D. Komiotis

发表

Synthesis of Novel Thiopurine Pyranonucleosides: Evaluation of Their Bioactivity

D. Schols, A. Dimopoulou, S. Manta, 2015, Nucleosides, Nucleotides & Nucleic Acids.

Multicomponent reaction of aldehydes, amines and oxalacetate analogues leading to biologically attractive pyrrole derivatives.

Ioannis Papanastasiou, S. Manta, D. Komiotis, 2020, Mini reviews in medicinal chemistry.

The σ‐Hole Phenomenon of Halogen Atoms Forms the Structural Basis of the Strong Inhibitory Potency of C5 Halogen Substituted Glucopyranosyl Nucleosides towards Glycogen Phosphorylase b

S. Zographos, D. Leonidas, A. Psarra, 2012, ChemMedChem.

Synthesis, Antiviral and Cytostatic Evaluation of Unsaturated Exomethylene and Keto D‐Lyxopyranonucleoside Analogues

J. Balzarini, S. Manta, D. Komiotis, 2009, Archiv der Pharmazie.

3′‐Axial CH2OH Substitution on Glucopyranose does not Increase Glycogen Phosphorylase Inhibitory Potency. QM/MM‐PBSA Calculations Suggest Why

D. Leonidas, P. Zoumpoulakis, V. Skamnaki, 2012, Chemical biology & drug design.

Synthesis and biological evaluation of unsaturated keto and exomethylene D-arabinopyranonucleoside analogs: novel 5-fluorouracil analogs that target thymidylate synthase.

J. Balzarini, S. Liekens, S. Manta, 2011, European journal of medicinal chemistry.

An Integrated In Silico Approach to Design Specific Inhibitors Targeting Human Poly(A)-Specific Ribonuclease

C. Stathopoulos, Athanasia Pavlopoulou, D. Vlachakis, 2012, PloS one.

Purification of the human blood platelet thromboxane A2/prostaglandin H2 receptor protein.

G. L. Le Breton, S. O. Kim, S. Hall, 1992, Biochemical pharmacology.

Synthesis of 3-fluoro-6-S-(2-S-pyridyl) nucleosides as potential lead cytostatic agents

J. Balzarini, S. Manta, D. Komiotis, 2010, Bioorganic Chemistry.

Triazole pyrimidine nucleosides as inhibitors of Ribonuclease A. Synthesis, biochemical, and structural evaluation.

D. Leonidas, A. Kantsadi, S. Manta, 2012, Bioorganic & medicinal chemistry.

Genome analysis of two type 6 echovirus (E6) strains recovered from sewage specimens in Greece in 2006

Z. Kyriakopoulou, D. Tsakogiannis, P. Markoulatos, 2011, Virus Genes.

Branched-chain sugar nucleosides: stereocontrolled synthesis and bioevaluation of novel 3'-C-trifluoromethyl and 3'-C-methyl pyranonucleosides.

D. Schols, T. Mavromoustakos, T. Kellici, 2015, Carbohydrate research.

Synthesis of dl-cis- and (4R,5R)-trans-7-[2,2-dimethyl-4-(phenylsulfonyl)-aminomethyl-1,3-dioxolan-5-yl]-5(Z)-heptenoic acid analogues as platelet thromboxane A2 receptor antagonist

K. Zaw, D. Komiotis, D. Venton, 1995 .

Genome analysis of two type 6 echovirus (E6) strains recovered from sewage specimens in Greece in 2006

Z. Kyriakopoulou, D. Tsakogiannis, P. Markoulatos, 2012, Virus Genes.

Synthesis of 7-[3-bromo-3,4-dideoxy-6-O-(2-hydroxyethyl)-β-d-glycero-hex-3-enopyranosyl-2-ulose]theophylline

K. Antonakis, D. Komiotis, T. Halmos, 1985 .

Synthesis of diphenoxyadamantane alkylamines with pharmacological interest.

S. Cole, A. Tsotinis, Ioannis Papanastasiou, 2019, Bioorganic & medicinal chemistry letters.

Branched-chain C-cyano pyranonucleosides: Synthesis of 3′-C-cyano & 3′-C-cyano-3′-deoxy pyrimidine pyranonucleosides as novel cytotoxic agents

J. Balzarini, S. Manta, V. Parmenopoulou, 2011, European Journal of Medicinal Chemistry.

Synthesis of 4,6-dideoxy-3-fluoro-2-keto-beta-D-glucopyranosyl analogues of 5-fluorouracil, N6-benzoyl adenine, uracil, thymine, N4-benzoyl cytosine and evaluation of their antitumor activities.

