Melvin E. Andersen

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Harmonization: Developing Consistent Guidelines for Applying Mode of Action and Dosimetry Information to Cancer and Noncancer Risk Assessment

Hugh A. Barton, Melvin E. Andersen, Harvey J. Clewell, 1998 .

Risk science in the 21st century: a data-driven framework for incorporating new technologies into chemical safety assessment

Melvin E. Andersen, Russell S. Thomas, Ricky Cheung, 2017 .

A Qualitative Modeling Approach for Whole Genome Prediction Using High-Throughput Toxicogenomics Data and Pathway-Based Validation

Melvin E. Andersen, Patrick D. McMullen, Saad Haider, 2018, Front. Pharmacol..

Physiologically-Based Pharmacokinetic Modeling*

Melvin E. Andersen, M. Andersen, 1994 .

Evaluation of Quantitative Models in Toxicology: Progress and Challenges

Melvin E. Andersen, Kannan Krishnan, 2010 .

A deterministic map of Waddington's epigenetic landscape for cell fate specification

Qiang Zhang, Melvin E. Andersen, Sudin Bhattacharya, 2011, BMC Systems Biology.

Life beyond the air phase: adding tissue disposition to models of nasal airway transport

Melvin E. Andersen, David C. Dorman, Jeffry D. Schroeter, 2006 .

SYMPOSIUM OVERVIEW Biologically Based, Quantitative Risk Assessment of Neurotoxicant s

Melvin E. Andersen, William Slikker, Kenny S. Crump, 1996 .

Incorporating New Technologies Into Toxicity Testing and Risk Assessment: Moving From 21st Century Vision to a Data-Driven Framework

Melvin E. Andersen, Harvey J. Clewell, Russell S. Thomas, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

Embracing Systems Toxicology at Single-Cell Resolution.

Melvin E. Andersen, Qiang Zhang, W. Michael Caudle, 2019, Current opinion in toxicology.

The Next Generation of Risk Assessment Multi-Year Study—Highlights of Findings, Applications to Risk Assessment, and Future Directions

Paul A. Schulte, Linda S. Birnbaum, Melvin E. Andersen, 2016, Environmental health perspectives.

Issues Surrounding Comparative Risk Assessments of Operational Materials: An Example with Air Force Hydraulic Fluids,

Melvin E. Andersen, Harvey J. Clewell, David R Mattie, 1993 .

The Human Toxome Collaboratorium: A Shared Environment for Multi-Omic Computational Collaboration within a Consortium

Melvin E. Andersen, Patrick D. McMullen, Thomas Hartung, 2016, Front. Pharmacol..

THE USE OF MEAN SURVIVAL TIME ANALYSIS TO DETERMINE COMPARATIVE TOXICITY OF FIRE ATMOSPHERES

Melvin E. Andersen, Robert A. Jones, Ljj Jenkins, 1976 .

A Molecular Perspective on Exposure–Dose–Response

Melvin E. Andersen, S. Bhattacharya, W. Hanneman, 2010 .

New directions in toxicity testing.

Melvin E. Andersen, Margit Westphal, Daniel Krewski, 2011, Annual review of public health.

1988 Herbert E. Stokinger Lecture: Quantitative Risk Assessment and Occupational Carcinogens

Melvin E. Andersen, 1988 .

Computational Systems Biology Modeling of Dosimetry and Cellular Response Pathways

Melvin E. Andersen, Qiang Zhang, Yu Mei Tan, 2008 .

Dose Response Relationship in Anti-Stress Gene Regulatory Networks

Qiang Zhang, Melvin E. Andersen, M. Andersen, 2006, PLoS Comput. Biol..

A Multiple Dose-Route Physiological Pharmacokinetic Model for Volatile Chemicals Using ACSL/PC,

Melvin E. Andersen, Harvey J. Clewell, 1986 .

