D. Tess

发表

RELATIONSHIP BETWEEN EXPOSURE AND NONSPECIFIC BINDING OF THIRTY-THREE CENTRAL NERVOUS SYSTEM DRUGS IN MICE

T. Maurer, D. Scott, Demetria B Debartolo, 2005, Drug Metabolism and Disposition.

Structural attributes influencing unbound tissue distribution.

Christopher E. Keefer, A. Kalgutkar, D. Scott, 2019, European journal of medicinal chemistry.

A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 2: Prospectively Predicting Systemic and Liver Exposure in Healthy Subjects

L. Tremaine, L. Di, E. Kimoto, 2018, Drug Metabolism and Disposition.

A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 1: Translating Systemic Plasma Concentration to Liver Exposure in Healthy Subjects

L. Tremaine, T. Maurer, L. Di, 2018, Drug Metabolism and Disposition.

Evaluation of Fraction Unbound Across Seven Tissues of Five Species.

L. Di, G. Chang, D. Tess, 2019, Journal of pharmaceutical sciences.

Influence of microsomal concentration on apparent intrinsic clearance: implications for scaling in vitro data.

T. Maurer, J. C. Kalvass, D. Tess, 2001, Drug metabolism and disposition: the biological fate of chemicals.

Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide.

Tara B. Manion, A. Vaz, R. Robinson, 2011, Bioorganic & medicinal chemistry letters.

A small-molecule oral agonist of the human glucagon-like peptide-1 receptor

Margaret S. Landis, A. Mathiowetz, P. Loria, 2020, bioRxiv.

Title: A small-molecule oral agonist of the human glucagon-like peptide-1 1 receptor 2

Margaret S. Landis, A. Mathiowetz, P. Loria, 2020 .

Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase (ACC) Inhibitors Through Liver Targeting.

David A. Price, A. Kalgutkar, S. Liras, 2020, Journal of medicinal chemistry.

Comparison of Species and Cell-Type Differences in Fraction Unbound of Liver Tissues, Hepatocytes, and Cell Lines

L. Di, Dhirender Singh, B. Kapinos, 2018, Drug Metabolism and Disposition.

Mechanistic Insights on Clearance and Inhibition Discordance between Liver Microsomes and Hepatocytes When Clearance in Liver Microsomes Is Higher than in Hepatocytes.

A. Carlo, J. Cianfrogna, R. Obach, 2020, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

A Novel Unified Approach to Predict Human Hepatic Clearance for Both Enzyme- and Transporter-Mediated Mechanisms Using Suspended Human Hepatocytes

L. Di, D. Tess, Jian Lin, 2019, Drug Metabolism and Disposition.

Comparison of Fraction Unbound Between Liver Homogenate and Hepatocytes at 4°C

L. Di, Lina Luo, D. Tess, 2020, The AAPS Journal.

Evaluation of Cu-64 and Ga-68 Radiolabeled Glucagon-Like Peptide-1 Receptor Agonists as PET Tracers for Pancreatic β cell Imaging

C. Limberakis, R. Waterhouse, Jianqing Chen, 2016, Molecular Imaging and Biology.

Current Approaches for Predicting Human PK for Small Molecule Development Candidates: Findings from the IQ Human PK Prediction Working Group Survey

A. Reichel, P. Marathe, G. Xiao, 2022, The AAPS Journal.

Transporter-Enzyme Interplay in the Pharmacokinetics of PF-06835919, a First-In-Class Ketohexokinase Inhibitor for Metabolic Disorders and Nonalcoholic Fatty Liver Disease

A. D. Rodrigues, A. Kalgutkar, L. Di, 2022, Drug Metabolism and Disposition.

Effect of a Ketohexokinase Inhibitor (PF‐06835919) on In Vivo OATP1B Activity: Integrative Risk Assessment Using Endogenous Biomarker and a Probe Drug

A. D. Rodrigues, M. Varma, A. Bergman, 2022, Clinical pharmacology and therapeutics.

Preclinical pharmacology of CP-424,391, and orally active pyrazolinone-piperidine growth hormone secretagogue

S. Toler, B. Lefker, J. A. Ragan, 2001, Endocrine.

Pyrazolinone-piperidine dipeptide growth hormone secretagogues (GHSs). Discovery of capromorelin.

S. Toler, B. Lefker, J. A. Ragan, 2003, Bioorganic & medicinal chemistry.

Preclinical pharmacology of CP-424,391, an orally active pyrazolinone-piperidine [correction of pyrazolidinone-piperidine] growth hormone secretagogue.

S. Toler, D. Thompson, B. Lefker, 2001, Endocrine.

Potent and selective, sulfamide-based human beta 3-adrenergic receptor agonists.

T. Maurer, D. Hargrove, R. L. Dow, 2004, Bioorganic & medicinal chemistry letters.

A new chemical tool for exploring the physiological function of the PDE2 isozyme.

Douglas A. L. Otte, D. Scott, N. Garceau, 2006, Bioorganic & medicinal chemistry letters.

