V. Scott

发表

Optimization of ADME Properties for Sulfonamides Leading to the Discovery of a T-Type Calcium Channel Blocker, ABT-639.

M. Jarvis, Qingwei Zhang, S. Joshi, 2015, ACS medicinal chemistry letters.

Pharmacological and molecular analysis of ATP-sensitive K(+) channels in the pig and human detrusor.

J. Sullivan, J. Brioni, S. Buckner, 2000, European journal of pharmacology.

Distribution and functional characterization of human Nav1.3 splice variants

M Gopalakrishnan, T. Neelands, M. Gopalakrishnan, 2005, The European journal of neuroscience.

Identification of critical amino acids involved in α 1‐β interaction in voltage‐dependent Ca2+ channels

K. Campbell, M. De Waard, V. Scott, 1996 .

Identification of critical amino acids involved in alpha1-beta interaction in voltage-dependent Ca2+ channels.

K. Campbell, M. De Waard, V. Scott, 1996, FEBS letters.

Pharmacology of human sulphonylurea receptor SUR1 and inward rectifier K+ channel Kir6.2 combination expressed in HEK‐293 cells

J. Sullivan, J. Brioni, C. Shieh, 2000, British journal of pharmacology.

Fluorescence-based functional assay for sarcolemmal ATP-sensitive potassium channel activation in cultured neonatal rat ventricular myocytes.

M. Gopalakrishnan, V. Scott, R. Davis-Taber, 2001, Journal of pharmacological and toxicological methods.

IL-23 induces regulatory T cell plasticity with implications for inflammatory skin diseases

S. Gauld, R. Duggan, P. Honore, 2017, Scientific Reports.

Small Molecule and Pooled CRISPR Screens Investigating IL17 Signaling Identify BRD2 as a Novel Contributor to Keratinocyte Inflammatory Responses.

D. Donnelly-roberts, Charles Lu, Namjin Chung, 2019, ACS chemical biology.

Assaying Pain-Related Genes: Preclinical and Clinical Correlates

P. Honore, V. Scott, R. Davis-Taber, 2008 .

Transcriptional profiling of dorsal root ganglia in a neuropathic pain model using microarray and laser capture microdissection

V. Scott, R. Davis-Taber, Rachel A. Davis‐Taber, 2006 .

Characterization of the ATP-sensitive potassium channels (KATP) expressed in guinea pig bladder smooth muscle cells.

J. Sullivan, J. Brioni, C. Shieh, 1999, The Journal of pharmacology and experimental therapeutics.

In vitro and in vivo characterization of a novel naphthylamide ATP‐sensitive K+ channel opener, A‐151892

J. Sullivan, C. Shieh, M. Gopalakrishnan, 2004, British journal of pharmacology.

Characterization of human ASIC2a homomeric channels stably expressed in murine Ltk- cells.

M. Gopalakrishnan, J. Malysz, C. Faltynek, 2008, Life sciences.

Pharmacological and molecular characterization of ATP-sensitive K+ channels in the TE671 human medulloblastoma cell line.

J. Brioni, M. Gopalakrishnan, L. Monteggia, 1999, European journal of pharmacology.

[125I]A-312110, a novel high-affinity 1,4-dihydropyridine ATP-sensitive K+ channel opener: characterization and pharmacology of binding.

G. Gintant, C. Shieh, M. Gopalakrishnan, 2003, Molecular pharmacology.

Comparative analysis of inactivated-state block of N-type (Cav2.2) calcium channels

D. Donnelly-roberts, A. Swensen, T. Neelands, 2011, Inflammation Research.

Histologic progression of acne inversa/hidradenitis suppurativa: Implications for future investigations and therapeutic intervention

Kathleen M. Smith, R. Burney, J. Gudjonsson, 2020, Experimental dermatology.

Subunit Heterogeneity in N-type Ca Channels (*)

K. Campbell, H. Liu, Hongyan Liu, 1996, The Journal of Biological Chemistry.

Characterization of human urinary bladder KATP channels containing SUR2B splice variants expressed in L-cells.

M. Gopalakrishnan, P. Kroeger, V. Scott, 2004, European journal of pharmacology.

Overlay and Bead Assay

K. Campbell, C. Gurnett, V. Scott, 1998 .

Characterization of Potassium Channel Binding

V. Scott, 1999 .

Phospholipase A2 enzymes represent a shared pathogenic pathway in psoriasis and pityriasis rubra pilaris

Kathleen M. Smith, G. Wang, L. Tsoi, 2021, JCI insight.

