Y. Shirasaka

发表

Physiologically Based Pharmacokinetic Model of All-trans-Retinoic Acid with Application to Cancer Populations and Drug Interactions

Nina Isoherranen, C. Nelson, N. Isoherranen, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Effect of P-glycoprotein expression levels on the concentration-dependent permeability of drugs to the cell membrane.

S. Yamashita, T. Sakane, Y. Shirasaka, 2008, Journal of pharmaceutical sciences.

Organic anion transporter 1 (OAT1/SLC22A6) enhances bioluminescence based on d-luciferin-luciferase reaction in living cells by facilitating the intracellular accumulation of d-luciferin.

Katsuhisa Inoue, Y. Shirasaka, Takahito Furuya, 2018, Biochemical and biophysical research communications.

Quantitative analysis of the effect of controlled-release formulation on nonlinear gastrointestinal absorption of P-glycoprotein substrate talinolol using physiologically based pharmacokinetic absorption model

Katsuhisa Inoue, P. Langguth, Y. Shirasaka, 2020 .

Absorption-Enhancing Effect of Nitric Oxide on the Absorption of Hydrophobic Drugs in Rat Duodenum.

Katsuhisa Inoue, Y. Shirasaka, Hisanao Kishimoto, 2016, Journal of pharmaceutical sciences.

Influence of osmolality on gastrointestinal fluid volume and drug absorption: potential impact on oral salt supplementation

Katsuhisa Inoue, I. Tamai, Y. Shirasaka, 2021, Journal of Pharmaceutical Health Care and Sciences.

Estimation of Michaelis-Menten constant of efflux transporter considering asymmetric permeability.

S. Yamashita, K. Sugano, Y. Shirasaka, 2011, International journal of pharmaceutics.

Interindividual variability of CYP2C19-catalyzed drug metabolism due to differences in gene diplotypes and cytochrome P450 oxidoreductase content

T. Thornton, E. Schuetz, A. Rettie, 2015, The Pharmacogenomics Journal.

Functional pleiotropy of organic anion transporting polypeptide OATP2B1 due to multiple binding sites.

T. Nakanishi, I. Tamai, Takanori Mori, 2012, Drug metabolism and pharmacokinetics.

Active intestinal absorption of fluoroquinolone antibacterial agent ciprofloxacin by organic anion transporting polypeptide, Oatp1a5

H. Arakawa, M. Haga, T. Nakanishi, 2012, Biopharmaceutics & drug disposition.

Concentration-Dependent Effect of Naringin on Intestinal Absorption of β1-Adrenoceptor Antagonist Talinolol Mediated by P-Glycoprotein and Organic Anion Transporting Polypeptide (Oatp)

Y. Kato, I. Tamai, P. Langguth, 2009, Pharmaceutical Research.

Differential effect of grapefruit juice on intestinal absorption of statins due to inhibition of organic anion transporting polypeptide and/or P-glycoprotein.

T. Nakanishi, I. Tamai, Y. Shirasaka, 2011, Journal of pharmaceutical sciences.

Characterization of gastrointestinal drug absorption in cynomolgus monkeys.

S. Yamashita, N. Suzuki, M. Hayashi, 2008, Molecular pharmaceutics.

Multiple Transport Mechanisms Involved in the Intestinal Absorption of Metformin: Impact on the Nonlinear Absorption Kinetics: Contribution of Transporters to Metformin Absorption.

Katsuhisa Inoue, I. Tamai, Joanne Wang, 2022, Journal of pharmaceutical sciences.

Involvement of organic cation transporter 3 (Oct3/Slc22a3) in the bioavailability and pharmacokinetics of antidiabetic metformin in mice.

Joanne Wang, Y. Shirasaka, D. Wagner, 2016, Drug metabolism and pharmacokinetics.

