M. Niosi

发表

A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 2: Prospectively Predicting Systemic and Liver Exposure in Healthy Subjects

L. Tremaine, L. Di, E. Kimoto, 2018, Drug Metabolism and Disposition.

A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 1: Translating Systemic Plasma Concentration to Liver Exposure in Healthy Subjects

L. Tremaine, T. Maurer, L. Di, 2018, Drug Metabolism and Disposition.

Utility of the carboxylesterase inhibitor bis-para-nitrophenylphosphate (BNPP) in the plasma unbound fraction determination for a hydrolytically unstable amide derivative and agonist of the TGR5 receptor

J. Bauman, A. Kalgutkar, Y. Chen, 2010, Xenobiotica; the fate of foreign compounds in biological systems.

Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase (ACC) Inhibitors Through Liver Targeting.

David A. Price, A. Kalgutkar, S. Liras, 2020, Journal of medicinal chemistry.

Novel Method to Predict In Vivo Liver-to-Plasma Kpuu for OATP Substrates Using Suspension Hepatocytes

L. Di, J. Litchfield, Jian Lin, 2017, Drug Metabolism and Disposition.

Determination of Unbound Partition Coefficient and in Vitro–in Vivo Extrapolation for SLC13A Transporter–Mediated Uptake

L. Di, D. Erion, Janice A. Brown, 2016, Drug Metabolism and Disposition.

Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5)

P. Loria, T. Rolph, D. Hepworth, 2015, Scientific Reports.

A sensitive method for the quantitation of the peptide-based glucagon-like peptide-1 receptor agonist liraglutide in plasma using microfluidics chromatography tandem MS.

A. Kalgutkar, C. Holliman, H. Eng, 2018, Bioanalysis.

Novel monobactams utilizing a siderophore uptake mechanism for the treatment of gram-negative infections.

V. Shanmugasundaram, M. Huband, T. Harris, 2012, Bioorganic & medicinal chemistry letters.

Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family.

T. Rolph, M. Hayward, D. Erion, 2016, Journal of medicinal chemistry.

Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase.

Margaret S. Landis, A. Mathiowetz, F. Vajdos, 2015, Bioorganic & medicinal chemistry letters.

In Vitro Characterization of Ertugliflozin Metabolism by UDP-Glucuronosyltransferase and Cytochrome P450 Enzymes

J. Cianfrogna, T. Goosen, Jian Lin, 2020, Drug Metabolism and Disposition.

Plasma Protein Binding of Challenging Compounds.

L. Di, Jian Lin, K. Riccardi, 2015, Journal of pharmaceutical sciences.

(Kpuu) and in Vitro-in Vivo Extrapolation for SLC13A Transporter-Mediated Uptake

L. Di, D. Erion, Janice A. Brown, 2016 .

Delineating the role of cooperativity in the design of potent PROTACs for BTK

Graham M. West, James Smith, V. Shanmugasundaram, 2018, Proceedings of the National Academy of Sciences.

Quantitative Characterization of Major Hepatic UDP-Glucuronosyltransferase Enzymes in Human Liver Microsomes: Comparison of Two Proteomic Methods and Correlation with Catalytic Activity

T. Goosen, A. Rostami-Hodjegan, B. Achour, 2017, Drug Metabolism and Disposition.

2-Aminopyridine-Based Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Inhibitors: Assessment of Mechanism-Based Safety.

M. Ammirati, L. Buckbinder, A. El‐Kattan, 2018, Journal of medicinal chemistry.

6-Chloro-5-[4-(1-Hydroxycyclobutyl)Phenyl]-1H-Indole-3-Carboxylic Acid is a Highly Selective Substrate for Glucuronidation by UGT1A1, Relative to β-Estradiol

A. Kalgutkar, L. Di, T. Goosen, 2018, Drug Metabolism and Disposition.

Leveraging of Rifampicin-Dosed Cynomolgus Monkeys to Identify Bile Acid 3-O-Sulfate Conjugates as Potential Novel Biomarkers for Organic Anion-Transporting Polypeptides

A. D. Rodrigues, G. S. Walker, L. Tremaine, 2017, Drug Metabolism and Disposition.

A-317491, a selective P2X3/P2X2/3 receptor antagonist, reverses inflammatory mechanical hyperalgesia through action at peripheral receptors in rats.

Gary Lee, M. Niosi, Gang Wu, 2004, European journal of pharmacology.

Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis.

P. Loria, J. Bauman, David A. Price, 2022, Journal of medicinal chemistry.

Small structural changes of the imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitors produce an improved safety profile.

D. Hepworth, T. Goosen, A. Shoieb, 2017, MedChemComm.

Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2).

C. C. Jorgensen, M. Boehm, D. Hepworth, 2015, Journal of medicinal chemistry.

Defining the key pharmacophore elements of PF-04620110: discovery of a potent, orally-active, neutral DGAT-1 inhibitor.

Angel Guzman-Perez, Dawn Mather, W. Zavadoski, 2013, Bioorganic & medicinal chemistry.

Organic Anion Transporter 2–Mediated Hepatic Uptake Contributes to the Clearance of High-Permeability–Low-Molecular-Weight Acid and Zwitterion Drugs: Evaluation Using 25 Drugs

A. Carlo, M. Varma, E. Kimoto, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Data Generated by Quantitative Liquid Chromatography-Mass Spectrometry Proteomics Are Only the Start and Not the Endpoint: Optimization of Quantitative Concatemer-Based Measurement of Hepatic Uridine-5′-Diphosphate–Glucuronosyltransferase Enzymes with Reference to Catalytic Activity

T. Goosen, A. Rostami-Hodjegan, B. Achour, 2018, Drug Metabolism and Disposition.

Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro–In Vivo Scaling of Hepatic Uptake Clearance

A. D. Rodrigues, A. David Rodrigues, Manthena V. S. Varma, 2018, Drug Metabolism and Disposition.

Quantitative Characterization of Major Hepatic UDP-Glucuronosyltransferase Enzymes in Human Liver Microsomes: Comparison of Two Proteomic Methods and Correlation with Catalytic Activity

T. Goosen, A. Rostami-Hodjegan, J. Barber, 2017, Drug Metabolism and Disposition.