J. Ghilardi

发表

Alzheimer's disease amyloid propagation by a template-dependent dock-lock mechanism.

J R Ghilardi, P W Mantyh, H. Vinters, 2000, Biochemistry.

Zinc-induced aggregation of human and rat beta-amyloid peptides in vitro.

P. Mantyh, E. R. Stimson, W. Esler, 1996, Journal of neurochemistry.

Spinal Neurons that Possess the Substance P Receptor Are Required for the Development of Central Sensitization

P. Mantyh, D. Simone, J. Ghilardi, 2002, The Journal of Neuroscience.

Deposition of monomeric, not oligomeric, Abeta mediates growth of Alzheimer's disease amyloid plaques in human brain preparations.

H. Vinters, P. Mantyh, C. Clish, 1999, Biochemistry.

Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia

A. Gomtsyan, P. Mantyh, J. Sullivan, 2009, Pain.

Noninvasive imaging of peripherally injected Alzheimer's disease type synthetic A beta amyloid in vivo.

H. Vinters, P. Mantyh, E. R. Stimson, 2002, Bioconjugate chemistry.

The involvement of prostaglandins in tumorigenesis, tumor-induced osteolysis and bone cancer pain.

P. Mantyh, J. Ghilardi, M. Sabino, 2002, Journal of musculoskeletal & neuronal interactions.

Intra-arterial infusion of [125I]A beta 1-40 labels amyloid deposits in the aged primate brain in vivo.

P. Mantyh, E. R. Stimson, L. Walker, 1996, Neuroreport.

Proteomic analysis of the reactive phenotype of astrocytes following endothelin‐1 exposure

P. Mantyh, Julie A. Schmidt, J. Pomonis, 2003, Proteomics.

β‐adrenergic receptors regulate astrogliosis and cell proliferation in the central nervous system in vivo

P. Mantyh, J. Ghilardi, S. Rogers, 1996, Glia.

Neuroplasticity of Sensory and Sympathetic Nerve Fibers in the Painful Arthritic Joint

P. Mantyh, M. Kuskowski, K. Freeman, 2012 .

Endothelin receptor expression in the normal and injured spinal cord: potential involvement in injury-induced ischemia and gliosis

P. Mantyh, Julie A. Schmidt, J. Pomonis, 2003, Experimental Neurology.

Some sensory neurons express neuropeptide Y receptors: potential paracrine inhibition of primary afferent nociceptors following peripheral nerve injury

P. Mantyh, P. Mannon, L. Kruger, 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Substance P activation of enteric neurons in response to intraluminal Clostridium difficile toxin A in the rat ileum.

M. Washington, J. Lapp, P. Mantyh, 1996, Gastroenterology.

Differential expression of two isoforms of the neurokinin-1 (substance P) receptor in vivo

P. Mantyh, S. Vigna, J. Ghilardi, 1996, Brain Research.

Trigeminal and dorsal root ganglion neurons express CCK receptor binding sites in the rat, rabbit, and monkey: possible site of opiate- CCK analgesic interactions

P. Mantyh, S. Vigna, J. Ghilardi, 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor.

P. Mantyh, D. Simone, R. Wiley, 1997, Science.

Zinc and Alzheimer's disease.

P. Mantyh, E. R. Stimson, W. Esler, 1995, Science.

Point substitution in the central hydrophobic cluster of a human beta-amyloid congener disrupts peptide folding and abolishes plaque competence.

H. Vinters, P. Mantyh, E. R. Stimson, 1996, Biochemistry.

Safety evaluation of intrathecal substance P-saporin, a targeted neurotoxin, in dogs.

P. Mantyh, M. Grafe, T. Yaksh, 2006, Toxicological sciences : an official journal of the Society of Toxicology.

The majority of myelinated and unmyelinated sensory nerve fibers that innervate bone express the tropomyosin receptor kinase A

P. Mantyh, W. Mantyh, J. Ghilardi, 2011, Neuroscience.

Capsaicin-sensitive sensory nerve fibers contribute to the generation and maintenance of skeletal fracture pain

P. Mantyh, M. Kuskowski, W. Mantyh, 2009, Neuroscience.

Breast cancer-induced bone remodeling, skeletal pain, and sprouting of sensory nerve fibers.

