A. Kaddoumi

发表

Development of a Physiologically Based Pharmacokinetic/Pharmacodynamic Model to Predict the Impact of Genetic Polymorphisms on the Pharmacokinetics and Pharmacodynamics Represented by Receptor/Transporter Occupancy of Central Nervous System Drugs

S. Alqahtani, A. Kaddoumi, 2016, Clinical Pharmacokinetics.

Development of Physiologically Based Pharmacokinetic/Pharmacodynamic Model for Indomethacin Disposition in Pregnancy

Saeed Alqahtani, S. Alqahtani, A. Kaddoumi, 2015, PloS one.

Development of a physiologically based pharmacokinetic/pharmacodynamic model to identify mechanisms contributing to entacapone low bioavailability

S. Alqahtani, A. Kaddoumi, 2015, Biopharmaceutics & drug disposition.

Oleocanthal-Rich Extra-Virgin Olive Oil Restores the Blood-Brain Barrier Function through NLRP3 Inflammasome Inhibition Simultaneously with Autophagy Induction in TgSwDI Mice.

A. Kaddoumi, Sweilem B Al Rihani, Lucy I. Darakjian, 2019, ACS chemical neuroscience.

Exposure of LS-180 cells to drugs of diverse physicochemical and therapeutic properties up-regulates P-glycoprotein expression and activity.

A. Kaddoumi, Alaa H. Abuznait, S. G. Patrick, 2011, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

Nonlinear Absorption Kinetics of Self-Emulsifying Drug Delivery Systems (SEDDS) Containing Tocotrienols as Lipophilic Molecules: In Vivo and In Vitro Studies

P. Sylvester, S. Nazzal, A. Alayoubi, 2013, The AAPS Journal.

Factors influencing regional differences in intestinal absorption of UK-343,664 in rat: possible role in dose-dependent pharmacokinetics.

D. Fleisher, T. Heimbach, A. Kaddoumi, 2006, Journal of pharmaceutical sciences.

Dexamethasone eluting 3D printed metal devices for bone injuries.

J. Pegues, N. Shamsaei, Seungjong Lee, 2020, Therapeutic delivery.

Liquid chromatography studies on the pharmacokinetics of phentermine and fenfluramine in brain and blood microdialysates after intraperitoneal administration to rats.

Y. Matsumura, J. Nakamura, T. Maki, 2003, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

High performance liquid chromatography with UV detection for the simultaneous determination of sympathomimetic amines using 4-(4,5-diphenyl-1H-imidazole-2-yl)benzoyl chloride as a label.

A. Kaddoumi, M. Nakashima, M. Takahashi, 2001, Biomedical chromatography : BMC.

HPLC OF (±)-FENFLURAMINE AND PHENTERMINE IN PLASMA AFTER DERIVATIZATION WITH DANSYL CHLORIDE

N. Kuroda, A. Kaddoumi, M. Nakashima, 2001 .

Fluorometric determination of DL-fenfluramine, DL-norfenfluramine and phentermine in plasma by achiral and chiral high-performance liquid chromatography.

A. Kaddoumi, M. Nakashima, K. Nakashima, 2001, Journal of chromatography. B, Biomedical sciences and applications.

Experimental models for predicting drug absorption and metabolism

S. Alqahtani, A. Kaddoumi, Loqman A. Mohamed, 2013, Expert opinion on drug metabolism & toxicology.

Simultaneous PET Imaging of P-Glycoprotein Inhibition in Multiple Tissues in the Pregnant Nonhuman Primate

F. O’Sullivan, D. Mankoff, M. Muzi, 2009, Journal of Nuclear Medicine.

Role of ABC transporters in the pathogenesis of Alzheimer's disease.

