S. Manta

发表

Synthesis of Novel Thiopurine Pyranonucleosides: Evaluation of Their Bioactivity

D. Schols, A. Dimopoulou, S. Manta, 2015, Nucleosides, Nucleotides & Nucleic Acids.

Multicomponent reaction of aldehydes, amines and oxalacetate analogues leading to biologically attractive pyrrole derivatives.

Ioannis Papanastasiou, S. Manta, D. Komiotis, 2020, Mini reviews in medicinal chemistry.

The σ‐Hole Phenomenon of Halogen Atoms Forms the Structural Basis of the Strong Inhibitory Potency of C5 Halogen Substituted Glucopyranosyl Nucleosides towards Glycogen Phosphorylase b

S. Zographos, D. Leonidas, A. Psarra, 2012, ChemMedChem.

Synthesis, Antiviral and Cytostatic Evaluation of Unsaturated Exomethylene and Keto D‐Lyxopyranonucleoside Analogues

J. Balzarini, S. Manta, D. Komiotis, 2009, Archiv der Pharmazie.

3′‐Axial CH2OH Substitution on Glucopyranose does not Increase Glycogen Phosphorylase Inhibitory Potency. QM/MM‐PBSA Calculations Suggest Why

D. Leonidas, P. Zoumpoulakis, V. Skamnaki, 2012, Chemical biology & drug design.

Synthesis and biological evaluation of unsaturated keto and exomethylene D-arabinopyranonucleoside analogs: novel 5-fluorouracil analogs that target thymidylate synthase.

J. Balzarini, S. Liekens, S. Manta, 2011, European journal of medicinal chemistry.

Antioxidant Activity of a Series of Fluorinated Pyrano-nucleoside Analogues of N4-benzoyl Cytosine and N6-benzoyl Adenine

D. Kouretas, S. Manta, C. Spanou, 2007, International Journal of Molecular Sciences.

Synthesis of 3-fluoro-6-S-(2-S-pyridyl) nucleosides as potential lead cytostatic agents

J. Balzarini, S. Manta, D. Komiotis, 2010, Bioorganic Chemistry.

Triazole pyrimidine nucleosides as inhibitors of Ribonuclease A. Synthesis, biochemical, and structural evaluation.

D. Leonidas, A. Kantsadi, S. Manta, 2012, Bioorganic & medicinal chemistry.

Branched-chain sugar nucleosides: stereocontrolled synthesis and bioevaluation of novel 3'-C-trifluoromethyl and 3'-C-methyl pyranonucleosides.

D. Schols, T. Mavromoustakos, T. Kellici, 2015, Carbohydrate research.

Design, Synthesis, and Biological Evaluation of Novel C5-Modified Pyrimidine Ribofuranonucleosides as Potential Antitumor or/and Antiviral Agents.

D. Schols, G. Andrei, S. Manta, 2020, Medicinal chemistry (Shariqah (United Arab Emirates)).

A novel and easy two-step, microwave-assisted method for the synthesis of halophenyl pyrrolo[2,3-b]quinoxalines via their pyrrolo precursors. Evaluation of their bioactivity

W. Dehaen, D. Hadjipavlou-Litina, J. Balzarini, 2014 .

Branched-chain C-cyano pyranonucleosides: Synthesis of 3′-C-cyano & 3′-C-cyano-3′-deoxy pyrimidine pyranonucleosides as novel cytotoxic agents

J. Balzarini, S. Manta, V. Parmenopoulou, 2011, European Journal of Medicinal Chemistry.

Synthesis of 4,6-dideoxy-3-fluoro-2-keto-beta-D-glucopyranosyl analogues of 5-fluorouracil, N6-benzoyl adenine, uracil, thymine, N4-benzoyl cytosine and evaluation of their antitumor activities.

J. Balzarini, S. Manta, D. Komiotis, 2010, Bioorganic chemistry.

Antiviral Unsaturated Nucleosides

S. Manta, D. Komiotis, E. Tsoukala, 2008 .

Stereocontrolled Facile Synthesis and Biological Evaluation of (3′S) and (3′R)-3′-Amino (and Azido)-3′-Deoxy Pyranonucleosides

J. Balzarini, A. Dimopoulou, S. Manta, 2012, Nucleosides, nucleotides & nucleic acids.

Unsaturated dideoxy fluoro-ketopyranosyl nucleosides as new cytostatic agents: a convenient synthesis of 2,6-dideoxy-3-fluoro-4-keto-beta-D-glucopyranosyl analogues of uracil, 5-fluorouracil, thymine, N4-benzoyl cytosine and N6-benzoyl adenine.

