H. Komura

发表

Application of a Physiologically Based Pharmacokinetic Model Informed by a Top-Down Approach for the Prediction of Pharmacokinetics in Chronic Kidney Disease Patients

Masahiro Iwaki, M. Iwaki, H. Takubo, 2014, The AAPS Journal.

Development of a hybrid physiologically based pharmacokinetic model with drug-specific scaling factors in rat to improve prediction of human pharmacokinetics.

Masahiro Iwaki, M. Iwaki, Hiroyuki Sayama, 2013, Journal of pharmaceutical sciences.

Application of Hybrid Approach Based on Empirical and Physiological Concept for Predicting Pharmacokinetics in Humans—Usefulness of Exponent on Prospective Evaluation of Predictability

Hiroyuki Sayama, H. Komura, M. Kogayu, 2013, Drug Metabolism and Disposition.

Constructing an in silico three-class predictor of human intestinal absorption with Caco-2 permeability and dried-DMSO solubility.

K. Mizuguchi, Tsuyoshi Esaki, C. Nagao, 2019, Journal of pharmaceutical sciences.

Characterization of gastrointestinal absorption of digoxin involving influx and efflux transporter in rats: application of mdr1a knockout (−/−) rats into absorption study of multiple transporter substrate

Motoya Suzuki, H. Takubo, H. Komura, 2014, Xenobiotica; the fate of foreign compounds in biological systems.

[High throughput screening of pharmacokinetics and metabolism in drug discovery (III)--investigation on in- silico model for membrane permeability and CYP1A2 inhibition].

H. Komura, T. Moriwaki, Yukie Shigemoto, 2005, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Phase Separation in Silica Sol–Gel System Containing Poly(ethylene oxide). I. Phase Relation and Gel Morphology

K. Nakanishi, N. Soga, Ryōji Takahashi, 1994 .

Usefulness of hepatocytes for evaluating the genetic polymorphism of CYP2D6 substrates

M. Iwaki, H. Komura, 2005, Xenobiotica; the fate of foreign compounds in biological systems.

Species differences in in vitro and in vivo small intestinal metabolism of CYP3A substrates.

M. Iwaki, H. Komura, 2008, Journal of pharmaceutical sciences.

Gender difference in relationship between body mass index and development of chronic kidney disease

J. Kato, K. Kitamura, K. Kuwasako, 2013, BMC Research Notes.

Plasma levels of natriuretic peptides and development of chronic kidney disease

J. Kato, K. Kitamura, K. Kuwasako, 2015, BMC Nephrology.

Impaired intrinsic chiral inversion activity of ibuprofen in rats with adjuvant-induced arthritis

M. Iwaki, A. Kawase, H. Komura, 2008, Xenobiotica; the fate of foreign compounds in biological systems.

Strain Differences in the Induction of Cytochrome P450 3A1/3A2 and Nuclear Receptors in the Liver by Phenobarbital and Dexamethasone in Sprague-Dawley Rats and Dark Agouti Rats

M. Iwaki, A. Kawase, H. Komura, 2011 .

Differences in cytochrome P450 and nuclear receptor mRNA levels in liver and small intestines between SD and DA rats.

M. Iwaki, A. Kawase, H. Komura, 2008, Drug metabolism and pharmacokinetics.

Pharmacokinetic analysis of enterohepatic circulation of 4-[2-(4-isopropylbenzamido)ethoxy]benzoic acid. Effect of intramolecular rearrangement of its acyl glucuronide.

H. Sasaki, H. Komura, A. Morino, 1992, Drug metabolism and disposition: the biological fate of chemicals.

Synthesis and structure-activity relationships of novel IKK-beta inhibitors. Part 3: Orally active anti-inflammatory agents.

T. Yoshino, K. Ziegelbauer, K. Bacon, 2004, Bioorganic & medicinal chemistry letters.

Pharmacokinetics and metabolism of metoprolol and propranolol in the female DA and female Wistar rat: the female DA rat is not always an animal model for poor metabolizers of CYP2D6.

M. Iwaki, H. Komura, 2005, Journal of pharmaceutical sciences.

Inhibition of eosinophilia in vivo by a small molecule inhibitor of very late antigen (VLA)-4.

M. Tajimi, K. Bacon, T. Rölle, 2007, European journal of pharmacology.

Utilizing public and private sector data to build better machine learning models for the prediction of pharmacokinetic parameters.

K. Mizuguchi, Tsuyoshi Esaki, T. Honma, 2022, Drug discovery today.

Prediction of Hepatic Clearance of Stereoselective Metabolism of Carvedilol in Liver Microsomes and Hepatocytes of Sprague-Dawley and Cytochrome P450 2D-Deficient Dark Agouti Rats.

