J D Lear

发表

A helical-dipole model describes the single-channel current rectification of an uncharged peptide ion channel.

P. Kienker, W. DeGrado, J. Lear, 1994, Proceedings of the National Academy of Sciences of the United States of America.

A new data analysis method to determine binding constants of small molecules to proteins using equilibrium analytical ultracentrifugation with absorption optics.

J. Lear, J D Lear, M Arkin, 2001, Analytical biochemistry.

Multivalent ligand-receptor binding interactions in the fibroblast growth factor system produce a cooperative growth factor and heparin mechanism for receptor dimerization.

J. Lear, M. Pantoliano, D. E. Van Dyk, 1994, Biochemistry.

Synthetic amphiphilic peptide models for protein ion channels.

W. DeGrado, J. Lear, Z. Wasserman, 1988, Science.

From synthetic coiled coils to functional proteins: automated design of a receptor for the calmodulin-binding domain of calcineurin.

W. DeGrado, J. Lear, G. Ghirlanda, 1998, Journal of molecular biology.

Fluorescence studies of the secondary structure and orientation of a model ion channel peptide in phospholipid vesicles.

W. DeGrado, J. Lear, W F DeGrado, 1992, Biochemistry.

De novo design, synthesis and characterization of membrane-active peptides.

W F DeGrado, J D Lear, H Gratkowski, 2001, Biochemical Society transactions.

Protein design, a minimalist approach.

W. DeGrado, J. Lear, Z. Wasserman, 1989, Science.

Polar side chains drive the association of model transmembrane peptides.

W. DeGrado, J. Lear, H. Gratkowski, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Charge selectivity of the designed uncharged peptide ion channel Ac-(LSSLLSL)3-CONH2.

P. Kienker, J. Lear, P K Kienker, 1995, Biophysical journal.

Exploration of the structural features defining the conduction properties of a synthetic ion channel.

K. Sharp, M. Klein, W. DeGrado, 1999, Biophysical journal.

Morphological changes and fusogenic activity of influenza virus hemagglutinin.

J. Lear, P. Axelsen, T. Shangguan, 1998, Biophysical journal.

Two possible conducting states of the influenza A virus M2 ion channel

Q Zhong, D M Newns, M L Klein, 2000, FEBS letters.

pH-dependent tetramerization and amantadine binding of the transmembrane helix of M2 from the influenza A virus.

W. DeGrado, J. Lear, D. Salom, 2000, Biochemistry.

A functionally defined model for the M2 proton channel of influenza A virus suggests a mechanism for its ion selectivity.

R. Lamb, W. DeGrado, L. Pinto, 1997, Proceedings of the National Academy of Sciences of the United States of America.