Soo-Kyung Kim

发表

Characterizing and predicting the functional and conformational diversity of seven-transmembrane proteins.

W. Goddard, R. Abrol, Jenelle K. Bray, 2011, Methods.

Identification by Site-directed Mutagenesis of Residues Involved in Ligand Recognition and Activation of the Human A3 Adenosine Receptor*

K. Jacobson, C. Müller, Zhang-Guo Gao, 2002, The Journal of Biological Chemistry.

Predicted structures of agonist and antagonist bound complexes of adenosine A3 receptor

W. Goddard, K. Jacobson, R. Abrol, 2011, Proteins.

Purine receptors: GPCR structure and agonist design.

K. Jacobson, Zhang-Guo Gao, S. Costanzi, 2004, Molecular interventions.

Identification of essential residues involved in the allosteric modulation of the human A(3) adenosine receptor.

Kenneth A Jacobson, K. Jacobson, Zhang-Guo Gao, 2003, Molecular pharmacology.

Demystifying the three dimensional structure of G protein-coupled receptors (GPCRs) with the aid of molecular modeling.

Francesca Deflorian, Barbara Cacciari, Giampiero Spalluto, 2003, Chemical communications.

Engineering of A3 adenosine and P2Y nucleotide receptors and their ligands

K. Jacobson, Zhang-Guo Gao, D. Barak, 2003, Drug development research.

Predicted Ligands for the Human Urotensin‐II G Protein‐Coupled Receptor with Some Experimental Validation

W. Goddard, K. Yi, B. Trzaskowski, 2014, ChemMedChem.

Predicted 3D structures for adenosine receptors bound to ligands: comparison to the crystal structure.

Bartosz Trzaskowski, Ravinder Abrol, William A Goddard, 2010, Journal of structural biology.

Prediction of the Three‐Dimensional Structure for the Rat Urotensin II Receptor, and Comparison of the Antagonist Binding Sites and Binding Selectivity between Human and Rat Receptors from Atomistic Simulations

Ravinder Abrol, William A Goddard, W. Goddard, 2010, ChemMedChem.

Mechanism of β-arrestin recruitment by the μ-opioid G protein-coupled receptor

W. Goddard, A. Mafi, Soo-Kyung Kim, 2020, Proceedings of the National Academy of Sciences.

The mechanism for ligand activation of the GPCR–G protein complex

W. Goddard, Soo-Kyung Kim, Amirhossein Mafi, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Computational prediction of homodimerization of the A3 adenosine receptor.

K. Jacobson, Soo-Kyung Kim, 2006, Journal of molecular graphics & modelling.

Selective A(3) adenosine receptor antagonists derived from nucleosides containing a bicyclo[3.1.0]hexane ring system.

K. Jacobson, Zhang-Guo Gao, L. Jeong, 2008, Bioorganic & medicinal chemistry.

Cardioselective anti-ischemic ATP-sensitive potassium channel (KATP) openers: benzopyranyl indoline and indole analogues.

K. Yi, H. Seo, J. Suh, 2003, European journal of medicinal chemistry.

Analysis of Plasma Long-Chain Fatty Acids in Hypertensive Patients

Soo-Kyung Kim, Jong Sun Kim, Gee-youn Kwon, 2011 .

Design and synthesis of 3'-ureidoadenosine-5'-uronamides: effects of the 3'-ureido group on binding to the A3 adenosine receptor.

K. Jacobson, Zhang-Guo Gao, M. Chun, 2004, Bioorganic & medicinal chemistry letters.

The 3D Structure of Human DP Prostaglandin G-Protein-Coupled Receptor Bound to Cyclopentanoindole Antagonist, Predicted Using the DuplexBiHelix Modification of the GEnSeMBLE Method.

W. Goddard, Vishnu Shankar, R. Abrol, 2017, Journal of chemical theory and computation.

KR 31372, a benzopyran derivative, inhibits oxidized LDL‐stimulated proliferation and migration of vascular smooth muscle cells

K. Hong, H. Ha, S. Yoo, 2000, Fundamental & clinical pharmacology.

Cloning and characterization of rat neuronal apoptosis inhibitory protein cDNA

Jong-Wook Park, T. Oh, Soo-Kyung Kim, 2003, Neurochemistry International.

