S. Bach

发表

Design of new disubstituted imidazo[1,2-b]pyridazine derivatives as selective Haspin inhibitors. Synthesis, binding mode and anticancer biological evaluation

S. Knapp, P. Bonnet, A. Chaikuad, 2020, Journal of enzyme inhibition and medicinal chemistry.

The Anti-Candida albicans Agent 4-AN Inhibits Multiple Protein Kinases

S. Ruchaud, M. Janeczko, O. Demchuk, 2019, Molecules.

The BRET technology and its application to screening assays

Cyril Couturier, R. Jockers, C. Couturier, 2008, Biotechnology journal.

Marine Natural Products from New Caledonia—A Review

C. Payri, M. Mehiri, S. Bach, 2016, Marine drugs.

Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins

P. Greengard, L. Meijer, G. Hager, 2004, Oncogene.

Marine Pigment Diversity: Applications and Potential

S. Bach, Benoît Serive, 2018, Blue Biotechnology.

Inhibition of RNA Recruitment and Replication of an RNA Virus by Acridine Derivatives with Known Anti-Prion Activities

P. D. Nagy, M. Blondel, S. Bach, 2009, PloS one.

Bioactive Metabolites from the Deep Subseafloor Fungus Oidiodendron griseum UBOCC-A-114129

B. Baratte, S. Ruchaud, G. Burgaud, 2017, Marine drugs.

Delayed Treatment with Systemic (S)-Roscovitine Provides Neuroprotection and Inhibits In Vivo CDK5 Activity Increase in Animal Stroke Models

L. Meijer, S. Timsit, M. Campbell, 2010, PloS one.

Kinase inhibitions in pyrido[4,3-h] and [3,4-g]quinazolines: Synthesis, SAR and molecular modeling studies.

B. Baratte, S. Ruchaud, B. Josselin, 2019, Bioorganic & medicinal chemistry.

Benzofuro[3,2-d]pyrimidines inspired from cercosporamide CaPkc1 inhibitor: Synthesis and evaluation of fluconazole susceptibility restoration.

P. Le Pape, B. Baratte, S. Ruchaud, 2018, Bioorganic & medicinal chemistry letters.

Exploration of 7-azaindole-coumaranone hybrids and their analogues as protein kinase inhibitors.

B. Baratte, S. Ruchaud, Richard M. Beteck, 2021, Chemico-biological interactions.

Neurymenolide A, a Novel Mitotic Spindle Poison from the New Caledonian Rhodophyta Phacelocarpus neurymenioides

B. Baratte, S. Ruchaud, C. Payri, 2019, Marine drugs.

Betulin, a Newly Characterized Compound in Acacia auriculiformis Bark, Is a Multi-Target Protein Kinase Inhibitor

M. Dimanche-Boitrel, M. Rousselot, B. Baratte, 2021, Molecules.

Constituents of Acacia nilotica (L.) Delile with Novel Kinase Inhibitory Activity

B. Baratte, S. Ruchaud, S. Bach, 2017 .

Phenytoin inhibits necroptosis

D. Green, A. Degterev, S. Bornstein, 2018, Cell Death & Disease.

A yeast-based assay to isolate drugs active against mammalian prions.

M. Blondel, H. Galons, N. Desban, 2006, Methods.

Structure Activity Relationship Studies around DB18, a Potent and Selective Inhibitor of CLK Kinases

B. Baratte, S. Ruchaud, N. Levoin, 2022, Molecules.

Marine dinoflagellates as a source of new bioactive structures

R. Siano, I. Probert, M. Mehiri, 2020 .

Streptomyces hygroscopicus UFPEDA 3370: A valuable source of the potent cytotoxic agent nigericin and its evaluation against human colorectal cancer cells.

C. Peixoto, B. Baratte, A. Wisniewski, 2020, Chemico-biological interactions.

An Optimized Workflow for the Discovery of New Antimicrobial Compounds Targeting Bacterial RNA Polymerase Complex Formation

B. Montanini, S. Ottonello, C. Guillou, 2022, Antibiotics.

A single step synthesis of 6-aminophenanthridines from anilines and 2-chlorobenzonitriles

M. Blondel, J. Vierfond, H. Galons, 2004 .

From Quinoxaline, Pyrido[2,3-b]pyrazine and Pyrido[3,4-b]pyrazine to Pyrazino-Fused Carbazoles and Carbolines

B. Baratte, E. Limanton, S. Ruchaud, 2018, Molecules.

Synthesis of N-pyridyl azoles using a deprotometalation-iodolysis-N-arylation sequence and evaluation of their antiproliferative activity in melanoma cells

V. Dorcet, S. Ruchaud, T. Roisnel, 2016 .

From simple quinoxalines to potent oxazolo[5,4-f]quinoxaline inhibitors of glycogen-synthase kinase 3 (GSK3).

