S. Ohkuma

发表

Uptake of basic drugs into rat lung granule fraction in vitro.

E. Nakashima, K. Yokogawa, F. Ichimura, 1998, Biological & pharmaceutical bulletin.

Different roles of proteolipids and 70‐kDa subunits of V‐ATPase in growth and death of cultured human cells

K. Yokoyama, H. Zhan, H. Otani, 2003, Genes to cells : devoted to molecular & cellular mechanisms.

Expression of 16 kDa proteolipid of vacuolar-type H(+)-ATPase in human pancreatic cancer.

Miyuki Yamamoto, H. Kitagawa, T. Nagakawa, 1996, British Journal of Cancer.

Bafilomycin A1 induces apoptosis in PC12 cells independently of intracellular pH

Y. Minemoto, S. Ohkuma, K. Kinoshita, 1996, FEBS letters.

Identification and characterization of a proton pump on lysosomes by fluorescein-isothiocyanate-dextran fluorescence.

T. Takano, S. Ohkuma, Y. Moriyama, 1982, Proceedings of the National Academy of Sciences of the United States of America.

SOME ASPECTS OF THE INTRACELLULAR BREAKDOWN OF EXOGENOUS AND ENDOGENOUS PROTEINS

S. Ohkuma, M. Warburton, B. Poole, 1978 .

Transcellular transport of lipoprotein through arterial endothelial cells in monolayer culture.

Y. Yoshida, T. Takano, S. Ohkuma, 1986, Cell structure and function.

A simple estimation of peroxisomal degradation with green fluorescent protein – an application for cell cycle analysis

K. Arai, S. Ohkuma, S. Kato, 2001, FEBS letters.

In bafilomycin A1‐resistant cells, bafilomycin A1 raised lysosomal pH and both prodigiosins and concanamycin A inhibited growth through apoptosis

S. Sasaki, S. Ohkuma, Keiji Tanigaki, 2003, FEBS letters.

Monoclonal DLR1a/104G antibody recognizing peroxidized lipoproteins in atherosclerotic lesions.

T. Takano, S. Ohkuma, H. Mowri, 1988, Biochimica et biophysica acta.

Influence of Ammonium Chloride on the Tissue Distribution of Anticholinergic Drugs in Rats

E. Nakashima, K. Yokogawa, F. Ichimura, 1998, The Journal of pharmacy and pharmacology.

Purification and characterization of lysosomal H(+)-ATPase. An anion-sensitive v-type H(+)-ATPase from rat liver lysosomes.

K. Arai, S. Ohkuma, A. Shimaya, 1993, The Journal of biological chemistry.

INVOLVEMENT OF MACROPHAGES IN ACCUMULATION AND ELIMINATION OF CHOLESTEROL ESTER IN ATHEROSCLEROTIC AORTA

T. Takano, T. Kanaseki, S. Ohkuma, 1986 .

Monoclonal antibodies recognizing lipid-laden cells and extracellular regions with lipid-deposits in atherosclerotic aorta

Y. Yoshida, T. Takano, S. Ohkuma, 1987, Virchows Archiv A.

Monoclonal antibody EMR1a/212D recognizing site of deposition of extracellular lipid in atherosclerosis: purification and characterization of the antigen.

R. Sato, T. Takano, S. Ohkuma, 1989, The American journal of pathology.

Expression and localization of mRNA encoding 16 kD subunit of vacuolar H+‐ATPase in rat brain

S. Ohkuma, S. Iseki, M. Numata, 1995, Cell biology international.

Expression and localization of mRNA for the 16 KD subunit of V-ATPase in the rat embryo.

S. Ohkuma, S. Iseki, M. Numata, 1995, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Effect of PGI2 on transcellular transport of fluorescein dextran through an arterial endothelial monolayer.

C. Mineo, T. Takano, S. Ohkuma, 1987, Biochemical pharmacology.

[Studies on the mechanism of subcellular distribution of basic drugs based on their lipophilicity].

K. Yokogawa, F. Ichimura, J. Ishizaki, 2001, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Inhibition of weak-base amine-induced lysis of lysosomes by cytosol.

K. Arai, S. Ohkuma, F. Isohashi, 2002, Journal of biochemistry.

Autophagosome-Lysosome Fusion Depends on the pH in Acidic Compartments in CHO Cells

N. Nakamura, S. Takano, S. Ohkuma, 2007, Autophagy.

Small GTP-binding proteins on rat liver lysosomal membranes.