A. Kaddoumi, Alaa H. Abuznait, 2012, ACS chemical neuroscience.

EGFR targeted delivery of paclitaxel and parthenolide co-loaded in PEG-Phospholipid micelles enhance cytotoxicity and cellular uptake in non-small cell lung cancer cells

S. Nazzal, A. Kaddoumi, K. K. Gill, 2016 .

Novel liquid-liquid extraction and self-emulsion methods for simplified isolation of extra-virgin olive oil phenolics with emphasis on (-)-oleocanthal and its oral anti-breast cancer activity

A. Siddique, S. Nazzal, Hassan Y. Ebrahim, 2019, PloS one.

Genomics and pharmacogenomics of breast cancer: current knowledge and trends.

N. Ayoub, A. Kaddoumi, Courtney Lucas, 2011, Asian Pacific journal of cancer prevention : APJCP.

ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10 (ABCC10) are not primary resistance factors for cabazitaxel

S. Ambudkar, Zhe-Sheng Chen, S. Shukla, 2015, Chinese journal of cancer.

The marine natural-derived inhibitors of glycogen synthase kinase-3beta phenylmethylene hydantoins: In vitro and in vivo activities and pharmacophore modeling.

M. Khanfar, K. E. El Sayed, A. Kaddoumi, 2009, Bioorganic & medicinal chemistry.

Oleocanthal Enhances Amyloid-β Clearance from the Brains of TgSwDI Mice and in Vitro across a Human Blood-Brain Barrier Model

J. Keller, K. E. El Sayed, A. Kaddoumi, 2015, ACS chemical neuroscience.

Epidermal growth factor receptor (EGFR) inhibitor PD153035 reverses ABCG2-mediated multidrug resistance in non-small cell lung cancer: In vitro and in vivo.

S. Bates, Zhe-Sheng Chen, J. Wurpel, 2018, Cancer letters.

Enhancement of Intestinal Permeability Utilizing Solid Lipid Nanoparticles Increases γ-Tocotrienol Oral Bioavailability

P. Sylvester, S. Nazzal, A. Alayoubi, 2012, Lipids.

Sesamin synergistically potentiates the anticancer effects of γ-tocotrienol in mammary cancer cell lines.

P. Sylvester, M. R. Akl, N. Ayoub, 2013, Fitoterapia.

Semi-micro column HPLC of triazolam in rat plasma and brain microdialysate and its application to drug interaction study with itraconazole.

O. Al-Dirbashi, A. Kaddoumi, M. Nakashima, 2003, Journal of pharmaceutical and biomedical analysis.

High performance liquid chromatographic determination of mazindol in human plasma.

A. Kaddoumi, K. Nakashima, M. Mori, 2001, The Analyst.

Characterization of Hit Compounds Identified from High-throughput Screening for their Effect on Blood–brain Barrier Integrity and Amyloid-β Clearance: In Vitro and In Vivo Studies

Quoc-Viet Duong, A. Kaddoumi, Khaled H. Elfakhri, 2018, Neuroscience.

The Value of Tocotrienols in the Prevention and Treatment of Cancer

P. Sylvester, S. Nazzal, K. E. El Sayed, 2010, Journal of the American College of Nutrition.

Effect of mouse strain as a background for Alzheimer's disease models on the clearance of amyloid-β.

A. Kaddoumi, H. Qosa, Hisham Qosa, 2016, Journal of systems and integrative neuroscience.

Pharmacokinetic interactions between phenylpropanolamine, caffeine and chlorpheniramine in rats.

A. Kaddoumi, M. Nakashima, K. Nakashima, 2004, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

High performance liquid chromatography with fluorescence detection for the determination of phenylpropanolamine in human plasma and rat's blood and brain microdialysates using DIB-Cl as a label.

A. Kaddoumi, M. Nakashima, K. Nakashima, 2004, Journal of pharmaceutical and biomedical analysis.

Nilotinib potentiates anticancer drug sensitivity in murine ABCB1-, ABCG2-, and ABCC10-multidrug resistance xenograft models.

Liwu Fu, Zhe-Sheng Chen, J. Gallo, 2013, Cancer letters.

