N. Ishiguro

发表

Physiologically Based Pharmacokinetic Modeling of Rosuvastatin to Predict Transporter-Mediated Drug-Drug Interactions

J. D. Gómez-Mantilla, N. Hanke, N. Ishiguro, 2021, Pharmaceutical Research.

Physiologically‐Based Pharmacokinetic Modeling Analysis for Quantitative Prediction of Renal Transporter–Mediated Interactions Between Metformin and Cimetidine

Yuichi Sugiyama, Wooin Lee, Kota Toshimoto, 2019, CPT: pharmacometrics & systems pharmacology.

Validation of a Drug Transporter Probe Cocktail Using the Prototypical Inhibitors Rifampin, Probenecid, Verapamil, and Cimetidine

F. Müller, M. Fromm, K. Hohl, 2020, Clinical Pharmacokinetics.

Erratum: Physiologically‐Based Pharmacokinetic Modeling Analysis for Quantitative Prediction of Renal Transporter–Mediated Interactions Between Metformin and Cimetidine

Y. Sugiyama, Wooin Lee, N. Ishiguro, 2020, CPT: pharmacometrics & systems pharmacology.

A Comprehensive Whole-Body Physiologically Based Pharmacokinetic Drug–Drug–Gene Interaction Model of Metformin and Cimetidine in Healthy Adults and Renally Impaired Individuals

F. Müller, T. Lehr, D. Selzer, 2020, Clinical Pharmacokinetics.

Optimization of a drug transporter probe cocktail: potential screening tool for transporter‐mediated drug–drug interactions

F. Müller, K. Hohl, M. Taub, 2018, British journal of clinical pharmacology.

Usefulness of A Model-Based Approach for Estimating In Vitro P-Glycoprotein Inhibition Potency in a Transcellular Transport Assay.

K. Maeda, Y. Sugiyama, T. Ebner, 2016, Journal of pharmaceutical sciences.

Establishment of a Set of Double Transfectants Coexpressing Organic Anion Transporting Polypeptide 1B3 and Hepatic Efflux Transporters for the Characterization of the Hepatobiliary Transport of Telmisartan Acylglucuronide

K. Maeda, Y. Sugiyama, Asami Saito, 2008, Drug Metabolism and Disposition.

DMD053769 257..263

T. Ebner, N. Ishiguro, O. Schaefer, 2013 .

Evaluation of hepatic uptake of OATP1B substrates by short term-cultured plated human hepatocytes: Comparison with isolated suspended hepatocytes.

H. Kusuhara, Y. Sugiyama, X. Chu, 2020, Journal of pharmaceutical sciences.

PREDOMINANT CONTRIBUTION OF OATP1B3 TO THE HEPATIC UPTAKE OF TELMISARTAN, AN ANGIOTENSIN II RECEPTOR ANTAGONIST, IN HUMANS

Kazuya Maeda, Yuichi Sugiyama, Thomas Ebner, 2006, Drug Metabolism and Disposition.

The impact of pharmacogenetics of metabolic enzymes and transporters on the pharmacokinetics of telmisartan in healthy volunteers

K. Maeda, Y. Sugiyama, S. Ikushiro, 2011, Pharmacogenetics and genomics.

Regional Differences in the Absolute Abundance of Transporters, Receptors and Tight Junction Molecules at the Blood-Arachnoid Barrier and Blood-Spinal Cord Barrier among Cervical, Thoracic and Lumbar Spines in Dogs

T. Terasaki, N. Ishiguro, Yasuo Uchida, 2022, Pharmaceutical Research.

A human blood–arachnoid barrier atlas of transporters, receptors, enzymes, and tight junction and marker proteins: Comparison with dog and pig in absolute abundance

T. Terasaki, N. Ishiguro, Yasuo Uchida, 2022, Journal of neurochemistry.

Rat Kidney Slices for Evaluation of Apical Membrane Transporters in Proximal Tubular Cells.

H. Arakawa, T. Nakanishi, I. Tamai, 2019, Journal of pharmaceutical sciences.

Cell-to-Medium Concentration Ratio Overshoot in the Uptake of Statins by Human Hepatocytes in Suspension, but Not in Monolayer: Kinetic Analysis Suggesting a Partial Loss of Functional OATP1Bs

K. Maeda, H. Kusuhara, Y. Sugiyama, 2020, The AAPS Journal.

Involvement of choline transporter-like proteins, CTL1 and CTL2, in glucocorticoid-induced acceleration of phosphatidylcholine synthesis via increased choline uptake.

T. Nakanishi, I. Tamai, N. Ishiguro, 2010, Biological & pharmaceutical bulletin.

TRANSPORT OF THE DOPAMINE D 2 AGONIST PRAMIPEXOLE BY RAT ORGANIC CATION TRANSPORTERS OCT 1 AND OCT 2 IN KIDNEY

I. Tamai, Asami Saito, T. Igarashi, 2005 .

Intestinal responses to hyperosmolar glucose infusion in dogs

Takuro Suzuki, N. Ishiguro, T. Muraki, 2007, Gastroenterologia Japonica.