Y. Sai, S. Ohkuma, 1992, Cell structure and function.

The role of vacuolar H(+)-ATPase in the control of intragranular pH and exocytosis in eosinophils.

Y. Sai, N. Ishizaka, M. Fujimura, 1996, Laboratory investigation; a journal of technical methods and pathology.

Studies on fine structure and location of lipids in quick-freeze replicas of atherosclerotic aorta of WHHL rabbits

T. Takano, T. Kanaseki, S. Ohkuma, 1987, Virchows Archiv A.

Intracellular transport of cholesteryl esters from lysosomes to cytoplasm in macrophages.

C. Mineo, M. Enomoto, T. Takano, 1988, Cell structure and function.

Antigenic differences between the outer and inner surfaces of plasma membranes of polymorphonuclear leukocytes shown with immunoferritin.

Y. Rikihisa, D. Mizuno, S. Ohkuma, 1976, Experimental cell research.

Influence of lipophilicity and lysosomal accumulation on tissue distribution kinetics of basic drugs: a physiologically based pharmacokinetic model.

K. Yokogawa, J. Ishizaki, S. Ohkuma, 2002, Methods and findings in experimental and clinical pharmacology.

Lipid composition of low-density lysosomal membrane fraction prepared from atheromatous aorta of cholesterol-fed rabbits.

T. Kanaseki, S. Ohkuma, T. Imanaka, 1983, Biochemistry international.

ATP-dependent lysis of isolated lysosomes by basic substances and acidic ionophores.

T. Takano, S. Ohkuma, 1997, Cell structure and function.

MEMBRANOUS ATPASES AND TRANSPORT FUNCTIONS OF LYSOSOMES

Y. Moriyama, K. Arai, S. Ohkuma, 1990 .

The effects of basic substances and acidic ionophores on the digestion of exogenous and endogenous proteins in mouse peritoneal macrophages

S. Ohkuma, B. Poole, J. Chudzik, 1986, The Journal of cell biology.

Protein degradation in cells in culture.

S. Ohkuma, M. Warburton, B. Poole, 1979, Ciba Foundation symposium.

V-Type H+-ATPase/Synthase from a Thermophilic Eubacterium, Thermus Thermophilus

H. Taguchi, K. Yokoyama, M. Yoshida, 2000, The Journal of Biological Chemistry.

Bafilomycin A1 induces apoptosis in the human pancreatic cancer cell line Capan‐1

T. Terada, H. Kitagawa, T. Nagakawa, 1998, The Journal of pathology.

Acridine orange as a fluorescent probe for lysosomal proton pump.

T. Takano, S. Ohkuma, Y. Moriyama, 1982, Journal of biochemistry.

Vacuolar H+-ATPase Plays a Crucial Role in Growth and Phenotypic Modulation of Myofibroblasts in Cultured Human Saphenous Vein

H. Otani, T. Yamamura, T. Ohta, 2000, Circulation.

Potential role of vacuolar H-adenosine triphosphatase in neointimal formation in cultured human saphenous vein.

H. Otani, S. Ohkuma, M. Kido, 2000, The Journal of thoracic and cardiovascular surgery.

The accumulation of weakly basic substances in lysosomes and the inhibition of intracellular protein degradation.

S. Ohkuma, M. Warburton, B. Poole, 1977, Acta biologica et medica Germanica.

Inhibition of NGF-induced neurite outgrowth of PC12 cells by Bacillus cereus sphingomyelinase, a bacterial hemolysin.

H. Ikezawa, S. Ohkuma, K. Kinoshita, 1994, Toxicon : official journal of the International Society on Toxinology.

Reversible and potent uncoupling of hog gastric (H(+)+K(+))-ATPase by prodigiosins.

T. Kataoka, S. Shimizu, K. Nagai, 2000, Biochemical pharmacology.

Purification of acid lipase from rabbit liver

T. Takano, S. Ohkuma, T. Imanaka, 1982, FEBS letters.

Purification and properties of rabbit liver acid-lipase (4-methylumbelliferyl oleate hydrolase).

