K. Toshimoto

发表

Physiologically Based Pharmacokinetic Modeling of Bosentan Identifies the Saturable Hepatic Uptake As a Major Contributor to Its Nonlinear Pharmacokinetics

Y. Sugiyama, A. Hisaka, Wooin Lee, 2018, Drug Metabolism and Disposition.

Evaluation of Alteration in Hepatic and Intestinal BCRP Function In Vivo from ABCG2 c.421C>A Polymorphism Based on PBPK Analysis of Rosuvastatin

Y. Sugiyama, Y. Kato, K. Toshimoto, 2018, Drug Metabolism and Disposition.

Quantitative Analysis of Complex Drug-Drug Interactions between Cerivastatin and Metabolism/Transport Inhibitors Using Physiologically Based Pharmacokinetic Modeling

Yuichi Sugiyama, Kota Toshimoto, Y. Sugiyama, 2018, Drug Metabolism and Disposition.

Analysis of Nonlinear Pharmacokinetics of a Highly Albumin-Bound Compound: Contribution of Albumin-Mediated Hepatic Uptake Mechanism.

Keisuke Kakimoto, Yoshitaka Hashimoto, Kota Toshimoto, 2017, Journal of pharmaceutical sciences.

Quantitative Analysis of Complex Drug-Drug Interactions Between Repaglinide and Cyclosporin A/Gemfibrozil Using Physiologically Based Pharmacokinetic Models With In Vitro Transporter/Enzyme Inhibition Data.

Yuichi Sugiyama, Kota Toshimoto, Y. Sugiyama, 2017, Journal of pharmaceutical sciences.

Virtual Clinical Studies to Examine the Probability Distribution of the AUC at Target Tissues Using Physiologically-Based Pharmacokinetic Modeling: Application to Analyses of the Effect of Genetic Polymorphism of Enzymes and Transporters on Irinotecan Induced Side Effects

Yuichi Sugiyama, Kota Toshimoto, Y. Sugiyama, 2017, Pharmaceutical Research.

Quantitative Analyses of Hepatic OATP‐Mediated Interactions Between Statins and Inhibitors Using PBPK Modeling With a Parameter Optimization Method

K. Maeda, H. Kusuhara, Y. Sugiyama, 2016, Clinical pharmacology and therapeutics.

Physiologically‐Based Pharmacokinetic Modeling Analysis for Quantitative Prediction of Renal Transporter–Mediated Interactions Between Metformin and Cimetidine

Yuichi Sugiyama, Wooin Lee, Kota Toshimoto, 2019, CPT: pharmacometrics & systems pharmacology.

Development of a Support Vector Machine-Based System to Predict Whether a Compound Is a Substrate of a Given Drug Transporter Using Its Chemical Structure.

T. Ishida, Y. Akiyama, K. Maeda, 2016, Journal of pharmaceutical sciences.

Strategies to improve the prediction accuracy of hepatic intrinsic clearance of three antidiabetic drugs: Application of the extended clearance concept and consideration of the effect of albumin on CYP2C metabolism and OATP1B‐mediated hepatic uptake

K. Maeda, Y. Sugiyama, Kiyomi Ito, 2018, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Erratum: Physiologically‐Based Pharmacokinetic Modeling Analysis for Quantitative Prediction of Renal Transporter–Mediated Interactions Between Metformin and Cimetidine

Y. Sugiyama, Wooin Lee, N. Ishiguro, 2020, CPT: pharmacometrics & systems pharmacology.

PBPK Modeling of Coproporphyrin I as an Endogenous Biomarker for Drug Interactions Involving Inhibition of Hepatic OATP1B1 and OATP1B3

A. D. Rodrigues, Kazuya Maeda, Yuichi Sugiyama, 2018, CPT: pharmacometrics & systems pharmacology.

Improved prediction of the drug-drug interactions of pemafibrate caused by cyclosporine A and rifampicin via PBPK modeling: Consideration of the albumin-mediated hepatic uptake of pemafibrate and inhibition constants with preincubation against OATP1B.

