Yang Chen

发表

Prediction of Atorvastatin Pharmacokinetics in High-Fat Diet and Low-Dose Streptozotocin-Induced Diabetic Rats Using a Semiphysiologically Based Pharmacokinetic Model Involving Both Enzymes and Transporters

Ping Li, Xiao-dong Liu, Li Liu, 2019, Drug Metabolism and Disposition.

Prediction of Deoxypodophyllotoxin Disposition in Mouse, Rat, Monkey, and Dog by Physiologically Based Pharmacokinetic Model and the Extrapolation to Human

Fei Liu, Li Liu, Kaijing Zhao, 2016, Front. Pharmacol..

Physiologically based pharmacokinetic–pharmacodynamic modeling for prediction of vonoprazan pharmacokinetics and its inhibition on gastric acid secretion following intravenous/oral administration to rats, dogs and humans

Ping Li, Xiao-dong Liu, Weimin Kong, 2020, Acta Pharmacologica Sinica.

Simultaneously predict pharmacokinetic interaction of rifampicin with oral versus intravenous substrates of cytochrome P450 3A/P‑glycoprotein to healthy human using a semi-physiologically based pharmacokinetic model involving both enzyme and transporter turnover.

Xiao-dong Liu, Li Liu, Kai-jing Zhao, 2019, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Chronic administration of caderofloxacin, a new fluoroquinolone, increases hepatic CYP2E1 expression and activity in rats

P. Xu, Xiao-dong Liu, Li Liu, 2016, Acta Pharmacologica Sinica.

Predicting Antitumor Effect of Deoxypodophyllotoxin in NCI-H460 Tumor-Bearing Mice on the Basis of In Vitro Pharmacodynamics and a Physiologically Based Pharmacokinetic-Pharmacodynamic Model

Xiao-dong Liu, Li Liu, Kai-jing Zhao, 2018, Drug Metabolism and Disposition.

Short‐chain fatty acids oppositely altered expressions and functions of intestinal cytochrome P4503A and P‐glycoprotein and affected pharmacokinetics of verapamil following oral administration to rats

Xiao-dong Liu, Weimin Kong, Li Liu, 2019, The Journal of pharmacy and pharmacology.

Acute liver failure impairs function and expression of breast cancer‐resistant protein (BCRP) at rat blood–brain barrier partly via ammonia‐ROS‐ERK1/2 activation

P. Xu, Xiao-dong Liu, Li Liu, 2016, Journal of neurochemistry.

Decreased exposure of atorvastatin in diabetic rats partly due to induction of hepatic Cyp3a and Oatp2

P. Xu, Xiao-dong Liu, Li Liu, 2016, Xenobiotica; the fate of foreign compounds in biological systems.

Aggravation of clozapine-induced hepatotoxicity by glycyrrhetinic acid in rats.

Y. Li, P. Xu, Xiao-dong Liu, 2014, Journal of pharmacological sciences.

Altered Function and Expression of ABC Transporters at the Blood–Brain Barrier and Increased Brain Distribution of Phenobarbital in Acute Liver Failure Mice

Xiao-dong Liu, Li Liu, Zhongjian Wang, 2018, Front. Pharmacol..

Acute liver failure enhances oral plasma exposure of zidovudine in rats by downregulation of hepatic UGT2B7 and intestinal P-gp

Fan Wang, Xiao-dong Liu, Li Liu, 2017, Acta Pharmacologica Sinica.

Paeoniflorin inhibits macrophage-mediated lung cancer metastasis.

Yang Chen, Qi Wu, Gang Chen, 2015, Chinese journal of natural medicines.

Laminaria japonica increases plasma exposure of glycyrrhetinic acid following oral administration of Liquorice extract in rats.

P. Xu, Xiao-dong Liu, Li Liu, 2015, Chinese journal of natural medicines.

Ciprofloxacin blocked enterohepatic circulation of diclofenac and alleviated NSAID-induced enteropathy in rats partly by inhibiting intestinal β-glucuronidase activity

Fan Wang, P. Xu, Xiao-dong Liu, 2016, Acta Pharmacologica Sinica.

In vitro metabolism of l-corydalmine, a potent analgesic drug, in human, cynomolgus monkey, beagle dog, rat and mouse liver microsomes.