Crocus sativus Extract Tightens the Blood-Brain Barrier, Reduces Amyloid β Load and Related Toxicity in 5XFAD Mice.

Ajay Kumar, S. Bharate, Sonali S. Bharate, 2017, ACS chemical neuroscience.

Up‐regulation of P‐glycoprotein reduces intracellular accumulation of beta amyloid: investigation of P‐glycoprotein as a novel therapeutic target for Alzheimer's disease

A. Kaddoumi, Courtney M Cain, D. Burk, 2011, The Journal of pharmacy and pharmacology.

Glial Cell-Mediated Neuroinflammation in Alzheimer’s Disease

Amer E. Alkhalifa, A. Kaddoumi, A. Roberts, 2022, International journal of molecular sciences.

In Vitro Investigation of Amyloid-β Hepatobiliary Disposition in Sandwich-Cultured Primary Rat Hepatocytes

A. Kaddoumi, Loqman A. Mohamed, 2013, Drug Metabolism and Disposition.

Intestinal Absorption of γ-Tocotrienol Is Mediated by Niemann-Pick C1-Like 1: In Situ Rat Intestinal Perfusion Studies

P. Sylvester, A. Kaddoumi, Bilal S. Abuasal, 2010, Drug Metabolism and Disposition.

Intestinal Absorption of γ -Tocotrienol is Mediated by NPC1L1: In Situ Rat Intestinal Perfusion Studies

P. Sylvester, A. Kaddoumi, Bilal S. Abuasal, 2010 .

Enhanced Solubility and Oral Bioavailability of γ-Tocotrienol Using a Self-Emulsifying Drug Delivery System (SEDDS)

P. Sylvester, S. Nazzal, A. Alayoubi, 2014, Lipids.

Redox-silent tocotrienol esters as breast cancer proliferation and migration inhibitors.

P. Sylvester, M. R. Akl, K. E. El Sayed, 2010, Bioorganic & medicinal chemistry.

Extra-Virgin Olive Oil Enhances the Blood–Brain Barrier Function in Mild Cognitive Impairment: A Randomized Controlled Trial

T. Denney, R. Beyers, G. Deshpande, 2022, Nutrients.

Pharmacokinetic properties of N-nitrosofenfluramine after its administration to rats.

A. Kaddoumi, K. Nakashima, M. Wada, 2011, Biomedical chromatography : BMC.

In vivo incorporation of fenfluramine and norfenfluramine into pigmented and nonpigmented hair of rats measured by HPLC-fluorescence detection

A. Kaddoumi, K. Nakashima, M. Wada, 2010, Forensic Toxicology.

Masitinib Antagonizes ATP-Binding Cassette Subfamily C Member 10–Mediated Paclitaxel Resistance: A Preclinical Study

Zhe-Sheng Chen, C. Ashby, Kang Chen, 2014, Molecular Cancer Therapeutics.

Mixed micelles of PEG(2000)-DSPE and vitamin-E TPGS for concurrent delivery of paclitaxel and parthenolide: enhanced chemosenstization and antitumor efficacy against non-small cell lung cancer (NSCLC) cell lines.

S. Nazzal, A. Kaddoumi, K. K. Gill, 2012, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Oleocanthalic Acid, a Chemical Marker of Olive Oil Aging and Exposure to a High Storage Temperature with Potential Neuroprotective Activity.

F. Priego-Capote, P. Magiatis, A. Kaddoumi, 2018, Journal of agricultural and food chemistry.

Spontaneous In Vitro and In Vivo Interaction of (-)-Oleocanthal with Glycine in Biological Fluids: Novel Pharmacokinetic Markers.

P. Panizzi, K. E. El Sayed, P. Magiatis, 2021, ACS pharmacology & translational science.

Olive-oil-derived oleocanthal enhances β-amyloid clearance as a potential neuroprotective mechanism against Alzheimer's disease: in vitro and in vivo studies.

