D. Hein

发表

Arylamine N-acetyltransferase 2 genotype-dependent N-acetylation of isoniazid in cryopreserved human hepatocytes

M. Doll, R. Salazar-González, S. Bodduluri, 2017, Acta pharmaceutica Sinica. B.

Relationship between N-acetyltransferase 2 single-nucleotide polymorphisms and phenotype.

M. Doll, D. Hein, L. Millner, 2010, Carcinogenesis.

A single nucleotide polymorphism tags variation in the arylamine N-acetyltransferase 2 phenotype in populations of European background

N. Malats, M. Kogevinas, N. Rothman, 2010, Pharmacogenetics and genomics.

N-acetyltransferase 2 genetic polymorphism: effects of carcinogen and haplotype on urinary bladder cancer risk

D. Hein, David W. Hein, 2006, Oncogene.

N-acetyltransferase 1 genetic polymorphism, cigarette smoking, well-done meat intake, and breast cancer risk.

J. Cerhan, T. Sellers, A. Folsom, 1999, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

N-Acetyltransferase-2 genetic polymorphism, well-done meat intake, and breast cancer risk among postmenopausal women.

A. Folsom, W. Wen, M. Gross, 2000, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

GSTM1 Null Genotype, Red Meat Consumption and Breast Cancer Risk (The Netherlands)

D. Grobbee, P. Peeters, M. Ocké, 2004, Cancer Causes & Control.

Variability in drug metabolizing enzyme activity in HIV-infected patients

A. Gaedigk, A. Kashuba, D. Hein, 2010, European Journal of Clinical Pharmacology.

Association of metabolic gene polymorphisms with tobacco consumption in healthy controls

P. Vineis, T. Rebbeck, L. Le Marchand, 2004, International journal of cancer.

Metabolic activation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Syrian hamsters congenic at the N-acetyltransferase 2 (NAT2) locus.

M. Doll, D. Hein, A. Fretland, 2003, Toxicological sciences : an official journal of the Society of Toxicology.

The T341C (Ile114Thr) polymorphism of N-acetyltransferase 2 yields slow acetylator phenotype by enhanced protein degradation.

J. States, M. Doll, D. Hein, 2004, Pharmacogenetics.

Metabolic Gene Polymorphism Frequencies in Control Populations 1

P. Vineis, T. Rebbeck, L. Marchand, 2001 .

Pharmacogenetics of the arylamine N-acetyltransferases: a symposium in honor of Wendell W. Weber.

D. Grant, F. Kadlubar, C. Mcqueen, 2000, Drug metabolism and disposition: the biological fate of chemicals.

A restriction fragment length polymorphism assay that differentiates human N-acetyltransferase-1 (NAT1) alleles.

A. Deitz, M. Doll, D. Hein, 1997, Analytical biochemistry.

Identification of a novel allele at the human NAT1 acetyltransferase locus.

T. Rustan, A. Deitz, M. Doll, 1997, Biochemical and biophysical research communications.

2-Aminofluorene-DNA adduct levels in tumor-target and nontarget organs of rapid and slow acetylator Syrian hamsters congenic at the NAT2 locus.

D. Hein, W. Jiang, Y. Feng, 1996, Toxicology and applied pharmacology.

Systemic Functional Expression of N-Acetyltransferase Polymorphism in the F344 Nat2 Congenic Rat

M. Doll, D. Hein, J. Neale, 2008, Drug Metabolism and Disposition.

N-Acetyltransferase (Nat) 1 and 2 Expression in Nat2 Knockout Mice

E. Sim, M. Doll, D. Hein, 2006, Journal of Pharmacology and Experimental Therapeutics.

Tissue distribution of N‐acetyltransferase 1 and 2 catalyzing the N‐acetylation of 4‐aminobiphenyl and O‐acetylation of N‐hydroxy‐4‐aminobiphenyl in the congenic rapid and slow acetylator Syrian hamster

M. Doll, D. Hein, A. Fretland, 2006, Molecular carcinogenesis.

Expression and genotype‐dependent catalytic activity of N‐acetyltransferase 2 (NAT2) in human peripheral blood mononuclear cells and its modulation by Sirtuin 1

E. E. Uresti-Rivera, R. Salazar-González, D. Hein, 2018, Biochemical pharmacology.

NATb/NAT1*4 promotes greater arylamine N‐acetyltransferase 1 mediated DNA adducts and mutations than NATa/NAT1*4 following exposure to 4‐aminobiphenyl

Jian Cai, J. States, M. Doll, 2012, Molecular carcinogenesis.

Phenotypic and Genotypic Characterization of N -Acetylation

D. Hein, C. K. Svensson, C. Svensson, 2005 .

Computational and Experimental Analyses of Mammalian Arylamine N-Acetyltransferase Structure and Function

J. Trent, D. Hein, J. Walraven, 2007, Drug Metabolism and Disposition.

Glutathione S-transferase genotypes and stomach cancer in a population-based case-control study in Warsaw, Poland.

K. Buetow, W. Chow, J. Lissowska, 2001, Pharmacogenetics.

PharmGKB summary: very important pharmacogene information for N-acetyltransferase 2.

R. Altman, E. McDonagh, T. Klein, 2014, Pharmacogenetics and genomics.

Acetylator phenotype and genotype in patients infected with HIV: discordance between methods for phenotype determination and genotype.

R. MacArthur, M. Doll, D. Hein, 2000, Pharmacogenetics.

Identification of N-Acetyltransferase 2 (NAT2) Transcription Start Sites and Quantitation of NAT2-Specific mRNA in Human Tissues

J. States, M. Doll, D. Hein, 2007, Drug Metabolism and Disposition.

Skin metabolism of aminophenols: human keratinocytes as a suitable in vitro model to qualitatively predict the dermal transformation of 4-amino-2-hydroxytoluene in vivo.

N. Hewitt, C. Goebel, D. Hein, 2009, Toxicology and applied pharmacology.

Genetic polymorphisms in heterocyclic amine metabolism and risk of colorectal adenomas.

R. Sinha, M. Kulldorff, N. Rothman, 2002, Pharmacogenetics.

Update on consensus arylamine N-acetyltransferase gene nomenclature.

D. Grant, E. Sim, D. Hein, 2000, Pharmacogenetics.

Lack of Association of the N-acetyltransferase NAT1*10 Allele with Prostate Cancer Incidence, Grade, or Stage Among Smokers in Finland

D. Albanes, J. Virtamo, P. Taylor, 2011, Biochemical Genetics.

Clinical Pharmacokinetics of Isoniazid

W. Weber, D. Hein, David W. Hein, 1979, Clinical pharmacokinetics.

Role of human CYP1A1 and NAT2 in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced mutagenicity and DNA adducts

W. Pierce, J. States, M. Doll, 2009, Xenobiotica; the fate of foreign compounds in biological systems.

Evaluation of Oxidative Stress Response Related Genetic Variants, Pro-oxidants, Antioxidants and Prostate Cancer

Nicole A. Lavender, G. Brock, D. Hein, 2015, AIMS medical science.

