A. Harrison

发表

Case studies addressing human pharmacokinetic uncertainty using a combination of pharmacokinetic simulation and alternative first in human paradigms

Alex Phipps, Maurice Dickins, Tanya L Hay, 2012, Xenobiotica; the fate of foreign compounds in biological systems.

N-[(3S)-Pyrrolidin-3-yl]benzamides as novel dual serotonin and noradrenaline reuptake inhibitors: impact of small structural modifications on P-gp recognition and CNS penetration.

P. Fish, T. Ryckmans, S. Phillips, 2009, Bioorganic & medicinal chemistry letters.

Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases.

W. Guba, W. Spooren, J. Peters, 2015, Journal of medicinal chemistry.

Comparative Analysis of CYP3A Heteroactivation by Steroid Hormones and Flavonoids in Different in Vitro Systems and Potential in Vivo Implications

A. Galetin, J. Houston, A. Harrison, 2008, Drug Metabolism and Disposition.

vitro clearance and permeability data

A. Galetin, J. Houston, Michael Gertz, 2010 .

Pharmacokinetic/pharmacodynamic assessment of the effects of E4031, cisapride, terfenadine and terodiline on monophasic action potential duration in dog

D. Walker, D. Leishman, A. Harrison, 2001, Xenobiotica; the fate of foreign compounds in biological systems.

Nonlinear oral pharmacokinetics of the alpha-antagonist 4-amino-5-(4-fluorophenyl)-6,7-dimethoxy-2-[4-(morpholinocarbonyl)-perhydro-1,4-diazepin-1-yl]quinoline in humans: use of preclinical data to rationalize clinical observations.

K. Beaumont, S. Roffey, P. Morgan, 2004, Drug metabolism and disposition: the biological fate of chemicals.

Grapefruit juice-drug interaction studies as a method to assess the extent of intestinal availability: utility and limitations.

John D. Davis, A. Galetin, J. Houston, 2008, Current drug metabolism.

Inhalation by design: novel tertiary amine muscarinic M₃ receptor antagonists with slow off-rate binding kinetics for inhaled once-daily treatment of chronic obstructive pulmonary disease.

M. Bunnage, David A. Price, A. Wood, 2011, Journal of medicinal chemistry.

Part 2: Design, synthesis and evaluation of hydroxyproline-derived α2δ ligands.

A. Harrison, Paul Turnpenny, G. Maw, 2011, Bioorganic & medicinal chemistry letters.

Prediction of Human Intestinal First-Pass Metabolism of 25 CYP3A Substrates from In Vitro Clearance and Permeability Data

Michael Gertz, Aleksandra Galetin, J Brian Houston, 2010, Drug Metabolism and Disposition.

Developmental toxicity of lersivirine in rabbits when administered throughout organogenesis and when limited to sensitive windows of axial skeletal development.

C. Bowman, M. Hurtt, G. Cappon, 2012, Birth defects research. Part B, Developmental and reproductive toxicology.

Pharmacology of Basimglurant (RO4917523, RG7090), a Unique Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator in Clinical Development for Depression

Stephen R. Morairty, A. Bruns, W. Spooren, 2015, The Journal of Pharmacology and Experimental Therapeutics.

Multiple factors govern the association between pharmacology and toxicity in a class of drugs: toward a unification of class effect terminology.

Dennis A. Smith, P. Morgan, A. Harrison, 2011, Chemical research in toxicology.

Pharmacology of Basimglurant ( RO 4917523 , RG 7090 ) , a Unique Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator in Clinical Development for Depression s

Stephen R. Morairty, A. Bruns, W. Spooren, 2015 .

Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reducing ion channel activity.

P. Fish, S. Phillips, G. Whitlock, 2010, Bioorganic & medicinal chemistry letters.

A new methodology for predicting human pharmacokinetics for inhaled drugs from oratracheal pharmacokinetic data in rats

A. Harrison, Anthony Harrison, Rhys M. Jones, 2012, Xenobiotica; the fate of foreign compounds in biological systems.

Comparative Analysis of CYP3A Heteroactivation by Steroid Hormones and Flavonoids in Different in Vitro Systems and Potential in Vivo Implications

A. Galetin, A. Harrison, J. Henshall, 2008, Drug Metabolism and Disposition.

Case studies addressing human pharmacokinetic uncertainty using a combination of pharmacokinetic simulation and alternative first in human paradigms

Tanya L Hay, K. Beaumont, I. Gardner, 2012, Xenobiotica; the fate of foreign compounds in biological systems.