J. Seydel

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NMR-studies on the molecular basis of drug-induced phospholipidosis--II. Interaction between several amphiphilic drugs and phospholipids.

O. Wassermann, J. Seydel, Joachim K. Seydel, 1976, Biochemical pharmacology.

Interactions between p-hydroxybenzoic acid esters and hydroxypropyl-β-cyclodextrin and their antimicrobial effect against Candida albicans

B. Müller, J. Seydel, S. Lehner, 1993 .

QSAR OF BACTERIAL FOLATE-SYNTHESIS INHIBITORS

V. Kulkarni, J. Seydel, E. Coats, 1983 .

QSAR and Multivariate Data Analysis of Amphiphilic Benzylamines and their Interaction with Various Phospholipids Determined by Different Methods

R. Lüllmann-Rauch, K. Mohr, M. Wiese, 1989 .

Kinetics and mechanisms of action of drugs on microorganisms. 8. Quantification and prediction of the biological activities of meta- and para-substituted N1-phenylsulfanilamides by microbial kinetics.

E. R. Garrett, J. Seydel, H. Kessler, 1969, Journal of medicinal chemistry.

Sulfonamide structure-activity relationship in a cell-free system. Correlation of inhibition of folate synthesis with antibacterial activity and physicochemical parameters.

J. Seydel, G. Miller, P. Doukas, 1972, Journal of medicinal chemistry.

Interactions of the Anticancer Drugs Doxorubicin and Thaliblastine with Model Membranes and their Relation to Multidrug Resistance

I. Pajeva, J. Seydel, D. Todorov, 2004 .

Membrane effects of the antitumor drugs doxorubicin and thaliblastine: comparison to multidrug resistance modulators verapamil and trans-flupentixol.

I. Pajeva, J. Seydel, D. Todorov, 2004, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Studies on the toxicity and efficacy of some ester analogues of dapsone in vitro using rat and human tissues.

M. Coleman, J. Seydel, K. Jorga, 2002, Environmental toxicology and pharmacology.

Studies on the Toxicity of Analogues of Dapsone In‐vitro Using Rat, Human and Heterologously Expressed Metabolizing Systems †

D. Kelly, S. Kelly, M. Coleman, 1996, The Journal of pharmacy and pharmacology.

Preliminary evaluation of the toxicity and efficacy of novel 2,4-diamino-5-benzylpyrimidine-sulphone derivatives using rat and human tissues in vitro.

S. Thorpe, M. Coleman, S. Lewis, 1996, Environmental toxicology and pharmacology.

Kinetics and Mechanisms of Action of Trimethoprim and Sulfonamides, Alone or in Combination, upon Escherichia coli (Part 2 of 2)

J. Seydel, G. Miller, E. Wempe, 1972 .

Design of a New Substituted 2,4‐Diamino‐5‐benzylpyrimidine as Inhibitor of Bacterial Dihydrofolate Reductase Assisted by Molecular Graphics

Manfred Kansy, M. Kansy, J. Seydel, 1987 .

The importance of drug-membrane interaction in drug research and development

M. Wiese, J. Seydel, E. Coats, 1992 .

Inhibitory activity and mode of action of diaminodiphenylsulfone in cell-free folate-synthesizing systems prepared from Mycobacterium lufu and Mycobacterium leprae. A comparison.

V. Kulkarni, J. Seydel, 1983, Chemotherapy.

Structure-activity correlations in a homologous series of 2-substituted isonicotinic acid hydrazides.

K. Schaper, J. Seydel, 1976, Experientia. Supplementum.

Physico-chemical studies on rifampicin.

J. Seydel, 1970, Antibiotica et chemotherapia. Fortschritte. Advances. Progres.

Application of bacterial growth kinetics to in vitro toxicity assessment of substituted phenols and anilines.

M. Nendza, J. Seydel, 1990, Ecotoxicology and environmental safety.

Penetration of rifampicin into the cerebrospinal fluid of adults with uninflamed meninges.

R. Nau, J. Seydel, H. Prange, 1992, The Journal of antimicrobial chemotherapy.

The Acid-Catalyzed Solvolysis of Pyrimidine Nucleosides1

E. R. Garrett, J. Seydel, A. J. Sharpen, 1966 .

Experimental drugs and combination therapy.

S. Rüsch-Gerdes, K. Schaper, J. Seydel, 1994, Immunobiology.

Folate-synthesizing enzyme system as target for development of inhibitors and inhibitor combinations against Candida albicans-synthesis and biological activity of new 2,4-diaminopyrimidines and 4'-substituted 4-aminodiphenyl sulfones.

K. Schaper, Klaus-Jürgen Schaper, J. Seydel, 2004, Journal of medicinal chemistry.

Stepwise Automated Solid Phase Synthesis of Naturally Occurring Peptaibols Using FMOC Amino Acid Fluorides

H. Wenschuh, F. Albericio, E. Krause, 1995 .

Multiple Regression and Principal Component Analysis of Antibacterial Activities of Sulfones and Sulfonamides in Whole Cell and Cell-Free Systems of Various DDS Sensitive and Resistant Bacterial Strains

V. Kulkarni, M. Wiese, K. Schaper, 1985 .

Sulfonamide structure-activity relationships in a cell-free system. 2. Proof for the formation of a sulfonamide-containing folate analog.