J. Balzarini, S. Manta, D. Komiotis, 2010, Bioorganic chemistry.

Antiviral Unsaturated Nucleosides

S. Manta, D. Komiotis, E. Tsoukala, 2008 .

Stereocontrolled Facile Synthesis and Biological Evaluation of (3′S) and (3′R)-3′-Amino (and Azido)-3′-Deoxy Pyranonucleosides

J. Balzarini, A. Dimopoulou, S. Manta, 2012, Nucleosides, nucleotides & nucleic acids.

Rapid and selective detritylation of primary alcohols using formic acid

K. Antonakis, M. Bessodes, D. Komiotis, 1986 .

Synthesis and structural characterization of neutral 3 + 2 oxorhenium and oxotechnetium complexes of the 2 -mercaptoethyl -N -glycine (SNO)/2,2' -bipyridine (NN) mixed ligand system

D. Benaki, A. Terzis, C. Raptopoulou, 2007 .

Unsaturated dideoxy fluoro-ketopyranosyl nucleosides as new cytostatic agents: a convenient synthesis of 2,6-dideoxy-3-fluoro-4-keto-beta-D-glucopyranosyl analogues of uracil, 5-fluorouracil, thymine, N4-benzoyl cytosine and N6-benzoyl adenine.

J. Balzarini, S. Manta, D. Komiotis, 2009, European journal of medicinal chemistry.

Dideoxy fluoro-ketopyranosyl nucleosides as potent antiviral agents: Synthesis and biological evaluation of 2,3- and 3,4-dideoxy-3-fluoro-4- and -2-keto-β-d-glucopyranosyl derivatives of N4-benzoyl cytosine

J. Balzarini, A. Cencič, S. Manta, 2009, European Journal of Medicinal Chemistry.

Unsaturated fluoro-ketopyranosyl nucleosides: synthesis and biological evaluation of 3-fluoro-4-keto-beta-d-glucopyranosyl derivatives of N(4)-benzoyl cytosine and N(6)-benzoyl adenine.

A. Cencič, S. Manta, D. Komiotis, 2008, European journal of medicinal chemistry.

Fluoro-ketopyranosyl nucleosides: synthesis and biological evaluation of 3-fluoro-2-keto-beta-D-glucopyranosyl derivatives of N4-benzoyl cytosine.

A. Cencič, S. Manta, D. Komiotis, 2007, Bioorganic & medicinal chemistry.

The binding of C5-alkynyl and alkylfurano[2,3-d]pyrimidine glucopyranonucleosides to glycogen phosphorylase b: synthesis, biochemical and biological assessment.

S. Zographos, D. Leonidas, A. Psarra, 2012, European journal of medicinal chemistry.

1-(3-Deoxy-3-fluoro-beta-d-glucopyranosyl) pyrimidine derivatives as inhibitors of glycogen phosphorylase b: Kinetic, crystallographic and modelling studies.

S. Zographos, D. Leonidas, V. G. Tsirkone, 2010, Bioorganic & medicinal chemistry.

A Facile, One‐Step Conversion of 6‐O‐Trityl and 6‐O‐TBDMS Monosaccharides into the Corresponding Formate Esters

K. Antonakis, S. Manta, D. Komiotis, 2006 .

A new bifunctional tridentate NSN ligand leading to cationic tricarbonyl fac-[M(NSN)(CO)3]+ (M = Re, 99mTc) complexes

A. Terzis, C. Raptopoulou, G. Patsis, 2013 .

An easy microwave-assisted synthesis of C8-alkynyl adenine pyranonucleosides as novel cytotoxic antitumor agents

D. Schols, A. Dimopoulou, S. Manta, 2015, Front. Chem..

Exomethylene pyranonucleosides: efficient synthesis and biological evaluation of 1-(2,3,4-trideoxy-2-methylene-beta-d-glycero-hex-3-enopyranosyl)thymine.

A. Cencič, D. Komiotis, G. Agelis, 2007, Bioorganic & medicinal chemistry.

Dissipation, metabolism and sorption of pesticides used in fruit-packaging plants: Towards an optimized depuration of their pesticide-contaminated agro-industrial effluents.

D. Karpouzas, M. Omirou, C. Ehaliotis, 2015, The Science of the total environment.

Purification of rat brain, rabbit aorta, and human platelet thromboxane A2/prostaglandin H2 receptors by immunoaffinity chromatography employing anti-peptide and anti-receptor antibodies.

G. L. Le Breton, D. Yeomans, D. Komiotis, 1994, The Journal of biological chemistry.

Keto-fluorothiopyranosyl nucleosides: a convenient synthesis of 2- and 4-keto-3-fluoro-5-thioxylopyranosyl thymine analogs.