Cytokine induced 3‐D organotypic psoriasis skin model demonstrates distinct roles for NF‐κB and JAK pathways in disease pathophysiology

A. Paller, S. Getsios, L. Miller, 2022, Experimental dermatology.

Quantitative ligand and receptor binding studies reveal the mechanism of interleukin-36 (IL-36) pathway activation

P. Richardson, Chaohong Sun, E. DiGiammarino, 2017, The Journal of Biological Chemistry.

Cell-Surface Receptor-Ligand Interaction Analysis with Homogeneous Time-Resolved FRET and Metabolic Glycan Engineering: Application to Transmembrane and GPI-Anchored Receptors.

P. Richardson, A. Vasudevan, V. Scott, 2017, Journal of the American Chemical Society.

Central pituitary adenylate cyclase 1 receptors modulate nociceptive behaviors in both inflammatory and neuropathic pain states.

S. Baker, C. Surowy, P. Honore, 2008, The journal of pain : official journal of the American Pain Society.

Effects of substitution on 9-(3-bromo-4-fluorophenyl)-5,9-dihydro-3H,4H-2,6-dioxa-4- azacyclopenta[b]naphthalene-1,8-dione, a dihydropyridine ATP-sensitive potassium channel opener.

R. Henry, M. Gopalakrishnan, M. Kort, 2006, Journal of medicinal chemistry.

Structure–activity studies for a novel series of tricyclic dihydropyridopyrazolones and dihydropyridoisoxazolones as KATP channel openers

R. Henry, M. Gopalakrishnan, J. Darbyshire, 2004 .

Pharmacological characterization of a 1,4‐dihydropyridine analogue, 9‐(3,4‐dichlorophenyl)‐3,3,6,6‐tetramethyl‐3,4,6,7,9,10‐hexahydro‐1,8(2H,5H)‐acridinedione (A‐184209) as a novel KATP channel inhibitor

J. Sullivan, M. Gopalakrishnan, S. Buckner, 2003, British journal of pharmacology.

A high throughput fluorescent assay for measuring the activity of fatty acid amide hydrolase

Jean M. Severin, P. Richardson, L. Traphagen, 2007, Journal of Neuroscience Methods.

Direct binding of G-protein βλ complex to voltage-dependent calcium channels

Denise S Walker, K. Campbell, Hongyan Liu, 1997, Nature.

Direct binding of G-protein betagamma complex to voltage-dependent calcium channels.

K. Campbell, H. Liu, M. De Waard, 1997, Nature.

(−)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-Dioxide (A-278637): A Novel ATP-Sensitive Potassium Channel Opener Efficacious in Suppressing Urinary Bladder Contractions. I. In Vitro Characterization

J. Sullivan, R. Chess-Williams, M. Williams, 2002, Journal of Pharmacology and Experimental Therapeutics.

Molecular characterization of human SUR2-containing K(ATP) channels.

Murali Gopalakrishnan, Paul E. Kroeger, R. Simmer, 2000, Gene.

Identification of Three Subunits of the High Affinity ω-Conotoxin MVIIC-sensitive Ca2+ Channel*

K. Campbell, Hongyan Liu, V. Lennon, 1996, The Journal of Biological Chemistry.

A peripherally acting, selective T-type calcium channel blocker, ABT-639, effectively reduces nociceptive and neuropathic pain in rats.

M. Jarvis, Qingwei Zhang, S. Joshi, 2014, Biochemical pharmacology.

Mechanistic insights into the analgesic efficacy of A-1264087, a novel neuronal Ca(2+) channel blocker that reduces nociception in rat preclinical pain models.

A. Swensen, Chih-Hung Lee, T. Neelands, 2014, The journal of pain : official journal of the American Pain Society.

IL‐36 receptor antagonistic antibodies inhibit inflammatory responses in preclinical models of psoriasiform dermatitis

P. Honore, R. Edelmayer, J. Seagal, 2018, Experimental dermatology.

Molecular Determinants of Species-Specific Activation or Blockade of TRPA1 Channels

P. Hajduk, J. R. Huth, Chaohong Sun, 2008, The Journal of Neuroscience.

Utility of Large-Scale Transiently Transfected Cells for Cell-Based High-Throughput Screens to Identify Transient Receptor Potential Channel A1 (TRPA1) Antagonists

Jing Xu, Murali Gopalakrishnan, Wende Niforatos, 2007, Journal of biomolecular screening.

Monocytes/Macrophages play a pathogenic role in IL-23 mediated psoriasis-like skin inflammation

S. Gauld, P. Honore, R. Edelmayer, 2019, Scientific Reports.

Validation of FLIPR Membrane Potential Dye for High Throughput Screening of Potassium Channel Modulators

Sujatha M. Gopalakrishnan, Char-Chang Shieh, U. Warrior, 2001, Journal of biomolecular screening.