K. Schaper, J. Seydel, G. Miller, 1974, Journal of medicinal chemistry.

Development of inhibitors of mycobacterial ribonucleotide reductase.

K. Schaper, J. Seydel, J. Kazda, 1986, Leprosy review.

Effect of Hydroxypropyl‐β‐cyclodextrin on the Antimicrobial Action of Preservatives

B. Müller, J. Seydel, S. Lehner, 1994, The Journal of pharmacy and pharmacology.

Interaction of prostaglandin E1 with alpha-cyclodextrin in aqueous systems: stability of the inclusion complex.

B. Müller, M. Wiese, J. Seydel, 1991, Journal of pharmaceutical sciences.

Syntheses and Biological Activities of New N1‐Aryl Substituted Quinolone Antibacterials

U. Holzgrabe, P. Heisig, J. Seydel, 1996, Archiv der Pharmazie.

Kinetics of Antibacterial Effects

J. Seydel, 1983 .

Response to treatment by multidrug regimens in the THELEP controlled clinical drug trials. Subcommittee on Clinical Trials of the Chemotherapy of Leprosy (THELEP) Scientific Working Group of the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases.

P. Christie, J. Grosset, M. Waters, 1996, Leprosy review.

Primary dapsone resistance in Bamako and Chingleput: final report; THELEP. Subcommittee on Clinical Trials of the Chemotherapy of Leprosy (THELEP) Scientific Working Group of the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases.

R. Rees, J. Grosset, M. Waters, 1987, Leprosy review.

Ligand‐Membrane Interaction

J. Seydel, 2007 .

Kinetics and mechanisms of action of trimethoprim and sulfonamides, alone or in combination, upon Escherichia coli.

J. Seydel, G. Miller, E. Wempe, 1972, Chemotherapy.

A simple and rapid thin-layer chromatography method to follow the kinetics of product formation by 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase and 7,8-dihydropteroate synthetase.

W. Butte, J. Seydel, L. Bock, 1978, Analytical biochemistry.

Quantitative structure-pharmacokinetic relationships and drug design.

K J Schaper, K. Schaper, J. Seydel, 1981, Pharmacology & therapeutics.

NMR-Studies on the molecular basis of drug-induced phospholipidosis

O. Wassermann, J. Seydel, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

Detection of externally induced impairments in single bacterial cells by laser microbe mass analysis.

B. Lindner, U. Seydel, J. Seydel, 1982, International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association.

A simple, fast and inexpensive kinetic method to differentiate between total and viable bacteria using Coulter counter technique.

J. Seydel, E. Wempe, 1980, Arzneimittel-Forschung.

5-methyl-3(2H)-furanone from acid-catalyzed solvolysis of 2-deoxy-D-ribose.

E. R. Garrett, K. Schaper, J. Seydel, 1967, Journal of pharmaceutical sciences.

SPECTROPHOTOMETRIC ANALYSES OF 2-DEOXY-D-RIBOSE IN PRESENCE OF NUCLEOSIDES.

E. R. Garrett, J. Seydel, 1965, Analytical chemistry.

Membrane interactions of some catamphiphilic drugs and relation to their multidrug-resistance-reversing ability

J. K. Seydel, I. Pajeva, M. Wiese, 2005, Journal of Cancer Research and Clinical Oncology.

Strategies in the development of new drugs and drug combinations against leprosy, demonstrated on the example of folate and gyrase inhibitors.

M. Kansy, M. Wiese, K. Schaper, 1986, Leprosy review.

Spectrophotometric analysis of ribose and 2-deoxy-D-ribose alone and in mixtures.

E. R. Garrett, J. Seydel, J. Blanch, 1967, Journal of pharmaceutical sciences.

Computer Modeling and NMR Studies of Interactions Between Phospholipids and Benzylamines

M. Wiese, J. Seydel, E. Coats, 1992 .

Substituted 2-acylpyridine-alpha-(N)-hetarylhydrazones as inhibitors of ribonucleotide reductase activity and L1210 cell growth.

J. G. Cory, K. Schaper, J. Seydel, 1994, Anticancer Research.

Structure-activity relationship studies on benzofuran analogs of propafenone-type modulators of tumor cell multidrug resistance.

K J Schaper, G Ecker, P Chiba, 1996, Journal of medicinal chemistry.

Drug Membrane Interaction and the Importance for Drug Transport, Distribution, Accumulation, Efficacy and Resistance

M. Wiese, J. Seydel, E. Coats, 1994, Archiv der Pharmazie.

Nuclear magnetic resonance and differential scanning calorimetry as tools for studying drug-membrane interactions.

J. Seydel, Joachim K. Seydel, 1991, Trends in pharmacological sciences.

In vitro and in vivo results of brodimoprim and analogues alone and in combination against E. coli and mycobacteria.

