S. Donnelly

发表

An Integrated Transcriptomics and Proteomics Analysis of the Secretome of the Helminth Pathogen Fasciola hepatica

Shoba Ranganathan, Ranjeeta Menon, S. Ranganathan, 2009, Molecular & Cellular Proteomics.

Proteomics and Phylogenetic Analysis of the Cathepsin L Protease Family of the Helminth Pathogen Fasciola hepatica

Ben Herbert, J. Dalton, B. Herbert, 2008, Molecular & Cellular Proteomics.

Cathelicidin-like Helminth Defence Molecules (HDMs): Absence of Cytotoxic, Anti-microbial and Anti-protozoan Activities Imply a Specific Adaptation to Immune Modulation

J. Dalton, Sophie Cotton, K. Thivierge, 2013, PLoS neglected tropical diseases.

Targeting the master regulator mTOR: a new approach to prevent the neurological of consequences of parasitic infections?

M. Labbate, Michael S. Johnson, B. Saunders, 2017, Parasites & Vectors.

Novel Therapeutics for Multiple Sclerosis Designed by Parasitic Worms

S. Donnelly, J. Greer, A. Tanaka, 2017, International journal of molecular sciences.

Glycerol-induced seizure: involvement of IL-1beta and glutamate.

M. Lynch, K. Mills, S. Donnelly, 1999, Neuroreport.

Immune signatures of pathogenesis in the peritoneal compartment during early infection of sheep with Fasciola hepatica

J. Dalton, K. Cwiklinski, S. Donnelly, 2017, Scientific Reports.

Fasciola hepatica vaccine: We may not be there yet but we’re on the right road

J. Dalton, V. Molina-Hernández, S. O'Neill, 2015, Veterinary parasitology.

Immunological Interactions between 2 Common Pathogens, Th1-Inducing Protozoan Toxoplasma gondii and the Th2-Inducing Helminth Fasciola hepatica

J. Dalton, S. Donnelly, Catherine M. D. Miller, 2009, PloS one.

Protection of cattle against a natural infection of Fasciola hepatica by vaccination with recombinant cathepsin L1 (rFhCL1).

J. Dalton, G. Mulcahy, C. Read, 2010, Vaccine.

Immunomodulatory molecules of Fasciola hepatica: candidates for both vaccine and immunotherapeutic development.

J. Dalton, S. O'Neill, G. Mulcahy, 2013, Veterinary parasitology.

How Pathogen-Derived Cysteine Proteases Modulate Host Immune Responses

J. Dalton, M. Robinson, S. Donnelly, 2011, Advances in experimental medicine and biology.

Proteomic Analysis of Extracellular HMGB1 Identifies Binding Partners and Exposes Its Potential Role in Airway Epithelial Cell Homeostasis.

J. Dalton, S. Djordjevic, M. Padula, 2018, Journal of proteome research.

A helminth cathelicidin‐like protein suppresses antigen processing and presentation in macrophages via inhibition of lysosomal vATPase

J. Dalton, C. Whitchurch, L. Turnbull, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Stage-specific miRNAs regulate gene expression associated with growth, development and parasite-host interaction during the intra-mammalian migration of the zoonotic helminth parasite Fasciola hepatica

N. Tran, J. Dalton, K. Cwiklinski, 2022, BMC Genomics.

A parasitic helminth-derived peptide that targets the macrophage lysosome is a novel therapeutic option for autoimmune disease.

J. Dalton, B. O'Brien, S. Donnelly, 2015, Immunobiology.

A prospective view of animal and human Fasciolosis

J. Dalton, S. O'Neill, K. Cwiklinski, 2016, Parasite immunology.

Fasciola hepatica tegumental antigens indirectly induce an M2 macrophage‐like phenotype in vivo

S. O'Neill, K. Vukman, S. Donnelly, 2014, Parasite immunology.

Thioredoxin Peroxidase Secreted by Fasciola hepatica Induces the Alternative Activation of Macrophages

J. Dalton, S. O'Neill, G. Mulcahy, 2005, Infection and Immunity.

Defense peptides secreted by helminth pathogens: antimicrobial and/or immunomodulator molecules?

J. Dalton, Sophie Cotton, K. Thivierge, 2012, Front. Immun..

Helminth Cysteine Proteases Inhibit TRIF-dependent Activation of Macrophages via Degradation of TLR3

J. Dalton, C. Whitchurch, L. Turnbull, 2009, The Journal of Biological Chemistry.

Fasciola hepatica: the therapeutic potential of a worm secretome.

