D. Scotcher

发表

Physiological scaling factors and mechanistic models for prediction of renal clearance from in vitro data

D. Scotcher, 2016 .

Towards Further Verification of Physiologically-Based Kidney Models: Predictability of the Effects of Urine-Flow and Urine-pH on Renal Clearance

A. Galetin, A. Darwich, A. Rostami-Hodjegan, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Delineating the Role of Various Factors in Renal Disposition of Digoxin through Application of Physiologically Based Kidney Model to Renal Impairment Populations

A. Galetin, A. Rostami-Hodjegan, D. Scotcher, 2017, The Journal of Pharmacology and Experimental Therapeutics.

PBPK Simulation-Based Evaluation of Ganciclovir Crystalluria Risk Factors: Effect of Renal Impairment, Old Age, and Low Fluid Intake

A. Galetin, D. Scotcher, 2021, The AAPS Journal.

Clinical Investigation on Endogenous Biomarkers to Predict Strong OAT-Mediated Drug–Drug Interactions

A. Galetin, M. Monshouwer, A. Rostami-Hodjegan, 2021, Clinical Pharmacokinetics.

Physiologically‐Based Pharmacokinetic Modelling of Creatinine‐Drug Interactions in the Chronic Kidney Disease Population

A. Galetin, P. Kalra, D. Scotcher, 2020, CPT: pharmacometrics & systems pharmacology.

Scaling Factors for Clearance in Adult Liver Cirrhosis

A. Rostami-Hodjegan, B. Achour, V. Athwal, 2020, Drug Metabolism and Disposition.

Microsomal and Cytosolic Scaling Factors in Dog and Human Kidney Cortex and Application for In Vitro-In Vivo Extrapolation of Renal Metabolic Clearance

A. Galetin, A. Rostami-Hodjegan, D. Scotcher, 2017, Drug Metabolism and Disposition.

Mass spectrometry‐based abundance atlas of ABC transporters in human liver, gut, kidney, brain and skin

N. Couto, A. Rostami-Hodjegan, B. Achour, 2020, FEBS letters.

Hepatic Scaling Factors for In Vitro–In Vivo Extrapolation of Metabolic Drug Clearance in Patients with Colorectal Cancer with Liver Metastasis

S. Peters, A. Rostami-Hodjegan, B. Achour, 2021, Drug Metabolism and Disposition.

Novel minimal physiologically-based model for the prediction of passive tubular reabsorption and renal excretion clearance

Aleksandra Galetin, Amin Rostami-Hodjegan, A. Galetin, 2016, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Key to Opening Kidney for In Vitro-In Vivo Extrapolation Entrance in Health and Disease: Part II: Mechanistic Models and In Vitro-In Vivo Extrapolation

A. Galetin, M. Posada, A. Rostami-Hodjegan, 2016, The AAPS Journal.

Noninvasive Preclinical and Clinical Imaging of Liver Transporter Function Relevant to Drug-Induced Liver Injury

J. G. Kenna, S. Sourbron, P. Hockings, 2018 .

Coproporphyrin I as an Endogenous Biomarker to Detect Reduced OATP1B Activity and Shift in Elimination Route in Chronic Kidney Disease

X. Chu, A. Galetin, K. Ogungbenro, 2022, Clinical pharmacology and therapy.

Quantitative Proteomic Map of Enzymes and Transporters in the Human Kidney: Stepping Closer to Mechanistic Kidney Models to Define Local Kinetics

A. Galetin, A. Rostami-Hodjegan, B. Achour, 2021, Clinical pharmacology and therapeutics.

Key to Opening Kidney for In Vitro-In Vivo Extrapolation Entrance in Health and Disease: Part II: Mechanistic Models and In Vitro-In Vivo Extrapolation

Aleksandra Galetin, Amin Rostami-Hodjegan, A. Galetin, 2016, The AAPS Journal.

Physiologically Based Pharmacokinetic Modeling of Transporter-Mediated Hepatic Disposition of Imaging Biomarker Gadoxetate in Rats

S. Sourbron, A. Galetin, K. Ogungbenro, 2021, Molecular pharmaceutics.

Toward Systems-Informed Models for Biologics Disposition: Covariates of the Abundance of the Neonatal Fc Receptor (FcRn) in Human Tissues and Implications for Pharmacokinetic Modelling.

A. Rostami-Hodjegan, B. Achour, Narciso Couto, 2023, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Mechanistic Models as Framework for Understanding Biomarker Disposition: Prediction of Creatinine‐Drug Interactions

Shiew-Mei Huang, Lei Zhang, A. Galetin, 2020, CPT: pharmacometrics & systems pharmacology.

Effect of Chronic Kidney Disease on the Renal Secretion via Organic Anion Transporters 1/3: Implications for Physiologically‐Based Pharmacokinetic Modeling and Dose Adjustment

A. Galetin, A. Rostami-Hodjegan, S. P. F. Tan, 2022, Clinical pharmacology and therapeutics.

Quantitative translation of microfluidic transporter in vitro data to in vivo reveals impaired albumin-facilitated indoxyl sulfate secretion in chronic kidney disease.

Aleksandra Galetin, Amin Rostami-Hodjegan, Rosalinde Masereeuw, 2019, Molecular pharmaceutics.

Key to Opening Kidney for In Vitro–In Vivo Extrapolation Entrance in Health and Disease: Part I: In Vitro Systems and Physiological Data

A. Galetin, M. Posada, A. Rostami-Hodjegan, 2016, The AAPS Journal.

A Novel Physiologically Based Model of Creatinine Renal Disposition to Integrate Current Knowledge of Systems Parameters and Clinical Observations

Shiew-Mei Huang, Lei Zhang, A. Galetin, 2020, CPT: pharmacometrics & systems pharmacology.

Using Prior Knowledge on Systems Through PBPK to Gain Further Insight into Routine Clinical Data on Trough Concentrations: The Case of Tacrolimus in Chronic Kidney Disease.

P. Kalra, A. Darwich, A. Rostami-Hodjegan, 2023, Therapeutic drug monitoring.

Use of In Vivo Imaging and Physiologically-Based Kinetic Modelling to Predict Hepatic Transporter Mediated Drug–Drug Interactions in Rats

J. G. Kenna, S. Sourbron, P. Hockings, 2023, Pharmaceutics.

Hepatic Scaling Factors for In Vitro-In Vivo Extrapolation (IVIVE) of Metabolic Drug Clearance in Patients with Colorectal Cancer with Liver Metastasis

A. Rostami-Hodjegan, D. Scotcher, Areti-Maria Vasilogianni, 2021 .