K. E. El Sayed, A. Kaddoumi, Alaa H. Abuznait, 2013, ACS chemical neuroscience.

Amyloid-β and Astrocytes Interplay in Amyloid-β Related Disorders

Quoc-Viet Duong, A. Kaddoumi, Sweilem B Al Rihani, 2016, International journal of molecular sciences.

Synthesis and P-glycoprotein induction activity of colupulone analogs.

Ajay Kumar, S. Bharate, R. Vishwakarma, 2015, Organic & biomolecular chemistry.

Discovery of novel GSK-3β inhibitors with potent in vitro and in vivo activities and excellent brain permeability using combined ligand- and structure-based virtual screening.

M. Khanfar, K. E. El Sayed, A. Kaddoumi, 2010, Journal of medicinal chemistry.

Overcoming Poor Aqueous Solubility of Drugs for Oral Delivery

Tycho Heimbach, D. Fleisher, T. Heimbach, 2007 .

PEG–lipid micelles as drug carriers: physiochemical attributes, formulation principles and biological implication

S. Nazzal, A. Kaddoumi, K. K. Gill, 2015, Journal of drug targeting.

High-Throughput Screening for Identification of Blood-Brain Barrier Integrity Enhancers: A Drug Repurposing Opportunity to Rectify Vascular Amyloid Toxicity.

J. Keller, Quoc-Viet Duong, A. Kaddoumi, 2016, Journal of Alzheimer's disease : JAD.

Cellular uptake, antioxidant and antiproliferative activity of entrapped α-tocopherol and γ-tocotrienol in poly (lactic-co-glycolic) acid (PLGA) and chitosan covered PLGA nanoparticles (PLGA-Chi).

P. Sylvester, S. Nazzal, C. Astete, 2015, Journal of colloid and interface science.

Physiologically Based Pharmacokinetic/Pharmacodynamic Model for Caffeine Disposition in Pregnancy.

A. Kaddoumi, Lucy I. Darakjian, 2019, Molecular pharmaceutics.

HPLC determination of phenylpropanolamine in pharmaceutical OTC preparations.

A. Kaddoumi, K. Nakashima, Saori Kanehara, 2002, Biomedical chromatography : BMC.

Comparison of the intestinal absorption and bioavailability of γ‐tocotrienol and α‐tocopherol: in vitro, in situ and in vivo studies

P. Sylvester, A. Kaddoumi, Bilal S. Abuasal, 2012, Biopharmaceutics & drug disposition.

Crocetin promotes clearance of amyloid-β by inducing autophagy via the STK11/LKB1-mediated AMPK pathway

Ajay Kumar, S. Bharate, Sonali S. Bharate, 2021, Autophagy.

High-performance liquid chromatography with fluorescence detection for the simultaneous determination of 3,4-methylenedioxymethamphetamine, methamphetamine and their metabolites in human hair using DIB-Cl as a label.

A. Kaddoumi, K. Nakashima, R. Kikura-Hanajiri, 2004, Biomedical chromatography : BMC.

Profiling Gene Expression in Human Placentae of Different Gestational Ages: An OPRU* Network and UW SCOR Study

A. Mikheev, M. Hebert, J. Unadkat, 2008, Reproductive Sciences.

Regorafenib antagonizes BCRP-mediated multidrug resistance in colon cancer.

S. Ambudkar, Zhe-Sheng Chen, S. Shukla, 2019, Cancer letters.

Regorafenib overcomes chemotherapeutic multidrug resistance mediated by ABCB1 transporter in colorectal cancer: In vitro and in vivo study.

S. Ambudkar, Zhe-Sheng Chen, S. Shukla, 2017, Cancer letters.

Development and qualification of an LC-MS/MS method for investigating the biological implications of micelle entrapped paclitaxel in cell culture and rats.

