Gary K. Smith

发表

Expression, preparation, and high-throughput screening of caspase-8: discovery of redox-based and steroid diacid inhibition.

Michael Cory, K. Blackburn, W. Dallas, 2002, Archives of biochemistry and biophysics.

Flux Control Coefficients of Glycinamide Ribonucleotide Transformylase for de novo Purine Biosynthesis

Mark Salter, Robert J. Mullin, Gary K. Smith, 1990 .

Distinct concentration-dependent effects of the polo-like kinase 1-specific inhibitor GSK461364A, including differential effect on apoptosis.

J. Jackson, A. Gilmartin, R. Kruger, 2009, Cancer research.

Novel Rho Kinase Inhibitors with Anti-inflammatory and Vasodilatory Activities

D. Behm, R. Bentley, C. Doe, 2007, Journal of Pharmacology and Experimental Therapeutics.

Destruction of WiDr multicellular tumor spheroids with the novel thymidylate synthase inhibitor 1843U89 at physiological thymidine concentrations

Gary K. Smith, S. Dickerson, W. Pendergast, 2004, Cancer Chemotherapy and Pharmacology.

Chapter 1:The Kinome and its Impact on Medicinal Chemistry

P. Bamborough, D. Drewry, Klaus Schneider, 2011 .

Discovery of novel urea-based hepatitis C protease inhibitors with high potency against protease-inhibitor-resistant mutants.

R. Hamatake, Suoming Zhang, S. Baker, 2012, Journal of medicinal chemistry.

Discovery of a potent boronic acid derived inhibitor of the HCV RNA-dependent RNA polymerase.

R. Hamatake, Z. Hong, Shawn P. Williams, 2014, Journal of medicinal chemistry.

Synthesis of new acylsulfamoyl benzoxaboroles as potent inhibitors of HCV NS3 protease.

Z. Ni, Suoming Zhang, S. Baker, 2010, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of novel alpha-amino cyclic boronates as inhibitors of HCV NS3 protease.

Z. Ni, P. Rowland, S. Baker, 2010, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluations of P4-benzoxaborole-substituted macrocyclic inhibitors of HCV NS3 protease.

Z. Ni, Suoming Zhang, S. Baker, 2010, Bioorganic & medicinal chemistry letters.

Benzoquinazoline Inhibitor of Thymidylate Synthase Biochemical and Cellular Pharmacology of 1843 U 89 , a Novel Updated

Pendergast, Kathleen, J. Humphreys, 2006 .

Toward Antibody-directed Enzyme Prodrug Therapy with the T268G Mutant of Human Carboxypeptidase A1 and Novel in VivoStable Prodrugs of Methotrexate*

John Miller, J. Humphreys, T. Blumenkopf, 1997, The Journal of Biological Chemistry.

Expression, purification, and characterization of an enzymatically active truncated human rho-kinase I (ROCK I) domain expressed in Sf-9 insect cells.

S. Khandekar, E. Hu, R. Kirkpatrick, 2006, Protein and peptide letters.

Biosynthesis and function of tetrahydrobiopterin

Gary K. Smith, D. Duch, 1991 .

Inhibition of Tumor Necrosis Factor-induced Cell Death in MCF7 by a Novel Inhibitor of Neutral Sphingomyelinase*

Y. Hannun, L. Obeid, Y. Okamoto, 2002, The Journal of Biological Chemistry.

Assessment of chemical coverage of kinome space and its implications for kinase drug discovery.

Gavin Harper, David Drewry, Paul Bamborough, 2008, Journal of medicinal chemistry.

Potent, selective and orally bioavailable dihydropyrimidine inhibitors of Rho kinase (ROCK1) as potential therapeutic agents for cardiovascular diseases.

S. Semus, D. Behm, R. Bentley, 2008, Journal of medicinal chemistry.

Development of dihydropyridone indazole amides as selective Rho-kinase inhibitors.