Carlos Roca, C. Pérez, Ana Martínez, 2019, Organic & biomolecular chemistry.

Cytotoxicity of diatom-derived oxylipins in organisms belonging to different phyla

M. Blondel, Thomas Wichard, G. Pohnert, 2004, Journal of Experimental Biology.

The Canadian Prairie Plant Thermopsis rhombifolia Contains Luteolin, a Flavone that Inhibits Cyclin Dependent Kinase 9 and Arrest Cells in the G1-Phase of the Cell Cycle

F. Sautel, B. Baratte, R. Golsteyn, 2020 .

Structure-based design of novel quinoxaline-2-carboxylic acids and analogues as Pim-1 inhibitors.

F. Gouilleux, P. Bonnet, S. Ruchaud, 2018, European journal of medicinal chemistry.

Comparison between Conventional and Nonconventional Methods for the Synthesis of Some 2-Oxazolidinone Derivatives and Preliminary Investigation of Their Inhibitory Activity Against Certain Protein Kinases

B. Baratte, S. Ruchaud, S. Bach, 2019, Russian Journal of Organic Chemistry.

Fused Systems Based on 2‐Aminopyrimidines: Synthesis Combining Deprotolithiation‐in situ Zincation with N‐Arylation Reactions and Biological Properties

O. Ivashkevich, B. Baratte, V. Dorcet, 2017 .

Synthetic Development of New 3-(4-Arylmethylamino)butyl-5-arylidene-rhodanines under Microwave Irradiation and Their Effects on Tumor Cell Lines and against Protein Kinases

B. Baratte, J. Bazureau, S. Ruchaud, 2015, Molecules.

Synthesis and evaluation of new isatin-aminorhodanine hybrids as PIM1 and CLK1 kinase inhibitors

A. Chouaih, S. Ruchaud, Salima Saidi-Besbes, 2019, Journal of Molecular Structure.

Biological Evaluation of Arylsemicarbazone Derivatives as Potential Anticancer Agents

B. Baratte, S. Ruchaud, M. Hernandes, 2019, Pharmaceuticals.

Synthesis and target identification of hymenialdisine analogs.

L. Meijer, D. Fabbro, N. Gray, 2004, Chemistry & biology.

Thiazolo[5,4‐ f ]quinoxalines, Oxazolo[5,4‐ f ]quinoxalines and Pyrazino[ b,e ]isatins: Synthesis from 6‐Aminoquinoxalines and Properties

V. Dorcet, T. Roisnel, W. Erb, 2021, European Journal of Organic Chemistry.

Synthesis, biological evaluation and molecular modeling studies of imidazo[1,2-a]pyridines derivatives as protein kinase inhibitors.

O. Lozach, B. Baratte, S. Ruchaud, 2016, European journal of medicinal chemistry.

2-Aminophenones, a common precursor to N-aryl isatins and acridines endowed with bioactivities

S. Ruchaud, T. Roisnel, W. Erb, 2018 .

New Quinoxaline Derivatives as Dual Pim-1/2 Kinase Inhibitors: Design, Synthesis and Biological Evaluation

F. Gouilleux, Cécile Croix, M. Viaud-Massuard, 2021, Molecules.

Microwave synthesis of new 3-(3-aminopropyl)-5-arylidene- 2-thioxo-1,3-thiazolidine-4-ones as potential Ser/Thr protein kinase inhibitors

J. Bazureau, S. Ruchaud, A. Corlu, 2016, Medicinal Chemistry Research.

From benzofuro-, benzothieno- and 10-methylindolo-[2,3-b]-fused benzothiopyrano[4,3,2-de]quinolines to the corresponding benzothiopyrano[4,3,2-de]1,8-naphthyridines: synthesis and properties of these hexacyclic heteroaromatic compounds

T. Roisnel, W. Erb, O. Mongin, 2023, New Journal of Chemistry.

Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3.

M. Bartolini, J. Sussman, M. Naldi, 2019, European journal of medicinal chemistry.

Dibenzofuran Derivatives Inspired from Cercosporamide as Dual Inhibitors of Pim and CLK1 Kinases

F. Gouilleux, B. Baratte, F. McCarthy, 2021, Molecules.

Regorafenib analogues and their ferrocenic counterparts: synthesis and biological evaluation

L. Corcos, C. Le Jossic-Corcos, B. Baratte, 2020 .

Bioprospecting Marine Plankton

C. Bowler, C. de Vargas, A. Humeau, 2013, Marine drugs.

New antimicrobials targeting bacterial RNA polymerase holoenzyme assembly identified with an in vivo BRET-based discovery platform.