Stochastic Modeling of B Lymphocyte Terminal Differentiation and Its Suppression by Dioxin

Qiang Zhang, Melvin E. Andersen, Douglas Kline, 2010, BMC Systems Biology.

Developing Microphysiological Systems for Use as Regulatory Tools - Supplementary File

Melvin E. Andersen, D. Lansing Taylor, James L. Stevens, 2014 .

Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling

Melvin E. Andersen, Brad Reisfeld, Raymond S. H. Yang, 2004 .

The need for a new toxicity testing and risk analysis paradigm to implement REACH or any other large scale testing initiative

Melvin E. Andersen, Bas J. Blaauboer, 2006, Archives of Toxicology.

Statistical Approaches to Identifying Androgen Response Elements

Li Li, Qiang Zhang, Melvin E. Andersen, 2007, Seventh IEEE International Conference on Data Mining Workshops (ICDMW 2007).

Quantitative modeling in toxicology

Melvin E. Andersen, Kannan Krishnan, M. Andersen, 2010 .

104. A Program Developed by a High-Tech Consortium for Acquiring Chemical Toxicity Data for New and Unique Chemicals

Melvin E. Andersen, James E. Dennison, Philip L. Bigelow, 2001 .

The TTC Data Mart: An interactive browser for threshold of toxicological concern calculations

Melvin E. Andersen, Harvey J. Clewell, Patrick D. McMullen, 2020 .

Future directions in risk science

Melvin E. Andersen, Margit Westphal, Daniel Krewski, 2017 .

Role of Core Biological Motifs in Dose–Response Modeling: An Example with Switchlike Circuits

Melvin E. Andersen, Sudin Bhattacharya, Qiang Zhang, 2011 .

Combining transcriptomics and PBPK modeling indicates a primary role of hypoxia and altered circadian signaling in dichloromethane carcinogenicity in mouse lung and liver

Melvin E. Andersen, Harvey J. Clewell, Michael B. Black, 2017, Toxicology and Applied Pharmacology.

Integrating pathway-based transcriptomic data into quantitative chemical risk assessment: a five chemical case study.

Melvin E. Andersen, Harvey J. Clewell, Longlong Yang, 2012, Mutation research.

Multiple receptors shape the estrogen response pathway and are critical considerations for the future of in vitro-based risk assessment efforts

Melvin E. Andersen, Rebecca A. Clewell, Patrick D. McMullen, 2017, Critical reviews in toxicology.

Competitive Inhibition of Thyroidal Uptake of Dietary Iodide by Perchlorate Does Not Describe Perturbations in Rat Serum Total T4 and TSH

Melvin E. Andersen, Jeffrey W. Fisher, Jerry L. Campbell, 2009, Environmental health perspectives.

Profiling Dose-Dependent Activation of p53-Mediated Signaling Pathways by Chemicals with Distinct Mechanisms of DNA Damage

Melvin E. Andersen, Rebecca A. Clewell, Patrick D. McMullen, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

PBTK Modeling Demonstrates Contribution of Dermal and Inhalation Exposure Components to End-Exhaled Breath Concentrations of Naphthalene

Melvin E. Andersen, Peter P. Egeghy, Stephen M. Rappaport, 2007, Environmental health perspectives.

Toxicogenomics for transcription factor-governed molecular pathways: moving on to roles beyond classification and prediction

Melvin E. Andersen, Patrick D. McMullen, Sudin Bhattacharya, 2012, Archives of Toxicology.

Genetic variability in a frozen batch of MCF-7 cells invisible in routine authentication affecting cell function

Melvin E. Andersen, Alexandra Maertens, Thomas Hartung, 2016, Scientific Reports.

PBPK Model for Atrazine and Its Chlorotriazine Metabolites in Rat and Human

Melvin E. Andersen, Harvey J. Clewell, Timothy P. Pastoor, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

Assessing interaction thresholds for trichloroethylene in combination with tetrachloroethylene and 1,1,1-trichloroethane using gas uptake studies and PBPK modeling

Melvin E. Andersen, Raymond S. Yang, Ivan D. Dobrev, 2001, Archives of Toxicology.