S. Manta, D. Komiotis, E. Tsoukala, 2011, Carbohydrate research.

Triazole double-headed ribonucleosides as inhibitors of eosinophil derived neurotoxin.

E. Boix, D. Leonidas, A. Kantsadi, 2015, Bioorganic chemistry.

Stereoselective facile synthesis of 2'-spiro pyrimidine pyranonucleosides via their key intermediate 2'-C-cyano analogues. Evaluation of their bioactivity.

J. Balzarini, A. Dimopoulou, S. Manta, 2014, Carbohydrate research.

Synthesis and biological evaluation of 3'-C-ethynyl and 3'-C-(1,4-disubstituted-1,2,3-triazolo) double-headed pyranonucleosides.

J. Balzarini, S. Manta, E. Coutouli-argyropoulou, 2012, Medicinal chemistry (Shariqah (United Arab Emirates)).

Stereocontrolled synthesis of 4'-C-cyano and 4'-C-cyano-4'-deoxy pyrimidine pyranonucleosides as potential chemotherapeutic agents.

J. Balzarini, A. Dimopoulou, S. Manta, 2012, Carbohydrate research.

Competitive inhibition of human poly(A)-specific ribonuclease (PARN) by synthetic fluoro-pyranosyl nucleosides.

C. Stathopoulos, D. Anastasakis, D. Vlachakis, 2009, Biochemistry.

A concise synthesis of 3-fluoro-5-thio-xylo- and glucopyranoses, useful precursors towards their corresponding pyranonucleoside derivatives.

S. Manta, D. Komiotis, G. Agelis, 2008, Carbohydrate research.

An efficient synthesis of 3-fluoro-5-thio-xylofuranosyl nucleosides of thymine, uracil, and 5-fluorouracil as potential antitumor or/and antiviral agents.

A. Cencič, D. Komiotis, G. Agelis, 2007, Bioorganic & medicinal chemistry.

Unsaturation: An Important Structural Feature to Nucleosides’ Antiviral Activity

A. Tsotinis, A. Dimopoulou, S. Manta, 2014 .

Rapid microwave-enhanced synthesis of C5-alkynyl pyranonucleosides as novel cytotoxic antitumor agents.

Jan Balzarini, Ioannis Papasotiriou, J. Balzarini, 2013, Bioorganic & medicinal chemistry letters.

Keto and exomethylene pyranonucleosides as antitumor agents.

S. Manta, D. Komiotis, E. Tsoukala, 2012, Mini reviews in medicinal chemistry.

Efficient synthesis of exomethylene- and keto-exomethylene-d-glucopyranosyl nucleoside analogs as potential cytotoxic agents.

J. Balzarini, S. Manta, D. Komiotis, 2011, Carbohydrate research.

Unsaturated Keto and Exomethylene Pyranonucleoside Analogues of Thymine and Uracil Exhibit Potent Antioxidant Properties

D. Kouretas, P. Margaris, S. Manta, 2011 .

Unsaturated Dideoxy Fluoro‐ketopyranosyl Nucleosides as New Cytostatic Agents: A Convenient Synthesis of 2,6‐Dideoxy‐3‐fluoro‐4‐keto‐β‐D‐glucopyranosyl Analogues of Uracil, 5‐Fluorouracil, Thymine, N4‐Benzoyl Cytosine and N6‐Benzoyl Adenine.

J. Balzarini, S. Manta, D. Komiotis, 2010 .

Unsaturated Fluoro‐ketopyranosyl Nucleosides: Synthesis and Biological Evaluation of 3‐Fluoro‐4‐keto‐β‐D‐glucopyranosyl Derivatives of N4‐Benzoyl Cytosine and N6‐Benzoyl Adenine.

A. Cencič, S. Manta, D. Komiotis, 2008 .

Synthesis and molecular modelling of unsaturated exomethylene pyranonucleoside analogues with antitumor and antiviral activities.

Theodore V. Tselios, A. Cencič, D. Komiotis, 2008, European journal of medicinal chemistry.

New Short Route to Unsaturated Fluoroketonucleosides: Case of 5-Fluoro-1-(6-O-Acetyl-3,4-Di-Deoxy-3-Fluoro-β-d-Glycero-Hex-3-Eno-Pyranos-2-Ulosyl) Uracil

J. Herscovici, K. Antonakis, M. Egron, 2005, Nucleosides, Nucleotides & Nucleic Acids.

New short route to unsaturated fluoroketonucleosides: case of 5-fluoro-1-(6-O-acetyl-3,4-di-deoxy-3-fluoro-beta-D-glycero-hex-3-eno-pyranos-2-ulosyl) uracil.

