Po‐Chang Chiang

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Physiologically‐Based Pharmacokinetic Model‐Informed Drug Development for Fenebrutinib: Understanding Complex Drug‐Drug Interactions

Jin Y. Jin, Yuan Chen, L. Chinn, 2020, CPT: pharmacometrics & systems pharmacology.

An Integrated Analysis of Solid Form Change Impact on Solubility and Permeability: Case Study of Oral Exposure in Rats of an RAR Related Orphan Receptor C Inhibitor.

K. Nagapudi, E. Plise, Jia Liu, 2019, Journal of pharmaceutical sciences.

Exploring a Kinetic Model Approach in Biopharmaceutics: Estimating the Fraction Absorbed of Orally Administered Drugs in Humans.

H. Wong, Jia Liu, Po‐Chang Chiang, 2018, Journal of pharmaceutical sciences.

Incorporation of Physiologically Based Pharmacokinetic Modeling in the Evaluation of Solubility Requirements for the Salt Selection Process: A Case Study Using Phenytoin

Po-Chang Chiang, Harvey Wong, H. Wong, 2013, The AAPS Journal.

The Impact of Dosing Interval in a Novel Tandem Oral Dosing Strategy: Enhancing the Exposure of Low Solubility Drug Candidates in a Preclinical Setting

Steve P. Wene, Sarah A South, Po‐Chang Chiang, 2011, Journal of drug delivery.

Utilizing a novel tandem oral dosing strategy to enhance exposure of low-solubility drug candidates in a preclinical setting.

Kimberly A. Foster, D. Thompson, J. S. Daniels, 2010, Journal of pharmaceutical sciences.

Utilizing Tiny-TIM to Assess the Effect of Acid-Reducing Agents on the Absorption of Orally Administered Drugs.

K. Nagapudi, Jia Liu, Po‐Chang Chiang, 2021, Journal of pharmaceutical sciences.

Mechanistic Oral Absorption Modeling of Halofantrine: Exploring the Role of Intestinal Lymphatic Transport.

Yuan Chen, Po‐Chang Chiang, M. Dolton, 2020, Journal of pharmaceutical sciences.

Nanosuspension delivery of paclitaxel to xenograft mice can alter drug disposition and anti-tumor activity

Po-Chang Chiang, Stephen Gould, Harvey Wong, 2014, Nanoscale Research Letters.

Novel nanoparticles formulation for cassette dosing via intravenous injection in rats for high throughput pharmacokinetic screening and potential applications.

Y. Ran, H. Wong, K. Chou, 2012, Journal of nanoscience and nanotechnology.

Novel Tight-Binding Inhibitory Factor-κB Kinase (IKK-2) Inhibitors Demonstrate Target-Specific Anti-Inflammatory Activities in Cellular Assays and following Oral and Local Delivery in an in Vivo Model of Airway Inflammation

J. F. Schindler, J. Guzova, S. Bonar, 2009, Journal of Pharmacology and Experimental Therapeutics.

Euthanasia method for mice in rapid time-course pulmonary pharmacokinetic studies.

Po‐Chang Chiang, A. Schoell, D. E. Weir, 2009, Journal of the American Association for Laboratory Animal Science : JAALAS.

Fluticasone and budesonide nanosuspensions for pulmonary delivery: preparation, characterization, and pharmacokinetic studies.

Po‐Chang Chiang, A. L. Young, D. Pretzer, 2008, Journal of pharmaceutical sciences.

Evaluating the Suitability of Using Rat Models for Preclinical Efficacy and Side Effects with Inhaled Corticosteroids Nanosuspension Formulations

D. Thompson, Po‐Chang Chiang, Yiding Hu, 2010, Nanoscale research letters.

A Physiologically Based Pharmacokinetic Model of Vismodegib: Deconvoluting the Impact of Saturable Plasma Protein Binding, pH-Dependent Solubility and Nonsink Permeation

Jin Y. Jin, Yuan Chen, Fang Ma, 2020, The AAPS Journal.

Modeling Drug Dissolution in 3-Dimensional Space.

Chip-Sup So, Chen Mao, Po‐Chang Chiang, 2022, Pharmaceutical research.

Combined use of pharmacokinetic modeling and a steady-state delivery approach allows early assessment of IkappaB kinase-2 (IKK-2) target safety and efficacy.

D. Thompson, Po‐Chang Chiang, N. Kishore, 2010, Journal of pharmaceutical sciences.

A Novel, Highly Selective, Tight Binding IκB Kinase-2 (IKK-2) Inhibitor: A Tool to Correlate IKK-2 Activity to the Fate and Functions of the Components of the Nuclear Factor-κB Pathway in Arthritis-Relevant Cells and Animal Models

D. Thompson, J. F. Schindler, J. Guzova, 2009, Journal of Pharmacology and Experimental Therapeutics.

Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma.