Human N-Acetyltransferase 1 and 2 Differ in Affinity Towards Acetyl-Coenzyme A Cofactor and N-Hydroxy-Arylamine Carcinogens

M. Doll, D. Hein, Mariam R. Habil, 2022, Frontiers in Pharmacology.

560G>A (rs4986782) (R187Q) Single Nucleotide Polymorphism in Arylamine N-Acetyltransferase 1 Increases Affinity for the Aromatic Amine Carcinogens 4-Aminobiphenyl and N-Hydroxy-4-Aminobiphenyl: Implications for Cancer Risk Assessment

M. Doll, D. Hein, 2022, Frontiers in Pharmacology.

Metabolic activation of carcinogenic arylamines by rapid acetylator, slow acetylator, and chimeric recombinant Syrian hamster NAT2 allozymes.

M. Doll, D. Hein, R. J. Ferguson, 1995, Proceedings of the Western Pharmacology Society.

Molecular genetics of human polymorphic N-acetyltransferase: enzymatic analysis of 15 recombinant wild-type, mutant, and chimeric NAT2 allozymes.

T. Rustan, M. Doll, D. Hein, 1994, Human molecular genetics.

Bioactivation, protein haptenation, and toxicity of sulfamethoxazole and dapsone in normal human dermal fibroblasts.

M. Doll, D. Hein, S. Roychowdhury, 2006, Toxicology and applied pharmacology.

Comprehensive human NAT2 genotype method using single nucleotide polymorphism-specific polymerase chain reaction primers and fluorogenic probes.

M. Doll, D. Hein, 2001, Analytical biochemistry.

Role of N-acetyltransferase 2 acetylation polymorphism in 4, 4'-methylene bis (2-chloroaniline) biotransformation.

M. Doll, D. Hein, Xiaoyan Zhang, 2018, Toxicology letters.

Genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2) and risk of non-Hodgkin lymphoma

J. Cerhan, N. Rothman, S. Chanock, 2006, Pharmacogenetics and genomics.

Effects of dietary factors and the NAT2 acetylator status on gastric cancer in Koreans

Yong-Dae Kim, Heon Kim, S. Eom, 2009, International journal of cancer.

N-Acetyltransferase 2 Genotype-Dependent N-Acetylation of Hydralazine in Human Hepatocytes

M. Doll, D. Hein, Cecily Allen, 2017, Drug Metabolism and Disposition.

The impact of NAT2 acetylator genotype on mutagenesis and DNA adducts from 2-amino-9H-pyrido[2,3-b]indole.

M. Doll, R. Turesky, D. Hein, 2009, Chemical research in toxicology.

The chemical form of selenium influences 3,2'-dimethyl-4-aminobiphenyl-DNA adduct formation in rat colon.

C. Davis, J. Finley, D. Hein, 1999, The Journal of nutrition.

Hexavalent chromium increases the metabolism and genotoxicity of aromatic amine carcinogens 4-aminobiphenyl and β-naphthylamine in immortalized human lung epithelial cells.

M. Doll, R. Salazar-González, D. Hein, 2022, Toxicology and applied pharmacology.

Differences between human slow N-acetyltransferase 2 alleles in levels of 4-aminobiphenyl-induced DNA adducts and mutations.

W. Pierce, M. Doll, N. Smith, 2009, Mutation research.

Reduced 4-aminobiphenyl-induced liver tumorigenicity but not DNA damage in arylamine N-acetyltransferase null mice.

W. Pierce, D. Grant, O. Sanchez, 2012, Cancer letters.

Functional analysis of arylamine N-acetyltransferase 1 (NAT1) NAT1*10 haplotypes in a complete NATb mRNA construct.

J. States, M. Doll, D. Hein, 2012, Carcinogenesis.

Association of prostate cancer with rapid N‐acetyltransferase 1 (NAT1*10) in combination with slow N‐acetyltransferase 2 acetylator genotypes in a pilot case‐control study

M. Weinrich, N. Caporaso, M. Doll, 2002, Environmental and molecular mutagenesis.

Metabolic activation of N-hydroxyarylamines and N-hydroxyarylamides by 16 recombinant human NAT2 allozymes: effects of 7 specific NAT2 nucleic acid substitutions.

T. Rustan, M. Doll, D. Hein, 1995, Cancer research.

Acetylator genotype-dependent expression of arylamine N-acetyltransferase in human colon cytosol from non-cancer and colorectal cancer patients.

D. Hein, W. Kirlin, R. J. Ferguson, 1991, Cancer research.

Nomenclature for N-acetyltransferases.

M. Relling, D. Grant, D. Bell, 1995, Pharmacogenetics.

Inactivation of GSK-3β by Metallothionein Prevents Diabetes-Related Changes in Cardiac Energy Metabolism, Inflammation, Nitrosative Damage, and Remodeling

Xiaokun Li, L. Cai, Yi Tan, 2009, Diabetes.

Relationship between N-acetylator phenotype and susceptibility toward hydrazine-induced lethal central nervous system toxicity in the rabbit.

W. Weber, D. Hein, 1984, The Journal of pharmacology and experimental therapeutics.

Method for determination of (-102C>T) single nucleotide polymorphism in the human manganese superoxide dismutase promoter

N. Rothman, J. Lissowska, Robert C. G. Martin, 2004, BMC Genetics.

Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases.

D. Grant, T. Rustan, M. Doll, 1993, Carcinogenesis.

4 – Pharmacogenetics: Pharmacogenomics

D. Grant, D. Hein, 2017 .

Functional Genomics of C190T Single Nucleotide Polymorphism in Human N-Acetyltransferase 2

M. Doll, D. Hein, Yuanqi Zhu, 2002, Biological chemistry.

Functional characterization of nucleotide polymorphisms in the coding region of N-acetyltransferase 1.

M. Doll, D. Hein, A. Fretland, 2001, Pharmacogenetics.

Functional characterization of human N-acetyltransferase 2 (NAT2) single nucleotide polymorphisms.

M. Doll, D. Hein, A. Fretland, 2001, Pharmacogenetics.

Novel Human N-Acetyltransferase 2 Alleles That Differ in Mechanism for Slow Acetylator Phenotype*

M. Doll, D. Hein, A. Fretland, 1999, The Journal of Biological Chemistry.

Prostate-specific human N-acetyltransferase 2 (NAT2) expression in the mouse.

T. Rustan, M. Doll, D. Hein, 1999, The Journal of pharmacology and experimental therapeutics.

Higher DNA adduct levels in urinary bladder and prostate of slow acetylator inbred rats administered 3,2'-dimethyl-4-aminobiphenyl.

D. Hein, W. Jiang, Y. Feng, 1999, Toxicology and applied pharmacology.

Quinoxaline – Induced DNA Adduct Formation and Mutagenesis in DNA Repair – Deficient Chinese Hamster Ovary Cells Expressing Human Cytochrome P 4501 A 1 and Rapid or Slow Acetylator N-Acetyltransferase 2

W. Pierce, J. States, M. Doll, 2007 .

2-Amino-3,8-Dimethylimidazo-[4,5-f]Quinoxaline–Induced DNA Adduct Formation and Mutagenesis in DNA Repair–Deficient Chinese Hamster Ovary Cells Expressing Human Cytochrome P4501A1 and Rapid or Slow Acetylator N-Acetyltransferase 2

W. Pierce, J. States, M. Doll, 2007, Cancer Epidemiology Biomarkers & Prevention.

- Acetyltransferase O-Hydroxyarylamine-N Hamster : Identity with Polymorphic-Acetyltransferase from Homozygous Rapid Acetylator Inbred N Purification of Hepatic Polymorphic Arylamine Updated

T. Rustan, D. Hein, W. Kirlin, 2006 .

Effect of nucleotide substitutions in N-acetyltransferase-1 on N-acetylation (deactivation) and O-acetylation (activation) of arylamine carcinogens: implications for cancer predisposition.

