G. Bisacchi

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Origins of the Quinolone Class of Antibacterials: An Expanded "Discovery Story".

G. Bisacchi, 2015, Journal of medicinal chemistry.

Chapter 19 Recent Advances in the Inhibition of Bacterial Type II Topoisomerases

J. Dumas, G. Bisacchi, 2009 .

Solid-phase synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors.

Malcolm E. Davis, A. Mathur, G. Bisacchi, 2004, Bioorganic & medicinal chemistry letters.

XYLOCANDIN: A NEW COMPLEX OF ANTIFUNGAL PEPTIDES

R. Sykes, E. Meyers, L. Dean, 1987 .

Xylocandin: a new complex of antifungal peptides. II. Structural studies and chemical modifications.

S. Unger, G. Bisacchi, W. Parker, 1987, The Journal of antibiotics.

Anticoagulants, Antithrombotics, and Hemostatics

G. Bisacchi, 2003 .

Discovery of nonbenzamidine factor VIIa inhibitors using a biaryl acid scaffold.

D. Cheney, S. Sheriff, E. Liu, 2013, Bioorganic & medicinal chemistry letters.

Ketene aminal-based lactam derivatives as a novel class of orally active FXa inhibitors.

E. Liu, P. Stein, A. Rendina, 2005, Bioorganic & medicinal chemistry letters.

Phenylimidazoles as potent and selective inhibitors of coagulation factor XIa with in vivo antithrombotic activity.

A. Mathur, P. Morin, D. Seiffert, 2014, Journal of medicinal chemistry.

BMS-200475, a novel carbocyclic 2′-deoxyguanosine analog with potent and selective anti-hepatitis B virus activity in vitro

O. Kocy, M. Young, R. Colonno, 1997 .

Aminodiol HIV protease inhibitors. 1. Design, synthesis, and preliminary SAR.

J. Barrish, M. Hermsmeier, E. Gordon, 1994, Journal of medicinal chemistry.

Synthesis of potent and highly selective nonguanidine azetidinone inhibitors of human tryptase.

A. Mathur, G. Bisacchi, W. Meng, 2004, Bioorganic & medicinal chemistry letters.

A “Double-Edged” Scaffold: Antitumor Power within the  Antibacterial Quinolone

G. Bisacchi, Michael R. Hale, Gregory S. Bisacchi, 2016, Current medicinal chemistry.

A Practical Asymmetric Synthesis of the Antiviral Agent Lobucavir, BMS-180194

O. Kocy, T. Mitt, Saleem Ahmad, 1998 .

Regioselective Coupling of Tetraalkylammonium Salts of 6-Iodo-2-aminopurine to a Cyclobutyl Triflate: Efficient Preparation of Homochiral BMS-180,194, a Potent Antiviral Carbocyclic Nucleoside

T. Mitt, G. Bisacchi, R. Zahler, 1995 .

Synthesis and antiviral activity of enantiomeric forms of cyclobutyl nucleoside analogues.

T. Mitt, J. Clark, C. Cianci, 1991, Journal of medicinal chemistry.

Synthesis of SQ-33,054, a novel cyclobutane nucleoside with potent antiviral activity

M. Young, G. Bisacchi, R. Zahler, 1989 .

An efficient and remarkably regioselective synthesis of benzocyclobutenones from benzynes and 1,1-dimethoxyethylene

G. Bisacchi, R. V. Stevens, 1982 .

A New-Class Antibacterial-Almost. Lessons in Drug Discovery and Development: A Critical Analysis of More than 50 Years of Effort toward ATPase Inhibitors of DNA Gyrase and Topoisomerase IV.

J. Manchester, G. Bisacchi, 2015, ACS infectious diseases.

Benzocyclobutenones as synthons for the synthesis of C-11 oxygenated diterpenoids. Application to the total synthesis of (.+-.)-taxodione

G. Bisacchi, R. V. Stevens, 1982 .

Synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors.