S. Semus, D. Behm, R. Bentley, 2007, Journal of medicinal chemistry.

Synthesis and SAR of acyclic HCV NS3 protease inhibitors with novel P4-benzoxaborole moieties.

Z. Ni, Suoming Zhang, S. Baker, 2011, Bioorganic & medicinal chemistry letters.

Thienyl and Thiazolyl Acyclic Analogues of 5‐Deazatetrahydrofolic Acid.

Gary K. Smith, E. Bigham, D. Duch, 1994 .

Multisubstrate Analogue Inhibitors of Glycinamide Ribonucleotide Transformylase Based on 5-Deazaacyclo Tetrahudrofolate (5-DACTHF)

R. Ferone, Gary K. Smith, E. Bigham, 1993 .

Discovery of an inhibitor of insulin-like growth factor 1 receptor activation: implications for cellular potency and selectivity over insulin receptor.

E. Alvarez, L. Shewchuk, H. Xie, 2009, Biochemical pharmacology.

Inhibition of translation and induction of apoptosis by Bunyaviral nonstructural proteins bearing sequence similarity to reaper.

Daniel A. Colón-Ramos, R. Morimoto, R. Hollingsworth, 2003, Molecular biology of the cell.

Pro-cathepsin D interacts with the extracellular domain of the β chain of LRP1 and promotes LRP1-dependent fibroblast outgrowth

B. Hyman, S. Pattingre, R. Hollingsworth, 2010, Journal of Cell Science.

Cell-based assays for kinase drug discovery.

E. Wood, Gary K. Smith, 2010, Drug discovery today. Technologies.

Biochemical characterization of GSK461364: A novel, potent, and selective inhibitor of Polo-like kinase-1 (Plk1)

R. Copeland, R. Gontarek, Gary K. Smith, 2007 .

Glucocorticoids Regulate Inducible Nitric Oxide Synthase by Inhibiting Tetrahydrobiopterin Synthesis and L-Arginine Transport*

R. Kelly, Gary K. Smith, W. W. Simmons, 1996, The Journal of Biological Chemistry.

Discovery of aminofurazan-azabenzimidazoles as inhibitors of Rho-kinase with high kinase selectivity and antihypertensive activity.

S. Semus, M. Head, D. Behm, 2007, Journal of medicinal chemistry.

Purification and Characterization of a Membrane Bound Neutral pH Optimum Magnesium-dependent and Phosphatidylserine-stimulated Sphingomyelinase from Rat Brain*

B. Liu, Y. Hannun, K. Weaver, 1998, The Journal of Biological Chemistry.

STUDIES ON THE BIOSYNTHESIS OF TETRAHYDROBIOPTERIN IN BOVINE ADRENAL MEDULLA PREPARATIONS

Gary K. Smith, C. A. Nichol, 1983 .

Imidazo[5,1-f][1,2,4]triazin-2-amines as novel inhibitors of polo-like kinase 1.

L. Shewchuk, T. J. Lansing, R. Mook, 2008, Bioorganic & medicinal chemistry letters.

Increases in neutral, Mg2+-dependent and acidic, Mg2+-independent sphingomyelinase activities precede commitment to apoptosis and are not a consequence of caspase 3-like activity in Molt-4 cells in response to thymidylate synthase inhibition by GW1843.

Y. Hannun, R. Sundseth, J. Strum, 1998, Blood.

LRP 1 receptor and inhibits LRP 1 regulated intramembrane proteolysis

S. Pattingre, V. Laurent-Matha, M. Beaujouin, 2011 .

Novel macrocyclic HCV NS3 protease inhibitors derived from α-amino cyclic boronates.

William McDowell, Yang Liu, Dazhong Fan, 2010, Bioorganic & medicinal chemistry letters.

Biochemical and cellular pharmacology of 1843U89, a novel benzoquinazoline inhibitor of thymidylate synthase.

R. Ferone, J. Humphreys, Gary K. Smith, 1993, Cancer research.