M. Doll, D. Hein, A. Fretland, 2002, Cancer detection and prevention.

Purification of hepatic polymorphic arylamine N-acetyltransferase from homozygous rapid acetylator inbred hamster: identity with polymorphic N-hydroxyarylamine-O-acetyltransferase.

T. Rustan, D. Hein, W. Kirlin, 1990, Cancer research.

Genetic polymorphism and cancer susceptibility: Evidence concerning acetyltransferases and cancer of the urinary bladder

D. Hein, 1988, BioEssays : news and reviews in molecular, cellular and developmental biology.

Role of the N-acetylation polymorphism in solithromycin metabolism.

M. Doll, D. Hein, 2017, Pharmacogenomics.

Identification and characterization of potent, selective, and efficacious inhibitors of human arylamine N-acetyltransferase 1

J. Trent, M. Doll, R. Salazar-González, 2021, Archives of Toxicology.

Functional effects of genetic polymorphisms in the N-acetyltransferase 1 coding and 3' untranslated regions.

J. States, D. Hein, Yang Wang, 2011, Birth defects research. Part A, Clinical and molecular teratology.

Genetic Polymorphism of N -Acetyltransferase Genes as Risk Modifiers of Colorectal Cancer from Consumption of Well-Done Meat

D. Hein, L. Kidd, Robert C. G. Martin, 2006 .

Polymorphisms of cytochrome P4501A2 and N-acetyltransferase genes, smoking, and risk of pancreatic cancer.

Manal M. Hassan, Douglas B. Evans, R. Wolff, 2006, Carcinogenesis.

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine induces a higher number of aberrant crypt foci in Fischer 344 (rapid) than in Wistar Kyoto (slow) acetylator inbred rats.

M. Wargovich, D. Hein, A. Fretland, 2000, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

4,4′-Methylenedianiline-Induced Hepatotoxicity Is Modified by N-Acetyltransferase 2 (NAT2) Acetylator Polymorphism in the Rat

G. Arteel, M. Doll, D. Hein, 2006, Journal of Pharmacology and Experimental Therapeutics.

Examination of polymorphic glutathione S-transferase (GST) genes, tobacco smoking and prostate cancer risk among Men of African Descent: A case-control study

Nicole A. Lavender, R. Kittles, G. Brock, 2009, BMC Cancer.

Rodent models of the human acetylation polymorphism: comparisons of recombinant acetyltransferases.

T. Rustan, A. Deitz, M. Doll, 1997, Mutation research.

Association between cigarette smoking and ovarian reserve among women seeking fertility care

K. Taylor, M. Doll, D. Hein, 2021, PloS one.

Role of the human N-acetyltransferase 2 genetic polymorphism in metabolism and genotoxicity of 4, 4′-methylenedianiline

M. Doll, R. Salazar-González, D. Hein, 2019, Archives of Toxicology.

Simultaneous determination of 7 N-acetyltransferase-2 single-nucleotide variations by allele-specific primer extension assay.

M. Doll, R. Valdes, D. Hein, 2006, Clinical chemistry.

Proteomic analysis of arylamine N-acetyltransferase 1 knockout breast cancer cells: Implications in immune evasion and mitochondrial biogenesis

M. Merchant, Daniel W. Wilkey, Jiong Cai, 2022, Toxicology reports.

Differences in β-naphthylamine metabolism and toxicity in Chinese hamster ovary cell lines transfected with human CYP1A2 and NAT2*4, NAT2*5B or NAT2*7B N-acetyltransferase 2 haplotypes

M. Doll, R. Salazar-González, D. Hein, 2022, Archives of Toxicology.

Symposium overview: the role of genetic polymorphism and repair deficiencies in environmental disease.

T. Kunkel, J. Taylor, M. Miller, 1999, Toxicological sciences : an official journal of the Society of Toxicology.

REVISION CARCIN-2008-00096 Interaction of the Cytochrome P4501A2, SULT1A1 and NAT Gene Polymorphisms with Smoking and Dietary Mutagen Intake in Modification of the Risk of Pancreatic Cancer

Jeffrey S. Morris, Manal M. Hassan, M. Hassan, 2007 .

Prostate expression of N-acetyltransferase 1 (NAT1) and 2 (NAT2) in rapid and slow acetylator congenic Syrian hamster.

M. Doll, D. Hein, Yi Feng, 2003, Pharmacogenetics.

Rapid genotype method to distinguish frequent and/or functional polymorphisms in human N-acetyltransferase-1.

M. Doll, D. Hein, 2002, Analytical biochemistry.

Human acetylator genotype: Relationship to colorectal cancer incidence and arylamine N-acetyltransferase expression in colon cytosol

T. Rustan, M. Doll, D. Hein, 2005, Archives of Toxicology.

Effect of rapid human N-acetyltransferase 2 haplotype on DNA damage and mutagenesis induced by 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ) and 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline (MeIQx).

W. Pierce, W. Mcgregor, J. States, 2010, Mutation research.

4-Aminobiphenyl downregulation of NAT2 acetylator genotype-dependent N- and O-acetylation of aromatic and heterocyclic amine carcinogens in primary mammary epithelial cell cultures from rapid and slow acetylator rats.

D. Hein, G. Xiao, Felicia A. Jefferson, 2008, Toxicological sciences : an official journal of the Society of Toxicology.

Functional characterization of single-nucleotide polymorphisms and haplotypes of human N-acetyltransferase 2.

J. States, M. Doll, D. Hein, 2007, Carcinogenesis.

Effects of single nucleotide polymorphisms in human N‐acetyltransferase 2 on metabolic activation (O‐acetylation) of heterocyclic amine carcinogens

M. Doll, D. Hein, A. Fretland, 2006, International journal of cancer.

No apparent association between NAT1 and NAT2 genotypes and risk of stomach cancer.

N. Rothman, W. Chow, J. Lissowska, 2003, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

DNA adduct levels and absence of tumors in female rapid and slow acetylator congenic hamsters administered the rat mammary carcinogen 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine

M. Doll, D. Hein, A. Fretland, 2001, Journal of biochemical and molecular toxicology.

Determination of human NAT2 acetylator genotype by restriction fragment-length polymorphism and allele-specific amplification.

A. Deitz, M. Doll, D. Hein, 1995, Analytical biochemistry.

Association of the Histamine N‐Methyltransferase C314T (Thr105Ile) Polymorphism with Atopic Dermatitis in Caucasian Children

G. Kearns, M. Doll, J. Sullivan, 2008, Pharmacotherapy.

Acetylator Phenotype and Genotype in HIV‐Infected Patients with and without Sulfonamide Hypersensitivity

R. MacArthur, M. Doll, D. Hein, 2002, Journal of clinical pharmacology.

Acetyl CoA:arylamine N-acetyltransferase activity in rat hepatocytes cultured on different extracellular matrices.

W. Lindblad, M. Doll, D. Hein, 1997, Toxicology in vitro : an international journal published in association with BIBRA.

Urinary acetylated metabolites and N-acetyltransferase-2 genotype in human subjects treated with a para-phenylenediamine-containing oxidative hair dye.

G. Nohynek, D. Hein, H. Toutain, 2004, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Inducible nitric oxide synthase is required in alcohol-induced liver injury: studies with knockout mice.

G. Arteel, E. Gäbele, R. Mason, 2003, Gastroenterology.

N-Acetyltransferase genetics and their role in predisposition to aromatic and heterocyclic amine-induced carcinogenesis.