Fan Wang, P. Xu, Xiao-dong Liu, 2016, Journal of pharmaceutical and biomedical analysis.

Unconjugated bilirubin elevation impairs the function and expression of breast cancer resistance protein (BCRP) at the blood-brain barrier in bile duct-ligated rats

P. Xu, Xiao-dong Liu, Li Liu, 2016, Acta Pharmacologica Sinica.

Simultaneous Determination of Deoxypodophyllotoxin and Its Major Metabolites in Rat Plasma by a Sensitive LC–MS/MS Method and Its Application in a Pharmacokinetic Study

P. Xu, Xiao-dong Liu, Li Liu, 2015, Chromatographia.

Validated LC-MS/MS assay for quantitative determination of deoxypodophyllotoxin in rat plasma and its application in pharmacokinetic study.

Xiao-dong Liu, Li Liu, Yang Chen, 2014, Journal of Pharmaceutical and Biomedical Analysis.

Paroxetine decreased plasma exposure of glyburide partly via inhibiting intestinal absorption in rats.

P. Xu, Xiao-dong Liu, Li Liu, 2015, Drug metabolism and pharmacokinetics.

Predicting anti-tumor effect of deoxypodophyllotoxin in NCI-H460 tumor-bearing mice based on in vitro pharmacodynamics and physiologically based pharmacokinetic-pharmacodynamic model

Kai-jing Zhao, Yang Chen, Ze-yu Zhong, 2018 .

Interspecies differences in metabolism of deoxypodophyllotoxin in hepatic microsomes from human, monkey, rat, mouse and dog.

Fan Wang, Xiao-dong Liu, Li Liu, 2016, Drug metabolism and pharmacokinetics.

Global Metabolomic and Lipidomic Analysis Reveal the Synergistic Effect of Bufalin in Combination with Cinobufagin against HepG2 Cells.

Yongjiang Wu, Z. Cai, Yanjun Hong, 2020, Journal of proteome research.

Application of pharmacodynamics-based optimization to the extraction of bioactive compounds from Chansu

Yongjiang Wu, Z. Cai, Yanjun Hong, 2020 .

Uncovering the antitumor effects and mechanisms of Shikonin against colon cancer on comprehensive analysis.

Yongjiang Wu, Yong Chen, Yang Chen, 2021, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Integration of Transcriptomics and Metabolomics Reveals the Antitumor Mechanism Underlying Shikonin in Colon Cancer

Yongjiang Wu, Zhongjian Chen, Yang Chen, 2020, Frontiers in Pharmacology.

Increase in P‐glycoprotein levels in the blood‐brain barrier of partial portal vein ligation /chronic hyperammonemia rats is medicated by ammonia/reactive oxygen species/ERK1/2 activation: In vitro and in vivo studies

Ping Li, Tingting Yang, Xiao-dong Liu, 2019, European journal of pharmacology.

Spatial Lipidomics Reveals Anticancer Mechanisms of Bufalin in Combination with Cinobufagin in Tumor-Bearing Mice

Yongjiang Wu, Yong Chen, Z. Cai, 2021, Frontiers in Pharmacology.

Glycyrrhizin protects against particulate matter-induced lung injury via regulation of endoplasmic reticulum stress and NLRP3 inflammasome-mediated pyroptosis through Nrf2/HO-1/NQO1 signaling pathway.

Chengshui Chen, Yang Chen, Nian Dong, 2023, International immunopharmacology.

DMD064881 1702..1710

P. Xu, Xiao-dong Liu, Li Liu, 2015 .

Combination of GC-MS based metabolomics analysis with mouse xenograft models reveals a panel of dysregulated circulating metabolites and potential therapeutic targets for colorectal cancer

Zhongjian Chen, Yang Chen, H. Ju, 2021, Translational cancer research.

Ping Li, Xiao-dong Liu, Weimin Kong, 2020, Acta Pharmacologica Sinica.

A novel design idea of high-stability silicon anodes for lithium-ion batteries: Building in-situ “high-speed channels” while reserving space

Li Liu, Yanchao Zhu, Zhongyu He, 2023, Chemical Engineering Journal.

Characteristics of β-oxidative and reductive metabolism on the acyl side chain of cinnamic acid and its analogues in rats

K. Zhao, Xiao-dong Liu, Yiting Yang, 2019, Acta Pharmacologica Sinica.