Physiologically Based Kinetic Modeling of Inhalation

Melvin E. Andersen, Jeffry D. Schroeter, Harvey, 2014 .

An Analysis of N-Acetylcysteine Treatment for Acetaminophen Overdose Using a Systems Model of Drug-Induced Liver Injury

Melvin E. Andersen, Harvey J. Clewell, Brett A. Howell, 2012, Journal of Pharmacology and Experimental Therapeutics.

Temporal concordance between apical and transcriptional points of departure for chemical risk assessment.

Melvin E. Andersen, Harvey J. Clewell, Michael B. Black, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

Reply to Invited Commentaries on Toxicity Testing in the 21st Century: Implications for Human Health Risk Assessment

Melvin E. Andersen, Daniel Krewski, Lauren Zeise, 2009 .

Editor’s Highlight: Screening ToxCast Prioritized Chemicals for PPARG Function in a Human Adipose-Derived Stem Cell Model of Adipogenesis

Melvin E. Andersen, Michael B. Black, Briana Foley, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

Mutagenicity oftrans-anethole, estragole, eugenol, and safrole in the amesSalmonella typhimurium assay

Melvin E. Andersen, M. Andersen, Leleng P. To, 1982 .

Introduction: A Historical Perspective of the Development and Applications of PBPK Models

Melvin E. Andersen, Harvey J. Clewell, Raymond S. H. Yang, 2005 .

What do we Mean by Dose

Melvin E. Andersen, M. Andersen, 1995 .

A physiologically based pharmacokinetic model for lactational transfer of PCB 153 with or without PCB 126 in mice

Melvin E. Andersen, Sun Ku Lee, Raymond S. H. Yang, 2007, Archives of Toxicology.

Application of transcriptomic data, visualization tools and bioinformatics resources for informing mode of action

Melvin E. Andersen, Michael B. Black, Patrick D. McMullen, 2018, Current Opinion in Toxicology.

Organotypic liver culture models: Meeting current challenges in toxicity testing

Melvin E. Andersen, Mark J. Powers, M. Powers, 2012, Critical reviews in toxicology.

Applying Mode-of-Action and Pharmacokinetic Considerations in Contemporary Cancer Risk Assessments: An Example with Trichloroethylene

Melvin E. Andersen, Harvey J. Clewell, M. Andersen, 2004 .

Accelerating the Development of 21st-Century Toxicology: Outcome of a Human Toxicology Project Consortium Workshop

Melvin E. Andersen, Michael P. Holsapple, Paul L. Carmichael, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

Perfluoro-n-decanoic acid: Induction of peroxisomal β-oxidation by a fatty acid with dioxin-like toxicity

Melvin E. Andersen, E. Harrison, M. Andersen, 1988, Lipids.

Pharmacokinetic modeling of 2,4-dichlorophenoxyacetic acid (2,4-D) in rat and in rabbit brain following single dose administration.

Melvin E. Andersen, M. Andersen, M. Gargas, 1994, Toxicology letters.

Developing tools for defining and establishing pathways of toxicity

Melvin E. Andersen, Daniel Krewski, Patrick D. McMullen, 2015, Archives of Toxicology.

Physiologically Based Pharmacokinetic Modeling : Science and Applications

Melvin E. Andersen, Harvey J. Clewell, Raymond S. H. Yang, 2005 .

Physiologically based pharmacokinetic and pharmacodynamic model for the inhibition of acetylcholinesterase by diisopropyfluorophosphate

Melvin E. Andersen, Harvey J. Clewell, Jeffery M. Gearhart, 1990 .

Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing

Melvin E. Andersen, Harvey J. Clewell, Barbara A. Wetmore, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Letters to the editor: To the editor

Melvin E. Andersen, Bette Meek, Yvonne P. Dragan, 1984 .

