Yoshitaka Hashimoto

发表

Analysis of Nonlinear Pharmacokinetics of a Highly Albumin-Bound Compound: Contribution of Albumin-Mediated Hepatic Uptake Mechanism.

Keisuke Kakimoto, Yoshitaka Hashimoto, Kota Toshimoto, 2017, Journal of pharmaceutical sciences.

Antiresorptive effect of a cathepsin K inhibitor ONO-5334 and its relationship to BMD increase in a phase II trial for postmenopausal osteoporosis

R. Eastell, Yoshitaka Hashimoto, Makoto Tanaka, 2017, BMC Musculoskeletal Disorders.

Effects of novel cathepsin K inhibitor ONO-5334 on bone resorption markers: a study of four sustained release formulations with different pharmacokinetic patterns

Masanobu Yamamoto, Yoshitaka Hashimoto, Makoto Tanaka, 2014, Journal of Bone and Mineral Metabolism.

Development and validation of an on-line two-dimensional reversed-phase liquid chromatography-tandem mass spectrometry method for the simultaneous determination of prostaglandins E(2) and F(2alpha) and 13,14-dihydro-15-keto prostaglandin F(2alpha) levels in human plasma.

J. Komaba, Yoshitaka Hashimoto, S. Nakade, 2009, Biomedical chromatography : BMC.

Pharmacodynamic Effects on Biochemical Markers of Bone Turnover and Pharmacokinetics of the Cathepsin K Inhibitor, ONO‐5334, in an Ascending Multiple‐Dose, Phase 1 Study

Yoshitaka Hashimoto, M. Small, Shinichi Nagase, 2012, Journal of clinical pharmacology.

Bone turnover markers and pharmacokinetics of a new sustained-release formulation of the cathepsin K inhibitor, ONO-5334, in healthy post-menopausal women

Yoshitaka Hashimoto, M. Small, Shinichi Nagase, 2013, Journal of Bone and Mineral Metabolism.

Population pharmacokinetics of landiolol hydrochloride in healthy subjects.

Y. Tanigawara, T. Kunisawa, H. Kasai, 2008, Drug Metabolism and Pharmacokinetics.

A study on the mechanism of action of santonin

Yoshitaka Hashimoto, 1953 .

Serum and urine bone resorption markers and pharmacokinetics of the cathepsin K inhibitor ONO-5334 after ascending single doses in post menopausal women.

Yoshitaka Hashimoto, M. Small, Shinichi Nagase, 2012, British journal of clinical pharmacology.

Ultra sensitive determination of limaprost, a prostaglandin E1 analogue, in human plasma using on-line two-dimensional reversed-phase liquid chromatography-tandem mass spectrometry.

J. Komaba, Yoshitaka Hashimoto, S. Nakade, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Population pharmacokinetics of aprepitant and dexamethasone in the prevention of chemotherapy-induced nausea and vomiting

Yoshitaka Hashimoto, S. Nakade, T. Ohno, 2008, Cancer Chemotherapy and Pharmacology.

An oral cathepsin K inhibitor ONO-5334 inhibits N-terminal and C-terminal collagen crosslinks in serum and urine at similar plasma concentrations in postmenopausal women.

Yoshitaka Hashimoto, Makoto Tanaka, Chihiro Hasegawa, 2015, Bone.

Validation and application of a 96-well format solid-phase extraction and liquid chromatography-tandem mass spectrometry method for the quantitation of digoxin in human plasma.

Yoshitaka Hashimoto, S. Nakade, Kimio Shibakawa, 2008, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

First Clinical Experience with ONO-4232: A Randomized, Double-blind, Placebo-controlled Healthy Volunteer Study of a Novel Lusitropic Agent for Acutely Decompensated Heart Failure.

I. Gussak, Yoshitaka Hashimoto, Fumitaka Suto, 2016, Clinical therapeutics.

No effect of imidafenacin, a novel antimuscarinic drug, on digoxin pharmacokinetics in healthy subjects.

A. Ohnishi, Yoshitaka Hashimoto, S. Nakade, 2008, Drug metabolism and pharmacokinetics.

A case of diabetic ketoacidosis complicated by fatal acute abdominal aortic thrombosis

K. Kamiuchi, M. Ishii, M. Isono, 2013, Diabetology International.