S. Ohkuma, T. Imanaka, T. Takano, 1981, Biochimica et biophysica acta.

Inhibition of cell growth by bafilomycin A1, a selective inhibitor of vacuolar H+-ATPase

Y. Sai, S. Ohkuma, K. Kinoshita, 1993, In Vitro Cellular & Developmental Biology - Animal.

Induction of phagocytic activity of M1 cells by an inhibitor of vacuolar FT‐ATPase, bafilomycin A1

S. Ohkuma, K. Kinoshita, Hiroyoshi Hidaka, 1994, FEBS letters.

Induction of neurite outgrowth of PC12 cells by an inhibitor of vacuolar H+‐ATPase, bafilomycin A1

S. Ohkuma, H. Tamura, H. Tamura, 1991, FEBS letters.

Prodigiosin 25‐C uncouples vacuolar type H+‐ATPase, inhibits vacuolar acidification and affects glycoprotein processing

M. Yamasaki, J. Magae, T. Kataoka, 1995, FEBS letters.

Formation of phagolysosomes containing dextran and Triton WR 1339 in mouse liver.

D. Mizuno, M. Futai, S. Ohkuma, 1975, Biochimica et biophysica acta.

GTPγS-Stimulated Lysosomal Lysis Dependent on the Assembly of Adaptor Protein on Lysosome

K. Arai, S. Ohkuma, Sachiyo Yoshida, 2002 .

Enhanced Acetylcholine Release from Cells that Have More 15‐kDa Proteolipid in Their Membrane, a Constituent V‐ATPase, and Mediatophore

S. Ohkuma, M. Israël, M. Tomasi, 1998, Journal of neurochemistry.

Prodigiosins uncouple lysosomal vacuolar-type ATPase through promotion of H+/Cl- symport.

T. Kataoka, K. Nagai, H. Wasserman, 1998, The Biochemical journal.

BE‐18591 as a new H+/Cl− symport ionophore that inhibits immunoproliferation and gastritis

K. Nagai, Tomohiko Sato, H. Kawashima, 2002, FEBS letters.

Prodigiosins as a New Group of H+/Cl−Symporters That Uncouple Proton Translocators*

T. Kataoka, K. Nagai, H. Wasserman, 1998, The Journal of Biological Chemistry.

Prodigiosins uncouple mitochondrial and bacterial F-ATPases: evidence for their H+/Cl- symport activity.

K. Yokoyama, T. Kataoka, K. Nagai, 1998, Journal of biochemistry.

Isolation of highly purified lysosomes from rat liver: identification of electron carrier components on lysosomal membranes.

K. Arai, T. Kanaseki, S. Ohkuma, 1991, Journal of biochemistry.

Use of fluorescein isothiocyanate-dextran to measure proton pumping in lysosomes and related organelles.

S. Ohkuma, 1989, Methods in enzymology.

Effect of weak bases on the intralysosomal pH in mouse peritoneal macrophages

S. Ohkuma, B. Poole, 1981, The Journal of cell biology.

Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents.

B Poole, S. Ohkuma, S Ohkuma, 1978, Proceedings of the National Academy of Sciences of the United States of America.

Uptake of imipramine in rat liver lysosomes in vitro and its inhibition by basic drugs.

K. Yokogawa, F. Ichimura, J. Ishizaki, 2000, The Journal of pharmacology and experimental therapeutics.

Quantifying manganese in lymphocytes to assess manganese nutritional status.

M. Kimura, Y. Itokawa, M. Kataoka, 1989, Clinical chemistry.

Proton translocating ATPase in lysosomal membrane ghosts. Evidence that alkaline Mg2+-ATPase acts as a proton pump.

T. Takano, S. Ohkuma, Y. Moriyama, 1984, Journal of biochemistry.

Positional specificity of lysosomal acid lipase purified from rabbit liver.

M. Yamaguchi, S. Ohkuma, T. Imanaka, 1985, Journal of biochemistry.

Knockdown of Mitochondrial Heat Shock Protein 70 Promotes Progeria-like Phenotypes in Caenorhabditis elegans*

N. Nakamura, S. Takano, S. Ohkuma, 2007, Journal of Biological Chemistry.

Lysosomes of rat liver and dab carcinogenesis

T. Yokoyama, D. Mizuno, T. Takano, 1971, International Journal of Cancer.

Characterization of lysosomal acid lipase purified from rabbit liver.

S. Ohkuma, T. Imanaka, T. Takano, 1984, Journal of biochemistry.

Esterastin: a potent inhibitor of lysosomal acid lipase.