S. Nazzal, A. Kaddoumi, K. K. Gill, 2017, Biomedical chromatography : BMC.

Thiazole-valine peptidomimetic (TTT-28) antagonizes multidrug resistance in vitro and in vivo by selectively inhibiting the efflux activity of ABCB1

Bhargav A. Patel, S. Ambudkar, Zhe-Sheng Chen, 2017, Scientific Reports.

The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated paclitaxel resistance: a preclinical and pharmacokinetic study

Zhe-Sheng Chen, C. Ashby, Kang Chen, 2014, Oncotarget.

Vitamin E Transporters in Cancer Therapy

S. Alqahtani, A. Kaddoumi, 2015, The AAPS Journal.

Alborixin clears amyloid-β by inducing autophagy through PTEN-mediated inhibition of the AKT pathway

Ajay Kumar, S. Bharate, R. Vishwakarma, 2019, Autophagy.

Comparison of Oleocanthal-Low EVOO and Oleocanthal against Amyloid-β and Related Pathology in a Mouse Model of Alzheimer’s Disease

Amer E. Alkhalifa, C. Guillaume, A. Kaddoumi, 2023, Molecules.

Oleuropein-Rich Olive Leaf Extract Attenuates Neuroinflammation in the Alzheimer's Disease Mouse Model.

C. Guillaume, A. Kaddoumi, Kamal M. Al-Shami, 2022, ACS chemical neuroscience.

Oleocanthal-rich extra-virgin olive oil enhances donepezil effect by reducing amyloid-β load and related toxicity in a mouse model of Alzheimer's disease.

A. Kaddoumi, Yazan S. Batarseh, 2017, The Journal of nutritional biochemistry.

Extra-virgin olive oil attenuates amyloid-β and tau pathologies in the brains of TgSwDI mice.

H. Levine, J. Keller, B. Ibrahim, 2015, The Journal of nutritional biochemistry.

Differences in amyloid-β clearance across mouse and human blood–brain barrier models: Kinetic analysis and mechanistic modeling

J. Keller, P. Couraud, I. Romero, 2014, Neuropharmacology.

Paclitaxel loaded PEG(5000)-DSPE micelles as pulmonary delivery platform: formulation characterization, tissue distribution, plasma pharmacokinetics, and toxicological evaluation.

Sami Nazzal, S. Nazzal, A. Kaddoumi, 2011, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Determination of methamphetamine and amphetamine in abusers' plasma and hair samples with HPLC-FL.

A. Kaddoumi, K. Nakashima, K. Taki, 2003, Biomedical chromatography : BMC.

Adult stem cell deficits drive Slc29a3 disorders in mice

Aaron M. Beedle, C. McElroy, A. Sparreboom, 2019, Nature Communications.

Transporters as Drug Targets in Neurological Diseases

S. Alqahtani, A. Kaddoumi, H. Qosa, 2016, Clinical pharmacology and therapeutics.

Hair analysis for fenfluramine and norfenfluramine as biomarkers for N-nitrosofenfluramine ingestion.

A. Kaddoumi, M. Nakashima, K. Nakashima, 2004, Forensic science international.

Oleocanthal ameliorates amyloid-β oligomers’ toxicity on astrocytes and neuronal cells: In vitro studies

A. Siddique, A. Kaddoumi, Loqman A. Mohamed, 2017, Neuroscience.

A. Kaddoumi, H. Qosa, Loqman A. Mohamed, 2015, ACS chemical neuroscience.

Neuroprotective Effects of Extra‐Virgin Olive Oil and its Components in Alzheimer's Disease

A. Kaddoumi, Alaa H. Abuznait, H. Qosa, 2017 .

Role of P-glycoprotein in mediating rivastigmine effect on amyloid-β brain load and related pathology in Alzheimer's disease mouse model.

J. Keller, A. Kaddoumi, Loqman A. Mohamed, 2016, Biochimica et biophysica acta.

Enhanced brain amyloid-β clearance by rifampicin and caffeine as a possible protective mechanism against Alzheimer's disease.

