Wataru Mizushima

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Hippo Deficiency Leads to Cardiac Dysfunction Accompanied by Cardiomyocyte Dedifferentiation During Pressure Overload

Lai-Hua Xie, M. Abdellatif, D. Lim, 2019, Circulation research.

Dipeptidyl peptidase-4 inhibitor improved exercise capacity and mitochondrial biogenesis in mice with heart failure via activation of glucagon-like peptide-1 receptor signalling.

Shinya Tanaka, H. Tsutsui, S. Matsushima, 2016, Cardiovascular research.

Yes-associated protein (YAP) mediates adaptive cardiac hypertrophy in response to pressure overload

S. Miyamoto, J. Sadoshima, A. Shirakabe, 2019, The Journal of Biological Chemistry.

Sesamin prevents decline in exercise capacity and impairment of skeletal muscle mitochondrial function in mice with high‐fat diet‐induced diabetes

H. Tsutsui, H. Shibata, Y. Ono, 2015, Experimental physiology.

Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure

T. Iwanaga, H. Sabe, Shinya Tanaka, 2021, Communications biology.

mitoNEET Regulates Mitochondrial Iron Homeostasis Interacting with Transferrin Receptor

K. Nakayama, M. Matsumoto, S. Hatakeyama, 2017, bioRxiv.

Instructions for use Title The experimental model of transition from compensated cardiac hypertrophy to failure created by transverse aorticconstriction in mice

H. Tsutsui, S. Matsushima, Wataru Mizushima, 2018 .

The experimental model of transition from compensated cardiac hypertrophy to failure created by transverse aortic constriction in mice

H. Tsutsui, S. Matsushima, Wataru Mizushima, 2016, International journal of cardiology. Heart & vasculature.

Direct renin inhibitor ameliorates insulin resistance by improving insulin signaling and oxidative stress in the skeletal muscle from post-infarct heart failure in mice.

H. Tsutsui, S. Matsushima, Wataru Mizushima, 2016, European journal of pharmacology.

Nampt Potentiates Antioxidant Defense in Diabetic Cardiomyopathy

J. Sadoshima, P. Zhai, S. Oka, 2021, Circulation research.

Mitophagy Is Essential for Maintaining Cardiac Function During High Fat Diet-Induced Diabetic Cardiomyopathy

J. Sadoshima, A. Shirakabe, P. Zhai, 2019, Circulation research.

BAG3 plays a central role in proteostasis in the heart.

J. Sadoshima, Wataru Mizushima, 2017, The Journal of clinical investigation.

Yes-Associated Protein (YAP) Facilitates Pressure Overload–Induced Dysfunction in the Diabetic Heart

H. Shimokawa, J. Sadoshima, P. Zhai, 2019, JACC. Basic to translational science.

Blockade of Fibroblast YAP Attenuates Cardiac Fibrosis and Dysfunction Through MRTF-A Inhibition

P. Zhai, S. Oka, M. Tallquist, 2020, JACC. Basic to translational science.

Angiotensin II receptor blocker improves the lowered exercise capacity and impaired mitochondrial function of the skeletal muscle in type 2 diabetic mice.

H. Tsutsui, Wataru Mizushima, S. Kinugawa, 2013, Journal of applied physiology.

of the skeletal muscle in type 2 diabetic mice exercise capacity and impaired mitochondrial function Angiotensin II receptor blocker improves the lowered

H. Tsutsui, S. Matsushima, Wataru Mizushima, 2013 .

Alternative Mitophagy Protects the Heart Against Obesity-Associated Cardiomyopathy

J. Sadoshima, A. Shirakabe, P. Zhai, 2021, Circulation research.

Deletion of NAD(P)H Oxidase 2 Prevents Angiotensin II-Induced Skeletal Muscle Atrophy

Wataru Mizushima, S. Kinugawa, K. Okita, 2018, BioMed research international.

Dual PPARα/γ activation inhibitsSIRT1-PGC1α axis and causes cardiac dysfunction

M. Civelek, M. Madesh, Ying Tian, 2019, JCI Insight.

Pioglitazone ameliorates the lowered exercise capacity and impaired mitochondrial 1 function of the skeletal muscle in type 2 diabetic mice 2 Running title : Exercise capacity and insulin resistance 3 4

H. Tsutsui, Wataru Mizushima, S. Kinugawa, 2018 .

Pioglitazone ameliorates the lowered exercise capacity and impaired mitochondrial function of the skeletal muscle in type 2 diabetic mice.

H. Tsutsui, S. Matsushima, Wataru Mizushima, 2014, European journal of pharmacology.

Dual peroxisome-proliferator-activated-receptor-a / g activation inhibits SIRT 1-PGC 1 a axis and causes cardiac dysfunction

Estela, M. Civelek, M. Madesh, 2019 .

