Xiaomei Zhuang

发表

Characterization of preclinical in vitro and in vivo ADME properties and prediction of human PK using a physiologically based pharmacokinetic model for YQA‐14, a new dopamine D3 receptor antagonist candidate for treatment of drug addiction

Xiaomei Zhuang, Chuang Lu, Jin Li, 2014, Biopharmaceutics & drug disposition.

Development and preclinical studies of broad-spectrum anti-HIV agent (3'R,4'R)-3-cyanomethyl-4-methyl-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone (3-cyanomethyl-4-methyl-DCK).

Hong Lu, Shibo Jiang, Keduo Qian, 2008, Journal of medicinal chemistry.

Assessment of the Roles of P-glycoprotein and Cytochrome P450 in Triptolide-induced Liver Toxicity in Sandwich-Cultured Rat Hepatocyte Model

Chuang Lu, Xiaomei Zhuang, Hua Li, 2013, Drug Metabolism and Disposition.

Neutralization of chemokine-like factor 1, a novel C-C chemokine, protects against focal cerebral ischemia by inhibiting neutrophil infiltration via MAPK pathways in rats

N. Chen, Z. Wang, Xiaomei Zhuang, 2014, Journal of Neuroinflammation.

Allosteric activation of midazolam CYP3A5 hydroxylase activity by icotinib - Enhancement by ketoconazole.

Mingshe Zhu, Haiying Yang, Chuang Lu, 2016, Biochemical pharmacology.

Role of CYP3A in regulating hepatic clearance and hepatotoxicity of triptolide in rat liver microsomes and sandwich-cultured hepatocytes.

Xiaomei Zhuang, Hua Li, Guolin Shen, 2014, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Development and in vivo evaluation of intranasal formulations of parathyroid hormone (1-34)

Meng Li, Wenpeng Zhang, Yimeng Du, 2021, Drug delivery.

Determination of 4-dimethylaminophenol concentrations in dog blood using LC-ESI/MS/MS combined with precolumn derivatization.

Xiaomei Zhuang, J. Ruan, M. Yuan, 2008, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Identification of human cytochrome P450 and UGT enzymes involved in the metabolism of ferulic acid, a major bioactive component in traditional Chinese medicines.

Chuang Lu, Hai-ying Yang, Yue Gao, 2017, Chinese journal of natural medicines.

Triclosan treatment decreased the antitumor effect of sorafenib on hepatocellular carcinoma cells

Wenpeng Zhang, Xiaomei Zhuang, Zhen-qing Zhang, 2018, OncoTargets and therapy.

Pre-column derivatization combined with UHPLC-MS/MS for rapid and sensitive quantification of bakuchiol in rat plasma.

Xiaomei Zhuang, Hua Li, M. Yuan, 2013, Journal of pharmaceutical and biomedical analysis.

Alterations in gut microbiota and metabolites associated with altitude-induced cardiac hypertrophy in rats during hypobaric hypoxia challenge

Ruifu Yang, Z. Xu, Wenpeng Zhang, 2022, Science China Life Sciences.

DMD053199 1914..1922

Chuang Lu, Xiaomei Zhuang, Weibin Xiao, 2013 .

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Chuang Lu, Xiaomei Zhuang, Weibin Xiao, 2013 .

Prediction of Drug–Drug Interaction between Tacrolimus and Principal Ingredients of Wuzhi Capsule in Chinese Healthy Volunteers Using Physiologically‐Based Pharmacokinetic Modelling

Weimin Cai, Jae-Gook Shin, Xiaomei Zhuang, 2018, Basic & clinical pharmacology & toxicology.

Metabonomics reveals that triclocarban affects liver metabolism by affecting glucose metabolism, β-oxidation of fatty acids, and the TCA cycle in male mice.

Haishan Li, Wenpeng Zhang, Hui-ming Chen, 2018, Toxicology letters.

Prodrug design, synthesis and pharmacokinetic evaluation of (3' R, 4' R)-3-hydroxymethyl-4-methyl-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone.

Xiao‐Feng Wang, Keduo Qian, K. Lee, 2012, Acta pharmaceutica Sinica. B.

New insights into the vancomycin‐induced nephrotoxicity using in vitro metabolomics combined with physiologically based pharmacokinetic modeling

Yongxiang Wei, Xiaomei Zhuang, Yang Lin, 2020, Journal of applied toxicology : JAT.

Zero-Order Release of Gossypol Improves Its Antifertility Effect and Reduces Its Side Effects Simultaneously.

Yongjun Zhang, Ying Guan, Chao Sun, 2018, Biomacromolecules.

Simultaneous quantification of L-tetrahydropalmatine and its urine metabolites by ultra high performance liquid chromatography with tandem mass spectrometry.

Xiaomei Zhuang, Guolin Shen, Weibin Xiao, 2014, Journal of separation science.

[In vitro O-demethylation of rotundine by recombinant human CYP isoenzymes].

Jianwei Xie, J. Xie, Chunhou Li, 2010, Yao xue xue bao = Acta pharmaceutica Sinica.

Separation and simultaneous quantification of nine furanocoumarins from Radix Angelicae dahuricae using liquid chromatography with tandem mass spectrometry for bioavailability determination in rats.

Xiaomei Zhuang, Ning Wei, Hua Li, 2015, Journal of separation science.

An LC–MS–MS Method for Quantification of CMDCK: A Novel Anti-HIV Agent in Rat Plasma and Its Application to a Pharmacokinetic Study

Xiao‐Feng Wang, Lan Xie, Xiaomei Zhuang, 2011 .