D. Hein, 2000, Toxicology letters.

N-acetyltransferase single nucleotide polymorphisms: Emerging concepts serve as a paradigm for understanding complexities of personalized medicine

D. Hein, 2009 .

Association between acetylator genotype and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) DNA adduct formation in colon and prostate of inbred Fischer 344 and Wistar Kyoto rats.

M. Wargovich, H. Schut, D. Hein, 2000, Cancer letters.

Recombinant expression and catalytic analysis of rapid and slow acetylator Syrian hamster chimeric NAT2 alleles

A. Deitz, M. Doll, D. Hein, 1997, Archives of Toxicology.

Effect of acetylator genotype on 3,2'-dimethyl-4-aminobiphenyl induced aberrant crypt foci in the colon of hamsters.

J. Alexander, E. Namork, J. Paulsen, 1996, Carcinogenesis.

Acetylator genotype (NAT2)-dependent formation of aberrant crypts in congenic Syrian hamsters administered 3,2'-dimethyl-4-aminobiphenyl.

T. P. Pretlow, D. Hein, A. Fretland, 1996, Cancer research.

Role of Human N‐Acetyltransferase 2 Genetic Polymorphism on Aromatic Amine Carcinogen‐Induced DNA Damage and Mutagenicity in a Chinese Hamster Ovary Cell Mutation Assay

W. Pierce, J. States, M. Doll, 2020, Environmental and molecular mutagenesis.

N-acetyltransferase 2 acetylator genotype-dependent N-acetylation of 4-aminobiphenyl in cryopreserved human hepatocytes

M. Doll, D. Hein, Mariam R. Habil, 2019, Pharmacogenetics and genomics.

Pharmacological analysis of the discriminative stimulus characteristics of ethylketazocine in the rhesus monkey.

J. Woods, A. Young, D. Hein, 1981, The Journal of pharmacology and experimental therapeutics.

Upregulation of cytidine deaminase in NAT1 knockout breast cancer cells

M. Doll, D. Hein, Kennedy M. Walls, 2022, Journal of Cancer Research and Clinical Oncology.

Phenotype of the Most Common “Slow Acetylator” Arylamine N-Acetyltransferase 1 Genetic Variant (NAT1*14B) Is Substrate-Dependent

Jian Cai, J. States, M. Doll, 2012, Drug Metabolism and Disposition.

Extrahepatic expression of the N-acetylation polymorphism toward arylamine carcinogens in tumor target organs of an inbred rat model.

T. Rustan, W. Martin, D. Hein, 1991, The Journal of pharmacology and experimental therapeutics.

Para‐phenylenediamine and allergic sensitization: risk modification by N‐acetyltransferase 1 and 2 genotypes

H. Dickel, T. Bruckner, P. Coenraads, 2009, The British journal of dermatology.

Effect of N-Acetyltransferase 2 Polymorphism on Tumor Target Tissue DNA Adduct Levels in Rapid and Slow Acetylator Congenic Rats Administered 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine or 2-Amino-3,8-dimethylimidazo-[4,5-f]quinoxaline

W. Pierce, N. Smith, D. Hein, 2009, Drug Metabolism and Disposition.

Cloning, expression, and functional characterization of two mutant (NAT2(191) and NAT2(341/803)) and wild-type human polymorphic N-acetyltransferase (NAT2) alleles.

T. Rustan, M. Doll, D. Hein, 1994, Drug metabolism and disposition: the biological fate of chemicals.

N-acetyltransferase 2 acetylator genotype-dependent N-acetylation and toxicity of the arylamine carcinogen β-naphthylamine in cryopreserved human hepatocytes

M. Doll, R. Salazar-González, D. Hein, 2022, Archives of Toxicology.

Acetylation of putative arylamine and alkylaniline carcinogens in immortalized human fibroblasts transfected with rapid and slow acetylator N-acetyltransferase 2 haplotypes

J. States, M. Doll, D. Hein, 2020, Archives of Toxicology.

Acetylation of putative arylamine and alkylaniline carcinogens in immortalized human fibroblasts transfected with rapid and slow acetylator N-acetyltransferase 2 haplotypes

J. States, M. Doll, D. Hein, 2020, Archives of Toxicology.

Human arylamine N-acetyltransferase 2 genotype-dependent protein expression in cryopreserved human hepatocytes

M. Doll, R. Salazar-González, D. Hein, 2020, Scientific Reports.

Arylamine N-acetyltransferase 1 in situ N-acetylation on CD3+ peripheral blood mononuclear cells correlate with NATb mRNA and NAT1 haplotype

R. Salazar-González, D. Hein, D. Portales-Pérez, 2018, Archives of Toxicology.

Oral administration of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) yields PhIP-DNA adducts but not tumors in male Syrian hamsters congenic at the N-acetyltransferase 2 (NAT2) locus.

D. Hein, A. Fretland, M. A. Leff, 2001, Toxicological sciences : an official journal of the Society of Toxicology.

Acetylator Genotype-Dependent Metabolic Activation of N-Hydroxy-2-Aminofluorene in Syrian Hamster Lines Congenic at the NAT2 Locus

T. Rustan, M. Doll, D. Hein, 1994 .

N-acetylation pharmacogenetics.

W. Weber, D. Hein, 1985, Pharmacological reviews.

In memoriam: Wendell W. Weber, PhD, MD (1925-2018).

C. Mcqueen, P. Hollenberg, D. Hein, 2018, Pharmacogenetics and genomics.

Rabbit N-acetyltransferase 2 genotyping method to investigate role of acetylation polymorphism on N- and O-acetylation of aromatic and heterocyclic amine carcinogens

M. Doll, D. Hein, 2017, Archives of Toxicology.

Mouse arylamine N-acetyltransferase 2 (Nat2) expression during embryogenesis: a potential marker for the developing neuroendocrine system

E. Sim, A. Kawamura, D. Hein, 2008, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

Acetylator genotype-dependent N-acetylation of arylamines in vivo and in vitro by hepatic and extrahepatic organ cytosols of Syrian hamsters congenic at the polymorphic acetyltransferase locus

T. Rustan, W. Martin, D. Hein, 2006, Archives of Toxicology.

Metabolic activation of N-hydroxy-2-aminofluorene and N-hydroxy-2-acetylaminofluorene by monomorphic N-acetyltransferase (NAT1) and polymorphic N-acetyltransferase (NAT2) in colon cytosols of Syrian hamsters congenic at the NAT2 locus.

T. Rustan, M. Doll, D. Hein, 1993, Cancer research.

A New Model for Toxic Risk Assessments: Construction of Homozygous Rapid and Slow Acetylator Congenic Syrian Hamster Lines

D. Hein, 1991 .

Human Arylamine N-Acetyltransferase 1 (NAT1) Knockout in MDA-MB-231 Breast Cancer Cell Lines Leads to Transcription of NAT2

Samantha M. Carlisle, M. Doll, D. Hein, 2022, Frontiers in Pharmacology.

Commentary: Reflections on G. M. Lower and colleagues' 1979 study associating slow acetylator phenotype with urinary bladder cancer: meta-analysis, historical refinements of the hypothesis, and lessons learned.

N. Rothman, M. García-Closas, D. Hein, 2007, International journal of epidemiology.

NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses

N. Malats, M. Kogevinas, A. Carrato, 2005, The Lancet.

A role for bioactivation and covalent binding within epidermal keratinocytes in sulfonamide-induced cutaneous drug reactions.