G protein coupling and activation of the metabotropic GABAB heterodimer

W. Goddard, M. Yang, Soo-Kyung Kim, 2022, Nature Communications.

Exploring distal regions of the A3 adenosine receptor binding site: sterically constrained N6-(2-phenylethyl)adenosine derivatives as potent ligands.

Kenneth A Jacobson, K. Jacobson, Zhang-Guo Gao, 2004, Bioorganic & medicinal chemistry.

Structures and Agonist Binding Sites of Bitter Taste Receptor TAS2R5 Complexed with Gi Protein and Validated against Experiment.

W. Goddard, S. Liggett, M. Yang, 2021, The journal of physical chemistry letters.

Screening for effective COVID-19 drugs using microtoroid optical resonators

W. Goddard, Adley Gin, Soo-Kyung Kim, 2022, 2022 Conference on Lasers and Electro-Optics (CLEO).

Random Mutagenesis of the M3 Muscarinic Acetylcholine Receptor Expressed in Yeast

J. Wess, K. Jacobson, Soo-Kyung Kim, 2005, Journal of Biological Chemistry.

G protein‐coupled odorant receptors: From sequence to structure

W. Goddard, S. Antonczak, C. D. de March, 2015, Protein science : a publication of the Protein Society.

Expression of neuropeptide Y by glutamatergic stimulation in rat C6 glioma cells

Soo-Kyung Kim, B. Choe, Gee-youn Kwon, 2000, Neurochemistry International.

Synergic Effects in the Activation of the Sweet Receptor GPCR Heterodimer for Various Sweeteners Predicted Using Molecular Metadynamics Simulations.

W. Goddard, Soo-Kyung Kim, Jaewan Jang, 2021, Journal of agricultural and food chemistry.

Modulation of adenosine receptor affinity and intrinsic efficacy in adenine nucleosides substituted at the 2-position.

K. Jacobson, Philippe van Rompaey, S. van Calenbergh, 2004, Bioorganic & medicinal chemistry.

Orthogonal activation of the reengineered A3 adenosine receptor (neoceptor) using tailored nucleoside agonists.

K. Jacobson, Philippe van Rompaey, S. van Calenbergh, 2006, Journal of medicinal chemistry.

Structure-activity relationships of thiazole and thiadiazole derivatives as potent and selective human adenosine A3 receptor antagonists.

K. Jacobson, Zhang-Guo Gao, Yong‐Chul Kim, 2004, Bioorganic & medicinal chemistry.

2-triazole-substituted adenosines: a new class of selective A3 adenosine receptor agonists, partial agonists, and antagonists.

K. Jacobson, S. van Calenbergh, Zhang-Guo Gao, 2006, Journal of medicinal chemistry.

(N)-methanocarba 2,N6-disubstituted adenine nucleosides as highly potent and selective A3 adenosine receptor agonists.

K. Jacobson, Zhang-Guo Gao, B. Joshi, 2005, Journal of medicinal chemistry.

Structural Determinants of A3 Adenosine Receptor Activation: Nucleoside Ligands at the Agonist/Antagonist Boundary

Kenneth A. Jacobson, Carl R. Johnson, Dov Barak, 2002 .

Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary.

Carl R. Johnson, Dov Barak, Kenneth A Jacobson, 2002, Journal of medicinal chemistry.

Multiple Residues in the Second Extracellular Loop Are Critical for M3 Muscarinic Acetylcholine Receptor Activation*

J. Wess, M. Scarselli, Soo-Kyung Kim, 2007, Journal of Biological Chemistry.

Identification of an Agonist-induced Conformational Change Occurring Adjacent to the Ligand-binding Pocket of the M3 Muscarinic Acetylcholine Receptor*

Bo Li, Sung-Jun Han, Kenneth A Jacobson, 2005, Journal of Biological Chemistry.