M. Iwaki, A. Kawase, H. Komura, 2019, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

Synthesis and structure–activity relationships of novel IKK-β inhibitors. Part 3: Orally active anti-inflammatory agents

K. Ziegelbauer, K. Bacon, K. Fukushima, 2004 .

In vitro and in vivo small intestinal metabolism of CYP3A and UGT substrates in preclinical animals species and humans: species differences

Masahiro Iwaki, M. Iwaki, H. Komura, 2011, Drug metabolism reviews.

Prediction of metabolic clearance of diclofenac in adjuvant-induced arthritis rats using a substrate depletion assay

M. Iwaki, A. Kawase, H. Komura, 2008 .

Intracellular inorganic carbon exists as protein carbamate in photosynthesizing Euglena gracilis z.

A. Yokota, H. Komura, S. Kitaoka, 1983, Biochemical and biophysical research communications.

NONLINEAR PHARMACOKINETICS OF PROPAFENONE IN RATS AND HUMANS: APPLICATION OF A SUBSTRATE DEPLETION ASSAY USING HEPATOCYTES FOR ASSESSMENT OF NONLINEARITY

M. Iwaki, H. Komura, 2005, Drug Metabolism and Disposition.

Application of a Physiologically Based Pharmacokinetic Model Informed by a Top-Down Approach for the Prediction of Pharmacokinetics in Chronic Kidney Disease Patients

M. Iwaki, Hiroyuki Sayama, H. Komura, 2014, The AAPS Journal.

A selective novel low‐molecular‐weight inhibitor of IκB kinase‐β (IKK‐β) prevents pulmonary inflammation and shows broad anti‐inflammatory activity

T. Niki, F. Gantner, K. Ziegelbauer, 2005 .

Species difference in nisoldipine oxidation activity in the small intestine.

Y. Sugiyama, H. Komura, Nagahiro H Yoshida, 2002, Drug metabolism and pharmacokinetics.

Current Status and Critical Issues on the Investigation of Small Intestinal Metabolism

H. Komura, 2000 .

Application of substrate depletion assay for early prediction of nonlinear pharmacokinetics in drug discovery: assessment of nonlinearity of metoprolol, timolol, and propranolol.

M. Iwaki, A. Kawase, H. Komura, 2005, Journal of pharmaceutical sciences.

A selective novel low-molecular-weight inhibitor of IkappaB kinase-beta (IKK-beta) prevents pulmonary inflammation and shows broad anti-inflammatory activity.

T. Niki, F. Gantner, K. Ziegelbauer, 2005, British journal of pharmacology.

Relative contribution of rat CYP isoforms responsible for stereoselective metabolism of carvedilol.

Yukiko Nakamura, M. Iwaki, A. Kawase, 2018, Journal of Toxicological Sciences.

Application of substrate depletion assay to evaluation of CYP isoforms responsible for stereoselective metabolism of carvedilol.

M. Iwaki, A. Kawase, H. Komura, 2016, Drug metabolism and pharmacokinetics.

Pharmacokinetics and disposition of dalcetrapib in rats and monkeys

O. Kuhlmann, H. Komura, M. Kogayu, 2014, Xenobiotica; the fate of foreign compounds in biological systems.

In Vitro Liver Systems to Study Induction/Inhibition: Prediction of In Vivo Metabolism and Drug–Drug Interactions

M. Iwaki, H. Komura, 2012 .

A public-private partnership to enrich the development of in silico predictive models for pharmacokinetic and cardiotoxic properties.

K. Mizuguchi, T. Honma, Tomohiro Sato, 2021, Drug discovery today.

Comparative assessment of empirical and physiological approaches on predicting human clearances.

S. Yamada, H. Komura, M. Kogayu, 2011, Journal of pharmaceutical sciences.

Development of an In Silico Prediction Model for P-glycoprotein Efflux Potential in Brain Capillary Endothelial Cells toward the Prediction of Brain Penetration.

K. Mizuguchi, Tsuyoshi Esaki, Hitoshi Kawashima, 2021, Journal of medicinal chemistry.

NONLINEAR PHARMACOKINETICS OF PROPAFENONE IN RATS AND HUMANS: APPLICATION OF A SUBSTRATE DEPLETION ASSAY USING HEPATOCYTES FOR ASSESSMENT OF NONLINEARITY

M. Iwaki, H. Komura, 2005, Drug Metabolism and Disposition.

Prediction of metabolic clearance of diclofenac in adjuvant-induced arthritis rats using a substrate depletion assay.

M. Iwaki, A. Kawase, H. Komura, 2008, Xenobiotica; the fate of foreign compounds in biological systems.