A. Kaddoumi, R. A. Hill, Alaa H. Abuznait, 2012, Journal of Alzheimer's disease : JAD.

Tacrine sinusoidal uptake and biliary excretion in sandwich-cultured primary rat hepatocytes.

A. Kaddoumi, Loqman A. Mohamed, 2014, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

Editorial: Model-informed drug development and evidence-based translational pharmacology

Jinxin Zhao, Yu-Wei Lin, S. Cheung, 2022, Frontiers in Pharmacology.

Nonlinear Absorption Kinetics of Self-Emulsifying Drug Delivery Systems (SEDDS) Containing Tocotrienols as Lipophilic Molecules: In Vivo and In Vitro Studies

P. Sylvester, S. Nazzal, A. Alayoubi, 2013, The AAPS Journal.

PEGylated γ-tocotrienol isomer of vitamin E: Synthesis, characterization, in vitro cytotoxicity, and oral bioavailability.

J. Cardelli, P. Sylvester, S. Nazzal, 2015, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Development and validation of a reversed-phase HPLC method for the determination of γ-tocotrienol in rat and human plasma.

P. Sylvester, A. Kaddoumi, Bilal S. Abuasal, 2011, Biomedical chromatography : BMC.

Blood-Brain Barrier Disruption Increases Amyloid-Related Pathology in TgSwDI Mice

A. Kaddoumi, Euitaek Yang, I. Abdallah, 2021, International journal of molecular sciences.

Plasma Rich in Growth Factors (PRGF) Disrupt the Blood-Brain Barrier Integrity and Elevate Amyloid Pathology in the Brains of 5XFAD Mice

Quoc-Viet Duong, A. Kaddoumi, Andrew Brannen, 2019, International journal of molecular sciences.

Amylin Enhances Amyloid-β Peptide Brain to Blood Efflux Across the Blood-Brain Barrier.

E. Wang, W. Qiu, Haihao Zhu, 2017, Journal of Alzheimer's disease : JAD.

Neuroprotective effects of oleocanthal in neurological disorders

A. Kaddoumi, Yazan S. Batarseh, S. Rihani, 2021 .

Induction of expression and functional activity of P-glycoprotein efflux transporter by bioactive plant natural products.

P. Sylvester, K. E. El Sayed, A. Kaddoumi, 2011, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

In silico modeling for the nonlinear absorption kinetics of UK-343,664: a P-gp and CYP3A4 substrate.

Michael B Bolger, D. Walker, M. Bolger, 2012, Molecular pharmaceutics.

Mixed oligomers and monomeric amyloid-β disrupts endothelial cells integrity and reduces monomeric amyloid-β transport across hCMEC/D3 cell line as an in vitro blood-brain barrier model.

H. Levine, J. Keller, A. Kaddoumi, 2014, Biochimica et biophysica acta.

Granisetron Alleviates Alzheimer's Disease Pathology in TgSwDI Mice Through Calmodulin-Dependent Protein Kinase II/cAMP-Response Element Binding Protein Pathway.

R. Lan, A. Kaddoumi, Sweilem B. Al Rihani, 2019, Journal of Alzheimer's disease : JAD.

Amylin and pramlintide modulate γ-secretase level and APP processing in lipid rafts

A. Kaddoumi, Douglas R. Martin, M. Hwang, 2020, Scientific Reports.

Pentazocine monitoring in rat hair and plasma by HPLC-fluorescence detection with DIB-Cl as a labelling reagent.

A. Kaddoumi, M. Nakashima, K. Nakashima, 2007, Luminescence (Chichester, England Print).

Inhibition of P-glycoprotein Activity at the Primate Blood-Brain Barrier Increases the Distribution of Nelfinavir into the Brain but Not into the Cerebrospinal Fluid

D. Whittington, R. Ho, B. D. Anderson, 2007, Drug Metabolism and Disposition.