B. Montanini, S. Ottonello, M. Benincasa, 2019, ACS chemical biology.

Co‐deletion of the MSB3 and MSB4 coding regions affects bipolar budding and perturbs the organization of the actin cytoskeleton

D. Portetelle, M. Vandenbol, S. Bach, 2000, Yeast.

Antiprion Drugs as Chemical Tools to Uncover Mechanisms of Prion Propagation

M. Blondel, H. Galons, S. Saupe, 2007, Prion.

Identification of intracellular targets of small molecular weight chemical compounds using affinity chromatography

L. Meijer, M. Blondel, H. Galons, 2007, Biotechnology journal.

In vitro identification of imidazo[1,2-a]pyrazine-based antileishmanial agents and evaluation of L. major casein kinase 1 inhibition.

P. Le Pape, B. Baratte, N. Rachidi, 2020, European journal of medicinal chemistry.

Phenytoin inhibits necroptosis

D. Green, A. Degterev, S. Bornstein, 2018, Cell Death & Disease.

Tamoxifen inhibits CDK5 kinase activity by interacting with p35/p25 and modulates the pattern of tau phosphorylation.

K. Kosik, I. Landrieu, P. Colas, 2015, Chemistry & biology.

Improved tumor control through circadian clock induction by Seliciclib, a cyclin-dependent kinase inhibitor.

L. Meijer, S. Iacobelli, F. Lévi, 2006, Cancer research.

Nigratine as dual inhibitor of necroptosis and ferroptosis regulated cell death

M. Dimanche-Boitrel, M. Rousselot, E. Meunier, 2022, Scientific Reports.

Using budding yeast to screen for anti-prion drugs.

D. Dormont, M. Blondel, H. Laude, 2006, Biotechnology journal.

Isolation of drugs active against mammalian prions using a yeast-based screening assay

L. Meijer, D. Dormont, M. Blondel, 2003, Nature Biotechnology.

Evaluation of CDK Inhibitor Selectivity: From Affinity Chromatography to Yeast Genetics

L. Meijer, M. Blondel, S. Bach, 2006 .

Antihypertensive Drug Guanabenz Is Active In Vivo against both Yeast and Mammalian Prions

C. Voisset, M. Blondel, H. Laude, 2008, PloS one.

Development of a CDK10/CycM in vitro Kinase Screening Assay and Identification of First Small-Molecule Inhibitors

Jared L. Johnson, L. Cantley, P. Colas, 2020, Frontiers in Chemistry.

Identification of potential cellular targets of aloisine A by affinity chromatography.

L. Meijer, O. Lozach, J. Lemoine, 2009, Bioorganic & medicinal chemistry.

Roscovitine Targets, Protein Kinases and Pyridoxal Kinase*[boxs]

Lin Tang, Hervé Galons, Olivier Lozach, 2005, Journal of Biological Chemistry.

Tamoxifen Inhibits CDK 5 Kinase Activity by Interacting with p 35 / p 25 and Modulates the Pattern of Tau Phosphorylation Graphical

K. Kosik, I. Landrieu, P. Colas, 2015 .

Synthesis and evaluation of C3 substituted chalcone‐based derivatives of 7‐azaindole as protein kinase inhibitors

S. Ruchaud, Richard M. Beteck, L. Legoabe, 2020, Chemical biology & drug design.

Crystal Structure of Pyridoxal Kinase in Complex with Roscovitine and Derivatives*

L. Meijer, N. Gray, Ming-hui Li, 2005, Journal of Biological Chemistry.

First BRET-based screening assay performed in budding yeast leads to the discovery of CDK5/p25 interaction inhibitors.

V. Tan, P. Colas, O. Lozach, 2011, Biotechnology journal.

Synthesis and biological evaluation of selected 7H-pyrrolo[2,3-d]pyrimidine derivatives as novel CDK9/CyclinT and Haspin inhibitors.

B. Baratte, S. Ruchaud, Richard M. Beteck, 2021, Chemico-biological interactions.

Synthesis and biological evaluation of selected 7-azaindole derivatives as CDK9/Cyclin T and Haspin inhibitors

S. Ruchaud, Richard M. Beteck, L. Legoabe, 2020, Medicinal Chemistry Research.

Synthesis and anticancer activity of novel bisindolylhydroxymaleimide derivatives with potent GSK-3 kinase inhibition.