Substrate- and Dose-Dependent Drug Interactions with Grapefruit Juice Caused by Multiple Binding Sites on OATP2B1

T. Nakanishi, I. Tamai, Takanori Mori, 2014, Pharmaceutical Research.

Model Analysis of the Concentration-Dependent Permeability of P-gp Substrates

Y. Sugiyama, Motohiro Kato, S. Yamashita, 2010, Pharmaceutical Research.

Quantitative Time-Lapse Imaging-Based Analysis of Drug-Drug Interaction Mediated by Hepatobiliary Transporter, Multidrug Resistance-Associated Protein 2, in Sandwich-Cultured Rat Hepatocytes

T. Nakanishi, I. Tamai, Kenji Yoshida, 2011, Drug Metabolism and Disposition.

Organic anion transporter OAT1 is involved in renal handling of citrulline.

T. Nakanishi, I. Tamai, Y. Shirasaka, 2009, American journal of physiology. Renal physiology.

Long-Lasting Inhibitory Effect of Apple and Orange Juices, but Not Grapefruit Juice, on OATP2B1-Mediated Drug Absorption

T. Nakanishi, I. Tamai, Takanori Mori, 2013, Drug Metabolism and Disposition.

Scaling of in Vitro Membrane Permeability to Predict P-glycoprotein-Mediated Drug Absorption in Vivo

Y. Masaoka, M. Kataoka, S. Yamashita, 2008, Drug Metabolism and Disposition.

Evaluation of human P-glycoprotein (MDR1/ABCB1) ATPase activity assay method by comparing with in vitro transport measurements: Michaelis-Menten kinetic analysis to estimate the affinity of P-glycoprotein to drugs.

T. Ishikawa, H. Nakagawa, S. Yamashita, 2006, Biological & pharmaceutical bulletin.

3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents.

C. Müller, M. Gütschow, A. Kawaguchi, 2021, Journal of medicinal chemistry.

Oseltamivir (Tamiflu) Efflux Transport at the Blood-Brain Barrier via P-Glycoprotein

T. Fujita, I. Tamai, T. Ogihara, 2008, Drug Metabolism and Disposition.

Expression levels of human P-glycoprotein in in vitro cell lines: correlation between mRNA and protein levels for P-glycoprotein expressed in cells.

S. Yamashita, T. Sakaeda, Y. Shirasaka, 2009, Biopharmaceutics & drug disposition.

Transport characteristics of L‐citrulline in renal apical membrane of proximal tubular cells

T. Nakanishi, I. Tamai, Masanobu Sato, 2009, Biopharmaceutics & drug disposition.

Identification and functional characterization of uric acid transporter Urat1 (Slc22a12) in rats.

T. Nakanishi, I. Tamai, Masanobu Sato, 2011, Biochimica et biophysica acta.

Functional characterization of apical transporters expressed in rat proximal tubular cells (PTCs) in primary culture.

T. Nakanishi, I. Tamai, Masato Kobayashi, 2011, Molecular pharmaceutics.

Organic Cation Transporter-Mediated Renal Secretion of Ipratropium and Tiotropium in Rats and Humans

T. Nakanishi, I. Tamai, Y. Shirasaka, 2011, Drug Metabolism and Disposition.

Model Analysis of the Apparent Saturation Kinetics of Purine Nucleobase Uptake in Cells co-Expressing Transporter and Metabolic Enzyme

Katsuhisa Inoue, I. Tamai, Y. Shirasaka, 2021, Pharmaceutical Research.

Quantitation of talinolol in rat plasma by LC-MS-MS.

I. Tamai, P. Langguth, Y. Shirasaka, 2010, Journal of chromatographic science.

Transport of ipratropium, an anti-chronic obstructive pulmonary disease drug, is mediated by organic cation/carnitine transporters in human bronchial epithelial cells: implications for carrier-mediated pulmonary absorption.