2-Aminopyridine-Based Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Inhibitors: Assessment of Mechanism-Based Safety.

M. Ammirati, L. Buckbinder, A. El‐Kattan, 2018, Journal of medicinal chemistry.

Quantitative Prediction of Human Renal Clearance and Drug-Drug Interactions of Organic Anion Transporter Substrates Using In Vitro Transport Data: A Relative Activity Factor Approach

Bo Feng, B. Feng, M. Varma, 2017, Drug Metabolism and Disposition.

Discovery of potent and orally bioavailable heterocycle-based beta3-adrenergic receptor agonists, potential therapeutics for the treatment of obesity.

T. Maurer, D. Hargrove, D. Tess, 2007, Bioorganic & medicinal chemistry letters.

Addressing the Accuracy of Plasma Protein Binding Measurement for Highly Bound Compounds Using the Dilution Method

L. Di, D. Tess, Sangwoo Ryu, 2022, The AAPS Journal.

Static and Dynamic Projections of Drug-Drug Interactions Caused by Cytochrome P450 3A Time-Dependent Inhibitors Measured in Human Liver Microsomes and Hepatocytes

R. Obach, T. Goosen, H. Eng, 2021, Drug Metabolism and Disposition.

Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice.

B. Viollet, R. Kurumbail, Jake E. Delmore, 2017, Cell metabolism.

Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models

M. Birnbaum, Jake E. Delmore, A. Kalgutkar, 2018, EBioMedicine.

Selective Activation of AMPK β1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy

R. Kurumbail, M. Birnbaum, A. Kalgutkar, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Quantitative Contribution of Six Major Transporters to the Hepatic Uptake of Drugs: “SLC-Phenotyping” Using Primary Human Hepatocytes

A. D. Rodrigues, L. Tremaine, B. Feng, 2019, The Journal of Pharmacology and Experimental Therapeutics.

A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one and congeners.

P. Oates, J. Coutcher, M. O’Gorman, 2005, Journal of Medicinal Chemistry.

A highly selective, non-hydantoin, non-carboxylic acid inhibitor of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran- 2-sulfonyl)-2-H-pyridazin-3-one.

P. Oates, J. Coutcher, M. O’Gorman, 2003, Journal of medicinal chemistry.

Evolving approaches on measurements and applications of intracellular free drug concentration and Kpuu in drug discovery

L. Di, D. Tess, K. Riccardi, 2021, Expert opinion on drug metabolism & toxicology.

Organic Anion Transporter 2–Mediated Hepatic Uptake Contributes to the Clearance of High-Permeability–Low-Molecular-Weight Acid and Zwitterion Drugs: Evaluation Using 25 Drugs

A. Carlo, M. Varma, E. Kimoto, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Evaluation of Prediction Accuracy for Volume of Distribution in Rat and Human Using In Vitro, In Vivo, PBPK and QSAR Methods.

S. Yamazaki, L. Di, G. Chang, 2020, Journal of pharmaceutical sciences.

Effect of Human Plasma on Hepatic Uptake of Organic Anion–Transporting Polypeptide 1B Substrates: Studies Using Transfected Cells and Primary Human Hepatocytes

A. D. Rodrigues, M. Varma, D. Tess, 2020, Drug Metabolism and Disposition.

In Vitro-In Vivo Extrapolation and Scaling Factors for Clearance of Human and Preclinical Species with Liver Microsomes and Hepatocytes

A. Carlo, L. Di, G. Chang, 2023, The AAPS Journal.

Predicting the Human Hepatic Clearance of Acidic and Zwitterionic Drugs.

A. Kalgutkar, M. Varma, J. Litchfield, 2020, Journal of medicinal chemistry.

A Novel Milli-fluidic Liver Tissue Chip with Continuous Recirculation for Predictive Pharmacokinetics Applications

Jason S. Sherfey, M. Cirit, J. Gosset, 2023, bioRxiv.

The Comparison of Machine Learning and Mechanistic In Vitro-In Vivo Extrapolation Models for the Prediction of Human Intrinsic Clearance.

Christopher E. Keefer, B. Kapinos, D. Tess, 2023, Molecular pharmaceutics.

First-pass metabolism and biliary recirculation of droloxifene in the female Sprague-Dawley rat.

S. Toler, D. Tess, D. Nickerson, 1997, Xenobiotica; the fate of foreign compounds in biological systems.

In Vitro - in Vivo Extrapolation of Hepatic Clearance in Preclinical Species

L. Di, D. Tess, Sangwoo Ryu, 2022, Pharmaceutical Research.

A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor

A. Mathiowetz, P. Loria, A. Kalgutkar, 2022, Journal of medicinal chemistry.

Title: A small-molecule oral agonist of the human glucagon-like peptide-1 1 receptor 2

Margaret S. Landis, A. Mathiowetz, P. Loria, 2020 .

Relationship of binding-site occupancy, transthyretin stabilisation and disease modification in patients with tafamidis-treated transthyretin amyloid cardiomyopathy

T. Maurer, C. Bulawa, D. Tess, 2022, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.