P. Woster, L. Lash, M. Doll, 2000, The Journal of investigative dermatology.

Acetyltransferases and susceptibility to chemicals.

T. Rustan, M. Doll, D. Hein, 1992, Toxicology letters.

Daily Rhythm in Plasma N-acetyltryptamine

C. Mason, P. Backlund, D. Klein, 2017, Journal of biological rhythms.

Reinforcing and discriminative stimulus properties of mixed agonist-antagonist opioids.

J. Woods, A. Young, D. Hein, 1984, The Journal of pharmacology and experimental therapeutics.

Narcotic discrimination in pigeons.

J. Woods, R. Valentino, D. Hein, 1980, The Journal of pharmacology and experimental therapeutics.

Interaction of cigarette smoking and carcinogen-metabolizing polymorphisms in the risk of colorectal polyps.

W. Zheng, Q. Cai, M. Shrubsole, 2013, Carcinogenesis.

Metabolic gene polymorphism frequencies in control populations.

P. Vineis, T. Rebbeck, L. Marchand, 2001, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Acetylator Genotype-Dependent Dyslipidemia in Rats Congenic for N-Acetyltransferase 2

G. Arteel, S. Barve, M. Doll, 2020, Toxicology reports.

Genetic profiling of colon cancer

J. Spratt, D. Hein, H. Neibergs, 2002, Journal of surgical oncology.

Clinical pharmacogenetics in pediatric patients.

D. Hein, Anwar Husain, Jennifer A. Loehle, 2007, Pharmacogenomics.

Human N-acetylation of benzidine: role of NAT1 and NAT2.

T. Rustan, V. Lakshmi, A. Deitz, 1996, Cancer research.

Retrospective analysis of estrogen receptor 1 and N-acetyltransferase gene expression in normal breast tissue, primary breast tumors, and established breast cancer cell lines

Samantha M. Carlisle, D. Hein, S. Carlisle, 2018, International journal of oncology.

Etiologic heterogeneity among non-Hodgkin lymphoma subtypes.

J. Cerhan, N. Rothman, S. Chanock, 2008, Blood.

Functional Analysis of the Human N-Acetyltransferase 1 Major Promoter: Quantitation of Tissue Expression and Identification of Critical Sequence Elements

J. States, M. Doll, D. Hein, 2007, Drug Metabolism And Disposition.

Functional properties of an alternative, tissue-specific promoter for human arylamine N-acetyltransferase 1

M. Doll, D. Hein, J. Neale, 2006, Pharmacogenetics and genomics.

Acetylator genotype and arylamine-induced carcinogenesis.

D. Hein, 1988, Biochimica et biophysica acta.

CRISPR/Cas9 knockout of human arylamine N-acetyltransferase 1 in MDA-MB-231 breast cancer cells suggests a role in cellular metabolism

Samantha M. Carlisle, M. Doll, D. Hein, 2020, Scientific Reports.

Arylamine N-acetyltransferase acetylation polymorphisms: paradigm for pharmacogenomic-guided therapy- a focused review

D. Hein, L. Millner, 2020, Expert opinion on drug metabolism & toxicology.

Interaction among apoptosis-associated sequence variants and joint effects on aggressive prostate cancer

Nicole A. Lavender, G. Brock, James Rudd, 2012, BMC Medical Genomics.

No Association Between Variant N-acetyltransferase Genes, Cigarette Smoking and Prostate Cancer Susceptibility Among Men of African Descent

D. Srivastava, G. Brock, V. Pihur, 2011, Biomarkers in cancer.

N-acetyltransferase 2 genotype modification of active cigarette smoking on breast cancer risk among hispanic and non-hispanic white women.

K. Baumgartner, M. Doll, Dongyan Yang, 2009, Toxicological sciences : an official journal of the Society of Toxicology.

Deletion of arylamine N‐acetyltransferase 1 in MDA‐MB‐231 human breast cancer cells reduces primary and secondary tumor growth in vivo with no significant effects on metastasis

P. Shah, M. Doll, L. Beverly, 2022, Molecular carcinogenesis.

N-Acetyltransferase 1 Knockout Elevates Acetyl Coenzyme A Levels and Reduces Anchorage-Independent Growth in Human Breast Cancer Cell Lines

M. Doll, R. Salazar-González, D. Hein, 2019, Journal of oncology.

GSTM1 null and NAT2 slow acetylation genotypes, smoking intensity and bladder cancer risk: results from the New England bladder cancer study and NAT2 meta-analysis.

M. García-Closas, D. Silverman, S. Chanock, 2011, Carcinogenesis.

N-acetyltransferase SNPs: emerging concepts serve as a paradigm for understanding complexities of personalized medicine

D. Hein, 2009 .

N-acetyltransferaseSNPs:emerging conceptsserveasaparadigmfor understandingcomplexitiesof personalizedmedicine

D. Hein, 2009 .

Evidence for an intensity-dependent interaction of NAT2 acetylation genotype and cigarette smoking in the Spanish Bladder Cancer Study.

Debra Silverman, Núria Malats, Nathaniel Rothman, 2007, International journal of epidemiology.

Impact of misclassification in genotype-exposure interaction studies: example of N-acetyltransferase 2 (NAT2), smoking, and bladder cancer.

R. Hayes, M. García-Closas, T. Rebbeck, 2004, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Molecular genetics and function of NAT1 and NAT2: role in aromatic amine metabolism and carcinogenesis.

D. Hein, 2002, Mutation research.

Accuracy of various human NAT2 SNP genotyping panels to infer rapid, intermediate and slow acetylator phenotypes.

M. Doll, D. Hein, 2012, Pharmacogenomics.

Smoking, variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphoma: a pooled analysis within the InterLymph consortium

D. Weisenburger, J. Cerhan, N. Rothman, 2012, Cancer Causes & Control.

Codominant Expression of N-Acetylation and O-Acetylation Activities Catalyzed by N-Acetyltransferase 2 in Human Hepatocytes

T. Moeller, M. Doll, D. Hein, 2010, Journal of Pharmacology and Experimental Therapeutics.

Manganese superoxide dismutase V16A single-nucleotide polymorphism in the mitochondrial targeting sequence is associated with reduced enzymatic activity in cryopreserved human hepatocytes.

Robert C. G. Martin, M. Doll, D. Hein, 2009, DNA and cell biology.

N-acetyltransferase SNPs: emerging concepts serve as a paradigm for understanding complexities of personalized medicine.

D. Hein, 2009, Expert opinion on drug metabolism & toxicology.

Structure/function evaluations of single nucleotide polymorphisms in human N-acetyltransferase 2.

J. Trent, D. Hein, Y. Zang, 2008, Current drug metabolism.

Molecular genetics and epidemiology of the NAT1 and NAT2 acetylation polymorphisms.

M. Doll, D. Hein, A J Fretland, 2000, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Hair dye use and risk of bladder cancer in the New England bladder cancer study

D. Silverman, N. Rothman, M. Karagas, 2011, International journal of cancer.

Hair dye use, genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphoma.

J. Cerhan, N. Rothman, P. Hartge, 2007, Carcinogenesis.

Permanent hair dyes and bladder cancer: risk modification by cytochrome P4501A2 and N-acetyltransferases 1 and 2.

