Kirsten S. Smith

发表

Embryotoxicity of artesunate in animal species related to drug tissue distribution and toxicokinetic profiles.

Q. Zeng, Qigui Li, Y. Si, 2008, Birth defects research. Part B, Developmental and reproductive toxicology.

New Potential Antimalarial Agents: Therapeutic-Index Evaluation of Pyrroloquinazolinediamine and Its Prodrugs in a Rat Model of Severe Malaria

Qigui Li, L. Xie, Jing Zhang, 2006, Antimicrobial Agents and Chemotherapy.

Pharmacokinetics and Absorption of Paromomycin and Gentamicin from Topical Creams Used To Treat Cutaneous Leishmaniasis

M. Grogl, A. Llanos-Cuentas, Philip L. Smith, 2013, Antimicrobial Agents and Chemotherapy.

Novel 4-aminoquinolines active against chloroquine-resistant and sensitive P. falciparum strains that also inhibit botulinum serotype A.

W. Milhous, R. Gussio, S. Bavari, 2008, Journal of medicinal chemistry.

Deoxycholic Acid-Derived Tetraoxane Antimalarials and Antiproliferatives

W. Milhous, B. Tinant, D. Milic, 2007 .

Synthesis and structure-activity relationship studies on tryprostatin A, an inhibitor of breast cancer resistance protein.

T. Macdonald, H. Kakeya, H. Osada, 2008, Bioorganic & medicinal chemistry.

An automated, polymer-assisted strategy for the preparation of urea and thiourea derivatives of 15-membered azalides as potential antimalarial chemotherapeutics.

W. Milhous, A. Hutinec, Dinko Žiher, 2011, Bioorganic & Medicinal Chemistry.

Role of Specific Cytochrome P450 Isoforms in the Conversion of Phenoxypropoxybiguanide Analogs in Human Liver Microsomes to Potent Antimalarial Dihydrotriazines

W. Milhous, T. Shearer, Kirsten S. Smith, 2008, Drug Metabolism and Disposition.

The Role of Specific P450 Isoforms in the Conversion of Phenoxypropoxybiguanide Analogs in Human Liver Microsomes to Potent Antimalarial Dihydrotriazines

T. Shearer, Kirsten S. Smith, D. Jacobus, 2007 .

New chimeric antimalarials with 4-aminoquinoline moiety linked to a tetraoxane skeleton.

W. Milhous, Igor M. Opsenica, B. Šolaja, 2008, Journal of Medicinal Chemistry.

In vitro and in vivo efficacy and in vitro metabolism of 1-phenyl-3-aryl-2-propen-1-ones against Plasmodium falciparum.

L. Gerena, D. A. Nichols, A. Bhattacharjee, 2006, Bioorganic & medicinal chemistry letters.

Synthesis, structure-activity relationship, and antimalarial activity of ureas and thioureas of 15-membered azalides.

W. Milhous, Dinko Žiher, M. Perić, 2011, Journal of medicinal chemistry.

Biological activity of the tryprostatins and their diastereomers on human carcinoma cell lines.

T. Macdonald, C. Dieckhaus, Kirsten S. Smith, 2002, Journal of medicinal chemistry.

Chemical stability of the peroxide bond enables diversified synthesis of potent tetraoxane antimalarials.

W. Milhous, Igor M. Opsenica, B. Šolaja, 2008, Journal of medicinal chemistry.

Topical paromomycin with or without gentamicin for cutaneous leishmaniasis.

Mara Kreishman-Deitrick, Hechmi Louzir, Alan J Magill, 2013, The New England journal of medicine.

Topical Par o mo my cin with or without Gentamicin for Cutaneous Leish ma ni a sis

J. Berman, M. Grogl, A. Magill, 2013 .

Regioselective Synthesis and Biological Evaluation of 1-Hydroxyl Modified Ailanthinone Derivatives as Antimalarials

M. Chordia, Philip L. Smith, Kirsten S. Smith, 2013 .

Antimalarial activity of 9a-N substituted 15-membered azalides with improved in vitro and in vivo activity over azithromycin.

W. Milhous, S. Alihodžić, A. Hutinec, 2012, Journal of medicinal chemistry.

The role of in vitro ADME assays in antimalarial drug discovery and development.

T. Shearer, Kirsten S. Smith, Todd W Shearer, 2005, Combinatorial chemistry & high throughput screening.

Antimalarial pharmacodynamics and pharmacokinetics of a third-generation antifolate--JPC2056--in cynomolgus monkeys using an in vivo in vitro model.

K. Rieckmann, D. Kyle, M. Edstein, 2007, The Journal of antimicrobial chemotherapy.

In vitro metabolism of tolcapone to reactive intermediates: relevance to tolcapone liver toxicity.

T. Macdonald, Philip L. Smith, Kirsten S. Smith, 2003, Chemical research in toxicology.

Tetraoxane antimalarials and their reaction with Fe(II).

W. Milhous, B. Tinant, Igor M. Opsenica, 2006, Journal of medicinal chemistry.

Mixed tetraoxanes containing the acetone subunit as antimalarials.

Philip L. Smith, B. Šolaja, N. Terzić, 2008, Bioorganic & medicinal chemistry.

Pharmacokinetics, Safety, and Hydrolysis of Oral Pyrroloquinazolinediamines Administered in Single and Multiple Doses in Rats

W. Milhous, Qigui Li, T. Shearer, 2007, Antimicrobial Agents and Chemotherapy.

On peroxide antimalarials

W. Milhous, Igor M. Opsenica, B. Šolaja, 2007 .

Utility of Alkylaminoquinolinyl Methanols as New Antimalarial Drugs

L. Gerena, D. Caridha, T. Shearer, 2006, Antimicrobial Agents and Chemotherapy.

Mefloquine Induces Dose-Related Neurological Effects in a Rat Model

D. Caridha, G. Dow, K. Smith, 2006, Antimicrobial Agents and Chemotherapy.

Malaria causal prophylactic activity of imidazolidinedione derivatives.

D. Kyle, W. Milhous, A. Magill, 2007, Journal of medicinal chemistry.

Pharmacokinetics, Safety, and Hydrolysis of Oral Pyrroloquinazolinediamines Administered in Single and Multiple Doses in Rats (cid:1)

W. Milhous, Qigui Li, T. Shearer, 2007 .