P. Mantyh, M. Kuskowski, K. Freeman, 2011, The journal of pain : official journal of the American Pain Society.

Pathological Sprouting of Adult Nociceptors in Chronic Prostate Cancer-Induced Bone Pain

P. Mantyh, M. Kuskowski, W. Mantyh, 2010, The Journal of Neuroscience.

Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation.

A. Basbaum, P. Mantyh, D. Simone, 1995, Science.

Pharmacology of Modality-Specific Transient Receptor Potential Vanilloid-1 Antagonists That Do Not Alter Body Temperature

A. Gomtsyan, P. Mantyh, J. Segreti, 2012, Journal of Pharmacology and Experimental Therapeutics.

Selective Blockade of the Capsaicin Receptor TRPV1 Attenuates Bone Cancer Pain

N. Carruthers, P. Mantyh, M. Kuskowski, 2005, The Journal of Neuroscience.

Pharmacology of Modality-Specific TRPV1 Antagonists That Do Not Alter Body Temperature

A. Gomtsyan, P. Mantyh, J. Segreti, 2012 .

Preventive or late administration of anti-NGF therapy attenuates tumor-induced nerve sprouting, neuroma formation, and cancer pain

P. Mantyh, M. Kuskowski, J. Ghilardi, 2011, PAIN.

Noxious Cutaneous Thermal Stimuli Induce a Graded Release of Endogenous Substance P in the Spinal Cord: Imaging Peptide ActionIn Vivo

B J Allen, S D Rogers, J R Ghilardi, 1997, The Journal of Neuroscience.

Constitutive Spinal Cyclooxygenase-2 Participates in the Initiation of Tissue Injury-Induced Hyperalgesia

P. Mantyh, C. Svensson, T. Yaksh, 2004, The Journal of Neuroscience.

Endogenous opioids inhibit early-stage pancreatic pain in a mouse model of pancreatic cancer.

P. Mantyh, M. Kuskowski, P. Mukherjee, 2006, Gastroenterology.

Transmission of chronic nociception by spinal neurons expressing the substance P receptor.

P. Mantyh, D. Simone, P. Honore, 1999, Science.

Primary afferent fibers that contribute to increased substance P receptor internalization in the spinal cord after injury.

P. Mantyh, D. Simone, J. Ghilardi, 1999, Journal of neurophysiology.

An evolving cellular pathology occurs in dorsal root ganglia, peripheral nerve and spinal cord following intravenous administration of paclitaxel in the rat

P. Mantyh, M. Kuskowski, J. Ghilardi, 2007, Brain Research.

Intravenous paclitaxel administration in the rat induces a peripheral sensory neuropathy characterized by macrophage infiltration and injury to sensory neurons and their supporting cells

G. Y. Wong, G. Wong, P. Mantyh, 2007, Experimental Neurology.

Cholecystokinin and neuropeptide Y receptors on single rabbit vagal afferent ganglion neurons: site of prejunctional modulation of visceral sensory neurons

P. Mantyh, S. Vigna, J. Ghilardi, 1994, Brain Research.

Intravenous ibandronate rapidly reduces pain, neurochemical indices of central sensitization, tumor burden, and skeletal destruction in a mouse model of bone cancer.

P. Mantyh, F. Bauss, J. Ghilardi, 2008, Journal of pain and symptom management.

Bone cancer pain: the effects of the bisphosphonate alendronate on pain, skeletal remodeling, tumor growth and tumor necrosis

Michael A. Kuskowski, P. Mantyh, M. Kuskowski, 2004, Pain.

Neuroplasticity of sensory and sympathetic nerve fibers in a mouse model of a painful arthritic joint.

P. Mantyh, M. Kuskowski, K. Freeman, 2012, Arthritis and rheumatism.

Spinal neurons that express NK-1 receptors modulate descending controls that project through the dorsolateral funiculus.

