Reduces Pain in the Cold Pressor Test in Humans

M. Postlethwaite, M. Andrews, P. Saintot, 2014, The Journal of Pharmacology and Experimental Therapeutics.

A Novel Milli-fluidic Liver Tissue Chip with Continuous Recirculation for Predictive Pharmacokinetics Applications

Jason S. Sherfey, M. Cirit, J. Gosset, 2023, bioRxiv.

Cold-Responsive Trigeminal Neurons From Rat TRPM8 mRNA Is Expressed in a Subset of

M. Postlethwaite, A. Dhaka, M. Caterina, 2015 .