A. Ebens, C. Noland, J. Lyssikatos, 2019, Journal of medicinal chemistry.

Quantification of Benzo[a]pyrene-Guanine Adducts in in vitro Samples by LC Tandem Mass Spectrometry with Stable Isotope Internal Standardization

J. Means, Po‐Chang Chiang, 2008 .

Evaluating the IVIVC by Combining Tiny-TIM Outputs and Compartmental PK Model to Predict Oral Exposure for Different Formulations of Ibuprofen.

G. Amidon, K. Nagapudi, Jia Liu, 2022, Journal of pharmaceutical sciences.

The Spatial Response of Penh as a Secondary Readout for the Airway Hyper-reactivity in Three Different Rodent Models of Airway Inflammation: A Pilot Comparison Study

Po‐Chang Chiang, D. Tung, James P. Warner, 2016 .

Elucidating a Potential Mechanism of Permeability Enhancer Sodium N-[8-(2-hydroxybenzoyl) amino] caprylate in Rats: Evidence of Lymphatic Absorption of Cyanocobalamin Using the Mesenteric Lymph Duct Cannulated Rat.

Liling Liu, K. Nagapudi, E. Plise, 2022, Journal of pharmaceutical sciences.

Synthesis of Organometallic Polymers

Po‐Chang Chiang, 1992 .

Investigation of Dose-Dependent Factors Limiting Oral Bioavailability: Case Study With the PI3K-δ Inhibitor.

D. Sutherlin, L. Salphati, Po‐Chang Chiang, 2016, Journal of pharmaceutical sciences.

In Vitro and In Vivo Evaluation of Amorphous Solid Dispersions Generated by Different Bench-Scale Processes, Using Griseofulvin as a Model Compound

Y. Ran, J. Lubach, H. Wong, 2013, The AAPS Journal.

Quantification Of Benzo[A]Pyrene-Guanine Adducts in In Vitro And in Vivo Tissue Samples By LC Tandem Mass Spectrometry

Po‐Chang Chiang, 2001 .

Exploring Multi-Compartment Plug-Flow Based Model Approach in Biopharmaceutics: Impact of Stomach Setting and the Estimation of the Fraction Absorbed of Orally Administered Basic Drugs.

Po-Chang Chiang, Karthik Nagapudi, Michael J Dolton, 2019, Journal of pharmaceutical sciences.

Comparison of In vitro Nanoparticles Uptake in Various Cell Lines and In vivo Pulmonary Cellular Transport in Intratracheally Dosed Rat Model

Po-Chang Chiang, Na Li, Yurong Lai, 2008, Nanoscale Research Letters.

Evaluating the Pharmacokinetics and Systemic Effects of a Permeability Enhancer Sodium N-[8-(2-hydroxybenzoyl)amino] caprylate in Rats.

K. Nagapudi, E. Plise, Jia Liu, 2020, Journal of pharmaceutical sciences.

Exploring the Use of a Kinetic pH Calculation to Correct the ACAT Model with a Single Stomach Compartment Setting: Impact of Stomach Setting on Food Effect Prediction for Basic Compounds.

Jia Liu, K. Nagapudi, Po‐Chang Chiang, 2023, Journal of pharmaceutical sciences.

Evaluation of Aerosol Delivery of Nanosuspension for Pre-clinical Pulmonary Drug Delivery

Y. Lai, Po‐Chang Chiang, Yiding Hu, 2009, Nanoscale research letters.

An Investigation of Oral Exposure Variability and Formulation Strategy: A Case Study of PI3Kδ Inhibitor and Physiologically Based Pharmacokinetic Modeling in Beagle Dogs.

Po-Chang Chiang, L. Salphati, Jia Liu, 2018, Journal of pharmaceutical sciences.

1,3-Dicyclohexyl urea nanosuspension for intravenous steady-state delivery in rats

S. Roberds, Steve P. Wene, Sarbani Ghosh, 2007 .

Pharmacokinetic evaluation of a 1,3-dicyclohexylurea nanosuspension formulation to support early efficacy assessment

Po-Chang Chiang, S. Roberds, Steve P. Wene, 2007, Nanoscale Research Letters.

Evaluation of Drug Load and Polymer by Using a 96-Well Plate Vacuum Dry System for Amorphous Solid Dispersion Drug Delivery

Y. Ran, A. Sambrone, K. Chou, 2012, AAPS PharmSciTech.

Impact of Surfactant Selection and Incorporation on in situ Nanoparticle Formation from Amorphous Solid Dispersions.

A. Estevez, Wei Zhang, K. Nagapudi, 2021, International journal of pharmaceutics.

Oral delivery of 1,3-dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive rats.

Po-Chang Chiang, Hideji Fujiwara, S. Roberds, 2008, Basic & clinical pharmacology & toxicology.

Investigation of Drug Delivery in Rats via Subcutaneous Injection: Case Study of Pharmacokinetic Modeling of Suspension Formulations.