S. Ohkuma, T. Imanaka, T. Takano, 1983, Journal of biochemistry.

Extended longevity of Caenorhabditis elegans by knocking in extra copies of hsp70F, a homolog of mot‐2 (mortalin)/mthsp70/Grp75

R. Hosono, K. Yokoyama, R. Wadhwa, 2002, FEBS letters.

Cytoplasmic vacuolation of mouse peritoneal macrophages and the uptake into lysosomes of weakly basic substances

B Poole, S. Ohkuma, S Ohkuma, 1981, The Journal of cell biology.

Effects of phospholipids on lysosomal acid lipase purified from rabbit liver.

S. Ohkuma, T. Imanaka, T. Takano, 1983, Journal of biochemistry.

Convergence of Cell Cycle Regulation and Growth Factor Signals on GRASP65*

K. Yoshioka, K. Nakayama, F. Barr, 2005, Journal of Biological Chemistry.

T. Takano, S. Ohkuma, Y. Moriyama, 1986, Biochimica et biophysica acta.

Elimination of Nonspecific Binding to Plasma Membranes in Indirect Immunoferritin Technique

Y. Rikihisa, D. Mizuno, S. Ohkuma, 1976 .

Peroxidized lipids isolated by HPLC from atherosclerotic aorta.

T. Takano, S. Ohkuma, H. Mowri, 1986, Biochemistry international.

Effect of dexamethasone on the multiplication of attenuated strains of hog cholera virus in pigs

S. Ohkuma, M. Shimizu, Y. Shimizu, 1976 .

Evidence for rotation of V1-ATPase

Hiroyuki Noji, Hiromi Imamura, Masasuke Yoshida, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Subunit Arrangement in V-ATPase from Thermus thermophilus*

Masasuke Yoshida, K. Nagata, K. Yokoyama, 2003, Journal of Biological Chemistry.

Properties of H(+)-ATPase from rat liver lysosomes as revealed by reconstitution into proteoliposomes.

K. Arai, M. Okamoto, S. Ohkuma, 1996, Journal of biochemistry.

Characterization of ArfGAP1 and FinGER7/FinGER8 interaction by quantitative yeast two-hybrid analysis

N. Nakamura, S. Ohkuma, Hashi Akhter, 2008 .

Cytosol Treated with GTPγS Disintegrates Lysosomes in Vitro

Y. Sai, K. Arai, S. Ohkuma, 1994 .

Differential expression of vacuolar-type H+-ATPase between normal human pancreatic islet B-cells and insulinoma cells.

T. Terada, H. Kitagawa, T. Nagakawa, 1997, International Journal of Oncology.

Dopamine release via the vacuolar ATPase V0 sector c-subunit, confirmed in N18 neuroblastoma cells, results in behavioral recovery in hemiparkinsonian mice

H. Hirai, H. Higashida, Hong-Xiang Liu, 2012, Neurochemistry International.

Molecular cloning of a rat liver cDNA encoding the 16 kDa subunit of vacuolar H(+)-ATPases: organellar and tissue distribution of 16 kDa proteolipids.

J. Nezu, S. Ohkuma, K. Motojima, 1992, Journal of biochemistry.

Electrogenic nature of lysosomal proton pump as revealed with a cyanine dye.

T. Takano, S. Ohkuma, Y. Moriyama, 1983, Journal of biochemistry.

Existence of catalase-less peroxisomes in Sf21 insect cells.

M. Nishimura, M. Morita, Y. Sakai, 2003, Biochemical and biophysical research communications.

Disintegration of lysosomes mediated by GTPgammaS-treated cytosol: possible involvement of phospholipases.

Y. Sai, K. Arai, S. Ohkuma, 1998, Journal of biochemistry.

Quantitative monitoring of autophagic degradation.

N. Nakamura, S. Takano, S. Ohkuma, 2006, Biochemical and biophysical research communications.

Transcellular transport of fluorescein dextran through an arterial endothelial cell monolayer.

T. Takano, S. Ohkuma, R. Hashida, 1986, Cell structure and function.

Transendothelial Transport of Macromolecules

T. Takano, S. Ohkuma, R. Hashida, 1988 .

Major ATPases on clofibrate-induced rat liver peroxisomes are not associated with 70 kDa peroxisomal membrane protein (PMP70).

S. Shimizu, S. Ohkuma, T. Imanaka, 1992, Journal of Biochemistry (Tokyo).

[A new strategy for the therapy of pancreatic cancer by proton pump inhibitor].

H. Kitagawa, T. Nagakawa, M. Kayahara, 1996, Gan to kagaku ryoho. Cancer & chemotherapy.