Blood-brain barrier transport of pramipexole, a dopamine D2 agonist.

I. Tamai, N. Ishiguro, Y. Deguchi, 2007, Life sciences.

In Vitro Predictability of Drug-Drug Interaction Likelihood of P-Glycoprotein-Mediated Efflux of Dabigatran Etexilate Based on [I]2/IC50 Threshold

Thomas Ebner, T. Ebner, Naoki Ishiguro, 2014, Drug Metabolism and Disposition.

Identification of CYP3A4 as the predominant isoform responsible for the metabolism of ambroxol in human liver microsomes.

Y. Funae, T. Igarashi, N. Ishiguro, 2000, Xenobiotica; the fate of foreign compounds in biological systems.

Synthesis of [¹¹C]uric acid, using [¹¹C]phosgene, as a possible biomarker in PET imaging for diagnosis of gout.

Yasuyoshi Watanabe, Masaaki Suzuki, H. Doi, 2012, Bioorganic & medicinal chemistry letters.

Impact of Experimental Conditions on the Evaluation of Interactions between Multidrug and Toxin Extrusion Proteins and Candidate Drugs

H. Kusuhara, H. Shimizu, N. Ishiguro, 2016, Drug Metabolism and Disposition.

TRANSPORT OF THE DOPAMINE D2 AGONIST PRAMIPEXOLE BY RAT ORGANIC CATION TRANSPORTERS OCT1 AND OCT2 IN KIDNEY

I. Tamai, Asami Saito, T. Igarashi, 2005, Drug Metabolism and Disposition.

Impact of Breast Cancer Resistance Protein Expression on the In Vitro Efficacy of Anticancer Drugs in Pancreatic Cancer Cell Lines

T. Nakanishi, I. Tamai, N. Ishiguro, 2018, Drug Metabolism and Disposition.

Industrial Evaluation of Drug Transporters in ADME

D. Tweedie, M. Taub, N. Ishiguro, 2013 .

Simultaneous Absolute Protein Quantification of Transporters, Cytochromes P450, and UDP-Glucuronosyltransferases as a Novel Approach for the Characterization of Individual Human Liver: Comparison with mRNA Levels and Activities

Tetsuya Terasaki, Thomas Ebner, Asami Saito, 2012, Drug Metabolism and Disposition.

Evaluation and Prediction of Potential Drug-Drug Interactions of Linagliptin Using In Vitro Cell Culture Methods

Thomas Ebner, H. Shimizu, T. Ebner, 2013, Drug Metabolism and Disposition.

linagliptin using in vitro cell culture methods

H. Shimizu, T. Ebner, N. Ishiguro, 2012 .

Proceedings of the 26th annual meeting Chiba, Japan, October 18–20, 1984

T. Takada, H. Hasegawa, M. Miyazaki, 1985, Gastroenterologia Japonica.

Brain Penetration of WEB 2086 (Apafant) and Dantrolene in Mdr1a (P-Glycoprotein) and Bcrp Knockout Rats

Holger Fuchs, Naoki Ishiguro, N. Ishiguro, 2014, Drug Metabolism and Disposition.

Quantification of Transporter and Receptor Proteins in Dog Brain Capillaries and Choroid Plexus: Relevance for the Distribution in Brain and CSF of Selected BCRP and P-gp Substrates.

T. Terasaki, N. Ishiguro, Michitoshi Watanabe, 2017, Molecular pharmaceutics.

Involvement of Rat and Human Organic Anion Transporter 3 in the Renal Tubular Secretion of Topotecan [(S)-9-Dimethylaminomethyl-10-hydroxy-camptothecin hydrochloride]

I. Tamai, Kenji Yoshida, N. Ishiguro, 2007, Journal of Pharmacology and Experimental Therapeutics.

Decreased Biosynthesis of Lung Surfactant Constituent Phosphatidylcholine Due to Inhibition of Choline Transporter by Gefitinib in Lung Alveolar Cells

I. Tamai, H. Minami, N. Ishiguro, 2008, Pharmaceutical Research.

Investigation of the Inhibitory Effects of Various Drugs on the Hepatic Uptake of Fexofenadine in Humans

Kazuya Maeda, Yuichi Sugiyama, K. Maeda, 2008, Drug Metabolism and Disposition.

Impact of Direction of Transport on the Evaluation of Inhibition Potencies of Multidrug and Toxin Extrusion Protein 1 Inhibitors

H. Kusuhara, Asami Saito, N. Ishiguro, 2020, Drug Metabolism and Disposition.

Influx and efflux transport of H1-antagonist epinastine across the blood-brain barrier.

I. Tamai, Asami Saito, T. Igarashi, 2004, Drug metabolism and disposition: the biological fate of chemicals.

Impact of P-glycoprotein on intracellular drug concentration in peripheral blood mononuclear cells and K562 cells.

N. Ishiguro, Kotaro Nishiyama, Y. Tsuda, 2022, Drug metabolism and pharmacokinetics.

Functional coupling of organic anion transporter OAT10 (SLC22A13) and monocarboxylate transporter MCT1 (SLC16A1) influencing the transport function of OAT10.