T. Nakanishi, I. Tamai, J. Keogh, 2010, Molecular pharmaceutics.

Microsoft Word-30462222-file00.docx

E. Schuetz, Shuoguo Wang, K. Thummel, 2015 .

Oseltamivir (Tamiflu) Is a Substrate of Peptide Transporter 1

I. Tamai, T. Ogihara, K. Morimoto, 2009, Drug Metabolism and Disposition.

Involvement of choline transporter-like proteins, CTL1 and CTL2, in glucocorticoid-induced acceleration of phosphatidylcholine synthesis via increased choline uptake.

T. Nakanishi, I. Tamai, N. Ishiguro, 2010, Biological & pharmaceutical bulletin.

110110_Text for DMD_Revised Ipra&OCT (clear)

T. Nakanishi, I. Tamai, Y. Shirasaka, 2010 .

Y. Naito, T. Yoshikawa, N. Yagi, 2013, Cellular Physiology and Biochemistry.

Major active components in grapefruit, orange, and apple juices responsible for OATP2B1-mediated drug interactions.

T. Nakanishi, I. Tamai, Takanori Mori, 2013, Journal of pharmaceutical sciences.

Involvement of functional groups on the surface of carboxyl group-terminated polyamidoamine dendrimers bearing arbutin in inhibition of Na⁺/glucose cotransporter 1 (SGLT1)-mediated D-glucose uptake.

M. Akashi, T. Kida, Y. Masaoka, 2012, Molecular pharmaceutics.

Stabilization of enzyme-susceptible glucoside bonds of phloridzin through conjugation with poly(gamma-glutamic acid).

M. Akashi, T. Kida, Y. Masaoka, 2009, Journal of controlled release : official journal of the Controlled Release Society.

Utilization of Sodium Nitroprusside as an Intestinal Permeation Enhancer for Lipophilic Drug Absorption Improvement in the Rat Proximal Intestine

Katsuhisa Inoue, Y. Shirasaka, Hisanao Kishimoto, 2021, Molecules.

Effects of angiotensin II receptor blockers on renal handling of uric acid in rats.

I. Tamai, Masanobu Sato, Y. Shirasaka, 2008, Drug metabolism and pharmacokinetics.

Identification of 5-Carboxyfluorescein as a Probe Substrate of SLC46A3 and Its Application in a Fluorescence-Based In Vitro Assay Evaluating the Interaction with SLC46A3.

Katsuhisa Inoue, Y. Shirasaka, T. Takada, 2022, Molecular pharmaceutics.

Renal secretion of uric acid by organic anion transporter 2 (OAT2/SLC22A7) in human.

T. Nakanishi, N. Anzai, I. Tamai, 2010, Biological & pharmaceutical bulletin.

Characterization of Aripiprazole Uptake Transporter in the Blood-Brain Barrier Model hCMEC/D3 Cells by Targeted siRNA Screening

H. Arakawa, I. Tamai, Y. Shirasaka, 2022, Pharmaceutical Research.

The effects of the SLCO2B1 c.1457C>T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans

T. Ohyama, K. Ohashi, I. Tamai, 2011, Pharmacogenetics and genomics.

Carboxyl group-terminated polyamidoamine dendrimers bearing glucosides inhibit intestinal hexose transporter-mediated D-glucose uptake.

M. Akashi, T. Kida, Y. Masaoka, 2010, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Food effects on gastrointestinal physiology and drug absorption.

Y. Shirasaka, A. Kambayashi, 2022, Drug metabolism and pharmacokinetics.

Inhibition of CYP2C19 and CYP3A4 by Omeprazole Metabolites and Their Contribution to Drug-Drug Interactions

N. Isoherranen, C. Davis, Y. Shirasaka, 2013, Drug Metabolism and Disposition.

Inhibition of CYP 2 C 19 and CYP 3 A 4 by Omeprazole Metabolites and Their Contribution to Drug-Drug Interactions s

N. Isoherranen, C. Davis, Y. Shirasaka, 2013 .

Atenolol Renal Secretion Is Mediated by Human Organic Cation Transporter 2 and Multidrug and Toxin Extrusion Proteins

Joanne Wang, B. Prasad, Y. Shirasaka, 2015, Drug Metabolism and Disposition.

