T. Yoshikado

发表

Physiologically Based Pharmacokinetic Modeling of Bosentan Identifies the Saturable Hepatic Uptake As a Major Contributor to Its Nonlinear Pharmacokinetics

Y. Sugiyama, A. Hisaka, Wooin Lee, 2018, Drug Metabolism and Disposition.

Evaluation of Alteration in Hepatic and Intestinal BCRP Function In Vivo from ABCG2 c.421C>A Polymorphism Based on PBPK Analysis of Rosuvastatin

Y. Sugiyama, Y. Kato, K. Toshimoto, 2018, Drug Metabolism and Disposition.

Quantitative Analysis of Complex Drug-Drug Interactions between Cerivastatin and Metabolism/Transport Inhibitors Using Physiologically Based Pharmacokinetic Modeling

Yuichi Sugiyama, Kota Toshimoto, Y. Sugiyama, 2018, Drug Metabolism and Disposition.

Quantitative Analysis of Complex Drug-Drug Interactions Between Repaglinide and Cyclosporin A/Gemfibrozil Using Physiologically Based Pharmacokinetic Models With In Vitro Transporter/Enzyme Inhibition Data.

Yuichi Sugiyama, Kota Toshimoto, Y. Sugiyama, 2017, Journal of pharmaceutical sciences.

Quantitative Analyses of the Influence of Parameters Governing Rate-Determining Process of Hepatic Elimination of Drugs on the Magnitudes of Drug-Drug Interactions via Hepatic OATPs and CYP3A Using Physiologically Based Pharmacokinetic Models.

K. Maeda, H. Kusuhara, Y. Sugiyama, 2017, Journal of pharmaceutical sciences.

Quantitative Analyses of Hepatic OATP‐Mediated Interactions Between Statins and Inhibitors Using PBPK Modeling With a Parameter Optimization Method

K. Maeda, H. Kusuhara, Y. Sugiyama, 2016, Clinical pharmacology and therapeutics.

NPC2 regulates biliary cholesterol secretion via stimulation of ABCG5/G8-mediated cholesterol transport.

Hiroshi Suzuki, T. Yoshikado, T. Takada, 2011, Gastroenterology.

Receptor for activated C‐kinase 1 regulates the cellular localization and function of ABCB4

Y. Kanai, N. Anzai, Hiroshi Suzuki, 2009, Hepatology research : the official journal of the Japan Society of Hepatology.

A Clinical Cassette Dosing Study for Evaluating the Contribution of Hepatic OATPs and CYP3A to Drug-Drug Interactions

K. Maeda, H. Kusuhara, Y. Sugiyama, 2017, Pharmaceutical Research.

Comparative Study of the Dose-Dependence of OATP1B Inhibition by Rifampicin Using Probe Drugs and Endogenous Substrates in Healthy Volunteers

K. Maeda, H. Kusuhara, Y. Sugiyama, 2018, Pharmaceutical Research.

PBPK Modeling of Coproporphyrin I as an Endogenous Biomarker for Drug Interactions Involving Inhibition of Hepatic OATP1B1 and OATP1B3

A. D. Rodrigues, Kazuya Maeda, Yuichi Sugiyama, 2018, CPT: pharmacometrics & systems pharmacology.

Physiologically‐based pharmacokinetic model‐based translation of OATP1B‐mediated drug–drug interactions from coproporphyrin I to probe drugs

K. Maeda, H. Kusuhara, X. Chu, 2022, Clinical and translational science.

Clarification of the Mechanism of Clopidogrel-Mediated Drug–Drug Interaction in a Clinical Cassette Small-dose Study and Its Prediction Based on In Vitro Information

Kazuya Maeda, Yuichi Sugiyama, Miyuki Kimura, 2016, Drug Metabolism and Disposition.

Effect of OATP1B1 genotypes on plasma concentrations of endogenous OATP1B1 substrates and drugs, and their association in healthy volunteers.

K. Maeda, H. Kusuhara, Y. Sugiyama, 2019, Drug metabolism and pharmacokinetics.

Small-Dosing Clinical Study: Pharmacokinetic, Pharmacogenomic (SLCO2B1 and ABCG2), and Interaction (Atorvastatin and Grapefruit Juice) Profiles of 5 Probes for OATP2B1 and BCRP.

K. Maeda, H. Kusuhara, Y. Sugiyama, 2017, Journal of pharmaceutical sciences.

Evaluation of hepatic uptake of OATP1B substrates by short term-cultured plated human hepatocytes: Comparison with isolated suspended hepatocytes.

H. Kusuhara, Y. Sugiyama, X. Chu, 2020, Journal of pharmaceutical sciences.

Total hepatocellular disposition profiling of rosuvastatin and pitavastatin in sandwich-cultured human hepatocytes.

K. Kanda, Y. Sugiyama, R. Takahashi, 2018, Drug metabolism and pharmacokinetics.

Itraconazole-Induced Cholestasis: Involvement of the Inhibition of Bile Canalicular Phospholipid Translocator MDR3/ABCB4

S. Tsuji, H. Yoshida, Y. Yatomi, 2011, Molecular Pharmacology.

Ticlopidine, a Cholestatic Liver Injury-Inducible Drug, Causes Dysfunction of Bile Formation via Diminished Biliary Secretion of Phospholipids: Involvement of Biliary-Excreted Glutathione-Conjugated Ticlopidine Metabolites

T. Santa, Hiroshi Suzuki, Kousei Ito, 2013, Molecular Pharmacology.

Synthesis of benzofurazan derivatization reagents for short chain carboxylic acids in liquid chromatography/electrospray ionization-tandem mass spectrometry (LC/ESI-MS/MS).

O. Al-Dirbashi, T. Santa, T. Fukushima, 2009, Biomedical chromatography : BMC.

Ursodeoxycholic acid stimulates the formation of the bile canalicular network.

Hiroshi Suzuki, Kousei Ito, T. Yoshikado, 2012, Biochemical pharmacology.

Comparison of Methods for Estimating Unbound Intracellular-to-Medium Concentration Ratios in Rat and Human Hepatocytes Using Statins

K. Maeda, H. Kusuhara, Y. Sugiyama, 2017, Drug Metabolism and Disposition.

Comparative Study of the Dose-Dependence of OATP1B Inhibition by Rifampicin Using Probe Drugs and Endogenous Substrates in Healthy Volunteers

K. Maeda, H. Kusuhara, Y. Sugiyama, 2018, Pharmaceutical Research.

Investigation of Glycochenodeoxycholate Sulfate and Chenodeoxycholate Glucuronide as Surrogate Endogenous Probes for Drug Interaction Studies of OATP1B1 and OATP1B3 in Healthy Japanese Volunteers

K. Maeda, H. Kusuhara, Y. Sugiyama, 2017, Pharmaceutical Research.

Compounds having thiourea moiety as derivatization reagents in liquid chromatography/electrospray ionization-tandem mass spectrometry (LC/ESI-MS/MS): synthesis of derivatization reagents for carboxylic acids.

T. Santa, T. Yoshikado, T. Nishiyama, 2011, Biomedical chromatography : BMC.

A Clinical Cassette Dosing Study for Evaluating the Contribution of Hepatic OATPs and CYP3A to Drug-Drug Interactions

K. Maeda, H. Kusuhara, Y. Sugiyama, 2017, Pharmaceutical Research.