B. Josselin

发表

Design of new disubstituted imidazo[1,2-b]pyridazine derivatives as selective Haspin inhibitors. Synthesis, binding mode and anticancer biological evaluation

S. Knapp, P. Bonnet, A. Chaikuad, 2020, Journal of enzyme inhibition and medicinal chemistry.

Kinase inhibitions in pyrido[4,3-h] and [3,4-g]quinazolines: Synthesis, SAR and molecular modeling studies.

B. Baratte, S. Ruchaud, B. Josselin, 2019, Bioorganic & medicinal chemistry.

Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3.

M. Bartolini, J. Sussman, M. Naldi, 2019, European journal of medicinal chemistry.

Synthesis and evaluation of C3 substituted chalcone‐based derivatives of 7‐azaindole as protein kinase inhibitors

S. Ruchaud, Richard M. Beteck, L. Legoabe, 2020, Chemical biology & drug design.

Synthesis and biological evaluation of selected 7-azaindole derivatives as CDK9/Cyclin T and Haspin inhibitors

S. Ruchaud, Richard M. Beteck, L. Legoabe, 2020, Medicinal Chemistry Research.

Identification of a new series of flavopiridol-like structures as kinase inhibitors with high cytotoxic potency.

P. Colas, P. Bonnet, J. Bignon, 2020, European journal of medicinal chemistry.

Discovery of thiazolidin-4-one analogue as selective GSK-3β inhibitor through structure based virtual screening.

Sukanya, S. Filipek, S. Ruchaud, 2021, Bioorganic & medicinal chemistry letters.

Imidazo[1,2-a]quinazolines as novel, potent EGFR-TK inhibitors: Design, synthesis, bioactivity evaluation, and in silico studies.

B. Baratte, R. Esmaeili, A. Foroumadi, 2023, Bioorganic chemistry.

From Synthetic Simplified Marine Metabolite Analogues to New Selective Allosteric Inhibitor of Aurora B Kinase.

B. Baratte, J. Bignon, S. Ruchaud, 2021, Journal of medicinal chemistry.

Design and biological evaluation of substituted 5,7-dihydro-6H-indolo[2,3-c]quinolin-6-one as novel selective Haspin inhibitors

P. Bonnet, S. Ruchaud, S. Routier, 2022, Journal of enzyme inhibition and medicinal chemistry.

New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis.

S. Knapp, A. Joerger, B. Baratte, 2019, European journal of medicinal chemistry.

Synthesis and evaluation of 7-azaindole derivatives bearing benzocycloalkanone motifs as protein kinase inhibitors.

S. Ruchaud, Richard M. Beteck, L. Legoabe, 2020, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of selected 7-azaindole derivatives as CDK9/Cyclin T and Haspin inhibitors

S. Ruchaud, Richard M. Beteck, L. Legoabe, 2020, Medicinal Chemistry Research.

Synthesis and biological evaluation of Haspin inhibitors: Kinase inhibitory potency and cellular activity.

S. Knapp, A. Chaikuad, B. Baratte, 2022, European journal of medicinal chemistry.

Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3.

M. Bartolini, J. Sussman, M. Naldi, 2019, European journal of medicinal chemistry.

Discovery of simplified benzazole fragments derived from the marine benzosceptrin B as necroptosis inhibitors involving the receptor interacting protein Kinase-1.

B. Baratte, S. Ruchaud, B. Iorga, 2020, European journal of medicinal chemistry.

Synthesis and Kinase Inhibitory Potencies of Pyrazolo[3,4-g]isoquinolines

S. Ruchaud, B. Josselin, P. Moreau, 2022, Molecules.

The pyrazolo[4,3-c]pyrazole core as a novel and versatile scaffold for developing dual DYRK1A-CLK1 inhibitors targeting key processes of Alzheimer’s disease pathology.

A. Skaltsounis, V. Myrianthopoulos, B. Josselin, 2024, European Journal of Medicinal Chemistry Reports.