Michael M. Cahill, S. Ruchaud, F. McCarthy, 2018, Bioorganic & medicinal chemistry.

Cellular coexistence of two high molecular subsets of eEF1B complex

P. Cormier, R. Bellé, O. Mulner-lorillon, 2006, FEBS letters.

Protein Folding Activity of Ribosomal RNA Is a Selective Target of Two Unrelated Antiprion Drugs

C. Voisset, S. Supattapone, S. Sanyal, 2008, PloS one.

Expression in a RabGAP yeast mutant of two human homologues, one of which is an oncogene.

A. Burny, F. Bontemps, D. Portetelle, 2003, Biochemical and biophysical research communications.

Synthesis, antileishmanial activity and cytotoxicity of 2,3-diaryl- and 2,3,8-trisubstituted imidazo[1,2-a]pyrazines.

P. Le Pape, B. Baratte, S. Ruchaud, 2015, European journal of medicinal chemistry.

Identification of a new series of flavopiridol-like structures as kinase inhibitors with high cytotoxic potency.

P. Colas, P. Bonnet, J. Bignon, 2020, European journal of medicinal chemistry.

Functionalization of 9-thioxanthone at the 1-position: From arylamino derivatives to [1]benzo(thio)pyrano[4,3,2-de]benzothieno[2,3-b]quinolines of biological interest.

B. Baratte, V. Dorcet, R. Duval, 2019, Bioorganic chemistry.

Degradation of Hof1 by SCFGrr1 is important for actomyosin contraction during cytokinesis in yeast

Matthias Peter, Laurent Meijer, Yves Barral, 2005, The EMBO journal.

Kinase-Based Screening of Marine Natural Extracts Leads to the Identification of a Cytotoxic High Molecular Weight Metabolite from the Mediterranean Sponge Crambe tailliezi

P. Colas, B. Baratte, S. Ruchaud, 2019, Marine drugs.

Practical approach to N-benzyl derivatives of 2-amino-8-methoxy-4H-chromene-3-carbonitrile by reductive amination: exploration of their effects against protein kinases and in silico ADME profiling

J. Bazureau, S. Bach, A. Bouattour, 2022, Journal of Molecular Structure.

Synthesis of New 2-Phenylamino-4H-chromene-3-carbonitrile Derivatives and Their Effects on Tumor Cell Lines and against Protein Kinases

J. Bazureau, S. Ruchaud, R. L. Guével, 2020, International Journal of Organic Chemistry.

Discovery of DB18, a potent inhibitor of CLK kinases with a high selectivity against DYRK1A kinase.

B. Baratte, S. Ruchaud, T. Roisnel, 2020, Bioorganic & medicinal chemistry.

An in silico approach for the discovery of CDK5/p25 interaction inhibitors.

Vincent B. C. Tan, Bing Zhang, Françoise Guéritte, 2011, Biotechnology journal.

Sibiriline, a new small chemical inhibitor of receptor‐interacting protein kinase 1, prevents immune‐dependent hepatitis

P. Vandenabeele, M. Dimanche-Boitrel, B. Baratte, 2017, The FEBS journal.

High‐Throughput Screening of Marine Resources

Arnaud Hochard, Luc Reininger, Sandrine Ruchaud, 2014 .

Nigratine as first-in-class dual inhibitor of necroptosis and ferroptosis regulated cell death

M. Dimanche-Boitrel, M. Rousselot, S. Bach, 2020, bioRxiv.

Oxazolo[5,4-f]quinoxaline-type selective inhibitors of glycogen synthase kinase-3α (GSK-3α): Development and impact on temozolomide treatment of glioblastoma cells.

Khaled M. Elokely, S. Knapp, A. Chaikuad, 2023, Bioorganic chemistry.

6E11, a highly selective inhibitor of Receptor-Interacting Protein Kinase 1, protects cells against cold hypoxia-reoxygenation injury

P. Vandenabeele, M. Dimanche-Boitrel, B. Baratte, 2017, Scientific Reports.

Discovery of thiazolidin-4-one analogue as selective GSK-3β inhibitor through structure based virtual screening.

Sukanya, S. Filipek, S. Ruchaud, 2021, Bioorganic & medicinal chemistry letters.

Imidazo[1,2-a]quinazolines as novel, potent EGFR-TK inhibitors: Design, synthesis, bioactivity evaluation, and in silico studies.