P. Mantyh, D. Simone, J. Ghilardi, 2005, Journal of neurophysiology.

Similarities and Differences in Tumor Growth, Skeletal Remodeling and Pain in an Osteolytic and Osteoblastic Model of Bone Cancer

P. Mantyh, T. Rosol, Patrick W Mantyh, 2006, The Clinical journal of pain.

Expression and Localization of Endothelin Receptors: Implications for the Involvement of Peripheral Glia in Nociception

P. Mantyh, J. Pomonis, J. Ghilardi, 2001, The Journal of Neuroscience.

A quantitative analysis of the sensory and sympathetic innervation of the mouse pancreas

P. Mantyh, M. Kuskowski, J. Ghilardi, 2006, Neuroscience.

Anti-NGF therapy profoundly reduces bone cancer pain and the accompanying increase in markers of peripheral and central sensitization

P. Mantyh, M. Kuskowski, J. Ghilardi, 2005, Pain.

Nerve growth factor sequestering therapy attenuates non-malignant skeletal pain following fracture

Ryan J. Buus, P. Mantyh, M. Kuskowski, 2007, PAIN®.

Vascularization of the dorsal root ganglia and peripheral nerve of the mouse: Implications for chemical-induced peripheral sensory neuropathies

Marina Vardanyan, P. Mantyh, O. Melemedjian, 2008, Molecular pain.

Simultaneous reduction in cancer pain, bone destruction, and tumor growth by selective inhibition of cyclooxygenase-2.

P. Mantyh, C. de Felipe, Mary Ann C Sabino, 2002, Cancer research.

Pathophysiology and medical treatment of pain in fibrous dysplasia of bone

P. Mantyh, R. Chapurlat, J. Ghilardi, 2012, Orphanet Journal of Rare Diseases.

Fibrillar b-Amyloid Induces Microglial Phagocytosis , Expression of Inducible Nitric Oxide Synthase , and Loss of a Select Population of Neurons in the Rat CNS In Vivo

S D Rogers, J R Ghilardi, P W Mantyh, 1998 .

Pancreatic cancer pain and its correlation with changes in tumor vasculature, macrophage infiltration, neuronal innervation, body weight and disease progression

G. Y. Wong, G. Wong, P. Mantyh, 2005, Pain.

Delayed behavioral effects following intrahippocampal injection of aggregated Aβ(1–42)

P. Mantyh, J. Cleary, M. Kuskowski, 1999, Brain Research.

Expression of Endothelin-B Receptors by Gliain VivoIs Increased after CNS Injury in Rats, Rabbits, and Humans

L. Levin, P. Mantyh, J. Ghilardi, 1997, Experimental Neurology.

Aluminum, Iron, and Zinc Ions Promote Aggregation of Physiological Concentrations of β‐Amyloid Peptide

P. Mantyh, E. R. Stimson, Patrick W. Mantyh, 1993, Journal of neurochemistry.

Blockade of nerve sprouting and neuroma formation markedly attenuates the development of late stage cancer pain

P. Mantyh, M. Kuskowski, W. Mantyh, 2010, Neuroscience.

Stereochemical specificity of Alzheimer's disease β-peptide assembly

H. Vinters, P. Mantyh, E. R. Stimson, 1999 .

Reversible in vitro growth of Alzheimer disease beta-amyloid plaques by deposition of labeled amyloid peptide.

H. Vinters, P. Mantyh, E. R. Stimson, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Activation barriers to structural transition determine deposition rates of Alzheimer's disease a beta amyloid.

J R Ghilardi, P W Mantyh, H. Vinters, 2000, Journal of structural biology.

Point Substitution in the Central Hydrophobic Cluster of a Human β-Amyloid Congener Disrupts Peptide Folding and Abolishes Plaque Competence†

H. Vinters, P. Mantyh, E. R. Stimson, 1996 .

1H NMR of A beta amyloid peptide congeners in water solution. Conformational changes correlate with plaque competence.

J R Ghilardi, P W Mantyh, P. Mantyh, 1995, Biochemistry.