Physiologically based pharmacokinetic/pharmacodynamic modeling of the toxicologic interaction between carbon tetrachloride and Kepone

Melvin E. Andersen, Harihara M. Mehendale, Raymond S. H. Yang, 1996, Archives of Toxicology.

Food for Thought ... Can Case Study Approaches Speed Implementation of the NRC Report : “ Toxicity Testing in the 21 st Century : A Vision and a Strategy ? ”

Melvin E. Andersen, Harvey J. Clewell, Paul L. Carmichael, 2011 .

Cross-species transcriptomic analysis of mouse and rat lung exposed to chloroprene.

Melvin E. Andersen, Harvey J. Clewell, Michael B. Black, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

Toxicity Testing in the 21st Century: Defining New Risk Assessment Approaches Based on Perturbation of Intracellular Toxicity Pathways

Melvin E. Andersen, Paul L. Carmichael, Sudin Bhattacharya, 2011, PloS one.

Identifying qualitative differences in PPARα signaling networks in human and rat hepatocytes and their significance for next generation chemical risk assessment methods.

Melvin E. Andersen, Rebecca A. Clewell, Patrick D. McMullen, 2020, Toxicology in vitro : an international journal published in association with BIBRA.

Use of a Physiologically Based Pharmacokinetic Model and Computer Simulation for Retrospective Assessment of Exposure to Volatile Toxicants

Melvin E. Andersen, Rory B. Conolly, M. Andersen, 1990 .

Preclinical Development Handbook: ADME and Biopharmaceutical Properties

Melvin E. Andersen, Harvey J. Clewell, Thierry Lavé, 2007 .

Molecular Signaling Network Motifs Provide a Mechanistic Basis for Cellular Threshold Responses

Melvin E. Andersen, Harvey J. Clewell, Sudin Bhattacharya, 2014, Environmental health perspectives.

Gas Uptake Inhalation Techniques and the Rates of Metabolism of Chloromethanes, Chloroethanes, and Chloroethylenes in the Rat

Melvin E. Andersen, Harvey J. Clewell, M. Andersen, 1990 .

Enhancing and Extending Biological Performance and Resilience

Melvin E. Andersen, Aalt Bast, Edward J. Calabrese, 2018, Dose-response : a publication of International Hormesis Society.

Data-Derived Uncertainty Factors: Boric Acid (BA) as a Case Study

Melvin E. Andersen, F. Jay Murray, 2001 .

Calling on Science: Making “Alternatives” the New Gold Standard

Melvin E. Andersen, M. Andersen, 2010 .

Associations of Perfluoroalkyl Substances (PFAS) with Lower Birth Weight: An Evaluation of Potential Confounding by Glomerular Filtration Rate Using a Physiologically Based Pharmacokinetic Model (PBPK)

Melvin E. Andersen, Harvey J. Clewell, Miyoung Yoon, 2015, Environmental health perspectives.

In vitro metabolism of di(2-ethylhexyl) phthalate (DEHP) by various tissues and cytochrome P450s of human and rat.

Melvin E. Andersen, Harvey J. Clewell, Rebecca A. Clewell, 2012, Toxicology in vitro : an international journal published in association with BIBRA.

Modeling Drug- and Chemical-Induced Hepatotoxicity with Systems Biology Approaches

Melvin E. Andersen, Sudin Bhattacharya, Brett A. Howell, 2012, Front. Physio..

Physiologically Based Pharmacokinetic Modeling

Melvin E. Andersen, Harvey J. Clewell, Thierry Lavé, 2010 .

In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI

Melvin E. Andersen, Harvey J. Clewell, Brett A. Howell, 2012, Journal of Pharmacokinetics and Pharmacodynamics.

The Future of Toxicity Testing

Melvin E. Andersen, Margit Westphal, Daniel Krewski, 2010, Journal of toxicology and environmental health. Part B, Critical reviews.