Atenolol Renal Secretion Is Mediated by Human Organic Cation Transporter 2 ( hOCT 2 ) and Multidrug and Toxin Extrusion Proteins ( hMATEs )

Joanne Wang, B. Prasad, Y. Shirasaka, 2015 .

Hepatic uptake of gamma-butyrobetaine, a precursor of carnitine biosynthesis, in rats.

T. Nakanishi, I. Tamai, Y. Shirasaka, 2009, American journal of physiology. Gastrointestinal and liver physiology.

Species Difference in the Effect of Grapefruit Juice on Intestinal Absorption of Talinolol between Human and Rat

T. Nakanishi, I. Tamai, P. Langguth, 2010, Journal of Pharmacology and Experimental Therapeutics.

Evaluation of Platinum Anticancer Drug-Induced Kidney Injury in Primary Culture of Rat Kidney Tissue Slices by Using Gas-Permeable Plates.

H. Arakawa, I. Tamai, Y. Shirasaka, 2022, Biological & pharmaceutical bulletin.

Carnitine precursor γ-butyrobetaine is a novel substrate of the Na(+)- and Cl(-)-dependent GABA transporter Gat2.

T. Nakanishi, I. Tamai, Y. Shirasaka, 2011, Drug metabolism and pharmacokinetics.

Hepatic uptake of -butyrobetaine, a precursor of carnitine biosynthesis, in rats

T. Nakanishi, I. Tamai, Y. Shirasaka, 2009 .

Osmolality of Orally Administered Solutions Influences Luminal Water Volume and Drug Absorption in Intestine.

Katsuhisa Inoue, Y. Shirasaka, Hisanao Kishimoto, 2017, Journal of pharmaceutical sciences.

The CYP2C19 Intron 2 Branch Point SNP is the Ancestral Polymorphism Contributing to the Poor Metabolizer Phenotype in Livers with CYP2C19*35 and CYP2C19*2 Alleles

D. Finkelstein, Gang Wu, E. Schuetz, 2015, Drug Metabolism and Disposition.

The CYP 2 C 19 Intron 2 Branch Point SNP is the Ancestral Polymorphism Contributing to the Poor Metabolizer Phenotype in Livers with CYP 2 C 19 * 35 and CYP 2 C 19 * 2 Alleles s

D. Finkelstein, Gang Wu, E. Schuetz, 2015 .

The Glycosylated N-Terminal Domain of MUC1 Is Involved in Chemoresistance by Modulating Drug Permeation Across the Plasma Membrane

Katsuhisa Inoue, Y. Shirasaka, Hisanao Kishimoto, 2022, Molecular Pharmacology.

Intestinal absorption mechanism of tebipenem pivoxil, a novel oral carbapenem: involvement of human OATP family in apical membrane transport.

I. Tamai, Y. Shirasaka, T. Kurosawa, 2010, Molecular pharmaceutics.

Effect of CYP3A5 Expression on the Inhibition of CYP3A-Catalyzed Drug Metabolism: Impact on Modeling CYP3A-Mediated Drug-Drug Interactions

A. D. Rodrigues, N. Isoherranen, K. Thummel, 2013, Drug Metabolism and Disposition.

Microsoft Word-40409234-file00.docx

A. D. Rodrigues, N. Isoherranen, Y. Shirasaka, 2013 .

Impact of CYP 3 A 5 Expression on the Inhibition of CYP 3 A-Catalyzed Drug Metabolism : Considerations for Modeling CYP 3 A-Mediated Drug-Drug Interactions

A. D. Rodrigues, N. Isoherranen, K. Thummel, 2013 .

Effect of CYP 3 A 5 Expression on the Inhibition of CYP 3 A-Catalyzed Drug Metabolism : Impact on Modeling CYP 3 A-Mediated Drug-Drug Interactions s

A. D. Rodrigues, N. Isoherranen, K. Thummel, 2013 .

Effect of Ingested Fluid Volume and Solution Osmolality on Intestinal Drug Absorption: Impact on Drug Interaction with Beverages.