J. Dalton, B. O'Brien, M. Robinson, 2013, International journal for parasitology.

Fasciola hepatica cathepsin L-like proteases: biology, function, and potential in the development of first generation liver fluke vaccines.

J. Dalton, G. Brennan, S. Doyle, 2003, International journal for parasitology.

Worm secretory molecules are causing alarm.

J. Dalton, M. Robinson, S. Donnelly, 2010, Trends in parasitology.

Major Secretory Antigens of the Helminth Fasciola hepatica Activate a Suppressive Dendritic Cell Phenotype That Attenuates Th17 Cells but Fails To Activate Th2 Immune Responses

P. Brophy, J. Dalton, S. O'Neill, 2009, Infection and Immunity.

Helminth 2‐Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages

J. Dalton, S. O'Neill, Ahmed A. Sayed, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Secreted Proteins from the Helminth Fasciola hepatica Inhibit the Initiation of Autoreactive T Cell Responses and Prevent Diabetes in the NOD Mouse

J. Dalton, A. Simpson, B. O'Brien, 2014, PloS one.

RAGE and TLR4 differentially regulate airway hyperresponsiveness: Implications for COPD

S. Phipps, W. Timens, C. Brandsma, 2020, Allergy.

The parasitic 68-mer peptide FhHDM-1 inhibits mixed granulocytic inflammation and airway hyperreactivity in experimental asthma.

J. Dalton, S. Phipps, M. Lund, 2018, The Journal of allergy and clinical immunology.

The immune modulatory peptide FhHDM‐1 secreted by the helminth Fasciola hepatica prevents NLRP3 inflammasome activation by inhibiting endolysosomal acidification in macrophages

J. Dalton, A. Mansell, B. O'Brien, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

S0031182022000749jrv 1364..1373

S. Donnelly, Brien, Susel Loli Quinteros, 2022 .

Interleukin-1β-dependent changes in the hippocampus following parenteral immunization with a whole cell pertussis vaccine

M. Lynch, K. Mills, S. Donnelly, 2000, Journal of Neuroimmunology.

Induction of protective immune responses against schistosomiasis using functionally active cysteine peptidases

J. Dalton, S. Donnelly, H. Tallima, 2014, Front. Genet..

Selective induction of the Notch ligand Jagged‐1 in macrophages by soluble egg antigen from Schistosoma mansoni involves ERK signalling

Kristian Brion, D. Hume, M. Sweet, 2009, Immunology.

Mechanisms of immune modulation by Fasciola hepatica: importance for vaccine development and for novel immunotherapeutics

J. Dalton, S. O'Neill, M. Robinson, 2011 .

Leucine aminopeptidase of the human blood flukes, Schistosoma mansoni and Schistosoma japonicum.

Michael T. Stewart, J. Dalton, P. Brindley, 2004, International journal for parasitology.

Macrophage migration inhibitory factor promotes glucocorticoid resistance of neutrophilic inflammation in a murine model of severe asthma

K. Chung, P. Sterk, R. Djukanović, 2022, Thorax.

Whole-Cell but Not Acellular Pertussis Vaccines Induce Convulsive Activity in Mice: Evidence of a Role for Toxin-Induced Interleukin-1β in a New Murine Model for Analysis of Neuronal Side Effects of Vaccination

K. Mills, S. Donnelly, C. Loscher, 2001, Infection and Immunity.

The choice of phorbol 12-myristate 13-acetate differentiation protocol influences the response of THP-1 macrophages to a pro-inflammatory stimulus.

B. O'Brien, J. To, S. Donnelly, 2016, Journal of immunological methods.

The M 18 Aspartyl Aminopeptidase of the Human Malaria Parasite Plasmodium falciparum *

J. Dalton, T. Spielmann, M. Dixon, 2007 .

Proteases in helminth- and allergen- induced inflammatory responses.

A. Loukas, J. Dalton, S. Donnelly, 2006, Chemical immunology and allergy.

Induction of inflammatory cytokines in the brain following respiratory infection with Bordetella pertussis

M. Lynch, K. Mills, S. Donnelly, 2000, Journal of Neuroimmunology.

The immunology of parasite infections: Grand challenges

S. Donnelly, 2022, Frontiers in Parasitology.

A parasite-derived 68-mer peptide ameliorates autoimmune disease in murine models of Type 1 diabetes and multiple sclerosis

J. Dalton, A. Simpson, B. O'Brien, 2016, Scientific Reports.

Aminopeptidases of malaria parasites: new targets for chemotherapy.