G. Coetzee, Jian-Min Yuan, D. Bell, 2003, Carcinogenesis.

Meat Intake, Heterocyclic Amine Exposure, and Metabolizing Enzyme Polymorphisms in Relation to Colorectal Polyp Risk

Yu Shyr, Reid M. Ness, Jirong Long, 2008, Cancer Epidemiology Biomarkers & Prevention.

Cigarette smoking, N-acetyltransferase genes and the risk of advanced colorectal adenoma.

Nilanjan Chatterjee, Timothy R Church, Meredith Yeager, 2006, Pharmacogenomics.

Dose-dependent reduction of 3,2'-dimethyl-4-aminobiphenyl-derived DNA adducts in colon and liver of rats administered celecoxib.

C. Srinivasan, Ramesh C. Gupta, D. Hein, 2008, Mutation research.

Functional effects of single nucleotide polymorphisms in the coding region of human N-acetyltransferase 1

D. Hein, Y. Zhu, 2008, The Pharmacogenomics Journal.

Molecular Genetics and Epidemiology of the NAT 1 and NAT 2 Acetylation Polymorphisms 1

M. Doll, D. Hein, Yi Feng, 2000 .

Acetyl coenzyme A kinetic studies on N-acetylation of environmental carcinogens by human N-acetyltransferase 1 and its NAT1*14B variant

M. Doll, D. Hein, Mariam R. Habil, 2022, Frontiers in Pharmacology.

Functional expression of human arylamine N-acetyltransferase NAT1*10 and NAT1*11 alleles: a mini review.

G. Fakis, S. Boukouvala, D. Hein, 2018, Pharmacogenetics and genomics.

Structure-Function Analyses of Single Nucleotide Polymorphisms in Human N-Acetyltransferase 1

J. Trent, D. Hein, J. Walraven, 2008, Drug metabolism reviews.

Functional characterization of the A411T (L137F) and G364A (D122N) genetic polymorphisms in human N-acetyltransferase 2

M. Doll, D. Hein, Y. Zang, 2007, Pharmacogenetics and genomics.

Identification of the major promoter and non-coding exons of the human arylamine N-acetyltransferase 1 gene (NAT1).

J. States, M. Doll, D. Hein, 2004, Pharmacogenetics.

Folate-dependent hydrolysis of acetyl-coenzyme A by recombinant human and rodent arylamine N-acetyltransferases

J. States, M. Doll, D. Hein, 2015, Biochemistry and biophysics reports.

Genetic and small molecule inhibition of arylamine N‐acetyltransferase 1 reduces anchorage‐independent growth in human breast cancer cell line MDA‐MB‐231

Samantha M. Carlisle, J. States, M. Doll, 2018, Molecular carcinogenesis.

Congenic rats with higher arylamine N-acetyltransferase 2 activity exhibit greater carcinogen-induced mammary tumor susceptibility independent of carcinogen metabolism

J. States, M. Doll, D. Hein, 2017, BMC Cancer.

Changes in consensus arylamine N-acetyltransferase gene nomenclature.

D. Grant, R. Minchin, E. Sim, 2008, Pharmacogenetics and genomics.

Polymorphic expression of acetyl coenzyme A-dependent arylamine N-acetyltransferase and acetyl coenzyme A-dependent O-acetyltransferase-mediated activation of N-hydroxyarylamines by human bladder cytosol.

P. K. Brady, D. Hein, W. Kirlin, 1989, Cancer research.

Manganese Superoxide Dismutase Expression as a Function of Genotype and Lung Cancer Pathology

Robert C. G. Martin, M. Doll, D. Hein, 2010, Cancer investigation.

Characterization of N-acetyltransferase 1 and 2 polymorphisms and haplotype analysis for inflammatory bowel disease and sporadic colorectal carcinoma

N. Crawford, S. Galandiuk, R. Petras, 2007, BMC Medical Genetics.

Dietary selenium reduces the formation of aberrant crypts in rats administered 3,2'-dimethyl-4-aminobiphenyl.

C. Davis, J. Finley, D. Hein, 1999, Toxicology and applied pharmacology.

Role of the renin‐angiotensin system in hepatic ischemia reperfusion injury in rats

G. Arteel, M. Doll, D. Hein, 2004, Hepatology.

No apparent association between genetic polymorphisms (-102 C>T) and (-9 T>C) in the human manganese superoxide dismutase gene and gastric cancer(1).

N. Rothman, J. Lissowska, Robert C. G. Martin, 2005, The Journal of surgical research.

Association between manganese superoxide dismutase promoter gene polymorphism and breast cancer survival

Robert C. G. Martin, C. Ambrosone, Jiyoung Ahn, 2006, Breast Cancer Research.

Genetic variation in N-acetyltransferases 1 and 2, cigarette smoking, and risk of non-Hodgkin lymphoma

N. Rothman, S. Chanock, P. Boyle, 2009, Cancer Causes & Control.

Interaction of the cytochrome P4501A2, SULT1A1 and NAT gene polymorphisms with smoking and dietary mutagen intake in modification of the risk of pancreatic cancer

Jeffrey S. Morris, Manal M. Hassan, M. Hassan, 2008, Carcinogenesis.

Higher frequency of aberrant crypt foci in rapid than slow acetylator inbred rats administered the colon carcinogen 3,2'-dimethyl-4-aminobiphenyl.

T. Rustan, D. Hein, A. Fretland, 1997, Toxicology and applied pharmacology.

N-acetyltransferase (NAT1, NAT2) and glutathione S-transferase (GSTM1, GSTT1) polymorphisms in breast cancer.

D. Noh, D. Kang, K. Yoo, 2003, Cancer letters.

NAT2 slow acetylation and GSTM1 null genotypes may increase postmenopausal breast cancer risk in long-term smoking women.

Diederick E Grobbee, D. Grobbee, P. Peeters, 2003, Pharmacogenetics.

Metabolic activation of aromatic and heterocyclicN-hydroxyarylamines by wild-type and mutant recombinant human NAT1 and NAT2 acetyltransferases

T. Rustan, M. Doll, D. Hein, 2007, Archives of Toxicology.

Using gene-environment interaction analyses to clarify the role of well-done meat and heterocyclic amine exposure in the etiology of colorectal polyps.

W. Zheng, Q. Cai, M. Shrubsole, 2012, The American journal of clinical nutrition.

Title Polymorphic genes of detoxification and mitochondrial enzymes and risk for progressive supranuclear palsy : A case control study

M. Farrer, D. Dickson, S. Rai, 2012 .

Polymorphic genes of detoxification and mitochondrial enzymes and risk for progressive supranuclear palsy: a case control study

M. Farrer, D. Dickson, S. Rai, 2012, BMC Medical Genetics.

2‐amino‐1‐methyl‐6‐phenylimidazo [4,5‐b] pyridine‐induced DNA adducts and genotoxicity in chinese hamster ovary (CHO) cells expressing human CYP1A2 and rapid or slow acetylator N‐acetyltransferase 2

W. Pierce, W. Mcgregor, J. States, 2007, Molecular carcinogenesis.

NAT2 slow acetylation and GSTM1 null genotypes increase bladder cancer risk: results from the Spanish Bladder Cancer Study and meta-analyses

Nilanjan Chatterjee, Debra Silverman, Núria Malats, 2008 .

Quantitative Tissue and Gene-Specific Differences and Developmental Changes in Nat1, Nat2, and Nat3 mRNA Expression in the Rat

J. States, M. Doll, D. Hein, 2008, Drug Metabolism and Disposition.

Tissue expression and genomic sequences of rat N-acetyltransferases rNat1, rNat2, rNat3, and Functional characterization of a novel rNat3*2 genetic variant.