J. Herscovici, K. Antonakis, M. Egron, 2005 .

Kinetic and in silico analysis of the slow-binding inhibition of human poly(A)-specific ribonuclease (PARN) by novel nucleoside analogues.

C. Stathopoulos, D. Vlachakis, S. Manta, 2012, Biochimie.

Biologically Important Nucleosides: A General Method for the Synthesis of Unsaturated Ketonucleosides of Uracil and its Analogs

E. Clercq, M. Iigo, D. Komiotis, 1991 .

Synthesis of novel N-acyl-β-d-glucopyranosylamines and ureas as potential lead cytostatic agents

D. Schols, A. Dimopoulou, S. Manta, 2016, Medicinal Chemistry Research.

Synthesis and Biological Evaluation of Unsaturated Keto and Exomethylene D-Arabinopyranonucleoside Analogues: Novel 5-Fluorouracil Analogues that Target Thymidylate Synthase.

J. Balzarini, S. Liekens, S. Manta, 2011 .

SPREMLJANJE PRETOKA V MOŽGANSKIH ARTERIJAH S TCD TCD MONITORING OF CEREBRAL BLOOD FLOW

S. Manta, D. Komiotis, Tanja Botić, 2010 .

Cancer oriented ketonucleosides: synthesis of 7-[6-O-(5-carboxypentyl)-3,4-dideoxy- and 3,4-dideoxy-6-O-(6-hydroxyhexyl)-beta-D-glycero-hex-3- enopyranosyl-2-ulose]theophyllines and their coupling with cancer-specific proteins.

K. Antonakis, D. Komiotis, T. Halmos, 1986, Carbohydrate research.

Labeling of human platelet plasma membrane thromboxane A2/prostaglandin H2 receptors using SQB, a novel biotinylated receptor probe.

G. L. Le Breton, D. Komiotis, C. Lim, 1996, Biochemical pharmacology.

Retrospective Characterization of a Vaccine-Derived Poliovirus Type 1 Isolate from Sewage in Greece

Z. Kyriakopoulou, P. Markoulatos, V. Pliaka, 2007, Applied and Environmental Microbiology.

Anti-peptide antibodies against the human blood platelet thromboxane A2/prostaglandin H2 receptor. Production, purification and characterization.

G. L. Le Breton, S. Lam, D. Komiotis, 1993 .

Duplex Real-time PCR assay and SYBR green I melting curve analysis for molecular identification of HPV genotypes 16, 18, 31, 35, 51 and 66.

Z. Kyriakopoulou, D. Tsakogiannis, P. Markoulatos, 2015, Molecular and cellular probes.

Evidence for Novel Action at the Cell‐Binding Site of Human Angiogenin Revealed by Heteronuclear NMR Spectroscopy, in silico and in vivo Studies

D. Leonidas, J. Hayes, G. Spyroulias, 2018, ChemMedChem.

Preparation of Monotritylated Symmetric 1,n-Diols

D. Komiotis, D. Venton, B. Currie, 1993 .

Synthesis of 1-[6,7-anhydro-4-O-tert-butyldimethylsilyl-2,3-O-isopropylidene-d(and -l)-threo-α-d-manno-octopyranosyl]thymines, precursors to higher-carbon sugar nucleosides

K. Antonakis, M. Bessodes, D. Komiotis, 1989 .

Conformational analysis of two novel cytotoxic C2-substituted pyrrolo[2,3-f]quinolines in aqueous media, organic solvents, membrane bilayers and at the putative active site.

S. Grdadolnik, A. Tsotinis, T. Mavromoustakos, 2012, Bioorganic & medicinal chemistry.

3′‐Axial CH2OH Substitution on Glucopyranose does not Increase Glycogen Phosphorylase Inhibitory Potency. QM/MM‐PBSA Calculations Suggest Why

D. Leonidas, P. Zoumpoulakis, V. Skamnaki, 2012, Chemical biology & drug design.

The σ‐Hole Phenomenon of Halogen Atoms Forms the Structural Basis of the Strong Inhibitory Potency of C5 Halogen Substituted Glucopyranosyl Nucleosides towards Glycogen Phosphorylase b

S. Zographos, D. Leonidas, A. Psarra, 2012, ChemMedChem.

Structure based inhibitor design targeting glycogen phosphorylase B. Virtual screening, synthesis, biochemical and biological assessment of novel N-acyl-β-d-glucopyranosylamines.

Georgios Archontis, Loranne Agius, S. Zographos, 2014, Bioorganic & medicinal chemistry.