Pronounced Conformational Changes following Agonist Activation of the M3 Muscarinic Acetylcholine Receptor*

J. Wess, K. Jacobson, F. Hamdan, 2005, Journal of Biological Chemistry.

Sorting and Activity-Dependent Secretion of BDNF Require Interaction of a Specific Motif with the Sorting Receptor Carboxypeptidase E

Y. Loh, B. Lu, C. Snell, 2005, Neuron.

Activation mechanism of the G protein-coupled sweet receptor heterodimer with sweeteners and allosteric agonists

W. Goddard, Yalu Chen, R. Abrol, 2017, Proceedings of the National Academy of Sciences.

Complete inhibition of a polyol nucleation by a micromolar biopolymer additive

W. Goddard, T. Pascal, A. Rheingold, 2022, Cell reports. Physical science.

Antifreeze proteins govern the precipitation of trehalose in a freezing-avoiding insect at low temperature

W. Goddard, A. Rios, R. Abrol, 2016, Proceedings of the National Academy of Sciences.

Structural Variation and Odorant Binding for Olfactory Receptors Selected from the Six Major Subclasses of the OR Phylogenetic Tree

W. Goddard, Soo-Kyung Kim, M. Malinska, 2021 .

How broadly tuned olfactory receptors equally recognize their agonists. Human OR1G1 as a test case

William A. Goddard, Jérôme Golebiowski, Landry Charlier, 2012, Cellular and Molecular Life Sciences.

Epimerization in Intramolecular Carbanilide Cyclization to Hydantoins: A Computational Study.

S. Yoo, Soo-Kyung Kim, M. Kurth, 2002 .

Hedgehog proteins create a dynamic cholesterol interface

W. Goddard, Erika Vielmas, A. Mafi, 2021, PloS one.

Distinct Structural Changes in a G Protein-coupled Receptor Caused by Different Classes of Agonist Ligands*

J. Wess, K. Jacobson, F. Hamdan, 2007, Journal of Biological Chemistry.

The atomistic level structure for the activated human κ-opioid receptor bound to the full Gi protein and the MP1104 agonist

W. Goddard, A. Mafi, Soo-Kyung Kim, 2020, Proceedings of the National Academy of Sciences.

The G protein-first activation mechanism of opioid receptors by Gi protein and agonists

W. Goddard, A. Mafi, Soo-Kyung Kim, 2021, QRB Discovery.

Predicted structure of fully activated human bitter taste receptor TAS2R4 complexed with G protein and agonists

W. Goddard, M. Yang, A. Mafi, 2021, QRB Discovery.

Discovery of Novel Biased Opioid Receptor Ligands through Structure‐Based Pharmacophore Virtual Screening and Experiment

Ki Duk Park, W. Goddard, Yong‐Chul Kim, 2019, ChemMedChem.

Intermediate-state-trapped mutants pinpoint G protein-coupled receptor conformational allostery

W. Goddard, C. Neale, Soo-Kyung Kim, 2023, Nature Communications.

Predicted Structure of Fully Activated Tas1R3/1R3' Homodimer Bound to G Protein and Natural Sugars: Structural Insights into G Protein Activation by a Class C Sweet Taste Homodimer with Natural Sugars.

W. Goddard, K. Chou, A. Mafi, 2021, Journal of the American Chemical Society.

Rapid identification of functionally critical amino acids in a G protein–coupled receptor

Bo Li, Kenneth A Jacobson, J. Wess, 2007, Nature Methods.

Novel interaction between neurotrophic factor-α1/carboxypeptidase E and serotonin receptor, 5-HTR1E, protects human neurons against oxidative/neuroexcitotoxic stress via β-arrestin/ERK signaling

W. Goddard, A. Inoue, D. Saiz-Sánchez, 2021, Cellular and Molecular Life Sciences.

Structure-Based Prediction of Subtype Selectivity of Histamine H3 Receptor Selective Antagonists in Clinical Trials

William A. Goddard, Soo-Kyung Kim, Ravinder Abrol, 2011, J. Chem. Inf. Model..

Predicted Structures for Kappa Opioid G-Protein Coupled Receptor Bound to Selective Agonists

Hongwei Tan, William A. Goddard, Guangju Chen, 2015, J. Chem. Inf. Model..

Conformational changes involved in G-protein-coupled-receptor activation.