J. Seydel, 1993, Journal of chemotherapy.

Workshop 3 - Chemotherapy

S. Franzblau, M. Waters, J. Seydel, 1993 .

[THE RELATION OF PHYSICAL AND CHEMICAL PROPERTIES TO THE BIOLOGICAL PROPERTIES OF CHEMOTHERAPEUTIC AGENTS].

J. Seydel, 1964, Antibiotica et chemotherapia. Fortschritte. Advances. Progres.

Effect of Cyclodextrin Derivatives on Indomethacin Stability in Aqueous Solution

B. Müller, M. Wiese, J. Seydel, 1990, Pharmaceutical Research.

QSAR and strategies in the design of bioactive compounds

J. K. Seydel, J. Seydel, 1985 .

H-BOND CONTRIBUTION TO OCTANOL-WATER PARTITION COEFFICIENTS OF POLAR COMPOUNDS

Oleg A. Raevsky, K. Schaper, O. Raevsky, 1995 .

Physicochemical Factors in Drug-Receptor Interactions Demonstrated on the Example of the Sulfanilamides*

J. Seydel, 1975 .

Drug-membrane interactions : analysis, drug distribution, modeling

Michael Wiese, M. Wiese, J. Seydel, 2002 .

Pyrimethamin-resistantPlasmodium falciparum lack cross-resistance to methotrexate and 2,4-diamino-5-(substituted benzyl) pyrimidines

B. Bergmann, R. D. Walter, M. Kansy, 2004, Parasitology Research.

A quantitative structure-activity relationship analysis of some 4-aminodiphenyl sulfone antibacterial agents using linear free energy and molecular modeling methods.

R A Pearlstein, A J Hopfinger, A. Hopfinger, 1987, Journal of medicinal chemistry.

Bacterial growth kinetics of Escherichia coli and mycobacteria in the presence of brodimoprim and metioprim alone and in combination with sulfamerazine and dapsone (VI).

J. Seydel, E. Wempe, M. Rosenfeld, 1983, Chemotherapy.

Synthesis of new 2,4-diamino-5-benzylpyrimidines active against various bacterial species

M. Wiese, J. Seydel, R. Haller, 1992 .

Persisting Mycobacterium leprae among THELEP trial patients in Bamako and Chingleput. Subcommittee on Clinical Trials of the Chemotherapy of Leprosy (THELEP) Scientific Working Group of the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases.

J. Grosset, M. Waters, J. M. Pearson, 1987, Leprosy review.

Prediction of the in vitro activity of sulfonamides synthesized from simple amines by use of electronic data obtained from the simple amines.

J. Seydel, 1971, Journal of medicinal chemistry.

Bacterial growth kinetics of "M. lufu" in the presence and absence of various drugs alone and in combination. A model for the development of combined chemotherapy against M. leprae?

J. Seydel, E. Wempe, 1982, International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association.

Mode of action and quantitative structure-activity correlations of tuberculostatic drugs of the isonicotinic acid hydrazide type.

K. Schaper, J. Seydel, H. Cordes, 1976, Journal of medicinal chemistry.

A comparison of QSARs proposed for the inhibition of dihydropteroate synthase by substituted 4-aminodiphenylsulfones

M. Koehler, A. Hopfinger, J. Seydel, 1988 .

An Extended QSAR Analysis of Some 4-Aminodiphenylsulfone Antibacterial Agents Using Molecular Modeling and LFE-Relationships

Anton J. Hopfinger, J. K. Seydel, M. Koehler, 1987 .

Mechanism of action of the folate blocker diaminodiphenylsulfone (dapsone, DDS) studied in E. coli cell-free enzyme extracts in comparison to sulfonamides (SA).

J. Seydel, E. Wempe, M. Richter, 1980, International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association.

New Antifolate 4,4′‐Diaminodiphenyl Sulfone Substituted 2,4‐Diamino‐5‐benzylpyrimidines. Proof of Their Dual Mode of Action and Autosynergism

M. Wiese, J. Seydel, D. Schmalz, 1996, Archiv der Pharmazie.

Multiple Regression Analysis of Antimalarial Activities of Sulfones and Sulfonamides in Cell-Free Systems and Principal Component Analysis to Compare with Antibacterial Activities

M. Wiese, J. Seydel, J. Keck, 1987 .

MOLECULAR BASIS FOR THE ACTION OF CHEMOTHERAPEUTIC DRUGS, STRUCTURE-ACTIVITY STUDIES ON SULFONAMIDES

J. Seydel, 1968 .

Drug‐Membrane Interaction and Pharmacokinetics of Drugs

J. Seydel, 2003 .

Synergistic antibacterial activity in vitro of trimethoprim and sulphonamides and the importance of pharmacokinetic properties for optimal therapy

J. Seydel, E. Wempe, 2005, Infection.

A comparative analysis of the synergistic interaction between N1-phenylsulfanilamides and benzylpyrimidines using qsar techniques.

M. Wiese, J. Seydel, E. Coats, 1987, Journal of enzyme inhibition.