H. Imawaka

发表

Analysis of Nonlinear Pharmacokinetics of a Highly Albumin-Bound Compound: Contribution of Albumin-Mediated Hepatic Uptake Mechanism.

Keisuke Kakimoto, Yoshitaka Hashimoto, Kota Toshimoto, 2017, Journal of pharmaceutical sciences.

Unique hydrolysis of an ester-type prodrug of levodopa in human plasma-Relay-type role sharing between alpha-1 acid glycoprotein and human serum albumin.

T. Maruyama, Hiroshi Watanabe, Yukina Fukuchi, 2019, Molecular pharmaceutics.

Analysis of the Metabolic Pathway of Bosentan and of the Cytotoxicity of Bosentan Metabolites Based on a Quantitative Modeling of Metabolism and Transport in Sandwich-Cultured Human Hepatocytes

T. Nakanishi, I. Tamai, K. Nunoya, 2016, Drug Metabolism And Disposition.

Sandwich-Cultured Hepatocytes for Mechanistic Understanding of Hepatic Disposition of Parent Drugs and Metabolites by Transporter–Enzyme Interplay

I. Tamai, Yukina Fukuchi, H. Imawaka, 2018, Drug Metabolism and Disposition.

Comprehensive PBPK Model of Rifampicin for Quantitative Prediction of Complex Drug‐Drug Interactions: CYP3A/2C9 Induction and OATP Inhibition Effects

Yuichi Sugiyama, Wooin Lee, Kota Toshimoto, 2018, CPT: pharmacometrics & systems pharmacology.

Expanded Physiologically‐Based Pharmacokinetic Model of Rifampicin for Predicting Interactions With Drugs and an Endogenous Biomarker via Complex Mechanisms Including Organic Anion Transporting Polypeptide 1B Induction

Yuichi Sugiyama, Wooin Lee, Hiroyuki Kusuhara, 2019, CPT: Pharmacometrics & Systems Pharmacology.

Studies on the Metabolic Fate of Neutrophil Elastase Inhibitor ONO-5046·Na(2): Plasma concentration profile, Distribusion and Excretion after Repeated Intravenous Bolus Administration to Rats and Effects on Metabolizing Enzyme Activities

J. Komaba, H. Imawaka, S. Hiraku, 1997 .

Studies on the Metabolic Fate of Ultra Short Acting β1 Blocker ONO-1101 (2): Plasma Concentration-Time Profile, Distribution, Excretion and Effects on Drug Metabolizing Enzyme Activities after Repeated Intravenous Administration to Rats

H. Imawaka, Kimio Shibakawa, S. Hiraku, 1997 .

Kinetic study of the hepatobiliary transport of a new prostaglandin receptor agonist.

Y. Sugiyama, H. Imawaka, 1998, The Journal of pharmacology and experimental therapeutics.

Effects of ONO-3708, an antagonist of the thromboxane A2/prostaglandin endoperoxide receptor, on blood vessels.

H. Imawaka, N. Omawari, K. Wakitani, 1989, European journal of pharmacology.

Inclusion of human intravenous study data in new drug applications-impact of the Japanese guidance.

Y. Sugiyama, Kiyomi Ito, M. Kusama, 2012, Journal of pharmaceutical sciences.

Hydrolase Activity of the Genetic Variants of Human Alpha-1-Acid Glycoprotein.

Panayiotis D. Megaloikonomos, Hiroshi Watanabe, Rui Fujimura, 2022, Molecular pharmaceutics.

Design and synthesis of new orally active inhibitors of human neutrophil elastase.

M. Toda, H. Nakai, H. Imawaka, 2001, Bioorganic & medicinal chemistry.

Studies on the Metabolic Fate of Ultra Short Acting β1 Blocker ONO-1101 (3): Metabolism and Protein Binding

H. Imawaka, Kimio Shibakawa, S. Hiraku, 1997 .

The effect of continuous arterial infusion of gabexate mesilate (FOY-007) on experimental acute pancreatitis.

S. Tashiro, H. Imawaka, M. Harada, 2004, The journal of medical investigation : JMI.

A human immortalized cell-based blood-brain barrier tri-culture model: development and characterization as a promising tool for drug brain permeability studies.

N. Anzai, H. Akita, Shota Suzuki, 2019, Molecular pharmaceutics.

Modeling approach for multiple transporters-mediated drug-drug interactions in sandwich-cultured human hepatocytes: effect of cyclosporin A on hepatic disposition of mycophenolic acid phenyl-glucuronide.

T. Nakanishi, I. Tamai, H. Imawaka, 2015, Drug metabolism and pharmacokinetics.

Species Difference in Hydrolysis of an Ester-type Prodrug of Levodopa in Human and Animal Plasma: Different Contributions of Alpha-1 Acid Glycoprotein.

T. Takeo, N. Nakagata, T. Maruyama, 2021, Molecular pharmaceutics.

Expanded Physiologically‐Based Pharmacokinetic Model of Rifampicin for Predicting Interactions With Drugs and an Endogenous Biomarker via Complex Mechanisms Including Organic Anion Transporting Polypeptide 1B Induction

Yuichi Sugiyama, Wooin Lee, Karsten Menzel, 2019, CPT: pharmacometrics & systems pharmacology.

Special Section on Transporters in Drug Disposition and Pharmacokinetic Prediction Sandwich-Cultured Hepatocytes for Mechanistic Understanding of Hepatic Disposition of Parent Drugs and Metabolites by Transporter – Enzyme Interplay s

Yukina Fukuchi, H. Imawaka, N. Matsunaga, 2022 .