Metabolism of novel anti-HIV agent 3-cyanomethyl-4-methyl-DCK by human liver microsomes and recombinant CYP enzymes

Lan Xie, Xiaomei Zhuang, J. Ruan, 2011, Acta Pharmacologica Sinica.

Identification and Characterization of Psoralen and Isopsoralen as Potent CYP1A2 Reversible and Time-Dependent Inhibitors in Human and Rat Preclinical Studies

Chuang Lu, Chuang Lu, Xiao-Mei Zhuang, 2013, Drug Metabolism and Disposition.

Hydrogen-Bonded Films for Zero-Order Release of Leuprolide.

Yongjun Zhang, Ying Guan, Qingbin Meng, 2020, Macromolecular bioscience.

PEGylated leuprolide with improved pharmacokinetic properties.

Yongjun Zhang, Ying Guan, Qingbin Meng, 2020, Bioorganic & medicinal chemistry.

Intranasal tetrandrine temperature-sensitive in situ hydrogels for the treatment of microwave-induced brain injury.

Xiang Yu, Yiguang Jin, Jinqiu Ma, 2020, International journal of pharmaceutics.

Simultaneous Quantitation of Six Cytochrome P450 Enzyme Probe Metabolites by Ultra-high Performance Liquid Chromatography Tandem Mass Spectrometry

Xiaomei Zhuang, Guolin Shen, Hua Li, 2013 .

Investigation of the Pharmacokinetic Interaction between Ritonavir and CMDCK, a New Non-nucleoside Reverse Transcriptase Inhibitor

Xiaomei Zhuang, Guolin Shen, M. Yuan, 2013, Drug Research.

PBPK modeling and simulation in drug research and development

Xiaomei Zhuang, Chuang Lu, Chuang Lu, 2016, Acta pharmaceutica Sinica. B.

Inhibition of P-glycoprotein Gene Expression and Function Enhances Triptolide-induced Hepatotoxicity in Mice

Hua Li, Hai-ying Yang, Xiaomei Zhuang, 2015, Scientific Reports.

Comparative pharmacokinetics and bioavailability of intranasal and rectal midazolam formulations relative to buccal administration in rabbits

Jinglai Li, Chuang Lu, Xiaomei Zhuang, 2015 .

Simultaneous determination of triptolide and its prodrug MC002 in dog blood by LC-MS/MS and its application in pharmacokinetic studies.

Y. Li, Xiaomei Zhuang, Zhen-qing Zhang, 2013, Journal of ethnopharmacology.

[Evaluation of P-glycoprotein mediated in vitro loperamide biliary excretion with sandwich-cultured rat hepatocytes model].

Xiaomei Zhuang, Hua Li, Guolin Shen, 2012, Yao xue xue bao = Acta pharmaceutica Sinica.

Biliary excretion and enterohepatic circulation of thienorphine and its glucuronide conjugate in rats

Xiaomei Zhuang, Hua Li, Guolin Shen, 2012 .

N-Quinary heterocycle-4-sulphamoylbenzamides exert anti-hypoxic effects as dual inhibitors of carbonic anhydrases I/II.

Xinhua He, Jing Wang, Xiaomei Zhuang, 2020, Bioorganic chemistry.

P-Glycoprotein on Blood-Brain Barrier Plays a Vital Role in Fentanyl Brain Exposure and Respiratory Toxicity in Rats

Haiying Yang, Xiaomei Zhuang, Chenchen Yu, 2018, Toxicological sciences : an official journal of the Society of Toxicology.

High-content imaging of human hepatic spheroids for researching the mechanism of duloxetine-induced hepatotoxicity

Jiahong Dong, Ting-ting Zhang, Xiaomei Zhuang, 2022, Cell Death & Disease.

Quadrupole Orbitrap Mass Spectrometer-Based Metabonomic Elucidation of Influences of Short-Term Di(2-ethylhexyl) phthalate Exposure on Cardiac Metabolism in Male Mice.

Haishan Li, Wenpeng Zhang, Nai-ning Song, 2018, Chemical research in toxicology.

Atipamezole is a promising non‐discriminative inhibitor against pan‐CYP450 including diclofenac 4′‐hydroxylation: A comparison with ABT for drug ADME optimization and mechanism study

Wenpeng Zhang, Chuang Lu, Xiaomei Zhuang, 2019, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Inhibition of P-Glycoprotein and Multidrug Resistance-Associated Protein 2 Regulates the Hepatobiliary Excretion and Plasma Exposure of Thienorphine and Its Glucuronide Conjugate

Xiaomei Zhuang, Guolin Shen, Weibin Xiao, 2016, Front. Pharmacol..

Application of armodafinil-loaded microneedle patches against the negative influence induced by sleep deprivation.

Yiguang Jin, Shouguo Zhang, Lin Wang, 2021, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Alkoxy cyanoacrylate-based nanoparticles with stealth and brain-targeting properties

Yuan Luo, Xuanzhi Wang, Yang Yang, 2021, Journal of drug targeting.

Contribution of carboxylesterase and cytochrome P450 to the bioactivation and detoxification of isocarbophos and its enantiomers in human liver microsomes.

Jianwei Xie, Chuang Lu, Hai-ying Yang, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

Metabolic Pathway of Icotinib In Vitro: The Differential Roles of CYP3A4, CYP3A5, and CYP1A2 on Potential Pharmacokinetic Drug-Drug Interaction.

Chuang Lu, Xiaomei Zhuang, Zheng Li, 2017, Journal of pharmaceutical sciences.

Characterization of human metabolism and disposition of levo-tetrahydropalmatine: Qualitative and quantitative determination of oxidative and conjugated metabolites.