Katsuhisa Inoue, Y. Shirasaka, M. Takemura, 2022, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Interspecies comparison of the functional characteristics of plasma membrane monoamine transporter (PMAT) between human, rat and mouse

Joanne Wang, Y. Shirasaka, Horace T. B. Ho, 2017, Journal of Chemical Neuroanatomy.

Intestinal absorption of HMG-CoA reductase inhibitor pitavastatin mediated by organic anion transporting polypeptide and P-glycoprotein/multidrug resistance 1.

T. Nakanishi, I. Tamai, Y. Shirasaka, 2011, Drug metabolism and pharmacokinetics.

Quantitative Analysis of Gastrointestinal Water Dynamics by Means of a Physiologically Based Fluid Kinetic Model

Katsuhisa Inoue, I. Tamai, Y. Shirasaka, 2023, The AAPS Journal.

Apple-derived extracellular vesicles modulate the expression of human intestinal bile acid transporter ASBT/SLC10A2 via downregulation of transcription factor RARα.

I. Tamai, T. Nishiuchi, Hisakazu Komori, 2023, Drug metabolism and pharmacokinetics.

Major active components in grapefruit, orange, and apple juices responsible for OATP2B1-mediated drug interactions.

T. Nakanishi, I. Tamai, Takanori Mori, 2013, Journal of pharmaceutical sciences.

Functional characterization of monocarboxylate transporter 12 (SLC16A12/MCT12) as a facilitative creatine transporter.

Katsuhisa Inoue, Y. Shirasaka, Hisanao Kishimoto, 2020, Drug metabolism and pharmacokinetics.

A role of prostaglandin transporter in regulating PGE₂ release from human bronchial epithelial BEAS-2B cells in response to LPS.

T. Nakanishi, I. Tamai, K. Hayashi, 2013, The Journal of endocrinology.

Mucins are Involved in the Intestinal Permeation of Lipophilic Drugs in the Proximal Region of Rat Small Intestine

Katsuhisa Inoue, Y. Shirasaka, Hisanao Kishimoto, 2019, Pharmaceutical Research.

Induction of human P-glycoprotein in Caco-2 cells: development of a highly sensitive assay system for P-glycoprotein-mediated drug transport.

S. Yamashita, T. Sakaeda, K. Okumura, 2006, Drug metabolism and pharmacokinetics.

Intestinal Absorption of HMG-CoA Reductase Inhibitor Pravastatin Mediated by Organic Anion Transporting Polypeptide

T. Nakanishi, I. Tamai, Y. Shirasaka, 2010, Pharmaceutical Research.

SLC46A3 is a lysosomal proton-coupled steroid conjugate and bile acid transporter involved in transport of active catabolites of T-DM1

Katsuhisa Inoue, Y. Shirasaka, T. Takada, 2022, PNAS nexus.

Ictal 99mTc-HMPAO SPECT in alternating hemiplegia.

H. Hattori, T. Okuno, H. Mikawa, 1991, Pediatric neurology.

CD38 assigns physiological function to soluble uric acid

H. Arakawa, H. Higashida, S. Yokoyama, 2023, bioRxiv.

Induction of open-form bile canaliculus formation by hepatocytes for evaluation of biliary drug excretion

H. Arakawa, I. Tamai, Y. Shirasaka, 2023, Communications biology.

The use of carboxyfluorescein reveals the transport function of MCT6/SLC16A5 associated with CD147 as a chloride-sensitive organic anion transporter in mammalian cells.

Y. Shirasaka, Takahito Furuya, Asuka Shimura, 2023, Journal of pharmaceutical sciences.

Expression levels of human P-glycoprotein in in vitro cell lines: correlation between mRNA and protein levels for P-glycoprotein expressed in cells.

S. Yamashita, T. Sakaeda, Y. Shirasaka, 2009, Biopharmaceutics & drug disposition.