J. Dalton, K. Trenholme, D. Gardiner, 2010, Infectious disorders drug targets.

Structural and Functional Relationships in the Virulence-associated Cathepsin L Proteases of the Parasitic Liver Fluke, Fasciola hepatica*

C. Craik, J. Dalton, R. Marion, 2008, Journal of Biological Chemistry.

The cathepsin-like cysteine peptidases of trematodes of the genus Fasciola.

J. Dalton, S. O'Neill, I. Pritsch, 2019, Advances in parasitology.

The Importance of pH in Regulating the Function of the Fasciola hepatica Cathepsin L1 Cysteine Protease

J. Dalton, J. Matthews, M. Robinson, 2009, PLoS neglected tropical diseases.

Helminth pathogen cathepsin proteases: it's a family affair.

Sheila Donnelly, John P Dalton, J. Dalton, 2008, Trends in biochemical sciences.

Complementary transcriptomic and proteomic analyses reveal the cellular and molecular processes that drive growth and development of Fasciola hepatica in the host liver

J. Dalton, K. Cwiklinski, M. Robinson, 2021, BMC Genomics.

Helminth defence molecules—immunomodulators designed by parasites!

J. Dalton, M. Robinson, S. Donnelly, 2013, Front. Microbiol..

A Family of Helminth Molecules that Modulate Innate Cell Responses via Molecular Mimicry of Host Antimicrobial Peptides

J. Dalton, R. Norton, M. Perugini, 2011, PLoS pathogens.

Proteases in trematode biology

A. Loukas, J. Dalton, M. Sajid, 2006 .

Cathepsin L1, the Major Protease Involved in Liver Fluke (Fasciola hepatica) Virulence

Michael T. Stewart, J. Dalton, S. O'Neill, 2004, Journal of Biological Chemistry.

The M17 leucine aminopeptidase of the malaria parasite Plasmodium falciparum: importance of active site metal ions in the binding of substrates and inhibitors.

J. Dalton, K. Trenholme, D. Gardiner, 2009, Biochemistry.

The helminth derived peptide FhHDM-1 redirects macrophage metabolism towards glutaminolysis to regulate the pro-inflammatory response

N. Snyder, B. O'Brien, S. Donnelly, 2023, Frontiers in Immunology.

Fasciola hepatica hijacks host macrophage miRNA machinery to modulate early innate immune responses

N. Tran, J. Dalton, M. Gama-Carvalho, 2021, Scientific Reports.

An Evaluation of the Fasciola hepatica miRnome Predicts a Targeted Regulation of Mammalian Innate Immune Responses

N. Tran, S. Donnelly, Alison Ricafrente, 2021, Frontiers in Immunology.

Helminths at mucosal barriers--interaction with the immune system.

Sheila Donnelly, Sandra O'Neill, J. Dalton, 2004, Advanced drug delivery reviews.

The Impact of Helminth Infection on the Incidence of Metabolic Syndrome: A Systematic Review and Meta-Analysis

S. Donnelly, R. Fernandez, K. McGrath, 2021, Frontiers in Endocrinology.

Helminth vaccines: from mining genomic information for vaccine targets to systems used for protein expression.

A. Loukas, P. Hotez, J. Dalton, 2003, International journal for parasitology.

Infection by the Helminth Parasite Fasciola hepatica Requires Rapid Regulation of Metabolic, Virulence, and Invasive Factors to Adjust to Its Mammalian Host

J. Dalton, S. O'Neill, P. McVeigh, 2018, Molecular & Cellular Proteomics.

Biochemical characterisation of the recombinant peroxiredoxin (FhePrx) of the liver fluke, Fasciola hepatica

J. Dalton, J. Irwin, G. Mulcahy, 2006, FEBS Letters.

Effectiveness of Helminth Therapy in the Prevention of Allograft Rejection: A Systematic Review of Allogeneic Transplantation

W. Hawthorne, H. Burns, S. Donnelly, 2020, Frontiers in Immunology.

Peroxiredoxin: a central player in immune modulation

J. Dalton, M. Robinson, S. Donnelly, 2010, Parasite immunology.

De-glycosylation of Pichia pastoris-produced Schistosoma mansoni cathepsin B eliminates non-specific reactivity with IgG in normal human serum.