J. Wess, K. Jacobson, Sung-jun Han, 2008, Trends in pharmacological sciences.

Stereochemical engineering yields a multifunctional peptide macrocycle inhibitor of Akt2 by fine-tuning macrocycle-cell membrane interactions

Samir R Das, W. Goddard, Yapeng Su, 2023, Communications chemistry.

Docking studies of agonists and antagonists suggest an activation pathway of the A3 adenosine receptor.

Kenneth A Jacobson, K. Jacobson, Zhang-Guo Gao, 2006, Journal of molecular graphics & modelling.

Conversion of A3 adenosine receptor agonists into selective antagonists by modification of the 5'-ribofuran-uronamide moiety.

K. Jacobson, Zhang-Guo Gao, L. Jeong, 2006, Bioorganic & medicinal chemistry letters.

Modeling the adenosine receptors: comparison of the binding domains of A2A agonists and antagonists.

Kenneth A Jacobson, K. Jacobson, Philippe van Rompaey, 2003, Journal of medicinal chemistry.

Action of Nucleosides and Nucleotides at 7 Transmembrane-Spanning Receptors

K. Jacobson, Zhang-Guo Gao, S. Costanzi, 2006, Nucleosides, nucleotides & nucleic acids.

Predicted Structures and Dynamics for Agonists and Antagonists Bound to Serotonin 5-HT2B and 5-HT2C Receptors

Jiyoung Heo, Youyong Li, William A. Goddard, 2011, J. Chem. Inf. Model..

Allosteric modulation of the adenosine family of receptors.

Kenneth A Jacobson, K. Jacobson, A. IJzerman, 2005, Mini reviews in medicinal chemistry.

A neoceptor approach to unraveling microscopic interactions between the human A2A adenosine receptor and its agonists.

K. Jacobson, Zhang-Guo Gao, S. Tchilibon, 2005, Chemistry & biology.

Predicted 3D structures of olfactory receptors with details of odorant binding to OR1G1

William A. Goddard, Soo-Kyung Kim, W. Goddard, 2014, Journal of Computer-Aided Molecular Design.

The dynamics of agonist-β2-adrenergic receptor activation induced by binding of GDP-bound Gs protein

W. Goddard, Soo-Kyung Kim, Amirhossein Mafi, 2023, Nature Chemistry.

Discovery and Binding Mechanism of Pyrazoloisoquinoline-Based Novel β-Arrestin Inverse Agonists of the Kappa-Opioid Receptor.

W. Goddard, M. Yang, Sunhong Kim, 2023, Journal of medicinal chemistry.

Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008

Charles L. Brooks, Adrian W. R. Serohijos, John Moult, 2009, Nature Reviews Drug Discovery.

Conformational ensemble view of G protein-coupled receptors and the effect of mutations and ligand binding.

W. Goddard, B. Trzaskowski, R. Abrol, 2013, Methods in enzymology.

Ligand-specific changes in M3 muscarinic acetylcholine receptor structure detected by a disulfide scanning strategy.

J. Wess, K. Jacobson, F. Hamdan, 2008, Biochemistry.

Homology modeling and molecular docking studies of Drosophila and Aedes sex peptide receptors.

W. Goddard, Soo-Kyung Kim, Yong-Chul Kim, 2016, Journal of molecular graphics & modelling.

Molecular-Docking-Based Drug Design and Discovery: Rational Drug Design for the Subtype Selective GPCR Ligands

William A. Goddard, W. Goddard, Soo-Kyung Kim, 2016 .

Predicted structures of agonist and antagonist bound complexes of adenosine A3 receptor

W. Goddard, K. Jacobson, R. Abrol, 2011, Proteins.

G protein‐coupled odorant receptors: From sequence to structure

W. Goddard, S. Antonczak, C. D. de March, 2015, Protein science : a publication of the Protein Society.

Predicted Three-Dimensional Structure of the GCR1 Putative GPCR in Arabidopsis thaliana and Its Binding to Abscisic Acid and Gibberellin A1.

Pedro M. Hernandez, W. Goddard, A. Jaramillo-Botero, 2023, Journal of agricultural and food chemistry.