B. Baratte, R. Esmaeili, A. Foroumadi, 2023, Bioorganic chemistry.

Overexpression of Eimeria tenella Rhoptry Kinase 2 Induces Early Production of Schizonts

F. Bussière, S. Lacroix-Lamandé, F. Laurent, 2023, Microbiology spectrum.

A combined experimental and theoretical study of the thermal [3+2] cycloaddition of carbonyl ylides with activated alkenes

L. Domingo, M. Ríos‐Gutiérrez, R. Duval, 2018 .

Effect of cell cycle arrest on intermediate metabolism in the marine diatom Phaeodactylum tricornutum

Christopher M. Brown, P. Falkowski, D. Lun, 2017, Proceedings of the National Academy of Sciences.

From Synthetic Simplified Marine Metabolite Analogues to New Selective Allosteric Inhibitor of Aurora B Kinase.

B. Baratte, J. Bignon, S. Ruchaud, 2021, Journal of medicinal chemistry.

6E11, a highly selective inhibitor of Receptor-Interacting Protein Kinase 1, protects cells against cold hypoxia-reoxygenation injury

P. Vandenabeele, M. Dimanche-Boitrel, B. Baratte, 2017, Scientific Reports.

Design and biological evaluation of substituted 5,7-dihydro-6H-indolo[2,3-c]quinolin-6-one as novel selective Haspin inhibitors

P. Bonnet, S. Ruchaud, S. Routier, 2022, Journal of enzyme inhibition and medicinal chemistry.

New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis.

S. Knapp, A. Joerger, B. Baratte, 2019, European journal of medicinal chemistry.

Synthesis and evaluation of 7-azaindole derivatives bearing benzocycloalkanone motifs as protein kinase inhibitors.

S. Ruchaud, Richard M. Beteck, L. Legoabe, 2020, Bioorganic & medicinal chemistry.

Development of new highly potent imidazo[1,2-b]pyridazines targeting Toxoplasma gondii calcium-dependent protein kinase 1.

N. Moiré, S. Ruchaud, A. Gueiffier, 2015, European journal of medicinal chemistry.

Synthesis and biological evaluation of selected 7-azaindole derivatives as CDK9/Cyclin T and Haspin inhibitors

S. Ruchaud, Richard M. Beteck, L. Legoabe, 2020, Medicinal Chemistry Research.

Synthesis of conjugates of 6-aminophenanthridine and guanabenz, two structurally unrelated prion inhibitors, for the determination of their cellular targets by affinity chromatography.

C. Voisset, M. Blondel, H. Galons, 2010, Bioconjugate chemistry.

Quinazoline-based VEGFR-2 inhibitors as potential anti-angiogenic agents: A contemporary perspective of SAR and molecular docking studies.

A. Foroumadi, S. Moghimi, S. Bach, 2023, European journal of medicinal chemistry.

[Budding yeast, a model and a tool… also for biomedical research].

M. Blondel, P. Colas, S. Bach, 2020, Medecine sciences : M/S.

The Tre2 Oncoprotein, Implicated in Ewing’s Sarcoma, Interacts with Two Components of the Cytoskeleton

D. Portetelle, M. Vandenbol, S. Bach, 2006, Biotechnology Letters.

Screening for Protein-Protein Interaction Inhibitors Using a Bioluminescence Resonance Energy Transfer (BRET)–Based Assay in Yeast

B. Montanini, P. Colas, E. Levati, 2017, SLAS discovery : advancing life sciences R & D.

Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3.

M. Bartolini, J. Sussman, M. Naldi, 2019, European journal of medicinal chemistry.

Identification of Novel Compounds Inhibiting the Kinase Activity of the CDK5/p25 Complex via Direct Binding to p25.

P. Loyer, A. Le Grand, O. Sire, 2023, Biochemistry.

Benzofuro[3,2-d]pyrimidines inspired from cercosporamide CaPkc1 inhibitor: Synthesis and evaluation of fluconazole susceptibility restoration.

P. Le Pape, B. Baratte, S. Ruchaud, 2018, Bioorganic & Medicinal Chemistry Letters.

First BRET-based screening assay performed in budding yeast leads to the discovery of CDK5/p25 interaction inhibitors.

V. Tan, P. Colas, O. Lozach, 2011, Biotechnology Journal.

Discovery of simplified benzazole fragments derived from the marine benzosceptrin B as necroptosis inhibitors involving the receptor interacting protein Kinase-1.

B. Baratte, S. Ruchaud, B. Iorga, 2020, European journal of medicinal chemistry.

A Single Step Synthesis of 6‐Aminophenanthridines from Anilines and 2‐Chlorobenzonitriles.

M. Blondel, J. Vierfond, H. Galons, 2004 .