The tumor suppressor RASSF1A modulates inflammation and injury in the reperfused murine myocardium

J. Sadoshima, P. Zhai, S. Oka, 2019, The Journal of Biological Chemistry.

YAP mediates compensatory cardiac hypertrophy through aerobic glycolysis in response to pressure overload

M. Abdellatif, J. Sadoshima, P. Zhai, 2022, The Journal of clinical investigation.

Ulk1-dependent alternative mitophagy plays a protective role during pressure overload in the heart.

J. Sadoshima, A. Shirakabe, P. Zhai, 2022, Cardiovascular research.

Abstract B19: Neurofibromin 2 regulates metabolism in the heart

P. Zhai, S. Oka, Wataru Mizushima, 2020 .

Instructions for use Title The E 3 ubiquitin ligase TRIM 23 regulates adipocyte differentiation via stabilization of the adipogenic activatorPPARγ

Y. Saeki, Keiji Tanaka, S. Hatakeyama, 2019 .

Instructions for use Title The E 3 ubiquitin ligase TRIM 23 regulates adipocyte differentiation via stabilization of the adipogenicactivator PPARγ

Y. Saeki, Keiji Tanaka, S. Hatakeyama, 2017 .

The E3 ubiquitin ligase TRIM23 regulates adipocyte differentiation via stabilization of the adipogenic activator PPARγ

Y. Saeki, Keiji Tanaka, S. Hatakeyama, 2015, eLife.

MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex

C. Tomomori-Sato, Shigeo Sato, R. Conaway, 2015, Nature Communications.

Dual peroxisome-proliferator-activated-receptor-α/γ activation inhibits SIRT1-PGC1α axis and causes cardiac dysfunction.

M. Civelek, M. Madesh, Ying Tian, 2019, JCI insight.

The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes.

K. Nakayama, M. Matsumoto, S. Yanagi, 2016, Journal of molecular and cellular cardiology.

Brain-Derived Neurotrophic Factor Improves Impaired Fatty Acid Oxidation Via the Activation of Adenosine Monophosphate-activated Protein Kinase-α - Proliferator-Activated Receptor-r Coactivator-1α Signaling in Skeletal Muscle of Mice With Heart Failure.

H. Sabe, Wataru Mizushima, S. Kinugawa, 2020, Circulation. Heart failure.

Angiotensin II can directly induce mitochondrial dysfunction, decrease oxidative fibre number and induce atrophy in mouse hindlimb skeletal muscle

H. Tsutsui, Wataru Mizushima, S. Kinugawa, 2015, Experimental physiology.

Thioredoxin-1 maintains mitochondrial function via mTOR signaling in the heart.

J. Yodoi, Y. Hirabayashi, J. Sadoshima, 2019, Cardiovascular research.

Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure

H. Sabe, J. Nio-Kobayashi, H. Tsutsui, 2021, Communications Biology.

Distinct Roles of DRP1 in Conventional and Alternative Mitophagy in Obesity Cardiomyopathy

J. Sadoshima, P. Zhai, S. Oka, 2023, Circulation research.

Thioredoxin-1 maintains mitochondrial function via mechanistic target of rapamycin signalling in the heart

J. Yodoi, Y. Hirabayashi, J. Sadoshima, 2020 .

Author response: The E3 ubiquitin ligase TRIM23 regulates adipocyte differentiation via stabilization of the adipogenic activator PPARγ

Y. Saeki, Keiji Tanaka, S. Hatakeyama, 2015 .

The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes.

K. Nakayama, M. Matsumoto, S. Yanagi, 2016, Journal of molecular and cellular cardiology.

Mitophagy Is Essential for Maintaining Cardiac Function During High Fat Diet-Induced Diabetic Cardiomyopathy

J. Sadoshima, A. Shirakabe, P. Zhai, 2019, Circulation research.

Direct renin inhibitor ameliorates insulin resistance by improving insulin signaling and oxidative stress in the skeletal muscle from post-infarct heart failure in mice.

H. Tsutsui, Wataru Mizushima, S. Kinugawa, 2016, European journal of pharmacology.

The E3 ubiquitin ligase TRIM23 regulates adipocyte differentiation via stabilization of the adipogenic activator PPARγ

Y. Saeki, S. Hatakeyama, Hidehisa Takahashi, 2015, eLife.

Thioredoxin 1 promotes autophagy through transnitrosylation of Atg7 during myocardial ischemia

J. Sadoshima, Hong Li, P. Zhai, 2022, The Journal of clinical investigation.