Functional analysis of large conductance Ca2(+)-activated K(+) channels: ion flux studies by atomic absorption spectrometry.

U. Warrior, C. Shieh, D. Groebe, 2003, Assay and drug development technologies.

Non-invasive tape-stripping with high-resolution RNA profiling effectively captures a pre-inflammatory state in nonlesional psoriatic skin.

Kathleen M. Smith, Y. Helfrich, J. Voorhees, 2021, The Journal of investigative dermatology.

Small Molecule IL-36 gamma Antagonist as a Novel Therapeutic Approach for Plaque Psoriasis.

P. Richardson, Chaohong Sun, R. Henry, 2019 .

Small Molecule IL-36γ Antagonist as a Novel Therapeutic Approach for Plaque Psoriasis

P. Richardson, Chaohong Sun, R. Henry, 2019, Scientific Reports.

Design of Aminobenzothiazole Inhibitors of Rho Kinases 1 and 2 by Using Protein Kinase A as a Structure Surrogate

Ana L. Aguirre, A. Hobson, V. Stoll, 2018, Chembiochem : a European journal of chemical biology.

Discovery and SAR of hydrazide antagonists of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor type 1 (PAC1-R).

M. Jarvis, X. Beebe, V. Scott, 2008, Bioorganic & medicinal chemistry letters.

Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS

P. Hajduk, D. Song, P. Richardson, 2007, Proceedings of the National Academy of Sciences.

A-1048400 is a novel, orally active, state-dependent neuronal calcium channel blocker that produces dose-dependent antinociception without altering hemodynamic function in rats.

A. Swensen, T. Neelands, T. Vortherms, 2012, Biochemical pharmacology.

Activation of TRPA1 Channels by the Fatty Acid Amide Hydrolase Inhibitor 3′-Carbamoylbiphenyl-3-yl cyclohexylcarbamate (URB597)

T. Holzman, T. Neelands, R. Moreland, 2007, Molecular Pharmacology.

Molecular characterization of human SUR2-containing K(ATP) channels.

M Gopalakrishnan, R. Simmer, J. Sullivan, 2000, Gene.

Evidence for a 95 kDa Short Form of the α1A Subunit Associated with the ω-Conotoxin MVIIC Receptor of the P/Q-type Ca2+ Channels

K. Campbell, R. Felix, J. Arikkath, 1998, The Journal of Neuroscience.

Evidence for a 95 kDa Short Form of the a 1 A Subunit Associated with the v-Conotoxin MVIIC Receptor of the P / Q-type Ca 2 1 Channels

K. Campbell, R. Felix, J. Arikkath, 1997 .

Design and synthesis of novel cyanoguanidine ATP-sensitive potassium channel openers for the treatment of overactive bladder.

J. Sullivan, M. Gopalakrishnan, M. Kort, 2004, Bioorganic & Medicinal Chemistry Letters.

IL-23 induces regulatory T cell plasticity with implications for inflammatory skin diseases

S. Gauld, P. Honore, M. Kort, 2019, Scientific Reports.

Differential action potentials and firing patterns in injured and uninjured small dorsal root ganglion neurons after nerve injury

Murali Gopalakrishnan, Prisca Honore, Char-Chang Shieh, 2004, Brain Research.

Activation of TRPA 1 Channels by the Fatty Acid Amide Hydrolase Inhibitor 3-Carbamoylbiphenyl-3-yl cyclohexylcarbamate ( URB 597 )

T. Holzman, T. Neelands, R. Moreland, 2007 .

534 Defining a mechanistic link between TRPV3 activity and psoriasis through IL-1α and EGFR signaling pathways

S. Gauld, T. Neelands, L. Miller, 2016 .

Synthesis and SAR of 4-aminocyclopentapyrrolidines as N-type Ca²⁺ channel blockers with analgesic activity.

Jill M. Wetter, R. Henry, A. Swensen, 2012, Bioorganic & medicinal chemistry.

A peripherally acting, selective T-type calcium channel blocker, ABT-639, effectively reduces nociceptive and neuropathic pain in rats.

M. Jarvis, Qingwei Zhang, S. Joshi, 2014, Biochemical pharmacology.

An automated electrophysiological assay for differentiating Ca(v)2.2 inhibitors based on state dependence and kinetics.

A. Swensen, Lance Lee, T. Vortherms, 2012, Assay and drug development technologies.

Mechanistic insights into the analgesic efficacy of A-1264087, a novel neuronal Ca(2+) channel blocker that reduces nociception in rat preclinical pain models.

A. Swensen, Chih-Hung Lee, T. Neelands, 2014, The journal of pain : official journal of the American Pain Society.