C. Hilgendorf

发表

IMI – Oral biopharmaceutics tools project – Evaluation of bottom‐up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

Amitava Mitra, Jian Lin, Mai Anh Nguyen, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Special Section on Prediction of Human Pharmacokinetic Parameters from In Vitro Systems Utility of In Vitro Systems and Preclinical Data for the Prediction of Human Intestinal First-Pass Metabolism during Drug Discovery and Preclinical Development s

Fredrik H. Karlsson, S. Peters, H. Dolgos, 2013 .

Utility of In Vitro Systems and Preclinical Data for the Prediction of Human Intestinal First-Pass Metabolism during Drug Discovery and Preclinical Development

Hugues Dolgos, Fredrik H Karlsson, Sheila Annie Peters, 2013, Drug Metabolism and Disposition.

IMI – Oral biopharmaceutics tools project – Evaluation of bottom‐up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results

Amitava Mitra, Jian Lin, Mai Anh Nguyen, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties

Richard Svensson, Giovanni Muncipinto, Fabrizio Giordanetto, 2014, Journal of medicinal chemistry.

The Effects of Pregnenolone 16α-Carbonitrile Dosing on Digoxin Pharmacokinetics and Intestinal Absorption in the Rat

N. Simmons, A. Ungell, J. Karlsson, 2010, Pharmaceutics.

Digoxin net secretory transport in bronchial epithelial cell layers is not exclusively mediated by P-glycoprotein/MDR1.

D. Pritchard, Alan P Brown, C. Bosquillon, 2014, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Evaluation of layers of the rat airway epithelial cell line RL-65 for permeability screening of inhaled drug candidates.

D. Pritchard, C. Bosquillon, C. Hilgendorf, 2012, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Gut Wall Metabolism. Application of Pre-Clinical Models for the Prediction of Human Drug Absorption and First-Pass Elimination

A. Ungell, A. Rostami-Hodjegan, S. Peters, 2016, The AAPS Journal.

Development of a Highly Sensitive Method Using Liquid Chromatography-Multiple Reaction Monitoring to Quantify Membrane P-Glycoprotein in Biological Matrices and Relationship to Transport Function

T. Andersson, T. Miliotis, J. Palm, 2011, Drug Metabolism and Disposition.

High-Activity P-Glycoprotein, Multidrug Resistance Protein 2, and Breast Cancer Resistance Protein Membrane Vesicles Prepared from Transiently Transfected Human Embryonic Kidney 293-Epstein-Barr Virus Nuclear Antigen Cells

T. Andersson, A. Rozkov, J. Karlsson, 2010, Drug Metabolism and Disposition.

In Vitro Assessment of the Drug–Drug Interaction Potential of Verinurad and Its Metabolites as Substrates and Inhibitors of Metabolizing Enzymes and Drug Transporters

Caroline A. Lee, T. Andersson, F. Erlandsson, 2021, The Journal of Pharmacology and Experimental Therapeutics.

Discovery of the Fibrinolysis Inhibitor AZD6564, Acting via Interference of a Protein-Protein Interaction.

W. Lindberg, A. Plowright, Yafeng Xue, 2014, ACS medicinal chemistry letters.

Cationic uremic toxins affect human renal proximal tubule cell functioning through interaction with the organic cation transporter

L. P. Van den Heuvel, L. Gustavsson, L. Heuvel, 2013, Pflügers Archiv - European Journal of Physiology.

Selective downregulation of the MDR1 gene product in Caco-2 cells by stable transfection to prove its relevance in secretory drug transport.

C. Regårdh, B. Löwenadler, P. Langguth, 2005, Molecular pharmaceutics.

High activity P-gp, MRP2 and BCRP membrane vesicles prepared from transiently transfected HEK293-EBNA cells

A. Rozkov, J. Karlsson, C. Heddle, 2010 .

Tenapanor administration and the activity of the H+‐coupled transporter PepT1 in healthy volunteers

E. Lisbon, J. Palm, C. Hilgendorf, 2017, British journal of clinical pharmacology.

Caco-2 versus Caco-2/HT29-MTX co-cultured cell lines: permeabilities via diffusion, inside- and outside-directed carrier-mediated transport.

G L Amidon, P Langguth, G. Amidon, 2000, Journal of pharmaceutical sciences.

Microsoft Word-42761122-file00.docx

S. Peters, H. Dolgos, C. Hilgendorf, 2013 .

Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories.

P. Artursson, R. Hayeshi, A. Ungell, 2008, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Expression of Thirty-six Drug Transporter Genes in Human Intestine, Liver, Kidney, and Organotypic Cell Lines

Per Artursson, P. Artursson, A. Ungell, 2007, Drug Metabolism and Disposition.

Characterization of THLE-Cytochrome P450 (P450) Cell Lines: Gene Expression Background and Relationship to P450-Enzyme Activity

Marie M. Ahlström, Alison J. Foster, J. G. Kenna, 2012, Drug Metabolism and Disposition.