J. Balzarini, S. Manta, D. Komiotis, 2009, European journal of medicinal chemistry.

Dideoxy fluoro-ketopyranosyl nucleosides as potent antiviral agents: Synthesis and biological evaluation of 2,3- and 3,4-dideoxy-3-fluoro-4- and -2-keto-β-d-glucopyranosyl derivatives of N4-benzoyl cytosine

J. Balzarini, A. Cencič, S. Manta, 2009, European Journal of Medicinal Chemistry.

Unsaturated fluoro-ketopyranosyl nucleosides: synthesis and biological evaluation of 3-fluoro-4-keto-beta-d-glucopyranosyl derivatives of N(4)-benzoyl cytosine and N(6)-benzoyl adenine.

A. Cencič, S. Manta, D. Komiotis, 2008, European journal of medicinal chemistry.

Fluoro-ketopyranosyl nucleosides: synthesis and biological evaluation of 3-fluoro-2-keto-beta-D-glucopyranosyl derivatives of N4-benzoyl cytosine.

A. Cencič, S. Manta, D. Komiotis, 2007, Bioorganic & medicinal chemistry.

The binding of C5-alkynyl and alkylfurano[2,3-d]pyrimidine glucopyranonucleosides to glycogen phosphorylase b: synthesis, biochemical and biological assessment.

S. Zographos, D. Leonidas, A. Psarra, 2012, European journal of medicinal chemistry.

1-(3-Deoxy-3-fluoro-beta-d-glucopyranosyl) pyrimidine derivatives as inhibitors of glycogen phosphorylase b: Kinetic, crystallographic and modelling studies.

S. Zographos, D. Leonidas, V. G. Tsirkone, 2010, Bioorganic & medicinal chemistry.

A Facile, One‐Step Conversion of 6‐O‐Trityl and 6‐O‐TBDMS Monosaccharides into the Corresponding Formate Esters

K. Antonakis, S. Manta, D. Komiotis, 2006 .

An easy microwave-assisted synthesis of C8-alkynyl adenine pyranonucleosides as novel cytotoxic antitumor agents

D. Schols, A. Dimopoulou, S. Manta, 2015, Front. Chem..

Dissipation, metabolism and sorption of pesticides used in fruit-packaging plants: Towards an optimized depuration of their pesticide-contaminated agro-industrial effluents.

D. Karpouzas, M. Omirou, C. Ehaliotis, 2015, The Science of the total environment.

Unusual seven-membered ring sugars and nucleosides: synthesis and biological properties

S. Manta, Nikolaos Kollatos, 2022, Nucleosides, nucleotides & nucleic acids.

Keto-fluorothiopyranosyl nucleosides: a convenient synthesis of 2- and 4-keto-3-fluoro-5-thioxylopyranosyl thymine analogs.

S. Manta, D. Komiotis, E. Tsoukala, 2011, Carbohydrate research.

Triazole double-headed ribonucleosides as inhibitors of eosinophil derived neurotoxin.

E. Boix, D. Leonidas, A. Kantsadi, 2015, Bioorganic chemistry.

Stereoselective facile synthesis of 2'-spiro pyrimidine pyranonucleosides via their key intermediate 2'-C-cyano analogues. Evaluation of their bioactivity.

J. Balzarini, A. Dimopoulou, S. Manta, 2014, Carbohydrate research.

Synthesis and biological evaluation of 3'-C-ethynyl and 3'-C-(1,4-disubstituted-1,2,3-triazolo) double-headed pyranonucleosides.

J. Balzarini, S. Manta, E. Coutouli-argyropoulou, 2012, Medicinal chemistry (Shariqah (United Arab Emirates)).

Stereocontrolled synthesis of 4'-C-cyano and 4'-C-cyano-4'-deoxy pyrimidine pyranonucleosides as potential chemotherapeutic agents.

J. Balzarini, A. Dimopoulou, S. Manta, 2012, Carbohydrate research.

Competitive inhibition of human poly(A)-specific ribonuclease (PARN) by synthetic fluoro-pyranosyl nucleosides.

C. Stathopoulos, D. Anastasakis, D. Vlachakis, 2009, Biochemistry.

A concise synthesis of 3-fluoro-5-thio-xylo- and glucopyranoses, useful precursors towards their corresponding pyranonucleoside derivatives.