M. Doll, D. Hein, J. Walraven, 2007, Toxicological sciences : an official journal of the Society of Toxicology.

Identification and Characterization of Functional Rat Arylamine N-Acetyltransferase 3: Comparisons with Rat Arylamine N-Acetyltransferases 1 and 2

M. Doll, D. Hein, J. Walraven, 2006, Journal of Pharmacology and Experimental Therapeutics.

Cloning, sequencing, and recombinant expression of NAT1, NAT2, and NAT3 derived from the C3H/HeJ (rapid) and A/HeJ (slow) acetylator inbred mouse: functional characterization of the activation and deactivation of aromatic amine carcinogens.

M. Doll, D. Hein, A. Fretland, 1997, Toxicology and applied pharmacology.

Acetylator phenotype-dependent and -independent expression of arylamine N-acetyltransferase isozymes in rapid and slow acetylator inbred rat liver.

T. Rustan, W. Martin, D. Hein, 1991, Drug metabolism and disposition: the biological fate of chemicals.

METHODS FOR AROMATIC AND HETEROCYCLIC AMINE CARCINOGEN-DNA ADDUCT ANALYSIS BY LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY

W. Pierce, N. Smith, D. Hein, 2008, Polycyclic aromatic compounds.

Metabolic Activation of yV-Hydroxy-2-aminofluorene and 7V-Hydroxy-2-acetylaminofluorene by Monomorphic W-Acetyltransferase (NATI) and Polymorphic W-Acetyltransferase (NAT2) in Colon Cytosols of Syrian Hamsters Congenie at the NAT2 Locus1

Timothy, M. Doll, D. Hein, 2006 .

Heterocyclic amines reduce insulin-induced AKT phosphorylation and induce gluconeogenic gene expression in human hepatocytes

D. Hein, Kennedy M. Walls, Kyung U Hong, 2023, Archives of Toxicology.

High N-Acetyltransferase 1 Expression is Associated with Estrogen Receptor Expression in Breast Tumors, but is not Under Direct Regulation by Estradiol, 5α-androstane-3β, 17β-Diol, or Dihydrotestosterone in Breast Cancer Cells

Samantha M. Carlisle, C. Klinge, Robert C. G. Martin, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Metallothionein suppresses angiotensin II-induced nicotinamide adenine dinucleotide phosphate oxidase activation, nitrosative stress, apoptosis, and pathological remodeling in the diabetic heart.

S. Prabhu, Xiaokun Li, L. Cai, 2008, Journal of the American College of Cardiology.

Haplotype of N-Acetyltransferase 1 and 2 and Risk of Pancreatic Cancer

Manal M. Hassan, J. Hixson, M. Hassan, 2007, Cancer Epidemiology Biomarkers & Prevention.

Polymorphic and monomorphic expression of arylamine carcinogen N-acetyltransferase isozymes in tumor target organ cytosols of Syrian hamsters congenic at the polymorphic acetyltransferase locus.

T. Rustan, D. Hein, K. D. Bucher, 1991, The Journal of pharmacology and experimental therapeutics.

Acetylator genotype-dependent expression of arylamine N-acetyltransferase and N-hydroxyarylamine O-acetyltransferase in Syrian inbred hamster intestine and colon. Identity with the hepatic acetylation polymorphism.

D. Hein, W. Kirlin, R. J. Ferguson, 1990, Drug metabolism and disposition: the biological fate of chemicals.

Kinetic characterization of acetylator genotype-dependent and -independent N-acetyltransferase isozymes in homozygous rapid and slow acetylator inbred hamster liver cytosol.

P. K. Brady, D. Hein, W. Kirlin, 1989, Drug metabolism and disposition: the biological fate of chemicals.

Identification and kinetic characterization of acetylator genotype-dependent and -independent arylamine carcinogen N-acetyltransferases in hamster bladder cytosol.

P. K. Brady, D. Hein, W. Kirlin, 1989, Drug metabolism and disposition: the biological fate of chemicals.

Acetylator genotype-dependent metabolic activation of carcinogenic N-hydroxyarylamines by S-acetyl coenzyme A-dependent enzymes of inbred hamster tissue cytosols: relationship to arylamine N-acetyltransferase.

D. Hein, W. Kirlin, T. Flammang, 1987, Carcinogenesis.

Inheritance of acetylator genotype-dependent arylamine N-acetyltransferase in hamster bladder cytosol.

D. Hein, W. Kirlin, T. Yerokun, 1987, Carcinogenesis.

Extrahepatic expression of N-acetylator genotype in the inbred hamster.

D. Hein, W. Kirlin, F. Ogolla, 1987, Drug metabolism and disposition: the biological fate of chemicals.

Biochemical investigation of the basis for the genetic N-acetylation polymorphism in the inbred hamster.

W. Weber, D. Hein, W. Kirlin, 1985, The Journal of pharmacology and experimental therapeutics.

Transcriptional Regulation of Human Arylamine N-Acetyltransferase 2 Gene by Glucose and Insulin in Liver Cancer Cell Lines.

R. Salazar-González, D. Hein, Kennedy M. Walls, 2022, Toxicological sciences : an official journal of the Society of Toxicology.

Effect of N-acetyltransferase 2 genetic polymorphism on 4,4′-methylenebis(2-chloroaniline)-induced genotoxicity and oxidative stress

M. Doll, R. Salazar-González, D. Hein, 2023, Archives of Toxicology.

DNA adduct levels and intestinal lesions in congenic rapid and slow acetylator syrian hamsters admi food mutagens 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) or 2-amino-3-methylimidazo[4,5-f]quinoline (IQ).

J. Alexander, T. Eide, J. Paulsen, 2000, Pharmacology & toxicology.

Dehydroepiandrosterone Activation of G-protein-coupled Estrogen Receptor Rapidly Stimulates MicroRNA-21 Transcription in Human Hepatocellular Carcinoma Cells*

C. Klinge, Y. Teng, R. Prough, 2015, The Journal of Biological Chemistry.

GSTM 1 null and NAT 2 slow acetylation genotypes , smoking intensity and bladder cancer risk : results from the New England bladder cancer study and NAT 2 meta-analysis

M. García-Closas, D. Silverman, S. Chanock, 2011 .

Effects of dose and human N-acetyltransferase 1 genetic polymorphism in benzidine metabolism and genotoxicity

D. Hein, Mariam R Habil, 2023, Archives of Toxicology.

N-acetyltransferase 2 genetic polymorphism modifies genotoxic and oxidative damage from new psychoactive substances

M. Doll, R. Salazar-González, D. Hein, 2022, Archives of Toxicology.

Relationship of acetylator status to isoniazid toxicity, lupus erythematosus, and bladder cancer.

W. Weber, D. Hein, G. Lower, 1983, Federation proceedings.

Non-coding and intergenic genetic variants of human arylamine N-acetyltransferase 2 (NAT2) gene are associated with differential plasma lipid and cholesterol levels and cardiometabolic disorders

D. Hein, Kennedy M. Walls, Kyung U Hong, 2023, Frontiers in Pharmacology.

Congenic rats with higher arylamine N-acetyltransferase 2 activity exhibit greater carcinogen-induced mammary tumor susceptibility independent of carcinogen metabolism

J. States, M. Sanders, M. Doll, 2017, BMC Cancer.

Arylamine N-Acetyltransferase 1 Activity is Regulated by the Protein Acetylation Status

M. Doll, R. Salazar-González, D. Hein, 2022, Frontiers in Pharmacology.

Knockout of human arylamine N‐acetyltransferase 1 (NAT1) in MDA‐MB‐231 breast cancer cells leads to increased reserve capacity, maximum mitochondrial capacity, and glycolytic reserve capacity

Samantha M. Carlisle, C. Klinge, M. Doll, 2018, Molecular carcinogenesis.

