Xuhai Be

发表

Prediction of Vss from In Vitro Tissue-Binding Studies

Zhiyang Zhao, Jonathan Roberts, L. Berry, 2010, Drug Metabolism and Disposition.

Deletion of Abcg2 Has Differential Effects on Excretion and Pharmacokinetics of Probe Substrates in Rats

B. Wong, Liyue Huang, Jonathan Roberts, 2012, Journal of Pharmacology and Experimental Therapeutics.

Use of uptake intrinsic clearance from attached rat hepatocytes to predict hepatic clearance for poorly permeable compounds

April Chen, L. Berry, Liyue Huang, 2012, Xenobiotica; the fate of foreign compounds in biological systems.

Discovery of a potent, selective, and orally bioavailable pyridinyl-pyrimidine phthalazine aurora kinase inhibitor.

P. Gallant, T. Bush, M. Morrison, 2010, Journal of medicinal chemistry.

Engineering NaV1.7 Inhibitory JzTx-V Peptides with a Potency and Basicity Profile Suitable for Antibody Conjugation To Enhance Pharmacokinetics.

Kristin L. Andrews, B. Herberich, B. Moyer, 2019, ACS chemical biology.

In vitro and in vivo pharmacokinetic characterizations of AMG 900, an orally bioavailable small molecule inhibitor of aurora kinases

L. Berry, Liyue Huang, Min-Hwa Jasmine Lin, 2011, Xenobiotica; the fate of foreign compounds in biological systems.

Discovery of Tarantula Venom-Derived NaV1.7-Inhibitory JzTx-V Peptide 5-Br-Trp24 Analogue AM-6120 with Systemic Block of Histamine-Induced Pruritis.

Dong Liu, Kristin L. Andrews, Zhulun Wang, 2018, Journal of medicinal chemistry.

Discovery of triazine-benzimidazoles as selective inhibitors of mTOR.

T. Bush, A. Cheng, D. Whittington, 2011, Bioorganic & medicinal chemistry letters.

Discovery of N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine (AMG 900), a highly selective, orally bioavailable inhibitor of aurora kinases with activity against multidrug-resistant cancer cell lines.

T. Bush, Grace Chung, R. Radinsky, 2015, Journal of Medicinal Chemistry.

Pharmacologic Characterization of AMG8379, a Potent and Selective Small Molecule Sulfonamide Antagonist of the Voltage-Gated Sodium Channel NaV1.7

Dong Liu, J. Luther, R. Fremeau, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species

Yuan Cheng, D. Rock, B. Herberich, 2019, Drug Metabolism and Disposition.

LC-MS/MS bioanalytical method development for AMG 900: resolution of an isobaric interference in rodent in vivo studies.

Xuhai Be, Zhiyang Zhao, Mary C Wells, 2013, Journal of pharmaceutical and biomedical analysis.

Pharmacologic Characterization of AMG8379, a Potent and Selective Small Molecule Sulfonamide Antagonist of the Voltage-Gated Sodium Channel NaV1.7

J. Luther, R. Fremeau, B. Moyer, 2017, The Journal of Pharmacology and Experimental Therapeutics.