S. Manta, D. Komiotis, G. Agelis, 2008, Carbohydrate research.

Unsaturation: An Important Structural Feature to Nucleosides’ Antiviral Activity

A. Tsotinis, A. Dimopoulou, S. Manta, 2014 .

Rapid microwave-enhanced synthesis of C5-alkynyl pyranonucleosides as novel cytotoxic antitumor agents.

Jan Balzarini, Ioannis Papasotiriou, J. Balzarini, 2013, Bioorganic & medicinal chemistry letters.

Keto and exomethylene pyranonucleosides as antitumor agents.

S. Manta, D. Komiotis, E. Tsoukala, 2012, Mini reviews in medicinal chemistry.

Efficient synthesis of exomethylene- and keto-exomethylene-d-glucopyranosyl nucleoside analogs as potential cytotoxic agents.

J. Balzarini, S. Manta, D. Komiotis, 2011, Carbohydrate research.

Unsaturated Keto and Exomethylene Pyranonucleoside Analogues of Thymine and Uracil Exhibit Potent Antioxidant Properties

D. Kouretas, P. Margaris, S. Manta, 2011 .

Unsaturated Dideoxy Fluoro‐ketopyranosyl Nucleosides as New Cytostatic Agents: A Convenient Synthesis of 2,6‐Dideoxy‐3‐fluoro‐4‐keto‐β‐D‐glucopyranosyl Analogues of Uracil, 5‐Fluorouracil, Thymine, N4‐Benzoyl Cytosine and N6‐Benzoyl Adenine.

J. Balzarini, S. Manta, D. Komiotis, 2010 .

Unsaturated Fluoro‐ketopyranosyl Nucleosides: Synthesis and Biological Evaluation of 3‐Fluoro‐4‐keto‐β‐D‐glucopyranosyl Derivatives of N4‐Benzoyl Cytosine and N6‐Benzoyl Adenine.

A. Cencič, S. Manta, D. Komiotis, 2008 .

Kinetic and in silico analysis of the slow-binding inhibition of human poly(A)-specific ribonuclease (PARN) by novel nucleoside analogues.

C. Stathopoulos, D. Vlachakis, S. Manta, 2012, Biochimie.

Synthesis of novel N-acyl-β-d-glucopyranosylamines and ureas as potential lead cytostatic agents

D. Schols, A. Dimopoulou, S. Manta, 2016, Medicinal Chemistry Research.

Synthesis and Biological Evaluation of Unsaturated Keto and Exomethylene D-Arabinopyranonucleoside Analogues: Novel 5-Fluorouracil Analogues that Target Thymidylate Synthase.

J. Balzarini, S. Liekens, S. Manta, 2011 .

SPREMLJANJE PRETOKA V MOŽGANSKIH ARTERIJAH S TCD TCD MONITORING OF CEREBRAL BLOOD FLOW

S. Manta, D. Komiotis, Tanja Botić, 2010 .

Comparison of the growth curves of cancer cells and cancer stem cells.

S. Manta, M. Toloudi, I. Papasotiriou, 2014, Current stem cell research & therapy.

Study of the interaction among Notch pathway receptors, correlation with stemness, as well as their interaction with CD44, dipeptidyl peptidase-IV, hepatocyte growth factor receptor and the SETMAR transferase, in colon cancer stem cells

S. Manta, M. Toloudi, I. Papasotiriou, 2013, Journal of receptor and signal transduction research.

3′‐Axial CH2OH Substitution on Glucopyranose does not Increase Glycogen Phosphorylase Inhibitory Potency. QM/MM‐PBSA Calculations Suggest Why

D. Leonidas, P. Zoumpoulakis, V. Skamnaki, 2012, Chemical biology & drug design.

The σ‐Hole Phenomenon of Halogen Atoms Forms the Structural Basis of the Strong Inhibitory Potency of C5 Halogen Substituted Glucopyranosyl Nucleosides towards Glycogen Phosphorylase b

S. Zographos, D. Leonidas, A. Psarra, 2012, ChemMedChem.

Structure based inhibitor design targeting glycogen phosphorylase B. Virtual screening, synthesis, biochemical and biological assessment of novel N-acyl-β-d-glucopyranosylamines.

Georgios Archontis, Loranne Agius, S. Zographos, 2014, Bioorganic & medicinal chemistry.