A Human Renal Proximal Tubule Cell Line with Stable Organic Anion Transporter 1 and 3 Expression Predictive for Antiviral-Induced Toxicity

R. Masereeuw, M. Wilmer, T. Nieskens, 2016, The AAPS Journal.

Primary human hepatocytes spheroid model as a 3D in vitro platform for metabolism studies.

T. Andersson, Kajsa P. Kanebratt, Anna Vildhede, 2020, Journal of pharmaceutical sciences.

Endogenous Gene and Protein Expression of Drug-Transporting Proteins in Cell Lines Routinely Used in Drug Discovery Programs

M. Uhlén, C. Szigyarto, P. Artursson, 2009, Drug Metabolism and Disposition.

P-Glycoprotein (P-gp) mediated efflux in Caco-2 cell monolayers: the influence of culturing conditions and drug exposure on P-gp expression levels.

P Langguth, W. Rubas, H. Merkle, 1998, Journal of pharmaceutical sciences.

Variability in mRNA expression of ABC- and SLC-transporters in human intestinal cells: comparison between human segments and Caco-2 cells.

A. Ungell, J. Karlsson, C. Hilgendorf, 2006, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Mass Spectrometry Imaging proves differential absorption profiles of well-characterised permeability markers along the crypt-villus axis

P. Andrén, R. Goodwin, A. Nilsson, 2017, Scientific Reports.

Characterization of binding properties to human P-glycoprotein: development of a [3H]verapamil radioligand-binding assay.

T. Andersson, C. Regårdh, P. Langguth, 1999, The Journal of pharmacology and experimental therapeutics.

Understanding the Critical Disposition Pathways of Statins to Assess Drug–Drug Interaction Risk During Drug Development: It's Not Just About OATP1B1

C. Hilgendorf, K. Fenner, R. Elsby, 2012, Clinical pharmacology and therapeutics.

Structural and conformational determinants of macrocycle cell permeability.

Ulf Norinder, Christian Tyrchan, Giovanni Muncipinto, 2016, Nature chemical biology.

In Vitro Intrinsic Permeability: A Transporter-Independent Measure of Caco-2 Cell Permeability in Drug Design and Development.

Susanne Winiwarter, Linda Fredlund, S. Winiwarter, 2017, Molecular pharmaceutics.

Resolving the distribution-metabolism interplay of eight OATP substrates in the standard clearance assay with suspended human cryopreserved hepatocytes.

S. Winiwarter, C. Hilgendorf, Pär Nordell, 2013, Molecular pharmaceutics.

Excised segments of rat small intestine in Ussing chamber studies: A comparison of native and stripped tissue viability and permeability to drugs.

E. Sjögren, C. Hilgendorf, Charlotta Vedin, 2016, International journal of pharmaceutics.

Innovative Methods to Study Human Intestinal Drug Metabolism in Vitro: Precision-Cut Slices Compared with Ussing Chamber Preparations

M. D. de Jager, I. A. D. de Graaf, G. Groothuis, 2006, Drug Metabolism and Disposition.

Industrial approach to determine the relative contribution of seven major UGT isoforms to hepatic glucuronidation.

C. Hilgendorf, M. Darnell, D. Busse, 2020, Journal of pharmaceutical sciences.

Gut Wall Metabolism. Application of Pre-Clinical Models for the Prediction of Human Drug Absorption and First-Pass Elimination

A. Ungell, A. Rostami-Hodjegan, S. Peters, 2016, The AAPS Journal.

Prediction of fraction metabolized via CYP3A in humans utilizing cryopreserved human hepatocytes from a set of 12 single donors

P. Bachellier, A. Ungell, C Hilgendorf, 2014, Xenobiotica; the fate of foreign compounds in biological systems.

Cationic uremic toxins affect human renal proximal tubule cell functioning through interaction with the organic cation transporter

L. Gustavsson, L. Heuvel, J. Hoenderop, 2013, Pflügers Archiv - European Journal of Physiology.

Expression of 36 drug transporter genes in human intestine, liver, kidney, and organotypic cell lines

Per Artursson, P. Artursson, A. Ungell, 2007 .

Mass Spectrometry Imaging proves differential absorption profiles of well-characterised permeability markers along the crypt-villus axis

P. Andrén, R. Goodwin, A. Nilsson, 2017, Scientific Reports.

Industry Perspective on Therapeutic Peptide Drug–Drug Interaction Assessments During Drug Development: A European Federation of Pharmaceutical Industries and Associations White Paper

A. Sonesson, Hilmar Schiller, U. Argikar, 2023, Clinical pharmacology and therapeutics.

Metabolism and Excretion of Therapeutic Peptides: Current Industry Practices, Perspectives, and Recommendations

Joe R. Cannon, C. Hilgendorf, M. Gunduz, 2023, Drug Metabolism and Disposition.