M. Fridén

发表

Development of a Novel Lung Slice Methodology for Profiling of Inhaled Compounds.

Margareta Hammarlund-Udenaes, Petter Svanberg, Markus Fridén, 2016, Journal of pharmaceutical sciences.

Systems Pharmacology Approach for Prediction of Pulmonary and Systemic Pharmacokinetics and Receptor Occupancy of Inhaled Drugs

A. Lundqvist, E. Boger, P. Ewing, 2016, CPT: pharmacometrics & systems pharmacology.

On The Rate and Extent of Drug Delivery to the Brain

Stina Syvänen, Margareta Hammarlund-Udenaes, Anubha Gupta, 2007, Pharmaceutical Research.

Improved Measurement of Drug Exposure in the Brain Using Drug-Specific Correction for Residual Blood

Ulf Bredberg, Margareta Hammarlund-Udenaes, Brian Middleton, 2010, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain—a Game Changing Parameter for CNS Drug Discovery and Development

S. Summerfield, C. Bundgaard, G. Terstappen, 2022, Pharmaceutical Research.

Exploring in silico prediction of the unbound brain-to-plasma drug concentration ratio: model validation, renewal, and interpretation.

Jonna C. Stålring, L. Carlsson, O. Engkvist, 2015, Journal of pharmaceutical sciences.

In Vitro Methods for Estimating Unbound Drug Concentrations in the Brain Interstitial and Intracellular Fluids

U. Bredberg, M. Hammarlund-Udenaes, M. Fridén, 2007, Drug Metabolism and Disposition.

Methodologies to assess brain drug delivery in lead optimization.

U. Bredberg, M. Hammarlund-Udenaes, M. Fridén, 2009, Current topics in medicinal chemistry.

Pulmonary PET imaging confirms preferential lung target occupancy of an inhaled bronchodilator

C. Halldin, L. Farde, A. Takano, 2019, EJNMMI Research.

Computational modeling of lung deposition of inhaled particles in chronic obstructive pulmonary disease (COPD) patients: identification of gaps in knowledge and data

K. Ganguly, G. Johanson, U. Eriksson, 2019, Critical reviews in toxicology.

Prediction of Drug Exposure in the Brain from the Chemical Structure

M. Fridén, 2014 .

Lung pharmacokinetics of inhaled and systemic drugs: A clinical evaluation

J. Hohlfeld, O. Holz, U. Eriksson, 2021, British journal of pharmacology.

Possible extraction of drugs from lung tissue during broncho-alveolar lavage suggest uncertainty in the procedure's utility for quantitative assessment of airway drug exposure.

K. Grime, E. Bäckström, M. Fridén, 2021, Journal of pharmaceutical sciences.

Translational model to predict pulmonary pharmacokinetics and efficacy in man for inhaled bronchodilators

U. Eriksson, K. Grime, M. Fridén, 2017, CPT: pharmacometrics & systems pharmacology.

Benchmarking of Human Dose Prediction for Inhaled Medicines from Preclinical In Vivo Data

K. Grime, M. Fridén, I. Dainty, 2017, Pharmaceutical Research.

Identification of positron emission tomography (PET) tracer candidates by prediction of the target-bound fraction in the brain

L. Farde, M. Schou, M. Fridén, 2014, EJNMMI Research.

Building on the success of osimertinib: achieving CNS exposure in oncology drug discovery.

P. Johnström, N. Colclough, D. Mcginnity, 2019, Drug discovery today.

Simultaneous determination of renal plasma flow and glomerular filtration rate in conscious mice using dual bolus injection.

M. Fridén, J. Sällström, 2013, Journal of pharmacological and toxicological methods.

Understanding the influence of nanocarrier-mediated brain delivery on therapeutic performance through pharmacokinetic-pharmacodynamic modeling.

M. Hammarlund-Udenaes, M. Fridén, Yang Hu, 2019, Journal of pharmaceutical sciences.

Uncovering the regional localization of inhaled salmeterol retention in the lung

Nicole Strittmatter, P. Andrén, G. Hamm, 2018, Drug delivery.

Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids.

Susanne Winiwarter, Ulf Bredberg, Margareta Hammarlund-Udenaes, 2009, Journal of medicinal chemistry.

Measurement of Unbound Drug Exposure in Brain: Modeling of pH Partitioning Explains Diverging Results between the Brain Slice and Brain Homogenate Methods

Ulf Bredberg, Margareta Hammarlund-Udenaes, Fredrik Bergström, 2011, Drug Metabolism and Disposition.

Mechanisms of a Sustained Anti‐inflammatory Drug Response in Alveolar Macrophages Unraveled with Mathematical Modeling

G. Cedersund, E. Nyman, William Lövfors, 2020, CPT: pharmacometrics & systems pharmacology.

Mechanisms of a sustained anti-inflammatory drug response in alveolar macrophages unraveled with mathematical modeling

G. Cedersund, E. Nyman, William Lövfors, 2020, bioRxiv.

The brain slice method for studying drug distribution in the CNS

M. Hammarlund-Udenaes, M. Fridén, I. Loryan, 2013, Fluids and Barriers of the CNS.

Revealing the Regional Localization and Differential Lung Retention of Inhaled Compounds by Mass Spectrometry Imaging.

Nicole Strittmatter, P. Andrén, M. Brülls, 2020, Journal of aerosol medicine and pulmonary drug delivery.

A Novel In Vivo Receptor Occupancy Methodology for the Glucocorticoid Receptor: Toward An Improved Understanding of Lung Pharmacokinetic/Pharmacodynamic Relationships

U. Eriksson, E. Boger, P. Ewing, 2015, The Journal of Pharmacology and Experimental Therapeutics.

Current Progress Toward a Better Understanding of Drug Disposition Within the Lungs: Summary Proceedings of the First Workshop on Drug Transporters in the Lungs.

Mark Gumbleton, Tetsuya Terasaki, William Couet, 2017, Journal of pharmaceutical sciences.

DRUG-DRUG INTERACTIONS OF ANTI-INFECTIVE DRUGS: UTILITY OF FLUORESCENCE CYP INHIBITION ASSAYS IN DRUG DISCOVERY

V. Nandi, M. Fridén, K. Vanaja, 2006, Drug metabolism and drug interactions.

Development of a High-Throughput Brain Slice Method for Studying Drug Distribution in the Central Nervous System

Ulf Bredberg, Frederic Ducrozet, Margareta Hammarlund-Udenaes, 2009, Drug Metabolism and Disposition.

Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Accurately Predicts the Better Bronchodilatory Effect of Inhaled Versus Oral Salbutamol Dosage Forms.

E. Boger, M. Fridén, 2019, Journal of aerosol medicine and pulmonary drug delivery.

Lung Retention by Lysosomal Trapping of Inhaled Drugs Can Be Predicted In Vitro With Lung Slices.

E. Bäckström, A. Lundqvist, E. Boger, 2016, Journal of pharmaceutical sciences.

Pharmacokinetic considerations of nanodelivery to the brain: Using modeling and simulations to predict the outcome of liposomal formulations.

A. Lindqvist, M. Hammarlund-Udenaes, M. Fridén, 2016, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

In silico prediction of unbound brain-to-plasma concentration ratio using machine learning algorithms.

Ola Engkvist, Susanne Winiwarter, Hongming Chen, 2011, Journal of molecular graphics & modelling.

Drug distribution in lung tissue

E. Bäckström, M. Fridén, 2021, Inhaled Medicines.

Exploring in silico prediction of the unbound brain-to-plasma drug concentration ratio: model validation, renewal, and interpretation.

Jonna C. Stålring, L. Carlsson, O. Engkvist, 2015, Journal of pharmaceutical sciences.

In Vitro Methods for Estimating Unbound Drug Concentrations in the Brain Interstitial and Intracellular Fluids

U. Bredberg, M. Hammarlund-Udenaes, M. Fridén, 2007, Drug Metabolism and Disposition.