Initial Results from the Survey of Organizational Research Climates (SOuRCe) in the U.S. Department of Veterans Affairs Healthcare System

D. Mohr, M. Charns, B. Martinson, 2016, PloS one.

Zinc‐Induced Aggregation of Human and Rat β‐Amyloid Peptides In Vitro

P. Mantyh, E. R. Stimson, W. Esler, 1996 .

Endothelin and the tumorigenic component of bone cancer pain

P. Mantyh, J. Pomonis, J. Ghilardi, 2004, Neuroscience.

In vitro growth of Alzheimer's disease beta-amyloid plaques displays first-order kinetics.

J R Ghilardi, P W Mantyh, H. Vinters, 1996, Biochemistry.

A blocking antibody to nerve growth factor attenuates skeletal pain induced by prostate tumor cells growing in bone.

P. Mantyh, T. Rosol, J. Ghilardi, 2005, Cancer research.

Neuropeptide Y/peptide YY receptor binding sites in the heart: Localization and pharmacological characterization

P. Mantyh, P. Mannon, S. Vigna, 1993, Neuroscience.

Organization of a unique net-like meshwork of CGRP+ sensory fibers in the mouse periosteum: Implications for the generation and maintenance of bone fracture pain

P. Mantyh, Patrick W. Mantyh, Joseph R. Ghilardi, 2007, Neuroscience Letters.

Tumor-induced injury of primary afferent sensory nerve fibers in bone cancer pain

P. Mantyh, J. Ghilardi, Molly A. Sevcik, 2005, Experimental Neurology.

Rapid endocytosis of a G protein-coupled receptor: substance P evoked internalization of its receptor in the rat striatum in vivo.

A. Basbaum, P. Mantyh, Hantao Liu, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Analgesic efficacy of bradykinin B1 antagonists in a murine bone cancer pain model.

P. Mantyh, J. Ghilardi, M. A. Sevcik, 2005, The journal of pain : official journal of the American Pain Society.

Sensory neurons and their supporting cells located in the trigeminal, thoracic and lumbar ganglia differentially express markers of injury following intravenous administration of paclitaxel in the rat

P. Mantyh, M. Kuskowski, Nicole A. Mejia, 2006, Neuroscience Letters.

Administration of a tropomyosin receptor kinase inhibitor attenuates sarcoma-induced nerve sprouting, neuroma formation and bone cancer pain

P. Mantyh, M. Kuskowski, W. Mantyh, 2010, Molecular pain.

LOCKADE OF NERVE SPROUTING AND NEUROMA FORMATION ARKEDLY ATTENUATES THE DEVELOPMENT OF LATE STAGE ANCER PAIN

K. Freeman, J. Ghilardi, M. Kaczmarska, 2022 .

Effects of a Monoclonal Antibody Raised Against Nerve Growth Factor on Skeletal Pain and Bone Healing After Fracture of the C57BL/6J Mouse Femur

Ryan J. Buus, P. Mantyh, M. Kuskowski, 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The effect of aging on the density of the sensory nerve fiber innervation of bone and acute skeletal pain

P. Mantyh, M. Kuskowski, W. Mantyh, 2012, Neurobiology of Aging.

Endothelin B receptors are expressed by astrocytes and regulate astrocyte hypertrophy in the normal and injured CNS

P. Mantyh, J. Pomonis, H. Hagiwara, 2003, Glia.

Apolipoprotein E affects amyloid formation but not amyloid growth in vitro: Mechanistic implications for ApoE4 enhanced amyloid burden and risk for Alzheimer's disease

H. Vinters, P. Mantyh, E. R. Stimson, 2002, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

the Dorsolateral Funiculus Modulate Descending Controls That Project Through Spinal Neurons That Express NK-1 Receptors

A. Beitz, P. Mantyh, D. Budai, 2015 .

A beta deposition inhibitor screen using synthetic amyloid.

H. Vinters, P. Mantyh, E. R. Stimson, 1997, Nature biotechnology.

A Fracture Pain Model in the Rat: Adaptation of a Closed Femur Fracture Model to Study Skeletal Pain

Ryan J. Buus, P. Mantyh, M. Kuskowski, 2008, Anesthesiology.

Sustained blockade of neurotrophin receptors TrkA, TrkB and TrkC reduces non-malignant skeletal pain but not the maintenance of sensory and sympathetic nerve fibers.

P. Mantyh, M. Kuskowski, W. Mantyh, 2011, Bone.