G. Bisacchi, W. Meng, R. Zahler, 2002, Bioorganic & medicinal chemistry letters.

Aminodiol HIV protease inhibitors. Synthesis and structure-activity relationships of P1/P1' compounds: correlation between lipophilicity and cytotoxicity.

S. Spergel, O. Kocy, J. Barrish, 1996, Journal of medicinal chemistry.

Synthesis of potent and highly selective inhibitors of human tryptase.

G. Bisacchi, W. Meng, R. Zahler, 2002, Bioorganic & medicinal chemistry letters.

Identification of BMS-200475 as a potent and selective inhibitor of hepatitis B virus

R. Colonno, M. Seifer, D. Standring, 1997, Antimicrobial agents and chemotherapy.

Xylocandin: a new complex of antifungal peptides. I. Taxonomy, isolation and biological activity.

R. Sykes, E. Meyers, L. Dean, 1987, The Journal of antibiotics.

Metabolic Studies on BMS-200475, a New Antiviral Compound Active against Hepatitis B Virus

P. Egli, R. Colonno, G. Bisacchi, 1999, Antimicrobial Agents and Chemotherapy.

On the mechanism of the sensitized photooxygenation of pyrroles

R. Norris, D. Lightner, G. Bisacchi, 1976 .

Selective activity and cellular pharmacology of (1R-1 alpha,2 beta,3 alpha)-9-[2,3-bis(hydroxymethyl)cyclobutyl]guanine in herpesvirus-infected cells.

M. Haffey, G. Bisacchi, B. Terry, 1991, Molecular pharmacology.

(2R, 4S, 5S)-1-(tetrahydro-4-hydroxy-5-methoxy-2-furanyl)thymine: a potent selective inhibitor of herpes simplex thymidine kinase

G. Bisacchi, B. Terry, C. Kim, 1993 .

PROCEDE DE PREPARATION AMELIORE DE L'AGENT ANTIVIRAL [1S-(1α, 3α, 4β)]-2-AMINO-1,9-DIHYDRO-9-[4-HYDROXY-3-(HYDROXYMETHYL)-2-METHYLENE-CYCLOPENTYL]-6-H-PURINE-6-ONE

G. Bisacchi, J. Sundeen, 1997 .

Regioselective Coupling of Tetraalkylammonium Salts of 6‐Iodo‐2‐ aminopurine to a Cyclobutyl Triflate: Efficient Preparation of Homochiral BMS‐180,194, a Potent Antiviral Carbocyclic Nucleoside.

T. Mitt, G. Bisacchi, R. Zahler, 1995 .

Synthesis and antiviral activity of 1-cyclobutyl-5-(2-bromovinyl)uracil nucleoside analogues and related compounds.

M. Young, G. Bisacchi, J. Tino, 1992, Journal of medicinal chemistry.

α-hydroxyamide derived aminodiols as potent inhibitors of hiv protease

Ping Chen, S. Spergel, J. Barrish, 1995 .

Synthesis of potent and selective 2-azepanone inhibitors of human tryptase.

G. Bisacchi, C. Kwon, S. Bolton, 2004, Bioorganic & medicinal chemistry letters.

Molecular determinants of AcrB-mediated bacterial efflux implications for drug discovery.

J. Manchester, R. Mclaughlin, G. Bisacchi, 2012, Journal of medicinal chemistry.

BMS-201620: a selective beta 3 agonist.

T. Waldron, K. Dickinson, R. George, 2004, Bioorganic & medicinal chemistry letters.

1,2-Benzisothiazol-3-one 1,1-dioxide inhibitors of human mast cell tryptase.

P. Stanley, N. Meanwell, B. Pearce, 1998, Journal of medicinal chemistry.

Synthesis of spiro-activated cyclopropanes from alkenes via the irradiation of isopropylidene diazomalonate. A reinvestigation

G. Bisacchi, C. Strouse, R. V. Stevens, 1980 .