J. Dalton, C. Stack, S. Donnelly, 2005, Journal of immunological methods.

Squamous cell carcinoma antigen 1 is an inhibitor of parasite‐derived cysteine proteases

J. Dalton, G. H. Coombs, J. Mottram, 2007, FEBS letters.

Cysteine Peptidases as Schistosomiasis Vaccines with Inbuilt Adjuvanticity

S. Selim, J. Dalton, Sophie Cotton, 2014, PloS one.

The enigmatic asparaginyl endopeptidase of helminth parasites.

J. Dalton, P. Brindley, M. Robinson, 2009, Trends in parasitology.

Schistosoma mansoni immunomodulatory molecule Sm16/SPO-1/SmSLP is a member of the trematode-specific helminth defence molecules (HDMs)

J. Dalton, Sophie Cotton, K. Thivierge, 2020, PLoS neglected tropical diseases.

Selection of reliable reference genes for the normalisation of gene expression levels following time course LPS stimulation of murine bone marrow derived macrophages

B. O'Brien, J. To, S. Donnelly, 2017, BMC Immunology.

Targeting the PI3K/Akt signaling pathway in pancreatic β‐cells to enhance their survival and function: An emerging therapeutic strategy for type 1 diabetes

B. O'Brien, S. Donnelly, Inah Camaya, 2022, Journal of diabetes.

Characterization of the Plasmodium falciparum M17 Leucyl Aminopeptidase

A. Bell, J. Dalton, J. Grembecka, 2007, Journal of Biological Chemistry.

The Major Secreted Cathepsin L1 Protease of the Liver Fluke, Fasciola hepatica

J. Dalton, L. Brinen, C. Stack, 2007, Journal of Biological Chemistry.

Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase

J. Whisstock, J. Dalton, A. Buckle, 2009, Proceedings of the National Academy of Sciences.

Glycerol-induced seizure : involvement of IL-1β and glutamate

Sheila Donnelly, Marina A. Lynch, M. Lynch, 1999 .

The M18 Aspartyl Aminopeptidase of the Human Malaria Parasite Plasmodium falciparum*

J. Dalton, T. Spielmann, M. Dixon, 2007, Journal of Biological Chemistry.

Commandeering the mammalian Ago2 miRNA network: a newly discovered mechanism of helminth immunomodulation.

N. Tran, S. Donnelly, 2021, Trends in parasitology.

The parasite-derived peptide FhHDM-1 activates the PI3K/Akt pathway to prevent cytokine-induced apoptosis of β-cells

N. Braidy, M. Robinson, J. To, 2021, Journal of Molecular Medicine.

How do parasitic worms prevent diabetes? An exploration of their influence on macrophage and β-cell crosstalk

B. O'Brien, S. Donnelly, Inah Camaya, 2023, Frontiers in endocrinology.

Targeting the master regulator mTOR: a new approach to prevent the neurological of consequences of parasitic infections?

M. Labbate, Michael S. Johnson, B. Saunders, 2017, Parasites & Vectors.

An Integrated Transcriptomics and Proteomics Analysis of the Secretome of the Helminth Pathogen Fasciola hepatica

S. Ranganathan, J. Dalton, M. Robinson, 2009, Molecular & Cellular Proteomics.

Exploring the role of macrophages in determining the pathogenesis of liver fluke infection

B. O'Brien, S. Donnelly, Susel Loli Quinteros, 2022, Parasitology.

Secreted Proteins from the Helminth Fasciola hepatica Inhibit the Initiation of Autoreactive T Cell Responses and Prevent Diabetes in the NOD Mouse

J. Dalton, A. Simpson, B. O'Brien, 2014, PloS one.

Antimicrobial peptides: utility players in innate immunity

M. Robinson, S. Donnelly, Andrew T Hutchinson, 2012, Front. Immun..

From the Cover: Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase

J. Whisstock, J. Dalton, A. Buckle, 2009 .

Characterization of the Plasmodium falciparum M17 Leucyl Aminopeptidase

A. Bell, J. Dalton, J. Grembecka, 2007, Journal of Biological Chemistry.

An integrated transcriptomic and proteomic analysis of the secretome of the helminth pathogen , Fasciola hepatica : proteins associated with invasion and infection of the mammalian host

Ranjeeta Menon, S. Donnelly, Shoba Ranganathan, 2009 .

Helminth Cysteine Proteases Inhibit TRIF-dependent Activation of Macrophages via Degradation of TLR3

J. Dalton, C. Whitchurch, L. Turnbull, 2009, The Journal of Biological Chemistry.