K. Nagapudi, Jia Liu, Po‐Chang Chiang, 2019, Journal of pharmaceutical sciences.

Systemic in vitro and in vivo evaluation for determining the feasibility of making an amorphous solid dispersion of a B-Raf (rapidly accelerated fibrosarcoma) inhibitor.

Y. Ran, E. Choo, J. Boggs, 2013, International journal of pharmaceutics.

Understanding the Effect of Hydroxypropyl‐β‐Cyclodextrin on Fenebrutinib Absorption in an Itraconazole–Fenebrutinib Drug–Drug Interaction Study

Yuan Chen, L. Chinn, K. Nagapudi, 2020, Clinical pharmacology and therapeutics.

Medium Throughput pK a Determinations of Drugs and Chemicals by Reverse Phase HPLC with an Organic Gradient

Kimberly A. Foster, Po‐Chang Chiang, Ching‐Chiang Su, 2006 .

Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase.

Jianwen A. Feng, P. McEwan, Lawren C. Wu, 2018, Journal of medicinal chemistry.

Incorporation of Physiologically Based Pharmacokinetic Modeling in the Evaluation of Solubility Requirements for the Salt Selection Process: A Case Study Using Phenytoin

H. Wong, Po‐Chang Chiang, 2013, The AAPS Journal.

Aqueous versus non-aqueous salt delivery strategies to enhance oral bioavailability of a mitogen-activated protein kinase-activated protein kinase (MK-2) inhibitor in rats.

Po-Chang Chiang, David R. Anderson, Steve P. Wene, 2009, Journal of pharmaceutical sciences.

Evaluation of Drug Load and Polymer by Using a 96-Well Plate Vacuum Dry System for Amorphous Solid Dispersion Drug Delivery

Y. Ran, A. Sambrone, K. Chou, 2012, AAPS PharmSciTech.

Investigation of utilization of nanosuspension formulation to enhance exposure of 1,3-dicyclohexylurea in rats: Preparation for PK/PD study via subcutaneous route of nanosuspension drug delivery

Y. Ran, H. Wong, K. Chou, 2011, Nanoscale research letters.

Systemic concentrations can limit the oral absorption of poorly soluble drugs: an investigation of non-sink permeation using physiologically based pharmacokinetic modeling.

Po-Chang Chiang, Harvey Wong, H. Wong, 2013, Molecular pharmaceutics.

Filling a nick in NIK: extending the half-life of a NIK inhibitor through structure-based drug design.

Matthew L Landry, P. McEwan, Adam Johnson, 2023, Bioorganic & medicinal chemistry letters.

Simultaneous determination of LogD, LogP, and pK(a) of drugs by using a reverse phase HPLC coupled with a 96-well plate auto injector.

Po‐Chang Chiang, Yiding Hu, 2009, Combinatorial chemistry & high throughput screening.

Pharmacokinetic and pharmacodynamic evaluation of the suitability of using fluticasone and an acute rat lung inflammation model to differentiate lung versus systemic efficacy.

Po-Chang Chiang, Yurong Lai, J. Guzova, 2009, Journal of pharmaceutical sciences.

The Use of Biopharmaceutic Classification of Drugs in Drug Discovery and Development: Current Status and Future Extension of Biopharmaceutics Classification System II Focus

K. Nagapudi, Jia Liu, Po‐Chang Chiang, 2019 .

Absorption and Physicochemical Properties of the NCE

Po‐Chang Chiang, J. Selbo, 2010 .

Discovering medical quality of total hip arthroplasty by rough set classifier with imbalanced class

Ching-Hsue Cheng, Po-Chang Chiang, Min-Hsiung Wei, 2013 .

In Vitro and In Vivo Evaluation of Amorphous Solid Dispersions Generated by Different Bench-Scale Processes, Using Griseofulvin as a Model Compound

Y. Ran, J. Lubach, H. Wong, 2013, The AAPS Journal.

A formulation-enabled preclinical efficacy assessment of a farnesoid X receptor agonist, GW4064, in hamsters and cynomolgus monkeys.

D. Thompson, Sarbani Ghosh, Po‐Chang Chiang, 2011, Journal of pharmaceutical sciences.

Medium Throughput pK a Determination of Drugs and Chemicals Using an HPLC Equipped with a DAD as a Flow Injection Apparatus

Po‐Chang Chiang, Katherine M. Block, Ching‐Chiang Su, 2005 .

Commentary: Liquid-filled Formulations

Po‐Chang Chiang, 2018 .

of Drug Commentary : Liquid-filled Formulations

K. Nagapudi, Po‐Chang Chiang, 2018 .

Utilizing a novel tandem oral dosing strategy to enhance exposure of low-solubility drug candidates in a preclinical setting.

Kimberly A. Foster, D. Thompson, Steve P. Wene, 2010, Journal of pharmaceutical sciences.