Cloning, sequencing and expression of NAT1 and NAT2 encoding genes from rapid and slow acetylator inbred rats.

M. Doll, D. Hein, 1995, Pharmacogenetics.

TaqMan Real Time–Polymerase Chain Reaction Methods for Determination of Nucleotide Polymorphisms in Human N‐Acetyltransferase‐1 (NAT1) and ‐2 (NAT2)

M. Doll, D. Hein, 2004, Current protocols in toxicology.

N-acetyltransferase 2 haplotype modifies risks for both dyslipidemia and urinary bladder cancer.

D. Hein, Kyung U Hong, Kyung U. Hong, 2023, Pharmacogenetics and genomics.

Manganese superoxide dismutase gene coding region polymorphisms lack clinical incidence in general population.

E. Bowman, C. Harris, Robert C. G. Martin, 2008, DNA and cell biology.

An Alternative Cyclin-D1 Splice Site is Not Linked to Inflammatory Bowel Disease-Associated Neoplasia

N. Crawford, S. Galandiuk, M. Eichenberger, 2010, The International journal of biological markers.

Stable Isotope Tracing Reveals an Altered Fate of Glucose in N-Acetyltransferase 1 Knockout Breast Cancer Cells

Xinmin Yin, D. Hein, J. Wise, 2023, Genes.

Untargeted polar metabolomics of transformed MDA-MB-231 breast cancer cells expressing varying levels of human arylamine N-acetyltransferase 1

Samantha M. Carlisle, Xinmin Yin, J. States, 2016, Metabolomics.

Simultaneous Determination of 7 N-Acetyltransferase-2 Sequence Variations by Allele-Specific Primer Extension Assay

M. Doll, R. Valdes, D. Hein, 2006 .

Design and Success of a 21st Century Cancer Education Program at the University of Louisville

D. Hein, L. Kidd, 2018, Journal of Cancer Education.

Cloning, expression, and functional characterization of rapid and slow acetylator polymorphic N-acetyl-transferase encoding genes of the Syrian hamster.

T. Rustan, M. Doll, D. Hein, 1996, Pharmacogenetics.

Syrian hamster monomorphic N-acetyltransferase (NAT1) alleles: amplification, cloning, sequencing, and expression in E. coli.

T. Rustan, M. Doll, D. Hein, 1994, Pharmacogenetics.

Polymorphic arylamine N-acetyltransferase encoding gene (NAT2) from homozygous rapid and slow acetylator congenic Syrian hamsters.

M. Doll, D. Hein, R. J. Ferguson, 1994, Gene.

Construction of Syrian hamster lines congenic at the polymorphic acetyltransferase locus (NAT2): acetylator genotype-dependent N- and O-acetylation of arylamine carcinogens.

T. Rustan, M. Doll, D. Hein, 1994, Toxicology and applied pharmacology.

Genetic heterogeneity among slow acetylator N-acetyltransferase 2 phenotypes in cryopreserved human hepatocytes

M. Doll, D. Hein, 2017, Archives of Toxicology.

Chemoprevention of Arylamine-Induced Colorectal Aberrant Crypts

M. Doll, D. Hein, Yi Feng, 2008, Experimental biology and medicine.

SCREENING METHOD FOR URINARY BLADDER TUMOR DETECTION IN THE SYRIAN HAMSTER

T. Rustan, D. Hein, Yi Feng, 1999 .

A unique pharmacogenetic expression of the N-acetylation polymorphism in the inbred hamster.

J. Brewer, J. Omichinski, W. Weber, 1982, The Journal of pharmacology and experimental therapeutics.

Correction: Acetylator phenotype and genoype in patients infected with HIV: Discordance between methods for phenotype determination and genotype (Pharmacogenetics (2000) 10 (171-182))

R. MacArthur, M. Doll, D. Hein, 2000 .

Identification of genetically homozygous rapid and slow acetylators of drugs and environmental carcinogens among established inbred rabbit strains.

W. Weber, D. Hein, T. N. Smolen, 1982, The Journal of pharmacology and experimental therapeutics.

Rabbit N-acetyltransferase 2 genotyping method to investigate role of acetylation polymorphism on N- and O-acetylation of aromatic and heterocyclic amine carcinogens

M. Doll, D. Hein, 2017, Archives of Toxicology.

Chemopreventive drug treatment in subjects with genetic predisposition to cancer: prescriber liability and healthcare disparities.

D. Hein, L. Palmer, R. Martin, 2004, Pharmacogenomics.

Method for determination of (-102C>T) single nucleotide polymorphism in the human manganese superoxide dismutase promoter

N. Rothman, J. Lissowska, Robert C. G. Martin, 2004, BMC Genetics.

Polymorphisms of cytochrome P4501A2 and N-acetyltransferase genes, smoking, and risk of pancreatic cancer.

Manal M. Hassan, Douglas B. Evans, R. Wolff, 2006, Carcinogenesis.

Induction of Glucose Production by Heterocyclic Amines is Dependent on N-acetyltransferase 2 Genetic Polymorphism in Cryopreserved Human Hepatocytes.

D. Hein, Kennedy M. Walls, Kyung U. Hong, 2023, Toxicology letters.

N-Acetyltransferase 2 Genotype-Dependent N-Acetylation of Hydralazine in Human Hepatocytes

M. Doll, D. Hein, C. Allen, 2017, Drug Metabolism and Disposition.

Discriminative stimulus, antagonist, and rate-decreasing effects of cyclorphan: multiple modes of action.

J. Woods, R. Valentino, D. Hein, 1982, Life sciences.

J. Woods, G. Winger, D. Hein, 2004, Psychopharmacology.

Biochemical evidence for the coexistence of monomorphic and polymorphic N-acetyltransferase activities on a common protein in rabbit liver.

W. Weber, D. Hein, M. Hirata, 1982, The Journal of pharmacology and experimental therapeutics.

Arylamine N-acetyltransferase 1 in situ N-acetylation on CD3+ peripheral blood mononuclear cells correlate with NATb mRNA and NAT1 haplotype

R. Salazar-González, D. Hein, D. Portales-Pérez, 2017, Archives of Toxicology.

Genetic control of acetyl coenzyme A-dependent arylamine N-acetyltransferase, hydrazine N-acetyltransferase, and N-hydroxy-arylamine O-acetyltransferase enzymes in C57BL/6J, A/J, AC57F1, and the rapid and slow acetylator A.B6 and B6.A congenic inbred mouse.

W. Weber, D. Hein, W. Kirlin, 1988, Drug metabolism and disposition: the biological fate of chemicals.

3,2'-Dimethyl-4-aminobiphenyl-DNA adduct formation in tumor target and nontarget organs of rapid and slow acetylator Syrian hamsters cogenic at the NAT2 locus.

A. Deitz, D. Hein, W. Jiang, 1996, Toxicology and applied pharmacology.

Arylamine N-Acetyltransferase Type 2 Polymorphism and Human Urinary Bladder and Breast Cancer Risks

D. Hein, 2018 .