Y. Kanai, N. Ishiguro, A. Matsui, 2022, Journal of pharmacological sciences.

Different Involvement of OAT in Renal Disposition of Oral Anticoagulants Rivaroxaban, Dabigatran, and Apixaban.

H. Kusuhara, T. Nakanishi, I. Tamai, 2017, Journal of pharmaceutical sciences.

Effects of Metformin and Furosemide on Rosuvastatin Pharmacokinetics in Healthy Volunteers: Implications for Their Use as Probe Drugs in a Transporter Cocktail

Mitchell E Taub, Fabian Müller, Thomas Ebner, 2017, European Journal of Drug Metabolism and Pharmacokinetics.

Absolute Quantification and Differential Expression of Drug Transporters, Cytochrome P450 Enzymes, and UDP-Glucuronosyltransferases in Cultured Primary Human Hepatocytes

Tetsuya Terasaki, Thomas Ebner, Asami Saito, 2012, Drug Metabolism and Disposition.

Reliability and robustness of simultaneous absolute quantification of drug transporters, cytochrome P450 enzymes, and Udp-glucuronosyltransferases in human liver tissue by multiplexed MRM/selected reaction monitoring mode tandem mass spectrometry with nano-liquid chromatography.

Tetsuya Terasaki, Hirotaka Kawakami, Sumio Ohtsuki, 2011, Journal of pharmaceutical sciences.

Pharmacokinetic Evaluation of a Drug Transporter Cocktail Consisting of Digoxin, Furosemide, Metformin, and Rosuvastatin

F Müller, F. Müller, K. Hohl, 2016, Clinical pharmacology and therapeutics.

Improvement of Protein Expression Profile in Three-Dimensional Renal Proximal Tubular Epithelial Cell Spheroids Selected Based on OAT1 Gene Expression: A Potential In Vitro Tool for Evaluating Human Renal Proximal Tubular Toxicity and Drug Disposition

H. Arakawa, I. Tamai, K. Osafune, 2023, Drug Metabolism and Disposition.

Usefulness of kidney slices for functional analysis of apical reabsorptive transporters

H. Arakawa, T. Nakanishi, N. Nakamichi, 2017, Scientific Reports.

The Use of Transporter Probe Drug Cocktails for the Assessment of Transporter-Based Drug-Drug Interactions in a Clinical Setting-Proposal of a Four Component Transporter Cocktail.

M. Taub, T. Ebner, N. Ishiguro, 2015, Journal of pharmaceutical sciences.

Effects of Metformin and Furosemide on Rosuvastatin Pharmacokinetics in Healthy Volunteers: Implications for Their Use as Probe Drugs in a Transporter Cocktail

F. Müller, K. Hohl, M. Taub, 2017, European Journal of Drug Metabolism and Pharmacokinetics.

Requirements for human iPS cell-derived hepatocytes as an alternative to primary human hepatocytes for assessing absorption, distribution, metabolism, excretion and toxicity of pharmaceuticals

Keisuke Nagata, Tomoaki Inoue, Y. Iwase, 2016 .

Effect of endogenous multidrug resistance 1 and P‐glycoprotein expression on anticancer drug resistance in colon cancer cell lines

T. Nakanishi, I. Tamai, N. Ishiguro, 2018, Biopharmaceutics & drug disposition.

Effect of 2-deoxy-glucose on gastric blood flow

N. Ishiguro, T. Fukushima, S. Tsuchiya, 1973, Gastroenterologia Japonica.

Impact of Endogenous Esterase Activity on In Vitro P-Glycoprotein Profiling of Dabigatran Etexilate in Caco-2 Monolayers

T. Ebner, N. Ishiguro, A. Volz, 2014, Drug Metabolism and Disposition.

Quantitative analysis of mRNA and protein expression levels of aldo-keto reductase and short-chain dehydrogenase/reductase isoforms in the human intestine.

T. Fukami, M. Nakajima, Gaku Morinaga, 2023, Drug metabolism and disposition: the biological fate of chemicals.

Pharmacokinetic-Interactions of BI 425809, a Novel Glycine Transporter 1 Inhibitor, With Cytochrome P450 and P-Glycoprotein Substrates

F. Müller, K. Hohl, T. Chan, 2023, Journal of clinical psychopharmacology.

Absolute Quantification and Differential Expression of Drug Transporters, Cytochrome P450 Enzymes, and UDP-Glucuronosyltransferases in Cultured Primary Human Hepatocytes

T. Terasaki, S. Ohtsuki, Asami Saito, 2012, Drug Metabolism and Disposition.

Sex-, Species-, and Tissue-Specific Metabolism of Empagliflozin in Male Mouse Kidney Forms an Unstable Hemiacetal Metabolite (M466/2) That Degrades to 4-Hydroxycrotonaldehyde, a Reactive and Cytotoxic Species.

Mitchell E Taub, Hongbin Yu, Donald Tweedie, 2015, Chemical research in toxicology.