Y. Sugiyama, J. Sahi, J. E. Park, 2020, Journal of pharmaceutical sciences.

Evaluation of hepatic uptake of OATP1B substrates by short term-cultured plated human hepatocytes: Comparison with isolated suspended hepatocytes.

H. Kusuhara, Y. Sugiyama, X. Chu, 2020, Journal of pharmaceutical sciences.

Comprehensive PBPK Model of Rifampicin for Quantitative Prediction of Complex Drug‐Drug Interactions: CYP3A/2C9 Induction and OATP Inhibition Effects

Yuichi Sugiyama, Wooin Lee, Kota Toshimoto, 2018, CPT: pharmacometrics & systems pharmacology.

Application of PBPK Modeling and Virtual Clinical Study Approaches to Predict the Outcomes of CYP2D6 Genotype‐Guided Dosing of Tamoxifen

Yuichi Sugiyama, Wooin Lee, Kota Toshimoto, 2018, CPT: pharmacometrics & systems pharmacology.

A Clinical Quantitative Evaluation of Hepatobiliary Transport of [11C]Dehydropravastatin in Humans Using Positron Emission Tomography

Kazuya Maeda, Yuichi Sugiyama, Yasuyoshi Watanabe, 2018, Drug Metabolism and Disposition.

A simple decision tree suited for identification of early oral drug candidates with likely pharmacokinetic nonlinearity by intestinal CYP3A saturation.

Y. Sugiyama, Wooin Lee, K. Toshimoto, 2020, Journal of pharmaceutical sciences.

Revisiting nonlinear bosentan pharmacokinetics by PBPK modeling: Target binding, albeit not a major contributor to nonlinearity, can offer prediction of target occupancy

Wooin Lee, K. Toshimoto, S. Koyama, 2021 .

Cluster Gauss–Newton method

K. Hayami, K. Toshimoto, Yuichi Sugiyama, 2020, Optimization and Engineering.

Comparison of Methods for Estimating Unbound Intracellular-to-Medium Concentration Ratios in Rat and Human Hepatocytes Using Statins

K. Maeda, H. Kusuhara, Y. Sugiyama, 2017, Drug Metabolism and Disposition.

Cluster Gauss–Newton method

Ken Hayami, Yasunori Aoki, Kota Toshimoto, 2020, Optimization and Engineering.

Cluster Gauss-Newton method for finding multiple approximate minimisers of nonlinear least squares problems with applications to parameter estimation of pharmacokinetic models

K. Hayami, K. Toshimoto, Yuichi Sugiyama, 2018, 1808.06714.

Revisiting Nonlinear Bosentan Pharmacokinetics by Physiologically Based Pharmacokinetic Modeling: Target Binding, Albeit Not a Major Contributor to Nonlinearity, Can Offer Prediction of Target Occupancy

Y. Sugiyama, Wooin Lee, K. Toshimoto, 2021, Drug Metabolism and Disposition.

Cluster Gauss-Newton method for sampling multiple solutions of nonlinear least squares problems - with applications to pharmacokinetic models

Yuichi Sugiyama, Ken Hayami, Yasunori Aoki, 2018 .

Analysis of the Change in the Blood Concentration-Time Profile Caused by Complex Drug-Drug Interactions in the Liver Considering the Enterohepatic Circulation: Examining Whether the Inhibition Constants for Uptake, Metabolism, and Biliary Excretion Can be Recovered by the Analyses Using Physiologica

Y. Sugiyama, K. Toshimoto, Yukana Tomoda, 2017, Journal of pharmaceutical sciences.

In Silico Prediction of Major Clearance Pathways of Drugs among 9 Routes with Two-Step Support Vector Machines

Takashi Ishida, Kazuya Maeda, Yuichi Sugiyama, 2018, Pharmaceutical Research.